Review
Biochemistry & Molecular Biology
Junya Hata, Yuki Harigane, Kanako Matsuoka, Hidenori Akaihata, Kei Yaginuma, Satoru Meguro, Seiji Hoshi, Yuichi Sato, Soichiro Ogawa, Motohide Uemura, Yoshiyuki Kojima
Summary: Benign prostatic hyperplasia (BPH) is a chronic proliferative disease mainly characterized by stromal proliferation. Although aging and androgen have been considered risk factors, recent studies suggest the involvement of androgen-independent factors, such as inflammation, in BPH development. In this study, whole-genome gene expression analysis using a stromal-dominant BPH rat model revealed activated immune response-related pathways and complement classical pathways. Moreover, the autoimmune reaction triggered complement pathway activation in the proliferative process of BPH. Understanding the role of androgen-independent factors, like immune responses, contributes to unraveling the pathogenesis of BPH and may lead to new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Liang Pan, Shiyu Su, Yuanyuan Li, Di Liu, Lingyu Shen, Haiying Wang, Jiayu Wen, Hui Hu, Ruwen Zheng
Summary: The effects of acupuncture and finasteride on the expression of oestrogen receptors (ERs) alpha and beta in testosterone-induced benign prostatic hyperplasia (BPH) in rats were investigated. The results showed that both acupuncture and finasteride significantly improved the distribution of ERs and could improve BPH. Additionally, ER beta mRNA expression in the finasteride group was significantly different compared to the control and acupuncture groups, suggesting a potential mechanism of action for the treatment of BPH.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Plant Sciences
Hyo-Jung Kim, Bo -Ram Jin, Hyo-Jin An
Summary: This study confirmed the efficacy of Psoralea corylifolia L. seed against BPH by regulating prostate cell proliferation and apoptosis, showing therapeutic potential in both in vitro cell lines and in vivo rat models.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bo-Ram Jin, Chae-Young Lim, Hyo-Jung Kim, Minho Lee, Hyo-Jin An
Summary: The study shows that MitoQ, a mitochondria-targeted antioxidant, has therapeutic effects in benign prostatic hyperplasia (BPH) models by inhibiting androgen receptor (AR) and NOD-like receptor family pyrin domain-containing 3 (NLRP3) signaling. Molecular modeling reveals the interaction between DHT, AR, NLRP3, and the inhibitory effects of MitoQ on AR and NLRP3. MitoQ administration alleviates prostate enlargement and exerts anti-proliferative and antioxidant effects in BPH rats by suppressing the AR and NLRP3 signaling pathways.
Article
Biochemistry & Molecular Biology
Jowon Jang, Junhui Song, Jiyun Lee, Sung-Kwon Moon, Bokyung Moon
Summary: Resveratrol inhibits abnormal proliferation of prostate stromal cells by inducing cell cycle arrest, suppressing multiple signaling pathways, reducing molecular markers affecting prostate development, and promoting apoptosis. These findings suggest that resveratrol may be beneficial for the prevention or treatment of prostatic hyperplasia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Hyo-Jung Kim, Byung-Hak Kim, Bo-Ram Jin, Sang Jae Park, Hyo-Jin An
Summary: Purple corn extract (PCE) has ameliorative effects on benign prostatic hyperplasia (BPH) by reducing androgen receptor (AR) expression and inhibiting the PI3K/AKT signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Xueni Wang, Junjie Zhu, Huimin Yan, Mengyao Shi, Qiaoqi Zheng, Yu Wang, Yan Zhu, Lin Miao, Xiumei Gao
Summary: Kaempferol has been identified as a natural compound that inhibits tumor development in androgenic related prostate cancer and suppresses testosterone-induced benign prostatic hyperplasia (BPH) via modulation of the androgen receptor function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Tiziana Genovese, Marika Cordaro, Rosalba Siracusa, Enrico Gugliandolo, Alessio Filippo Peritore, Livia Interdonato, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Daniela Impellizzeri
Summary: The study revealed that ultra-micronized um-PEA/Baic can reduce prostate weight and DHT production in BPH-induced rats, while modulating apoptotic and inflammatory pathways as well as oxidative stress.
