Getting to the heart of intracellular glucocorticoid regeneration: 11β-HSD1 in the myocardium

Bidirectional crosstalk via IL-6, PGE2 and PGD2 between murine myofibroblasts and alternatively activated macrophages enhances anti-inflammatory phenotype in both cells

(2016) Maria R Fernando et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cushing Syndrome Cardiomyopathy

(2016) Andrea Frustaci et al.   Circulation-Cardiovascular Imaging

Corticosteroids Are Essential for Maintaining Cardiovascular Function in Male Mice

(2016) Diana Cruz-Topete et al.   ENDOCRINOLOGY

Cardiomyocyte and Vascular Smooth Muscle-Independent 11β-Hydroxysteroid Dehydrogenase 1 Amplifies Infarct Expansion, Hypertrophy, and the Development of Heart Failure After Myocardial Infarction in Male Mice

(2016) Christopher I. White et al.   ENDOCRINOLOGY

11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice

(2016) Agnes E. Coutinho et al.   ENDOCRINOLOGY

Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype

(2016) Michael Horckmans et al.   EUROPEAN HEART JOURNAL

Alternatively activated macrophages determine repair of the infarcted adult murine heart

(2016) Manabu Shiraishi et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory and fibrotic responses of cardiac fibroblasts to myocardial damage associated molecular patterns (DAMPs)

(2016) Neil A. Turner   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac GR and MR: From Development to Pathology

(2016) Rachel V. Richardson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Optical projection tomography permits efficient assessment of infarct volume in the murine heart postmyocardial infarction

(2015) X. Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Functional crosstalk between cardiac fibroblasts and adult cardiomyocytes by soluble mediators

(2015) James E. Cartledge et al.   CARDIOVASCULAR RESEARCH

Bridging the Gap: The Potential Role of Corticosteroid Binding Globulin in Cardiac Steroid Facilitation

(2015) Hans Schafer et al.   CURRENT DRUG TARGETS

Role of microRNAs in Vascular Remodeling

(2015) Y. Fang et al.   CURRENT MOLECULAR MEDICINE

Glucocorticoids and 11β-hydroxysteroid dehydrogenases: mechanisms for hypertension

(2015) Robert W Hunter et al.   CURRENT OPINION IN PHARMACOLOGY

Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease

(2015) Karen Sooy et al.   ENDOCRINOLOGY

11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story

(2015) Alex Odermatt et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Glucocorticoid signaling in the heart: A cardiomyocyte perspective

(2015) Robert H. Oakley et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Short-term inhibition of 11β-hydroxysteroid dehydrogenase type 1 reversibly improves spatial memory but persistently impairs contextual fear memory in aged mice

(2015) Nicola Wheelan et al.   NEUROPHARMACOLOGY

Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α

(2014) E A Rog-Zielinska et al.   CELL DEATH AND DIFFERENTIATION

Cardiogenic Genes Expressed in Cardiac Fibroblasts Contribute to Heart Development and Repair

(2014) Milena B. Furtado et al.   CIRCULATION RESEARCH

Activation of a TGF- -Specific Multistep Gene Expression Program in Mature Macrophages Requires Glucocorticoid-Mediated Surface Expression of TGF-  Receptor II

(2014) A. Gratchev et al.   JOURNAL OF IMMUNOLOGY

Transcriptome from circulating cells suggests dysregulated pathways associated with long-term recurrent events following first-time myocardial infarction

(2014) Rahul Suresh et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The inflammatory response in myocardial injury, repair and remodelling

(2014) Nikolaos G. Frangogiannis   Nature Reviews Cardiology

A Transgenic Platform for Testing Drugs Intended for Reversal of Cardiac Remodeling Identifies a Novel 11βHSD1 Inhibitor Rescuing Hypertrophy Independently of Re-Vascularization

(2014) Oren Gordon et al.   PLoS One

11 -HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess

(2014) S. A. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin

(2014) Jennifer L. Bolton et al.   PLoS Genetics

Cortisol stimulates proliferation and apoptosis in the late gestation fetal heart: differential effects of mineralocorticoid and glucocorticoid receptors

