Article
Cell Biology
Shi-Qin Lv, Wutian Wu
Summary: ISP and PAP4 promote nerve regeneration and motor functional recovery after peripheral nerve injury in rats, suggesting their potential therapeutic effects in treating such injuries.
NEURAL REGENERATION RESEARCH
(2021)
Article
Engineering, Biomedical
Philip J. Hanwright, Chenhu Qiu, Jennifer Rath, Yang Zhou, Nicholas von Guionneau, Karim A. Sarhane, Thomas G. W. Harris, Gregory P. Howard, Harsha Malapati, Michael J. Lan, Sashank Reddy, Ahmet Hoke, Hai-Quan Mao, Sami H. Tuffaha
Summary: This study demonstrates the potential of a novel nanoparticle delivery system for targeted and sustained release of IGF-1, leading to improved motor recovery through amelioration of denervation-induced muscle atrophy and SC senescence and enhanced axonal regeneration.
Article
Engineering, Biomedical
Fangguo Liang, Yusheng Yang, Yuyong Chen, Jiajun Xie, Shencai Liu, Zilin Tan, Liangjie Tian, Zhiqiang Yu, Zhanjun Shi, Peigen Xie, Hong Ding, Qinfeng Yang
Summary: In this study, an electroconductive hydrogel loaded with sustained-release analgesic microspheres was designed as a promising therapeutic approach for diabetic peripheral nerve injury. In vitro and in vivo experiments demonstrated that this treatment strategy can enhance nerve regeneration, functional recovery, and pain relief in diabetic patients.
MATERIALS TODAY BIO
(2023)
Review
Biochemistry & Molecular Biology
Trevor Poitras, Douglas W. Zochodne
Summary: Common mechanisms of peripheral axon regeneration are recruited following diverse forms of damage to peripheral nerve axons. Supporting peripheral axon regrowth could be achieved through direct axon support or manipulation of the inflammatory milieu. Understanding the molecular barriers to regrowth and exploiting the downstream signaling pathways that impact neuron growth are promising approaches for promoting adult peripheral axon regeneration. This review emphasizes intrinsic aspects of adult peripheral axon regeneration and highlights several molecular barriers to regrowth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jung Il Lee, Ji Hun Park, Yeong-Rim Kim, Kihak Gwon, Hae Won Hwang, Gayoung Jung, Joo-Yup Lee, Jeong-Yun Sun, Jong Woong Park, Jae Ho Shin, Myoung-Ryul Ok
Summary: This study demonstrates the use of NO-releasing silica nanoparticles to enhance revascularization and improve nerve regeneration in a rat model of peripheral nerve injury, suggesting a potential therapeutic strategy for promoting functional recovery after nerve damage.
NEURAL REGENERATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Raju Poongodi, Ying-Lun Chen, Tao-Hsiang Yang, Ya-Hsien Huang, Kuender D. Yang, Hsin-Chieh Lin, Jen-Kun Cheng
Summary: Various natural polymers and protein polymers have been utilized to create bio-scaffolds for nerve repair, supporting in vitro cell adhesion, mechano-transduction, proliferation, and differentiation, as well as controlled degradation and re-absorption for successful clinical outcomes. Recent advances in 3D bio-printing have also shown promise for nerve regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Qianru He, Fanhui Yu, Meng Cong, Yuhua Ji, Qi Zhang, Fei Ding
Summary: Peripheral nerve repair and functional recovery depend on the rate of nerve regeneration and the quality of target reinnervation. A quantitative proteomic technique was used to analyze the protein expression pattern between injured motor and sensory nerves, revealing 176 proteins with differential expressions. Functional categorization indicated that these differentially expressed proteins are linked to various molecular functions, which might play a crucial role in peripheral nerve regeneration.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Max Y. Y. Jin, Tristan E. Weaver, Adam Farris, Mayank Gupta, Alaa Abd-Elsayed
Summary: While denervation can occur with aging, peripheral nerve injuries often result in loss of function and neuropathic pain. Neuromodulation has shown promise in enhancing peripheral nerve regeneration, but additional interventions are needed to control the direction of reinnervation. More human studies are required to validate findings from animal studies and optimize neuromodulation for functional restoration.
Article
Biochemistry & Molecular Biology
Muhammad Imran, Ghulam Hussain, Arruje Hameed, Iqra Iftikhar, Muhammad Ibrahim, Rahat Asghar, Izzat Nisar, Tahir Farooq, Tanzila Khalid, Kanwal Rehman, Mohammed A. Assiri
Summary: This study screened the functional metabolites of Moringa oleifera and found that they play an important role in accelerated functional recovery after peripheral nerve injury. The extracts from Moringa showed potential in promoting the recovery of sensory and motor functions, as well as controlling oxidative stress and facilitating nerve regeneration. This study highlights the significance of Moringa as a sustainable source of nutritive metabolites and a valuable target for drug development.