Article
Cell Biology
Bo-Ram Jin, Hyo-Jin An
Summary: Benign prostatic hyperplasia (BPH) is a common chronic disease in men over 50, and studies have shown that chronic inflammation is associated with its progression. Berberine, a natural compound found in various plants, has been shown to alleviate BPH-induced pathological alterations, suppress inflammatory markers, and regulate macrophage activation via NF-kappa B signaling pathway inhibition in animal models. Furthermore, in vitro studies demonstrated that Berberine can inhibit inflammation and cell proliferation in prostatic cells exposed to macrophage conditioned medium.
Article
Medicine, Research & Experimental
Bo Wang, Di Pan, Yong Ban, Zhaolin Sun, Ye Tian, Guangheng Luo
Summary: This study found that androgens play an important role in regulating prostatic microvessel density in SD rats, and a decrease in DHT concentration can lead to a decrease in prostatic MVD, while increasing DHT concentration can lead to an increase in prostatic MVD. Additionally, prostatic MVD can gradually increase with increasing estrogen concentration.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Jiang Liu, Junchao Zhang, Xun Fu, Shu Yang, Yan Li, Jianmin Liu, Michael E. DiSanto, Ping Chen, Xinhua Zhang
Summary: Benign prostatic hyperplasia (BPH) is a common disease in elderly men, characterized by prostatic enlargement and lower urinary tract symptoms (LUTs). Pathological processes of prostate hyperplasia are related to cell proliferation and apoptosis imbalance, inflammation, epithelial-mesenchymal transition (EMT) and growth factors. Cell adhesion molecules (CAMs), such as integrins and cadherins, play important roles in both physiological and pathological processes of BPH. Targeting CAMs may have potential therapeutic value for BPH treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Hyo-Jung Kim, Bo -Ram Jin, Hyo-Jin An
Summary: Excessively activated TGF-131 exacerbates BPH by triggering EMT and cell differentiation. HSP, a flavanone in citrus peels, shows safe anti-cancer activity and inhibits prostate cancer cell growth. This study explores the therapeutic effect of HSP in BPH models and reveals its underlying mechanisms. HSP inhibits prostate cell proliferation and reduces inflammatory and mesenchymal markers by blocking TGF-131 activation, providing evidence for a new therapeutic approach against BPH.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Kyung-Hyun Kim, Geum-Lan Hong, Yae-Ji Kim, Hui-Ju Lee, Ju-Young Jung
Summary: LLGL2 regulates autophagosome formation in prostate cells and affects their proliferation. These findings provide a better understanding of the mechanism behind the impact of LLGL2 on prostate cell proliferation.
Review
Immunology
Dehong Cao, Ruonan Sun, Lei Peng, Jinze Li, Yin Huang, Zeyu Chen, Bo Chen, Jin Li, Jianzhong Ai, Lu Yang, Liangren Liu, Qiang Wei
Summary: This article provides a comprehensive review of the role of inflammation in the pathogenesis and progression of benign prostatic hyperplasia (BPH). Inflammation plays a significant role in the occurrence and development of BPH, and its mechanisms include tissue damage, autoimmunity, and interaction with androgens. Early intervention in prostate tissue inflammation during treatment can slow down the progression of BPH, and combining standard therapies with anti-inflammatory measures may offer new insights for BPH treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Sha-sha Wang, Kai Li, Zhiwei Liu, Shukang Gui, Nian Liu, Xiangyun Liu
Summary: The study demonstrated that aerobic exercise could slow fat mass gain, improve BPH-related indicators, reduce blood lipid levels, and alleviate BPH symptoms in obese mice by regulating the AR/androgen/PI3K/AKT signaling pathway.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Endocrinology & Metabolism
Gillian A. Gray, Christopher I. White, Raphael F. P. Castellan, Sara J. McSweeney, Karen E. Chapman
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2017)
