Review
Cell Biology
Manuel Ruiss, Oliver Findl, Martin Kronschlaeger
Summary: Cataract is a leading cause of blindness globally, and surgery is currently the only treatment option. However, complications and limited access to ophthalmic care may arise. With a growing and aging population, there will be an increase in cataract prevalence, presenting a challenge to society. As oxidative stress is a major pathological process in cataract formation, antioxidant supplementation may be a strategy to delay or prevent its progression. Caffeine, a widely consumed antioxidant, shows potential for preventing cataract.
AGEING RESEARCH REVIEWS
(2022)
Article
Biology
Eugene Serebryany, Sourav Chowdhury, Christopher N. Woods, David C. Thorn, Nicki E. Watson, Arthur A. McClelland, Rachel E. Klevit, Eugene Shakhnovich
Summary: Cataract, a protein aggregation disorder, is a common cause of vision loss worldwide. Researchers have discovered that myo-inositol, an abundant lens metabolite, can suppress the aggregation of lens crystallins, suggesting it as a potential strategy to prevent or delay age-onset cataracts.
Article
Biochemistry & Molecular Biology
Chandrika Mittal, Ashwani Kumari, Indranil De, Manish Singh, Ramswaroop Harsolia, Jay Kant Yadav
Summary: Exposure of soluble lens proteins to elevated temperatures leads to the formation of non-fibrillar amyloid-like aggregates, similar to those found in the insoluble fraction of proteins from cataracts.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Ignacio Gutierrez-del-Rio, Sara Lopez-Ibanez, Patricia Magadan-Corpas, Luis Fernandez-Calleja, Alvaro Perez-Valero, Mateo Tunon-Granda, Elisa M. Miguelez, Claudio J. Villar, Felipe Lombo
Summary: Synthetic antioxidant food additives like BHA, BHT and TBHQ are facing challenges due to negative consumer perception, prompting food manufacturers to seek safer natural alternatives. Terpenoids and polyphenols, widely distributed in fruits and vegetables, show broad antioxidant effects and have the potential to replace synthetic antioxidants in food preservation, particularly in preventing lipid oxidation in high fat-containing foods.
Article
Chemistry, Multidisciplinary
Yao Li, Yuxing Li, Xi Liu, Yonghong He, Tian Guan
Summary: The study investigated the cellular mechanisms of cold cataract in young lenses of mice and found that cold cataract formation is associated with uneven distribution of lens proteins and water. The fluctuation degrees of Raman spectroscopy data revealed new mechanistic information about cold cataract formation, showing that opaque regions had higher fluctuation degrees at different temperatures, while transparent regions had lower fluctuation degrees. Additionally, the redistribution of lens proteins and the instability of water molecule structure were observed in regions with cold cataract formation.
FRONTIERS IN CHEMISTRY
(2021)
Article
Public, Environmental & Occupational Health
Parvin Dehghan, Marzieh Nejati, Farhad Vahid, Amir Almasi-Hashiani, Sevda Saleh-Ghadimi, Reza Parsi, Hamed Jafari-Vayghan, Nitin Shivappa, James R. Hebert
Summary: This study investigated the association between dietary inflammatory index (DII), dietary antioxidant index (DAI), and mental health in female adolescents. The results showed the importance of a healthy and anti-inflammatory diet for mental health in this population.
