Article
Clinical Neurology
Song Li, Zhengzhi Wu, Weidong Le
Summary: In Western medicine, dementia affects cognition, mental health, and physical abilities, while Traditional Chinese Medicine explains it from the perspectives of brain dystrophy, Spleen-Kidney weakness, Blood stasis, and Phlegm stagnation. Ancient Chinese physicians believed that dementia manifests not only as cognitive symptoms but also as psychiatric disorders and sleep disturbance, offering various treatment methods.
ALZHEIMERS & DEMENTIA
(2021)
Article
Biochemistry & Molecular Biology
Xianhai Li, Qiang Tang, Fanbo Meng, Pufeng Du, Wei Chen
Summary: The application of network pharmacology has advanced the scientific interpretation of traditional Chinese medicine in disease treatment mechanisms. The development of the INPUT platform has integrated data from multiple resources, offering an automatic analysis of network pharmacology and facilitating drug discovery research.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Lei Li, Man Wang, Jikuai Chen, Juelin Chen, Yawei Wang, Minghao Zhao, Qing Song, Shuogui Xu
Summary: As global warming continues, heat waves are becoming more frequent and intense, leading to an increase in the incidence of heat stroke. Heat stroke is associated with significant morbidity and mortality, and further research is urgently needed to address this issue. Traditional Chinese medicine offers potential treatment methods, including herbal therapies and external treatments, which may provide clinical benefits and research directions for heat stroke.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Xulong Yang, Tiancheng Wang, Yiping Tang, Yawen Shao, Yaqin Gao, Peng Wu
Summary: This study assessed the curative effect of traditional Chinese medicine (TCM) in the treatment of hepatolenticular degeneration (HLD) and liver fibrosis (LF) through meta-analysis. Network pharmacology and molecular dynamics simulation were used to investigate the mechanism of TCM against LF in HLD. The results showed that the addition of Chinese herbal medicine (CHM) in treating HLD had a higher clinical effective rate compared to western medicine alone. Network pharmacological experiments and molecular dynamics simulation revealed the potential targets and pathways involved in treating LF with TCM.
FRONTIERS IN MEDICINE
(2023)
Review
Plant Sciences
Si-min Qi, Jing-tian Zhang, Hong-yan Zhu, Zi Wang, Wei Li
Summary: Glaucoma is the second most common blindness in the world, affecting the life quality of patients. Traditional Chinese Medicines (TCM) have become an important content in ophthalmology, characterized by more targets and lower toxicity. This review presents an overview of glaucoma pathogenesis and therapeutic effects of TCM, as well as the application of acupuncture.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Qian Li, Ciqiu Tian, Xiangjie Liu, Dinglin Li, Hao Liu
Summary: Osteoporosis is a metabolic bone disorder characterized by decreased bone mass and compromised microarchitecture, which leads to bone deterioration and increased fracture risk. The main causes of osteoporosis are increased osteoclast activity or quantity and decreased osteoblast viability. Various mechanisms, including estrogen shortage, aging, chemical agents, and decreased mechanical loads, have been linked to osteoporosis, and recently inflammation and oxidative stress have also been found to play a role. Currently, bisphosphonates and selective estrogen receptor modulators (SERMs) are the primary medications used to treat osteoporosis, but they do not target inflammation and oxidative stress-induced osteoporosis and have limitations due to side effects. Traditional Chinese medicine (TCM) has a long history in osteoporosis treatment and is considered safe. This review focuses on botanical drugs that have an effect on inflammation and oxidative stress-induced osteoporosis, discussing the pharmacologically active ingredients and pathways, aiming to discover more safe and effective drugs for osteoporosis treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xuan Wang, Taiyi Wang, Shuwen Ding, Yu-Ling Ma
Summary: Xin Su Ning (XSN) is a patented multicomponent medicine developed by Prof. Shuwen Ding of Shandong University, with significant efficacy in treating cardiac ventricular arrhythmia, especially those induced by cardiac ischemia and viral myocarditis. Its clinical use and pharmacological properties have been supported by clinical trials and cellular electrophysiological studies, which demonstrate its potential as an effective antiarrhythmic agent according to traditional Chinese medicine theory.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Plant Sciences
Yuan-yuan Ren, Xiao-rui Zhang, Ting-na Li, Yi-jia Zeng, Jin Wang, Qin-wan Huang
