Article
Food Science & Technology
Dushyant Kshatriya, Lihong Hao, Nicholas T. Bello
Summary: This study found that raspberry ketone has a dose-dependent metabolic signature in white adipose tissue of mice, which is associated with weight control and loss of righting reflex. Raspberry ketone can regulate gene expression related to weight control and metabolic effects in adipose tissue.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Cell Biology
Ji Hyeon Kang, Hyung Sik Kim, Seon Hyang Park, Ye Seon Kim, Yoe-Sik Bae
Summary: Obesity is a metabolic disorder caused by an imbalance of energy intake and consumption, and its chronic inflammation can lead to various complications. This study investigates the effects of WKYMVm, an anti-inflammatory agent, against obesity. The results show that WKYMVm attenuates body weight gain, improves insulin sensitivity, ameliorates hepatic steatosis and adipose tissue hypertrophy induced by a high fat diet. WKYMVm also improves lipid metabolism and leptin signaling, suggesting its potential as an anti-obesity agent.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Engineering, Chemical
Seung-Min Lee, So-Hyeon Bok, Min-Hee Kim, Ki Sun Lee, Dae-Hun Park
Summary: In 2016, 13% of the global adult population was obese. By 2030, this number is projected to reach 34%. Obesity is a non-communicable disease that can lead to various health problems. Study results showed that P. erosus effectively controls obesity by regulating leptin-C/EBPa-PPARgamma and FAS levels, and preventing lipid droplet accumulation.
Article
Gastroenterology & Hepatology
Maria Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodriguez, Luis Leiva-Vega, Aranzazu Pintor-Chocano, Daniel Horrillo, Lourdes Hernandez-Cosido, Jorge L. Torres, Eva Novoa, Ruben Nogueiras, Gema Medina-Gomez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio
Summary: Obesity leads to chronic low-grade inflammation, causing diabetes, steatosis, and insulin resistance. Activation of the p38 pathway in macrophages plays a crucial role in this inflammation, suggesting p38 inhibition as a potential treatment for obesity comorbidities. However, lack of p38 activation in myeloid cells worsens high-fat diet-induced obesity, diabetes, and steatosis. Deficient p38 activation increases macrophage IL-12 production, leading to inhibition of hepatic FGF21 and reduction of thermogenesis in the brown fat.
Article
Neurosciences
Mirjam C. M. Wever, Floor van Meer, Lisette Charbonnier, Daniel R. Crabtree, William Buosi, Angeliki Giannopoulou, Odysseas Androutsos, Alexandra M. Johnstone, Yannis Manios, Claire L. Meek, Jens J. Holst, Paul A. M. Smeets
Summary: This study found that fasting ghrelin levels are positively related to neural FCR in brain regions related to visual attention, while leptin levels are positively related to high-calorie FCR in regions associated with assessing reward value. The results suggest that individuals with higher ghrelin and leptin levels may be more attracted to high-calorie foods when hungry.
Article
Endocrinology & Metabolism
Veronica Pena-Leon, Cintia Folgueira, Silvia Barja-Fernandez, Raquel Perez-Lois, Natalia Da Silva Lima, Marion Martin, Violeta Heras, Sara Martinez-Martinez, Paola Valero, Cristina Iglesias, Mannon Duquenne, Omar Al-Massadi, Daniel Beiroa, Yara Souto, Miguel Fidalgo, Rasika Sowmyalakshmi, Diana Guallar, Juan Cunarro, Cecilia Castelao, Ana Senra, Patricia Gonzalez-Saenz, Rocio Vazquez-Cobela, Rosaura Leis, Guadalupe Sabio, Helge Mueller-Fielitz, Markus Schwaninger, Miguel Lopez, Sulay Tovar, Felipe F. Casanueva, Emmanuel Valjent, Carlos Dieguez, Vincent Prevot, Ruben Nogueiras, Luisa M. Seoane
Summary: Delayed weaning can protect rats from diet-induced obesity in adulthood by increasing thermogenesis and energy expenditure. This protective mechanism is mediated by liver-produced FGF21 signaling to the hypothalamus.
Article
Biochemistry & Molecular Biology
Paola Sousa Santos, Caio Cesar Ruy, Cintia Rabelo Paiva Caria, Alessandra Gambero
Summary: The study found that sucralose consumption can reduce weight gain in high-fat diet-fed mice, but has no effect on weight gain in mice fed with a normal diet. In high-fat diet-fed mice, sucralose supplementation improved glycemic homeostasis, hepatic steatosis, and increased energy expenditure.
Article
Nutrition & Dietetics
Natalia Wawrzyniak, Joanna Suliburska, Bartosz Kulczynski, Pawel Kolodziejski, Pawel Kurzawa, Anna Gramza-Michalowska
Summary: The study showed that calcium-enriched pumpkin can reduce bone marrow adipocytes, decrease serum leptin levels, and subsequently reduce fat content, potentially leading to a decrease in weight gain commonly observed after menopause.