Article
Biochemistry & Molecular Biology
Susanne Weininger, Malte Neudorf, Stefan Groeger, Eric Plato, Robert Broneske, Kay Saalwaechter, Ulrich Weininger, Jochen Balbach
Summary: Crystallin proteins in the human eye lenses play a role in maintaining transparency, light refraction, and UV light protection. Imbalance in the interaction between alpha-, beta-, and gamma-crystallin can lead to cataracts. The research looks into the effects of UV-B radiation on gamma D-crystallin, specifically observing changes in the N-terminal domain. It is found that some photoprotective properties remain in extracts from cataract patients. Additionally, a genetic mutation in the eye lens core of infants with cataracts increases sensitivity to UV-B irradiation.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Physiology
Kevin L. Schey, Romell B. Gletten, Carla V. T. O'Neale, Zhen Wang, Rosica S. Petrova, Paul J. Donaldson
Summary: This article discusses the structure and function of lens AQPs, their impact on water flow, and provides a detailed explanation of age-related changes and their effects on the lens. The article suggests that AQPs could be potential therapeutic targets for the prevention or treatment of cataract and presbyopia.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Elena Martinez-Plaza, Pedro Ruiz-Fortes, Roberto Soto-Negro, Carlos J. Hernandez-Rodriguez, Ainhoa Molina-Martin, Alfonso Arias-Puente, David P. Pinero
Summary: This study found that the Dysfunctional Lens Index (DLI) is correlated with age and pupil diameter, and may be used as a complementary diagnostic measurement for assessing dysfunctional lens syndrome.
Article
Ophthalmology
Guowei Zhang, Min Zhang, Jianfeng Yu, Lihua Kang, Huaijin Guan
Summary: The study demonstrated that Rg1 could effectively prevent lens opacification induced by H2O2, increase antioxidant levels, reduce oxidative damage, and enhance cell viability. Additionally, Rg1 was found to protect the lens against cataracts by locally administering, suggesting its potential therapeutic application in preventing oxidative stress-induced cataracts.
CURRENT EYE RESEARCH
(2021)
Article
Ophthalmology
Sheldon Rowan, Shuhong Jiang, Sarah G. Francisco, Laura C. D. Pomatto, Zhiwei Ma, Xiaodong Jiao, Maria M. Campos, Sandeep Aryal, Shaili D. Patel, Binapani Mahaling, S. Amer Riazuddin, Elia J. Duh, Salil A. Lachke, J. Fielding Hejtmancik, Rafael de Cabo, Paul G. FitzGerald, Allen Taylor
Summary: The study found that aged mice lacking Nrf2 develop cataracts between 11 and 15 months, including advanced cortical, posterior subcapsular, anterior subcapsular, and nuclear cataracts. This offers insight into how defective antioxidant signaling causes different forms of cataracts and could be a useful tool for screening drugs to prevent or delay cataractogenesis in susceptible adults.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Nutrition & Dietetics
Zongbiao Tan, Yang Meng, Lu Li, Yanrui Wu, Chuan Liu, Weiguo Dong, Changzheng Chen
Summary: This study found that dietary fiber intake was positively correlated with the composite dietary antioxidant index (CDAI) in tumor survivors. Multivariable Cox proportional hazards regression models showed that high dietary fiber intake and CDAI levels were associated with reduced risks of all-cause and tumor death in tumor survivors.
Article
Ophthalmology
Eugene Serebryany, David C. Thorn, Liliana Quintanar
Summary: The nuclear region of the lens is metabolically quiescent, but far from inert chemically, with changes in the lens proteome, lipidome, and metabolome after decades of environmental exposures. Crystallins have mechanisms to resist chemical modifications and minimize light-scattering aggregation in the lens over a lifetime. Redox chemistry, mediated by Cys residues, plays a major role in these damages and adaptations, making it a key component of potential therapeutic strategies for preserving lens transparency during aging.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Chemistry, Applied
Antonia Dayane Jenyffer de Farias Marques, Jerffeson de Lima Tavares, Leila Moreira de Carvalho, Thaianaly Leite Abreu, Deyse Alves Pereira, Miriane Moreira Fernandes Santos, Marta Suely Madruga, Lorena Lucena de Medeiros, Taliana Kenia Alencar Bezerra
Summary: The addition of organic coffee husk extract to chicken burgers effectively inhibits lipid oxidation without significant impact on protein oxidation. This additive is considered a potential natural additive that helps reduce agro-industrial by-products generated by the coffee industry.