Summary: Galla chinensis is a traditional Chinese medicine with diverse pharmacological properties used for over 1400 years. Research has focused on its traditional uses, botanical characteristics, chemical composition, pharmacology, and toxicology, showing potential therapeutic benefits for various diseases. Further studies are needed on the relationship between its components and biological activities, as well as quality control and dynamics of chemical accumulation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ning Wang, Ninglin Du, Yonghong Peng, Kuo Yang, Zixin Shu, Kai Chang, Di Wu, Jian Yu, Caiyan Jia, Yana Zhou, Xiaodong Li, Baoyan Liu, Zhuye Gao, Runshun Zhang, Xuezhong Zhou
Summary: This study explores the regularities of multidrug combinations in herbal prescriptions using a complex network approach. The weight distribution of herbal combinations follows a power law, while a negative correlation between clustering coefficients and node degree in the herbal combination network suggests hierarchical properties. The research also reveals that a more hierarchical prescription leads to better effects and aligns with the Jun-Chen-Zuo-Shi principle in traditional Chinese medicine formula theories, providing guidance for multidrug combination development and clinical use in chronic diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Yinyin Wang, Hongbin Yang, Linxiao Chen, Mohieddin Jafari, Jing Tang
Summary: Traditional Chinese medicine has been practiced for treating human diseases for thousands of years, where one of its advantages is the principle of herb compatibility in TCM formulae, consisting of multiple herbs to achieve maximum treatment effects. A network-based method was proposed to quantify interactions in herb pairs, revealing that frequently used herb pairs tend to affect neighboring proteins in the human interactome. The study provides a network pharmacology framework to explore herb combinations more effectively based on network topology.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Integrative & Complementary Medicine
Chen Liang, Binbin Zhang, Ruichun Li, Shiwen Guo, Xiaoxuan Fan
Summary: In this study, a network pharmacology method was used to analyze the underlying mechanism of the traditional Chinese medicine prescription Yi Qi Qu Yu Jie Du Fang (YYQQJDF) in treating glioblastoma multiforme (GBM). The results showed that YYQQJDF may exert its effects in GBM treatment by activating the G protein-coupled receptor (GPCR) signaling pathway and regulating hypoxia-related processes. Molecular docking and cell assays confirmed that the core active ingredients of YYQQJDF significantly inhibited the proliferation and invasion of glioma cells.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Pharmacology & Pharmacy
Concepcion Obon, Diego Rivera, Elena Fonolla, Francisco Alcaraz, Latifa Attieh
Summary: This study combines ethnobotany and ethnopharmacology field work techniques to study the traditional herbal mixtures with flowers in Greece and the Eastern Mediterranean countries. The botanical ingredients of these mixtures are identified and their local medicinal uses recorded, with analysis using morphological and multivariate analysis techniques.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Genhao Fan, Menglin Liu, Jia Liu, Yuhong Huang, Wei Mu
Summary: Traditional Chinese medicine (TCM) has obvious advantages in preventing and treating ischemic stroke (IS) and is scientifically proven to be effective. This review summarizes commonly used TCM medicines and their mechanisms in the treatment of IS.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Facheng Bai, Zhenguang Huang, Jun Luo, Yue Qiu, Shuwen Huang, Chenglong Huang, Taotao Liu, Hongliang Zhang, Dandan Wang
Summary: This study analyzed the status and hotspots of traditional Chinese medicine (TCM) in cancer research from 2002 to 2022. The publication rate of TCM cancer research has been steadily increasing, with China being the leading country in terms of published articles and international collaborations. The most studied cancer types in TCM research are breast cancer, colorectal cancer, gastric cancer, liver cancer, and lung cancer. Pathway-related apoptosis, anti-inflammation, and oxidative stress are the hotspots in TCM's anti-cancer mechanism. Metabolomics combined with network pharmacology is the main research method.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Wan Zhong, Si-Yu Tao, Xiang Guo, Xiao-Fang Cheng, Qing Yuan, Chu-Xing Li, Hong-Yuan Tian, Song Yang, Diwas Sunchuri, Zhu-Ling Guo
Summary: This study used network pharmacology to investigate the molecular mechanism of Astragalus membranaceus (AM) in the treatment of oral ulcer. It was found that AM can regulate multiple signal pathways through multiple targets to treat oral ulcer.
