Article
Cardiac & Cardiovascular Systems
Shiyang Song, Chih-Liang Tien, Hao Cui, Paul Basil, Ningxia Zhu, Yingyun Gong, Wenbo Li, Hui Li, Qiying Fan, Jong Min Choi, Weijia Luo, Yanfeng Xue, Rui Cao, Wenjun Zhou, Andrea R. Ortiz, Brittany Stork, Vatsala Mundra, Nagireddy Putluri, Brian York, Maoping Chu, Jiang Chang, Sung Yun Jung, Liang Xie, Jiangping Song, Lilei Zhang, Zheng Sun
Summary: This study investigates the function of cardiac Rev-erb in heart diseases and the relationship between cardiac molecular clock dysfunction and the progression of naturally occurring human heart diseases. The researchers found that Rev-erb knockout in mice leads to dilated cardiomyopathy and heart failure. They also discovered the role of cardiac molecular clock in the obesity paradox and found altered temporal patterns of cardiac Rev-erb gene expression in human hearts with dilated cardiomyopathy. The findings suggest that targeting myocardial bioenergetics downstream of Rev-erb may be a potential approach for treating heart failure and dilated cardiomyopathy.
Article
Geriatrics & Gerontology
Suriya Prausmueller, Gregor Heitzinger, Noemi Pavo, Georg Spinka, Georg Goliasch, Henrike Arfsten, Cornelia Gabler, Guido Strunk, Christian Hengstenberg, Martin Huelsmann, Philipp E. Bartko
Summary: The paradoxical association between high BMI and better outcome in heart failure patients is examined in this study. The researchers found that malnutrition significantly changes the impact of BMI on prognosis, with obese patients who are also malnourished having a worse outcome compared to well-nourished patients with normal weight.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Biochemistry & Molecular Biology
Giandomenico Bisaccia, Fabrizio Ricci, Sabina Gallina, Angela Di Baldassarre, Barbara Ghinassi
Summary: The myocardium burns a significant amount of ATP within the mitochondria, crucial for its functions. Mitochondrial dysfunction is linked to a wide range of heart diseases and can contribute to the development of heart failure. Targeting mitochondrial function may be a potential treatment strategy for heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Roberto Spoladore, Giuseppe Pinto, Francesca Daus, Sara Pezzini, Damianos Kolios, Gabriele Fragasso
Summary: In dilated cardiomyopathy (DCM), heart failure occurs due to the stretching and thinning of the heart muscle, resulting in an abnormal cardiac metabolism and energetic inefficiency. The optimal metabolic environment for a failing heart is still unknown and debated. Previous studies have shown intriguing findings in increasing glucose oxidation, but none of the drugs have been tested in large-scale clinical trials. Other studies suggest that increasing fatty acid oxidation and raising ketone body levels may benefit the treatment of metabolic dysfunction in heart failure. Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have shown improvement in cardiac function by increasing ketone body levels, and may provide a potential therapeutic approach. This review aims to identify the best metabolic therapeutic approach for DCM patients and explore the effects of different drugs on cardiac metabolism, with a special focus on SGLT2i.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Kyra K. Peczkowski, Mohammed A. Mashali, Nancy S. Saad, Austin Hare, Courtney M. Campbell, Bryan A. Whitson, Nahush A. Mokadam, Paul M. L. Janssen
Summary: The study found that nonfailing hearts generally have higher EAT content compared to end-stage failing hearts, and there is no strong correlation between EAT quantity and BMI in both nonfailing and failing hearts. Atrial EAT is closely correlated with ventricular EAT in both nonfailing and failing hearts.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Medicine, Research & Experimental
Xiaoguang Wu, Yi Li, Shuchen Zhang, Xiang Zhou
Summary: Cell death is a significant factor in cardiovascular disease pathophysiology. Ferroptosis, a regulated cell death form characterized by iron overload and lipid hydroperoxide accumulation, is closely associated with various diseases and plays critical roles in cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, and heart failure. Targeting ferroptosis may offer potential novel therapeutic strategies for cardiovascular diseases.
Review
Cardiac & Cardiovascular Systems
Mahmoud Abdellatif, Simon Sedej, Guido Kroemer
Summary: NAD(+) plays a crucial role in metabolic health and age-related diseases, with supplementation showing positive effects. Decline in NAD(+) pools is associated with cardiovascular disease risk factors, and replenishment can improve related conditions.