Article
Engineering, Biomedical
Long Chen, Xiongbo Song, Zhicheng Yao, Conglai Zhou, Junjun Yang, Qiming Yang, Junrong Chen, Jiarui Wu, Zeyu Sun, Liling Gu, Yi Ma, Shin-Jae Lee, Chi Zhang, Hai-Quan Mao, Li Sun
Summary: An engineered composite membrane, Gel nanofiber-dAM, consisting of gelatin nanofiber membrane and decellularized amniotic membrane, showed improved mechanical properties and biocompatibility, promoting axon regeneration and reducing fibrotic response in peripheral nerve injury repair. It exhibits great potential for clinical translation in surgical treatment of PNI as a fully natural materials-derived off-the-shelf matrix.
Article
Engineering, Biomedical
Jianfeng Pan, Meng Zhao, Xiangjiao Yi, Jianguo Tao, Shaobo Li, Zengxin Jiang, Biao Cheng, Hengfeng Yuan, Feng Zhang
Summary: This study used iPSCs-derived exosomes to supplement ANGs for restoring peripheral nerve defects, and achieved satisfactory regenerative outcomes. This cell-free strategy shows promise for future clinical applications.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Yao Liu, Xiaonong Zhang, Chunsheng Xiao, Bin Liu
Summary: Peripheral nerve injury (PNI) is a complex disease that commonly affects young adults and has limited treatment options and poor clinical outcomes. Tissue-engineered hydrogels have shown promising results in promoting neural tissue regeneration and recovery of impaired neural function. This review discusses recent advances and various therapeutic strategies of hydrogels in peripheral nerve repair, as well as the prospects and challenges in their application for PNI treatment.
MATERIALS TODAY BIO
(2023)
Review
Immunology
Xiaoxuan Tang, Qiaoyuan Li, Tingting Huang, Han Zhang, Xiaoli Chen, Jue Ling, Yumin Yang
Summary: This review mainly discusses the beneficial impact of T-cell subsets in the repair of both peripheral nervous system and central nervous system injuries and introduces studies on various therapies based on T-cell regulation. Further discoveries in T-cell mechanisms and multifunctional biomaterials will provide novel strategies for nerve regeneration.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Peter J. Nicksic, D'Andrea T. Donnelly, Weifeng Zeng, Allison J. Seitz, Samuel O. Poore, Aaron J. Suminski, Aaron M. Dingle
Summary: The study demonstrates that trigeminal nerve stimulation (TNS) or peripheral nerve stimulation (PNS) can improve functional outcomes of peripheral nerve injury in rats. This finding is important in translating the therapy as a non-invasive treatment for high, mixed nerve injuries in humans.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Immunology
Jiawei Xu, Jinkun Wen, Lanya Fu, Liqiang Liao, Ying Zou, Jiaqi Zhang, Junyao Deng, Haowen Zhang, Jingmin Liu, Xianghai Wang, Daming Zuo, Jiasong Guo
Summary: The depletion of RhoA in macrophages has a negative impact on Wallerian degeneration and nerve regeneration, mainly due to impaired migration and phagocytosis of macrophages resulting from disrupted RhoA/ROCK/MLCK pathway. Since previous research has shown that RhoA inhibition in neurons promotes axonal regeneration, the study highlights the importance of considering cellular specificity of RhoA-targeted drugs in future applications for treating peripheral nerve injuries.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Orthopedics
Zhongdi Liu, Na Han, Hailin Xu, Zhongguo Fu, Dianying Zhang, Tianbing Wang, Baoguo Jiang
BMC MUSCULOSKELETAL DISORDERS
(2016)
Article
Neurosciences
Xu Chungui, Bai Lili, Chen Yuhong, Fan Chengming, Hu Zanmin, Xu Hailin, Jiang Baoguo
NEUROSCIENCE LETTERS
(2016)
Article
Behavioral Sciences
Wentao Chen, Tingting Yu, Bo Chen, Yisong Qi, Peixun Zhang, Dan Zhu, Xiaofeng Yin, Baoguo Jiang
BRAIN AND BEHAVIOR
(2016)
Review
Medicine, General & Internal
Baoguo Jiang, Song Liang, Zhong-Ren Peng, Haozhe Cong, Morgan Levy, Qu Cheng, Tianbing Wang, Justin V. Remais
Review
Biotechnology & Applied Microbiology
Zhang Peixun, Han Na, Yuhui Kou, Yin Xiaofeng, Baoguo Jiang
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2017)
Article
Multidisciplinary Sciences
Yichong Zhang, Yuanbo Zhan, Na Han, Yuhui Kou, Xiaofeng Yin, Peixun Zhang
SCIENTIFIC REPORTS
(2017)
Article
Engineering, Biomedical
Dong Bian, Weirui Zhou, Jiuxu Deng, Yang Liu, Wenting Li, Xiao Chu, Peng Xiu, Hong Cai, Yuhui Kou, Baoguo Jiang, Yufeng Zheng
ACTA BIOMATERIALIA
(2017)
Article
Oncology
Yixun Chen, Jian Weng, Duanyang Han, Bo Chen, Mingtai Ma, Youlai Yu, Ming Li, Zhongdi Liu, Peixun Zhang, Baoguo Jiang
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2016)
Article
Oncology
Youlai Yu, Peixun Zhang, Na Han, Yuhui Kou, Xiaofeng Yin, Baoguo Jiang
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2016)
Article
Oncology
Duanyang Han, Yixun Chen, Yuhui Kou, Jian Weng, Bo Chen, Youlai Yu, Peixun Zhang, Baoguo Jiang
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2016)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)