Article
Pharmacology & Pharmacy
Dongxing Zhu, Nabil A. Rashdan, Karen E. Chapman, Patrick W. F. Hadoke, Vicky E. MacRae
VASCULAR PHARMACOLOGY
(2016)
Article
Dermatology
Hui M. Liew, Colin W. Tan, Clement K. M. Ho, Jade N. Chee, Mark J. A. Koh
PEDIATRIC DERMATOLOGY
(2017)
Article
Pathology
Nicky Josman, Nancy W. S. Tee, Matthias Maiwald, Liat Hui Loo, Clement K. M. Ho
JOURNAL OF CLINICAL PATHOLOGY
(2018)
Article
Medical Laboratory Technology
Hong Liu, Lingkai Wong, Sharon Yong, Qinde Liu, Tang Lin Teo, Tong Kooi Lee, Tze Ping Loh, Sunil Kumar Sethi, Moh Sim Wong, Shelia Marie Delos Santos Cosio, Clement K. M. Ho, Johnson Weng Sung Setoh, Sok Fong Maria Lim, Grace Lay Lay Lee, Hafash Khalid, Sharine Lim, Choong-Weng Lam, Mee-Yin Lee, Chin Pin Yeo, Pallavi Ravikiran Chincholkar, Robert Hawkins, Bih-Yann Ng
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2019)
Article
Multidisciplinary Sciences
Leen Vandermosten, Thao-Thy Pham, Sofie Knoops, Charlotte De Geest, Natacha Lays, Kristof Van der Molen, Christopher J. Kenyon, Manu Verma, Karen E. Chapman, Frans Schuit, Karolien De Bosscher, Ghislain Opdenakker, Philippe E. Van den Steen
NATURE COMMUNICATIONS
(2018)
Letter
Pathology
Jun Guan Tan, Rashida F. Vasanwala, Fabian Yap, Ngee Lek, Clement K. M. Ho
JOURNAL OF CLINICAL PATHOLOGY
(2019)
Editorial Material
Biochemistry & Molecular Biology
Karen E. Chapman
Article
Immunology
Johnson Weng Sung Setoh, Clement Kam Man Ho, Chee Fu Yung, Clarence Tam, Yelen, Nancy Wen Sim Tee
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2019)
Article
Medicine, General & Internal
Karen M. L. Tan, Anne H. Y. Chu, See Ling Loy, Victor Samuel Rajadurai, Clement K. M. Ho, Yap Seng Chong, Neerja Karnani, Yung Seng Lee, Fabian Kok Peng Yap, Shiao-yng Chan
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2020)
Article
Neurosciences
Jessica R. Ivy, Roderic N. Carter, Jin-Feng Zhao, Charlotte Buckley, Helena Urquijo, Eva A. Rog-Zielinska, Emma Panting, Lenka Hrabalkova, Cara Nicholson, Emma J. Agnew, Matthew W. Kemp, Nicholson N. Morton, Sarah J. Stock, Caitlin Wyrwoll, Ian G. Ganley, Karen E. Chapman
Summary: The late gestational increase in glucocorticoids helps in the maturation of the fetal heart, particularly in the switch from carbohydrate to fatty acid oxidation. Excessive use of exogenous glucocorticoids may interfere with normal fetal heart development and pose potential clinical risks.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Medicine, General & Internal
Pallavi Chincholkar, Chin Pin Yeo, Clement Kam Man Ho
Summary: The study aimed to establish locally relevant reference intervals for serum prolactin and PEG precipitation prolactin concentrations in both genders, and compare the impact of PEG precipitation in different solvents on prolactin concentrations.
PROCEEDINGS OF SINGAPORE HEALTHCARE
(2022)
Article
Pathology
Ming Hwee Lim, Clement K. M. Ho
Summary: This retrospective study reviewed the screening and reporting policy of macroprolactin, finding that macroprolactin is common in patients with hyperprolactinaemia, even in those with very high serum prolactin concentrations. The coexistence of true hyperprolactinaemia and macroprolactin is also not rare.
MALAYSIAN JOURNAL OF PATHOLOGY
(2022)
Article
Medical Laboratory Technology
Clement K. M. Ho, Claire Chen, Johnson W. S. Setoh, Willie W. T. Yap, Robert C. W. Hawkins
Summary: The study revealed that interference by hemolysis, icterus, and lipemia on chemistry assays is common, and different interferents have varying impacts and directions on different analyses. It is recommended to establish criteria for defining assay interference based on both clinical needs and laboratory standards.
PRACTICAL LABORATORY MEDICINE
(2021)
Article
Medical Laboratory Technology
Clement K. M. Ho, Edward T. H. Tan, Mor Jack Ng, George S. H. Yeo, Bernard Chern, Nancy W. S. Tee, Kenneth Y. C. Kwek, Kok Hian Tan
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2017)