Review
Pharmacology & Pharmacy
Joshua R. Barton, Adam E. Snook, Scott A. Waldman
Summary: The use of obese mouse models, especially the 'obese' and 'diabetic' mice, has revolutionized obesity research by revealing the powerful satiety hormone leptin. Research on leptin therapy and its clinical response in humans, as well as the study of targetable mechanisms for genetic forms of human obesity using modern mouse genetics, are discussed in this article. Additionally, mouse models of neuromodulation are described for unraveling neural circuits that govern appetite and metabolism, presenting new opportunities for the development of safe and effective obesity therapy.
EXPERT OPINION ON DRUG DISCOVERY
(2021)
Review
Nutrition & Dietetics
Sarah Hubner, Julie Blaskewicz Boron, Karsten Koehler
Summary: This systematic review examined the impact of exercise on appetite in older adults, finding that exercise and physical activity may modulate resting hunger and satiety in this population. Decreases in fasting leptin and glucose hormones suggest that exercise promotes satiety sensitivity in adults aged 60+. The findings suggest that engaging in exercise programs may provide a meaningful avenue for improving chronic and functional disease burden in later life by promoting appetite control and balanced energy intake.
FRONTIERS IN NUTRITION
(2021)
Article
Endocrinology & Metabolism
Maria Andrikopoulou, Sunil K. Panigrahi, Giselle D. Jaconia, Cynthia Gyamfi-Bannerman, Richard M. Smiley, Gabrielle Page-Wilson
Summary: The study revealed that during early pregnancy, there are specific adaptations in the central regulation of energy balance, including reduced transport of leptin into the brain and decreased melanocortin tone favoring increased appetitive drive.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Critical Care Medicine
Zichen Song, Leilei Meng, Zhixiang He, Jing Huang, Fang Li, Jingjing Feng, Zhuoran Jia, Yue Huang, Wei Liu, Anding Liu, Haoshu Fang
Summary: The study reveals the protective role of LBP in hepatic mitochondria against LPS-induced damage, potentially through the LBP-PPAR alpha-CYP4a2 signaling pathway.
Article
Biochemistry & Molecular Biology
Junewoo Na, Byong Seo Park, Doohyeong Jang, Donggue Kim, Thai Hien Tu, Youngjae Ryu, Chang Man Ha, Marco Koch, Sungchil Yang, Jae Geun Kim, Sunggu Yang
Summary: This study extensively characterizes the AgRP, POMC, and dopaminergic neurons in the hypothalamic arcuate nucleus (Arc). The distinct anatomical and physiological properties of these neurons in response to appetite-regulating hormones are identified. This research highlights the importance of hypothalamic Arc neurons in appetite control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Farah Javaid, Malik Hassan Mehmood, Bushra Shaukat
Summary: The study found that Alpinia officinarum has antihypertensive and diuretic activities, providing a rationale for its medicinal use in cardiovascular ailments.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Camilla O. D. Araujo, Renan M. Montenegro, Amanda P. Pedroso, Virginia O. Fernandes, Ana Paula D. R. Montenegro, Annelise B. de Carvalho, Lila M. Oyama, Carla S. C. Maia, Eliane B. Ribeiro
Summary: This study found that patients with congenital generalized lipodystrophy (CGL) have appetite disturbances compared to eutrophic individuals, with lower fasting acylated ghrelin levels and no physiological drop after meal intake. These disturbances seem to play a role in hunger attenuation and satiety, but not in acute satiation.
Article
Chemistry, Multidisciplinary
Sunhyo Jeong, Michung Yoon
ACTA PHARMACOLOGICA SINICA
(2011)
Article
Biochemistry & Molecular Biology
Sunhyo Jeong, Michung Yoon
EXPERIMENTAL AND MOLECULAR MEDICINE
(2009)
Article
Plant Sciences
Jinmi Lee, Kyungsil Chae, Juran Ha, Byung-Young Park, Hee Suk Lee, Sunhyo Jeong, Min-Young Kim, Michung Yoon
JOURNAL OF ETHNOPHARMACOLOGY
(2008)
Article
Nutrition & Dietetics
Sunhyo Jeong, Michung Yoon
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2012)
Article
Endocrinology & Metabolism
Sunhyo Jeong, Michung Yoon
Article
Endocrinology & Metabolism
S Jeong, M Han, H Lee, M Kim, J Kim, CJ Nicol, BH Kim, JH Choi, KH Nam, GT Oh, M Yoon
METABOLISM-CLINICAL AND EXPERIMENTAL
(2004)
Article
Endocrinology & Metabolism
S Jeong, M Kim, MY Han, H Lee, J Ahn, M Kim, YH Song, C Shin, KH Nam, TW Kim, GT Oh, M Yoon
METABOLISM-CLINICAL AND EXPERIMENTAL
(2004)
Article
Pharmacology & Pharmacy
M Yoon, H Lee, S Jeong, JJ Kim, CJ Nicol, KW Nam, M Kim, BG Cho, GT Oh
BRITISH JOURNAL OF PHARMACOLOGY
(2003)
Article
Biochemistry & Molecular Biology
M Yoon, S Jeong, H Lee, M Han, JH Kang, EY Kim, M Kim, GT Oh
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2003)
Article
Biochemistry & Molecular Biology
M Yoon, S Jeong, CJ Nicol, H Lee, MY Han, JJ Kim, YJ Seo, C Ryu, GT Oh
EXPERIMENTAL AND MOLECULAR MEDICINE
(2002)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)