Article
Pharmacology & Pharmacy
B. Siva Lokesh, Prakash Haloi, V. Badireenath Konkimalla
Summary: In this study, PEITC-loaded biocompatible nanoparticles were successfully developed using BSA and PEG as biodegradable polymers. The optimized nanoparticles exhibited smaller particle size, good stability, higher drug encapsulation efficiency and drug loading. The nanoparticles showed sustained release of PEITC and demonstrated enhanced antibacterial activity compared to free PEITC. In a mice infection model, PEITC nanoparticles significantly reduced the area of infection and bacterial viability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Article
Nanoscience & Nanotechnology
Shounak Roy, Prakash Haloi, Rajat Choudhary, Saurabh Chawla, Monika Kumari, V. Badireenath Konkimalla, Amit Jaiswal
Summary: The rapid emergence of multidrug-resistant bacterial strains poses a global threat to public health. Hospital-acquired infections in diabetic and burn patients impede wound healing and result in high mortality. Researchers have developed a new biomaterial, MCP glycosheets, that synergistically destroys pathogenic strains and promotes wound healing. These glycosheets efficiently eradicate both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus within a short period of time, leading to rapid and highly efficient in vivo wound disinfection and healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biology
Onat Kadioglu, Faranak Bahramimehr, Mona Dawood, Nuha Mahmoud, Mohamed Elbadawi, Xiaohua Lu, Yagmur Buelbuel, Jana Agnieszka Schulz, Lisa Kraemer, Marie-Kathrin Urschel, Zoe Kuenzli, Leila Abdulrahman, Fadwa Aboumaachar, Lajien Kadalo, Le Van Nguyen, Sara Shaidaei, Nawal Thaher, Kathrin Walter, Karolin Christiane Besler, Andreas Spuller, Markus Munder, Henry Johannes Greten, Thomas Efferth
Summary: RNA-sequencing is utilized to develop individualized therapy concepts for cancer patients based on their tumor-specific mutational profiles. In this study, drugs and inhibitors were identified through virtual drug screening of FDA-approved drugs and mining the Drug Gene Interaction (DGI) database for missense mutated proteins in 35 tumors. The approach offers new treatment options for patients with refractory tumors that do not respond to standard chemotherapy.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Prakash Haloi, B. Siva Lokesh, Saurabh Chawla, V. Badireenath Konkimalla
Summary: A study reported a method to treat rheumatoid arthritis (RA) by co-delivering methotrexate (MTX) and phenethyl isothiocyanate (PEITC) using a sodium alginate-pluronic F127 in situ hydrogel formulation. The co-delivery of MTX and PEITC in nanoparticulate form enhanced stability and solubility, and facilitated greater penetration into arthritic tissues. The method significantly reduced chronic inflammation, delayed bone erosion, and improved joint morphology in RA rats.
Article
Medicine, Research & Experimental
Jasmin Taubenschmid-Stowers, Michael Orthofer, Anna Laemmerer, Christian Krauditsch, Marianna Rozsova, Christian Studer, Daniela Loetsch, Johannes Gojo, Lisa Gabler, Matheus Dyczynski, Thomas Efferth, Astrid Hagelkruys, Georg Widhalm, Andreas Peyrl, Sabine Spiegl-Kreinecker, Dominic Hoepfner, Shan Bian, Walter Berger, Juergen A. Knoblich, Ulrich Elling, Moritz Horn, Josef M. Penninger
Summary: The natural compound Artemisinin is widely used as an antimalarial drug and has potential for anticancer therapy. Through screening with yeast and haploid stem cells, it has been discovered that the porphyrin biosynthesis pathway is crucial for the cytotoxicity of Artemisinin. In various human brain tumor models, a combination treatment of Artemisinin and the porphyrin enhancer 5-aminolevulinic acid sensitizes and kills brain tumor cells.
EMBO MOLECULAR MEDICINE
(2023)
Article
Chemistry, Applied
Inas Y. Younis, Rana M. Ibrahim, Ali. M. El-Halawany, Mohamed-Elamir F. Hegazy, Thomas Efferth, Engy Mohsen
Summary: In this study, LC-QTOF-MS and multivariate statistical tools were used to analyze the composition differences of dragon fruit peel and pulp from Egypt, Germany, Philippines, and China. It was found that dragon fruits from China and Egypt were the most distinct due to their high betalains content. Moreover, different extracts from dragon fruit showed different activities as inhibitors of alpha-glucosidase and AGE formation, as well as antioxidants.
