Article
Biochemistry & Molecular Biology
Xiyi Hu, Zhenguo Liu, Yuntao Lu, Xuepeng Chi, Kai Han, Hongfang Wang, Ying Wang, Lanting Ma, Baohua Xu
Summary: 10-HDA has a hypoglycemic effect on diabetic mice and acts through the PI3K/AKT/GSK3 beta signaling pathway.
Article
Plant Sciences
Maria Aslam, Nawazish-i-Husain Syed, Shah Jahan
Summary: The experimental extract and fractions of Caralluma tuberculata significantly decreased glycogen content in liver and skeletal muscle tissues. Analysis by qRT-PCR showed that glucose transport via GLUT-2 was profoundly declined by ME and HF, and the expression of genes related to glycogenesis and gluconeogenesis was significantly affected.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Kongphop Parunyakul, Krittika Srisuksai, Sawanya Charoenlappanit, Narumon Phaonakrop, Sittiruk Roytrakul, Wirasak Fungfuang
Summary: Cordycepin may help prevent hepatic metabolism in T1DM by regulating the expression of energy-related proteins and UPS to maintain cell survival, as observed in the study on streptozotocin-induced T1DM mice. The improvement in liver function with cordycepin treatment was related to changes in metabolic pathways and protein expression. Further research is needed to explore the therapeutic potential of cordycepin in metabolic mechanisms.
Article
Biochemistry & Molecular Biology
Hassan N. Althurwi, Gamal A. Soliman, Rehab F. Abdel-Rahman, Reham M. Abd-Elsalam, Hanan A. Ogaly, Mohammed H. Alqarni, Faisal F. Albaqami, Maged S. Abdel-Kader
Summary: This study assessed the effect of Vulgarin, obtained from Artemisia judaica, on the antidiabetic potential of glibenclamide using streptozotocin to induce diabetes. The combination treatment of glibenclamide and Vulgarin showed better glycemic improvement in diabetic rats compared to glibenclamide alone, through its antioxidant effect and modulation of gene expression in the liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Mohammad Babaei, Shahin Alizadeh-Fanalou, Alireza Nourian, Sahar Yarahmadi, Navid Farahmandian, Mohsen Nabi-Afjadi, Iraj Alipourfard, Elham Bahreini
Summary: The study investigated the effects of Securigera securidaca seed extract (HESS), glibenclamide, and their combination on fertility in hyperglycemic rats. HESS improved sperm parameters but had limited restorative effects on damaged testicular tissue, while glibenclamide was more effective in restoring tissue characteristics and sperm parameters, especially when combined with HESS.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shiva Gholizadeh-Ghaleh Aziz, Roya Naderi, Nima Mahmodian
Summary: This study demonstrated that tropisetron effectively mitigates liver injury induced by diabetes, and its effects are comparable to glibenclamide. These findings suggest that tropisetron could be a promising therapeutic agent in alleviating diabetic complications.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Ivonne Helena Valderrama, Sandra Milena Echeverry, Diana Patricia Rey, Ingrid Andrea Rodriguez, Fatima Regina Mena Barreto Silva, Geison M. Costa, Luis Fernando Ospina-Giraldo, Diana Marcela Aragon
Summary: This study evaluated the anti-diabetic activity of the butanol fraction from Physalis peruviana in induced type 2 diabetic mice. The results showed that the butanol fraction at a higher dose (100 mg/kg) had better regulation of blood glucose levels in mice, improved lipid metabolism, and protected against oxidative stress.
Article
Biochemistry & Molecular Biology
Petra Meszaros, Sara Kovacs, Gyozo Kulcsar, Melinda Paskuj, Attila Almasi
Summary: Phenolic drug molecules can be metabolized by enterocytes in the small intestine, with conjugation reactions playing a significant role. Pathologic conditions such as hyperglycemia and diabetes can alter the metabolic pattern and lead to oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Salman Khan, Hammad Ullah, Daniele Giuseppe Buccato, Kannan R. R. Rengasamy, Jianbo Xiao, Maria Daglia
Summary: This study demonstrated that the total alkaloids extracted from S. wightiana have potential hypoglycaemic activity, as they significantly reduce hyperglycaemia and improve body weight and food intake. Additionally, TASW reduces levels of triglycerides, cholesterol, and LDL, while increasing HDL and Hb levels, and decreases serum liver enzyme activity. These findings suggest that TASW is non-toxic at the tested doses and exhibits potential for hypoglycaemic effects.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Pharmacology & Pharmacy
Sajed Amjadi, Fatemeh Shahnaz, Behrooz Shokouhi, Yadollah Azarmi, Mohammadreza Siahi-Shadbad, Saeed Ghanbarzadeh, Maryam Kouhsoltani, Alireza Ebrahimi, Hamed Hamishehkar
Summary: Encapsulation of rutin into nanophytosomes showed enhanced therapeutic effects in diabetic rats by controlling hyperglycemia and hyperlipidemia, regulating liver marker enzymes, improving antioxidant defenses, and alleviating diabetic complications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Suresh Kumar, Suman Chowdhury, Ajay Razdan, Deepa Kumari, Ram Singh Purty, Heera Ram, Pramod Kumar, Prasunpriya Nayak, Sunil Dutt Shukla
Summary: There is a growing body of evidence indicating the increased risk of neuronal impairment in hyperglycemia conditions like diabetes, but piperine shows protective effects on STZ-induced hyperglycemic rats, potentially offering a new strategy for treating Alzheimer's disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Rita Silva-Reis, Ana I. I. Faustino-Rocha, Jessica Silva, Abigael Valada, Tiago Azevedo, Lara Anjos, Lio Goncalves, Maria de Lurdes Pinto, Rita Ferreira, Artur M. S. Silva, Susana M. M. Cardoso, Paula A. A. Oliveira
Summary: This study assessed a humane endpoint scoring system to detect animal suffering in a rat model of type 2 diabetes. Results showed that weight loss, polyuria, polyphagia, abnormal posture, abdominal distension, and abnormal stool appearance were the most effective parameters to evaluate humane endpoints in this rat model. This study is important for defining humane endpoints in a rat model of type 2 diabetes.
Article
Infectious Diseases
Jenna Wurster, Rachel L. Peterson, Peter Belenky
Summary: The microbiome plays key roles in human health and the host metabolic environment may influence microbiome function during antibiotic challenge.
Article
Biochemistry & Molecular Biology
Zheling Feng, Zhujun Fang, Cheng Chen, Chi Teng Vong, Jiali Chen, Ruohan Lou, Maggie Pui Man Hoi, Lishe Gan, Ligen Lin
Summary: This study identified polysaccharides and flavonoids as the key components responsible for the anti-hyperglycemic effect of Cyclocarya paliurus leaves, which work by enhancing insulin secretion and improving diabetic complications. Further refinement of the clinical application of Cyclocarya paliurus is needed based on these findings.
Article
Food Science & Technology
Ju Ri Ham, Hae-In Lee, Yongjin Lee, Hyun-Jin Lee, Hyun Young Kim, Young-Jin Son, Mi-Kyung Lee, Mi Ja Lee
Summary: This study demonstrated the dual beneficial effects of a newly developed naked barley Betaone extract on hyperglycemia and hepatosteatosis in HFD/STZ-induced T2DM mice by modifying hepatic glucose and lipid metabolism.
JOURNAL OF CEREAL SCIENCE
(2021)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)