Article
Biochemistry & Molecular Biology
Ieva Rinkunaite, Egidijus Simoliunas, Milda Alksne, Gabriele Bartkute, Siegfried Labeit, Virginija Bukelskiene, Julius Bogomolovas
Summary: Myocarditis is an inflammatory disease that can lead to sudden death and chronic heart failure. The molecular mechanisms during the post-myocarditis phase are not well understood. This study suggests that ANKRD1, a stress-responsive protein, may play a role in cardiac remodeling after myocarditis.
Article
Cardiac & Cardiovascular Systems
Danielle J. Beetler, Katelyn A. Bruno, Damian N. Di Florio, Erika J. Douglass, Swikriti Shrestha, Carsten Tschoepe, Madeleine W. Cunningham, Jan Krejci, Julie Bienertova-Vasku, Sabine Pankuweit, Dennis M. McNamara, Eun-Seok Jeon, Sophie van Linthout, Lori A. Blauwet, Leslie T. Cooper, DeLisa Fairweather
Summary: This study aimed to investigate the sex and age differences in soluble ST2 (sST2) levels for various cardiovascular diseases (CVDs). Using ELISA kit, sST2 levels were measured in patients with myocarditis, cardiomyopathy, coronary artery disease (CAD), myocardial infarct (MI), and congestive heart failure (CHF) and compared to controls without CVDs. The results showed that myocarditis occurred in younger patients around the age of 40, while other CVDs were more common in individuals around the age of 60. There were significant differences in sST2 levels between sexes in myocarditis and cardiomyopathy, but not in other CVDs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Yuting Guo, Wei Zhang, Xinger Zhou, Shihao Zhao, Jian Wang, Yi Guo, Yichao Liao, Haihui Lu, Jie Liu, Yanbin Cai, Jiao Wu, Mingzhi Shen
Summary: Ferroptosis, an iron-dependent regulated cell death, has been shown to be closely related to various cardiovascular diseases. This article reviews the contributions of ferroptosis to cardiovascular diseases and discusses potential strategies for treating these diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zhangwei Chen, Danbo Lu, Baoling Qi, Yuan Wu, Yan Xia, Ao Chen, Su Li, Huiru Tang, Juying Qian, Junbo Ge
Summary: This study measured serum carnitine levels in heart failure patients and found that all 25 carnitines were increased in these patients, with 20 being independently associated with heart failure diagnosis. In non-ischemic dilated cardiomyopathy patients, seven carnitines were identified to independently increase the diagnostic probability. Adding isobutyryl-L-carnitine and stearoyl-L-carnitine to clinical factors improved the accuracy of DCM-HF diagnosis. Certain carnitine levels were found to independently predict the risk of death and rehospitalization in heart failure patients. Therefore, serum carnitines can serve as diagnostic, prognostic, and etiological biomarkers in heart failure.
Review
Endocrinology & Metabolism
Stamatia Simati, Alexander Kokkinos, Maria Dalamaga, Georgia Argyrakopoulou
Summary: The obesity paradox refers to the observation that certain chronic diseases show a protective association between body mass index (BMI) and clinical outcomes. However, this association may be influenced by factors such as limitations of BMI, unintended weight loss due to chronic illness, different phenotypes of obesity, and cardiorespiratory fitness levels. Recent evidence suggests that cardioprotective medications, obesity duration, and smoking status also play a role in the obesity paradox.
CURRENT OBESITY REPORTS
(2023)
Review
Pathology
Abeer Al-Masri
Summary: Heart disease is a leading cause of death globally. Recent research indicates that long non-coding RNAs play a role in causing cell death in different cardiovascular diseases, offering potential new treatments for heart diseases.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew N. Rosenbaum, Jeffrey B. Geske, John M. Stulak, Sudhir S. Kushwaha, Alfredo L. Clavell, Atta Behfar
Summary: This study investigated the relationship between intrinsic left ventricular hemodynamics and reverse remodeling on continuous flow left ventricular assist device (CF-LVAD) therapy. The results showed significant correlations between peak LV dP/dt and tau with reverse remodeling, and tau was identified as a prognostic marker.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Linjuan Guo, Xiao Liu, Peng Yu, Wengen Zhu
Summary: The obesity paradox exists in patients with heart failure with preserved ejection fraction (HFpEF) regardless of comorbid atrial fibrillation (AF).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Genetics & Heredity
Adam Waring, Andrew Harper, Silvia Salatino, Christopher Kramer, Stefan Neubauer, Kate Thomson, Hugh Watkins, Martin Farrall
Summary: This study introduces methods for gene association and variant interpretation that detect clustering of rare missense variants in Mendelian disease genes, which can enhance disease-gene discovery. The statistical methods presented in this study are more powerful and computationally faster than alternative methods, and can effectively integrate ACMG criteria to provide strong evidence of pathogenicity for variants of uncertain significance.