Article
Pharmacology & Pharmacy
Mohamed Elbadawi, Joelle C. Boulos, Mona Dawood, Min Zhou, Waseem Gul, Mahmoud A. ElSohly, Sabine M. Klauck, Thomas Efferth
Summary: The proto-oncogenic transcription factor c-MYC is a key player in tumorigenesis, cellular proliferation, and cell death control. This study aimed to investigate the anticancer activity and molecular mechanisms of the artemisinin dimer isoniazide in drug-sensitive and multidrug-resistant leukemia cells. The compound showed potent growth inhibitory activity, good binding with c-MYC, downregulated c-MYC expression, and induced DNA damage, apoptosis, and autophagy.
Editorial Material
Nutrition & Dietetics
Haroon Khan, Thomas Efferth, Silvia Tejada
FRONTIERS IN NUTRITION
(2023)
Article
Integrative & Complementary Medicine
Laetitia M. Youmbi, Yves S. D. Makong, Armelle T. Mbaveng, Simplice B. Tankeo, Ghislain W. Fotso, Bruno L. Ndjakou, Jean D. Wansi, Veronique P. Beng, Norbert Sewald, Bonaventure T. Ngadjui, Thomas Efferth, Victor Kuete
Summary: This study aimed to identify the cytotoxic constituents of Brucea antidysenterica and demonstrate their mode of induction of apoptosis on cancer cell lines. The results showed that Brucea antidysenterica and its constituents have potential antiproliferative effects and can induce apoptosis through caspase activation, alteration of mitochondrial membrane potential, and increased reactive oxygen species levels.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Pharmacology & Pharmacy
Min Zhou, Joelle C. Boulos, Ejlal A. Omer, Hadi Amiri Rudbari, Tanja Schirmeister, Nicola Micale, Thomas Efferth
Summary: The study selected two palladium (II) complexes with double chlorine or double iodine substitution, which showed the best cytotoxicity against drug-sensitive leukemia cells. Surprisingly, these complexes induced a novel mode of cell death called parthanatos. This study suggests that these complexes may be potential drug candidates to overcome tumor resistance to apoptosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Julia Schaefer, Vincent Julius Kloesgen, Ejlal A. Omer, Onat Kadioglu, Armelle T. Mbaveng, Victor Kuete, Andreas Hildebrandt, Thomas Efferth
Summary: Cancer therapy is often hindered by drug resistance and severe side effects. Phytochemicals are a valuable resource for developing less toxic drugs. Bioinformatics can simplify the drug development process. This study analyzed 375 phytochemicals and identified six compounds with potential anticancer activity and P-gp inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Anand Kar, Durgesh Mahar, Sagarika Biswas, Debolina Chakraborty, Thomas Efferth, Sunanda Panda
Summary: This study aimed to evaluate the effect of Ficus religiosa leaf extract in ameliorating hypothyroidism in rats and identify the major bioactive compounds responsible for this activity. The results showed that FL extract could improve hypothyroidism, and the major compounds betulinic acid, chlorogenic acid, and quinic acid may increase thyroid hormone levels by interacting with thyroid hormone receptor and TSH receptor through molecular docking analysis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Assia I. Drif, Bharathi Avula, Ikhlas A. Khan, Thomas Efferth
Summary: This study investigated the inhibitory activities of secondary metabolites from chamomile against COX2, an enzyme involved in inflammation and cancer development. It also evaluated the cytotoxicity of these compounds on cancer cell lines. Myricetin, a compound found in chamomile tea, was further studied to determine its effects on tumor cells and its potential as a therapeutic agent. Overall, this study provides insight into the molecular mechanisms of chamomile secondary metabolites and their potential in cancer prevention or treatment.
APPLIED SCIENCES-BASEL
(2023)
Article
Oncology
Joelle C. Boulos, Manik Chatterjee, Letian Shan, Thomas Efferth
Summary: Hematological neoplasms are difficult to cure, and new treatment approaches targeting c-MYC are needed. In this study, adapalene, an FDA-approved drug, was identified as a potential c-MYC inhibitor, providing hope for the development of new anticancer medications. Adapalene showed cytotoxicity against multiple myeloma cells and decreased c-MYC expression and transcriptional activity, resulting in cell cycle arrest, DNA damage, and induction of apoptosis and autophagy.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)