Article
Emergency Medicine
Sally Mahmoud, Erik Anderson, Aidan Vosooghi, Andrew A. Herring
Summary: This study examined a cohort of patients treated with buprenorphine and phenobarbital or benzodiazepines for concurrent opioid and alcohol withdrawal in the ED. The results showed no serious adverse events related to the medications used for treatment. Further research should focus on optimizing medical therapy and transitioning patients to maintenance treatment for substance use disorders.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Pediatrics
Mary Beth Sutter, Hannah Watson, Nicole Yonke, Sherry Weitzen, Lawrence Leeman
Summary: Treatment of neonatal opioid withdrawal syndrome with morphine versus methadone showed no significant differences in hospital length of stay or length of treatment in this pilot study. However, infants treated with morphine received lower total morphine equivalents compared to those treated with methadone, and the methadone group had more transfers to the Neonatal Intensive Care Unit due to over sedation.
Review
Behavioral Sciences
Sean J. O'Sullivan, James S. Schwaber
Summary: Alcohol and opioids, despite their distinct effects on mammalian systems, share commonalities in withdrawal syndromes, indicating potential similar addiction mechanisms. Neurovisceral feedback may generate antireward effects for both substances. Gut dysbiosis may contribute to alcohol and opioid withdrawal syndromes by stimulating peripheral and neuroinflammation pathways.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Nursing
Deborah Salani, Deana Goldin, Beatriz Valdes, Mary McKay
Summary: Substance use disorders (SUDs) pose serious risks to nurses and patients, emphasizing the importance of early recognition and treatment for maintaining patient safety and professional retention.
AMERICAN JOURNAL OF NURSING
(2022)
Article
Health Care Sciences & Services
Binh Nguyen, Chenyue Zhao, Eric Bailly, Winnie Chi
Summary: This study examines the characteristics of patients initiating buprenorphine treatment via telehealth and its association with treatment outcomes and health outcomes. The findings suggest that telehealth-initiated buprenorphine treatment is associated with reduced opioid overdose rate and improved patient engagement.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Florian Traxler, Haoqi Zhang, Wiratchanee Mahavorasirikul, Katharina Krivanek, Xiang-Hai Cai, Wichai Aiyakool, Martin Pfeiffer, Lothar Brecker, Johann Schinnerl
Summary: Phytochemical investigation of two Tabernaemontana species revealed closely related biosynthetic pathways leading to various alkaloids. Among them, two novel Iboga-type alkaloids and a javaniside derivative were identified for the first time. Bioassays showed that extracts containing Iboga alkaloids had inhibitory effects on insects and cells, while the hydrophilic fractions containing javaniside derivatives had no effects.
Article
Substance Abuse
Scott E. Hadland, Sarah M. Bagley, Mam Jarra Gai, Joel J. Earlywine, Samantha F. Schoenberger, Jake R. Morgan, Joshua A. Barocas
Summary: Among US youth, complications after an initial opioid prescription appear to be relatively rare and are associated with mood/anxiety disorders, substance use, comorbid substance use disorders, and prescriptions involving long-acting opioids or long durations.
Article
Public, Environmental & Occupational Health
Alejandro Salazar, Soledad Moreno-Pulido, Pablo Prego-Meleiro, Jesus Henares-Montiel, Jose Pulido, Marta Donat, Gabriel Sotres-Fernandez, Luis Sordo
Summary: This study found a correlation between prescribed opioid drugs and opioid-related deaths in Spain. This correlation can serve as a tool to monitor legal opioids and potential issues in the illegal market.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Multidisciplinary Sciences
Emery R. Eaves, Jarrett Barber, Ryann Whealy, Sara A. Clancey, Rita Wright, Jill Hager Cocking, Joseph Spadafino, Crystal M. Hepp
Summary: This study characterized the population of neonates with neonatal opioid withdrawal syndrome (NOWS) and mothers who were opioid dependent at the time of giving birth in Arizona, using data from the Arizona Department of Health Services Hospital Discharge Database. The findings indicated that non-Hispanic White and economically disadvantaged women and neonates tend to be part of the populations of interest more frequently than expected. Additionally, unmarried women who are opioid dependent at the time of giving birth were identified more often than expected, suggesting that marital status could be a proxy for support. Additionally, comorbidities associated with neonates who have NOWS and mothers who are opioid dependent were identified.
Review
Endocrinology & Metabolism
Lindsey Parnarouskis, Adam M. Leventhal, Stuart G. Ferguson, Ashley N. Gearhardt
Summary: This study examines the theories of addiction to explain compulsive overeating of highly processed foods. The researchers found evidence that animals experience withdrawal symptoms when reducing or eliminating the intake of these foods, similar to withdrawal from other addictive substances. However, more research is needed to evaluate this phenomenon in humans.