JOURNAL OF MEDICAL GENETICS
(2021)
Article
Endocrinology & Metabolism
Zahra Raisi-Estabragh, Luca Biasiolli, Jackie Cooper, Nay Aung, Kenneth Fung, Jose M. Paiva, Mihir M. Sanghvi, Ross J. Thomson, Elizabeth Curtis, Julien Paccou, Jennifer J. Rayner, Konrad Werys, Henrike Puchta, Katharine E. Thomas, Aaron M. Lee, Stefan K. Piechnik, Stefan Neubauer, Patricia B. Munroe, Cyrus Cooper, Steffen E. Petersen, Nicholas C. Harvey
Summary: The study found a positive association between bone health and vascular health with consistent patterns in men and women. Blood biomarkers played an important role in mediating the association, with different directions of effect, but did not fully explain the observed effects.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrew Apps, Ladislav Valkovic, Mark Peterzan, Justin Y. C. Lau, Moritz Hundertmark, William Clarke, Elizabeth M. Tunnicliffe, Jane Ellis, Damian J. Tyler, Stefan Neubauer, Oliver J. Rider, Christopher T. Rodgers, Albrecht Ingo Schmid
Summary: Phosphorus spectroscopy is an effective method for studying cardiac energetics and can provide valuable information about myocardial conditions through the calculation of different phosphorus compound ratios. This study introduces a method to accurately measure Pi by overcoming interference from 2,3-DPG signals, and demonstrates the stability of myocardial Pi/PCr and pH at rest and during stress.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Computer Science, Artificial Intelligence
Yan Xia, Le Zhang, Nishant Ravikumar, Rahman Attar, Stefan K. Piechnik, Stefan Neubauer, Steffen E. Petersen, Alejandro F. Frangi
Summary: A new robust approach called Image Imputation Generative Adversarial Network (I2-GAN) is proposed to learn and infer missing slices in cardiac magnetic resonance sequences, improving accuracy of cardiac volume measurements. Experimental results show significant improvements in missing slice imputation for CMR using this method.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Cardiac & Cardiovascular Systems
Cole B. Hirschfeld, Maurizio Dondi, Thomas N. B. Pascual, Mathew Mercuri, Joao Vitola, Ganesan Karthikeyan, Nathan Better, John J. Mahmarian, Salah E. Bouyoucef, Henry Hee-Seung Bom, Vikram Lele, Vincent Peter C. Magboo, Erick Alexanderson, Adel H. Allam, Mouaz H. Al-Mallah, Albert Flotats, Scott Jerome, Philipp A. Kaufmann, Osnat Luxenburg, S. Richard Underwood, Madan M. Rehani, Jenia Vassileva, Diana Paez, Andrew J. Einstein
Summary: This study established worldwide and regional diagnostic reference levels and achievable administered activities for SPECT MPI, showing significant differences between regions and emphasizing the importance of standardized reporting methods for improving the validity and comparability of regional DRLs.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Genetics & Heredity
Andrew R. Harper, Anuj Goel, Christopher Grace, Kate L. Thomson, Steffen E. Petersen, Xiao Xu, Adam Waring, Elizabeth Ormondroyd, Christopher M. Kramer, Carolyn Y. Ho, Stefan Neubauer, Rafik Tadros, James S. Ware, Connie R. Bezzina, Martin Farrall, Hugh Watkins
Summary: The study identified 12 genome-wide significant susceptibility loci for HCM, showing a strong polygenic influence, especially for sarcomere-negative HCM. A genetic risk score influenced the odds of HCM and phenotypic severity in carriers of sarcomere variants. Mendelian randomization identified diastolic blood pressure as a key modifiable risk factor for sarcomere-negative HCM.