Article
Health Care Sciences & Services
Haiting Wang, Yongbing Chen
Summary: This study found a significant association between antioxidant-rich diets and reduced risk of aging, particularly in young and middle-aged individuals and non-smokers.
Article
Biochemistry & Molecular Biology
Akinwunmi O. Adeoye, Babatunde Joseph Oso, Ige Francis Olaoye, Habibu Tijjani, Ahmed I. Adebayo
Summary: The study demonstrated the potential inhibitory effects of drugs like lopinavir and remdesivir on coronavirus, suggesting their repurposing as valuable treatments for preventing cellular entry and replication of the virus.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Toxicology
O. K. Ijomone, O. L. Erukainure, P. Shallie, T. Naicker
Summary: Women with a history of pre-eclampsia are at higher risk of developing cardiovascular and neurological diseases later in life. This study found that pre-eclampsia leads to oxidative imbalance, increased acetylcholinesterase activity, and decreased proteolytic and purinergic activities, resulting in neurotoxicity.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Babatunde Joseph Oso, Akinwunmi Oluwaseun Adeoye, Ige Francis Olaoye
Summary: This study demonstrates the potential inhibitory effects of curcumin, allicin, and gingerol on cathepsin K, COVID-19 main protease, and SARS-CoV 3C-like protease. The calculated binding affinities and free energy suggest that curcumin may be a valuable compound for the development of drugs against coronavirus.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Obstetrics & Gynecology
Philemon D. Shallie, Thajasvarie Naicker
Summary: The study found significant upregulation of apoptotic markers SMAC and LAMIN B in HIV-positive patients, while these markers were downregulated in preeclamptic patients, regardless of their HIV status. This suggests that apoptosis promotes deregulation of mitochondrial dynamics in pregnancies complicated by preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xiujun Fan, Shanmugam Muruganandan, Philemon D. Shallie, Sabita Dhal, Matthew Petitt, Nihar R. Nayak
Summary: VEGF signaling is crucial for maintaining the homeostasis of the maternal vascular space in mouse placenta through modulation of TGC development and differentiation, similar to its effect on endothelial cells in other vascular beds.
Article
Neurosciences
Philemon D. Shallie, Adedeji Sulaiman, Motunrayo K. Oladejo, Oluwadamilola F. Shallie, Thajasvarie Naicker
Summary: The study found that early intervention with glutathione has significant therapeutic potential by upregulating VGLUT1 expression and enhancing spatial memory in the IUGR rat model.
IBRO NEUROSCIENCE REPORTS
(2021)
Article
Health Care Sciences & Services
Philemon D. Shallie, Firoza Haffejee
Summary: This study evaluated Nigerian university students' knowledge, attitudes and behavior (KAB) towards COVID-19. The respondents demonstrated good knowledge of COVID-19, which positively influenced their attitudes and behaviors in compliance with safety practices. However, there is a need to intensify health education campaigns, especially targeting the less educated population.