Article
Public, Environmental & Occupational Health
Caitlin E. Martin, Bhushan Thakkar, DaShaunda D. H. Taylor, Derek A. Chapman
Summary: This study aimed to report the sex-specific prevalence of COVID-19 test positivity among opioid use disorder patients and assess the sex-specific rates of opioid overdose and mortality. The study found that opioid overdose had a greater impact on the health of patients than COVID-19. The COVID-19 test positivity rates were similar across sexes in the opioid use disorder cohort, but racial disparities emerged with notable sex-related variation.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Health Care Sciences & Services
Haiden A. Huskamp, Lauren Riedel, Isabella Campa, Alisa B. Busch, Sherri Rose, Ateev Mehrotra, Lori Uscher-Pines
Summary: A survey was conducted to understand OUD clinician views and preferences regarding telemedicine. The results showed a decrease in the percentage of OUD visits delivered via telemedicine from December 2020 to March 2022. Most clinicians believed that telemedicine had positive impacts for themselves and their patients.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Emergency Medicine
Anthony Spadaro, Brit Long, Alex Koyfman, Jeanmarie Perrone
Summary: This narrative review provides an evidence-based update on the epidemiology, prevention strategies, and management of buprenorphine precipitated opioid withdrawal (BPOW) for emergency clinicians. BPOW can be prevented by waiting for the onset of moderate opioid withdrawal symptoms and a sufficient amount of time since last full opioid agonist use before buprenorphine administration. Alternative dosing strategies may impact the development of BPOW. Treating BPOW with additional buprenorphine and adjunctive medications has shown effectiveness in case reports.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Neurosciences
M. L. Eckard, S. G. Kinsey
Summary: Gabapentin may be effective in reducing cannabis withdrawal symptoms, particularly somatic and affective symptoms, but may act independently of endocrine stress activation.
Article
Multidisciplinary Sciences
Yan Yan, Bridget Truitt, Junyi Tao, Sean Michael Boyles, Danielle Antoine, William Hulme, Sabita Roy
Summary: The cycle of substance use disorder leading to dependence is a complex process involving multiple neurocircuitries and brain regions. This study focused on the amygdala, a core brain region involved in withdrawal, anxiety, and depressive-like behaviors, to examine the transcriptional changes in different cell types during substance use disorder. Using single-cell RNA sequencing, the researchers classified all cell types in the mouse amygdala and identified distinct gene expression changes in glial cells during dependence compared to naive or withdrawal state. The findings provide unique insights into the biological processes involved in substance use disorder and the alterations in the brain.
Article
Cardiac & Cardiovascular Systems
Kenneth Alper, Rong Bai, Nian Liu, Steven J. Fowler, Xi-Ping Huang, Silvia G. Priori, Yanfei Ruan
CARDIOVASCULAR TOXICOLOGY
(2016)
Article
Psychology, Clinical
Thomas Kingsley Brown, Kenneth Alper
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2018)
Article
Clinical Neurology
Kenneth Alper, Ruben Kuzniecky, Chad Carlson, William B. Barr, Charles K. Vorkas, Jignasa G. Patel, Angela L. Carrelli, Karen Starner, Peter L. Flom, Orrin Devinsky
ANNALS OF NEUROLOGY
(2008)
Editorial Material
Clinical Neurology
Jocelyn Soffer, Kenneth R. Alper, Samuel Basch
Article
Behavioral Sciences
Jesse G. Brand, Leslie A. Burton, Sarah G. Schaffer, Kenneth R. Alper, Orrin Devinsky, William B. Barr
EPILEPSY & BEHAVIOR
(2009)
Article
Behavioral Sciences
J. M. DuBois, O. Devinsky, C. Carlson, R. Kuzniecky, B. T. Quinn, K. Alper, T. Butler, K. Starner, E. Halgren, T. Thesen
EPILEPSY & BEHAVIOR
(2011)
Article
Behavioral Sciences
Jesse G. Brand, Monica Rivera Mindt, Sarah G. Schaffer, Kenneth R. Alper, Orrin Devinsky, William B. Barr
EPILEPSY & BEHAVIOR
(2012)
Article
Plant Sciences
Kenneth Alper, Maarten E. A. Reith, Henry Sershen
JOURNAL OF ETHNOPHARMACOLOGY
(2012)
Review
Medicine, Legal
Kenneth R. Alper, Marina Stajic, James R. Gill
JOURNAL OF FORENSIC SCIENCES
(2012)
Review
Immunology
Souhel Najjar, Daniel M. Pearlman, Kenneth Alper, Amanda Najjar, Orrin Devinsky
JOURNAL OF NEUROINFLAMMATION
(2013)
Article
Neurosciences
Kenneth Alper, Manoj Raghavan, Robert Isenhart, Bryant Howard, Werner Doyle, Roy John, Leslie Prichep
Article
Multidisciplinary Sciences
Tamara Antonio, Steven R. Childers, Richard B. Rothman, Christina M. Dersch, Christine King, Martin Kuehne, William G. Bornmann, Amy J. Eshleman, Aaron Janowsky, Eric R. Simon, Maarten E. A. Reith, Kenneth Alper
Article
Clinical Neurology
Kenneth Alper, Jaini Shah, Bryant Howard, E. Roy John, Leslie S. Prichep
PSYCHIATRY RESEARCH-NEUROIMAGING
(2013)
Article
Pharmacology & Pharmacy
Kenneth Alper, Bin Dong, Relish Shah, Henry Sershen, K. Yaragudri Vinod
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Medicine, General & Internal
Kenneth Alper
FRONTIERS IN MEDICINE
(2020)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)