Article
Cardiac & Cardiovascular Systems
Judit Simon, Kenneth Fung, Marton Kolossvary, Mihir M. Sanghvi, Nay Aung, Jose Miguel Paiva, Elena Lukaschuk, Valentina Carapella, Bela Merkely, Marcio S. Bittencourt, Julia Karady, Aaron M. Lee, Stefan K. Piechnik, Stefan Neubauer, Pal Maurovich-Horvat, Steffen E. Petersen
Summary: Data from the UK Biobank showed that regular alcohol intake was independently associated with marginally increased left and right ventricular volumes in men, and increased left atrium volume in women, in an asymptomatic middle-aged population. The study suggests only a minimal relationship between regular alcohol consumption and cardiac morphology and function.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Zahra Raisi-Estabragh, Amine M'Charrak, Celeste McCracken, Luca Biasiolli, Maddalena Ardissino, Elizabeth M. Curtis, Nay Aung, Claudia K. Suemoto, Clare Mackay, Sana Suri, Thomas E. Nichols, Nicholas C. Harvey, Steffen E. Petersen, Stefan Neubauer
Summary: The study found that better cognitive performance was associated with certain cardiovascular magnetic resonance (CMR) measures in participants from the UK Biobank, suggesting a link between brain and cardiovascular health. These associations remained significant even after adjusting for various confounding factors.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Afifah Mohamed, Maciej Marciniak, Wilby Williamson, Odaro J. Huckstep, Winok Lapidaire, Angus McCance, Stefan Neubauer, Paul Leeson, Adam J. Lewandowski
Summary: Preterm-born adults show altered left ventricular structure and function in response to systolic blood pressure elevation, indicating increased susceptibility to cardiac remodeling. Additional primary prevention strategies targeting cardiovascular risk reduction in this population may be necessary.
Article
Cardiac & Cardiovascular Systems
Moritz J. Hundertmark, Olorunsola F. Agbaje, Ruth Coleman, Jyothis T. George, Rolf Grempler, Rury R. Holman, Hanan Lamlum, Jisoo Lee, Joanne E. Milton, Heiko G. Niessen, Oliver Rider, Christopher T. Rodgers, Ladislav Valkovic, Eleanor Wicks, Masliza Mahmod, Stefan Neubauer
Summary: Empagliflozin has shown significant benefits in reducing HF hospitalization and cardiovascular mortality. The EMPA-VISION trial aims to study the effects of empagliflozin on cardiac energy metabolism using MRS and CMR, shedding light on its mechanistic action in HF patients.
Article
Computer Science, Artificial Intelligence
Yan Xia, Nishant Ravikumar, John P. Greenwood, Stefan Neubauer, Steffen E. Petersen, Alejandro F. Frangi
Summary: The study presents a novel super-resolution algorithm based on conditional generative adversarial networks for generating high-quality cardiac MR images, which benefits subsequent image analyses and demonstrates superior performance in experiments.
MEDICAL IMAGE ANALYSIS
(2021)
Review
Cardiac & Cardiovascular Systems
Zahra Raisi-Estabragh, Nicholas C. Harvey, Stefan Neubauer, Steffen E. Petersen
Summary: The UK Biobank is a valuable health research resource with a large sample size and comprehensive health tracking data. The incorporation of imaging studies enhances the dataset, providing more detailed information for interdisciplinary health research.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Geriatrics & Gerontology
Zahra Raisi-Estabragh, Celeste McCracken, Jackie Cooper, Kenneth Fung, Jose M. Paiva, Mohammed Y. Khanji, Elisa Rauseo, Luca Biasiolli, Betty Raman, Stefan K. Piechnik, Stefan Neubauer, Patricia B. Munroe, Nicholas C. Harvey, Steffen E. Petersen
Summary: The study found that individuals with adverse baseline cardiovascular magnetic resonance phenotypes had a higher likelihood of testing positive for COVID-19, independent of traditional cardiovascular risk factors. Therefore, observational reports of cardiovascular involvement after COVID-19 may partly reflect pre-existing cardiac conditions.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Marco Spartera, Guilherme Pessoa-Amorim, Antonio Stracquadanio, Adam Von Ende, Alison Fletcher, Peter Manley, Stefan Neubauer, Vanessa M. Ferreira, Barbara Casadei, Aaron T. Hess, Rohan S. Wijesurendra
Summary: This study systematically investigated the reproducibility and temporal stability of left atrial 4D flow in atrial fibrillation and sinus rhythm subjects. The results showed that peak velocity and vorticity are the most reproducible and temporally stable novel biomarkers, robust to changes in heart rate, blood pressure, and differences in heart rhythm.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Cardiac & Cardiovascular Systems
Fabrizio Ricci, Nay Aung, Sabina Gallina, Filip Zemrak, Kenneth Fung, Giandomenico Bisaccia, Jose Miguel Paiva, Mohammed Y. Khanji, Cesare Mantini, Stefano Palermi, Aaron M. Lee, Stefan K. Piechnik, Stefan Neubauer, Steffen E. Petersen
Summary: This study established CMR-derived age- and sex-specific reference values for mitral annular (MA) and tricuspid annular (TA) dimensions and tethering indices in truly healthy Caucasian adults. The reference ranges presented may improve the distinction between normal and pathological states, prompting the identification of subjects who may benefit from advanced cardiac imaging for annular sizing and planning of valvular interventions.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