HEALTH SA GESONDHEID
(2022)
Article
Chemistry, Multidisciplinary
Akinwunmi O. Adeoye, John A. Falode, Olabimpe C. Oladipupo, Tajudeen O. Obafemi, Babatunde J. Oso, Ige F. Olaoye
Summary: This study explored the effects of myricetin on liver mitochondria and its potential as an inhibitor for proteins involved in apoptosis. The results showed that myricetin inhibited the opening of mitochondrial pores and reversed lipid peroxidation caused by calcium. It also reduced the expression of caspase 3 and 9 and affected calcium ATPase activity. Molecular docking revealed strong binding affinity between myricetin and the target proteins. The study suggests that myricetin may be useful in managing diseases characterized by excessive apoptosis and in protecting cell membranes from severe damage.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Immunology
Philemon D. Shallie, Thajasvarie Naicker, Nihar R. Nayak
Summary: Preeclampsia and HIV are major burdens to maternal health, especially in low-middle income countries like South Africa. This study examined the impact of the comorbidity of Preeclampsia and HIV on placental stress and neurodevelopment. The findings showed higher maternal weight and blood pressure in the Preeclampsia group compared to the normotensive group, regardless of HIV status. Significant changes were also observed in placental weight, fetoplacental ratio, and placental efficiency coefficient.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2023)
Article
Biotechnology & Applied Microbiology
John Adeolu Falode, Oluwaseun Igbekele Ajayi, Tolulope Victoria Isinkaye, Akinwunmi Oluwaseun Adeoye, Basiru Olaitan Ajiboye, Bartholomew I. C. Brai
Summary: This study aimed to evaluate the anti-diabetic potentials of Justicia carnea extracts in streptozotocin-induced type-1 diabetes in rats. The extracts ameliorated the harmful effects of diabetes in the liver by enhancing liver biomarkers and reducing pro-inflammatory cytokines.
Article
Biochemistry & Molecular Biology
Akinwunmi O. Adeoye, Daniela J. Porta, Maria A. Rivoira, Nestor H. Garcia
Summary: This study demonstrates the positive impact of Coenzyme Q10 (CoQ10) on cardiovascular diseases like hypertension and atherosclerosis, which is attributed to its antioxidant action. CoQ10 shows favorable binding affinity to angiotensin-converting enzyme (ACE) and has potential inhibitory effects on ACE activity, making it a potential candidate for regulating and reducing hypertension. Additionally, both CoQ10 and PCK exhibit drug-like properties and favorable pharmacokinetics and toxicology profiles.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Medicinal
Kehinde Oluseun Sodeinde, Akinwunmi Oluwaseun Adeoye, Adedeji Adesipo, Adebayo A. Adeniyi, John Adeolu Falode, Tajudeen Olabisi Obafemi, Samuel Olalekan Olusanya, Linette Twigge, Jeanet Conradie, Timothy O. Mosaku
Summary: The study showed that /3-stigmasterol and xylopic acid isolated from Anchomanes difformis can reverse the opening of mitochondrial permeability transition pores caused by calcium and glucose, indicating their potential protective effects on cells.
CHINESE HERBAL MEDICINES
(2023)
Article
Biochemical Research Methods
Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye, Oluwafemi Adeleke Ojo, Olaolu Ebenezer Lawal, Yesirat Abimbola Jokomba, Basheer Ajibola Balogun, Akinwunmi Oluwaseun Adeoye, Olawale Rasaq Ajuwon
Summary: This study investigated the antioxidant, cholinergic, monoaminergic, and purinergic activities of flavonoid-rich extract from Dalbergiella welwitschii leaf (FEDW) on oxidative testicular injury. The results showed that FEDW significantly increased antioxidant activity and enzyme levels, as well as zinc and sialic acid levels, while decreasing levels of oxidative damage indicators.
BIOINFORMATICS AND BIOLOGY INSIGHTS
(2022)
Review
Chemistry, Applied
Akinwunmi Adeoye, Atinuke Odugbemi, Tolulope Ajewole
Summary: Aquaporins are integral membrane proteins that facilitate the transportation of water across membranes. They are present in various organisms and have important roles in controlling cell volume and water passage. Aquaporins have distinctive structures and functions, and are involved in physiological processes and clinical disorders.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Akinwunmi O. Adeoye, Babatunde Joseph Oso
Summary: The study revealed that extracts from Vernonia amygdalina leaves have inhibitory effects on amyloid protein aggregation, with aqueous extract showing stronger anti-glycation potential and methanol extract demonstrating better protection on protein thiol groups and inhibition of aggregate formation. Different compounds within the extracts exhibited varying degrees of binding affinity with amyloid beta proteins, suggesting their potential as potent inhibitors of protein aggregation.
ADVANCES IN TRADITIONAL MEDICINE
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)