(2013) Xiaodi Feng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mass Spectrometry Imaging for Dissecting Steroid Intracrinology within Target Tissues

(2013) Diego F. Cobice et al.   ANALYTICAL CHEMISTRY

11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo

(2013) Tijana Mitić et al.   BIOCHEMICAL PHARMACOLOGY

Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through Myeloid-Epithelial-Reproductive Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction

(2013) Elaine Wan et al.   CIRCULATION RESEARCH

Extracellular Matrix Secretion by Cardiac Fibroblasts

(2013) Mélanie Abonnenc et al.   CIRCULATION RESEARCH

Modulation of 11β-Hydroxysteroid Dehydrogenase as a Strategy to Reduce Vascular Inflammation

(2013) Patrick W. F. Hadoke et al.   Current Atherosclerosis Reports

11β-HSD1 Inhibitors for the Treatment of Type 2 Diabetes and Cardiovascular Disease

(2013) Anna Anderson et al.   DRUGS

11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis

(2013) Tiina Kipari et al.   FASEB JOURNAL

Glucocorticoid receptor is required for foetal heart maturation

(2013) Eva A. Rog-Zielinska et al.   HUMAN MOLECULAR GENETICS

Dilated Cardiomyopathy as a Presenting Feature of Cushing's Syndrome

(2013) Nobuyuki Shibusawa et al.   INTERNAL MEDICINE

Displacement of Cortisol From Human Heart by Acute Administration of a Mineralocorticoid Receptor Antagonist

(2013) Javaid Iqbal et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Proinflammatory Cytokine Induction of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) in Human Adipocytes Is Mediated by MEK, C/EBPβ, and NF-κB/RelA

(2013) Cristina L. Esteves et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects

(2013) Ana Tiganescu et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibroblasts in myocardial infarction: A role in inflammation and repair

(2013) Arti V. Shinde et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Glucocorticoids and foetal heart maturation; implications for prematurity and foetal programming

(2013) Eva A Rog-Zielinska et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation

(2013) Karen E. Chapman et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

11β-Hydroxysteroid Dehydrogenases: Intracellular Gate-Keepers of Tissue Glucocorticoid Action

(2013) Karen Chapman et al.   PHYSIOLOGICAL REVIEWS

Mast Cells Express 11β-hydroxysteroid Dehydrogenase Type 1: A Role in Restraining Mast Cell Degranulation

(2013) Agnes E. Coutinho et al.   PLoS One

11β-Hydroxysteroid Dehydrogenase Type 1 Gene Knockout Attenuates Atherosclerosis and In Vivo Foam Cell Formation in Hyperlipidemic apoE−/− Mice

(2013) Ricardo A. García et al.   PLoS One

Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells

(2012) Mohammad M. Ahasan et al.   ARTHRITIS AND RHEUMATISM

Fibroblasts in post-infarction inflammation and cardiac repair

(2012) Wei Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol

(2012) Tijana Mitić et al.   BIOCHIMIE

Cooperativity and complementarity: Synergies in non-classical and classical glucocorticoid signaling

(2012) Ranmal A. Samarasinghe et al.   CELL CYCLE

Scar extent, left ventricular end-diastolic volume, and wall motion abnormalities identify high-risk patients with previous myocardial infarction: a multiparametric approach for prognostic stratification

(2012) G. Di Bella et al.   EUROPEAN HEART JOURNAL

Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction: integrating evidence into clinical practice

(2012) F. Zannad et al.   EUROPEAN HEART JOURNAL

Insights into Negative Regulation by the Glucocorticoid Receptor from Genome-wide Profiling of Inflammatory Cistromes

(2012) N. Henriette Uhlenhaut et al.   MOLECULAR CELL

The role of cardiac fibroblasts in the transition from inflammation to fibrosis following myocardial infarction

(2012) Frans A. van Nieuwenhoven et al.   VASCULAR PHARMACOLOGY

Deletion of Cardiomyocyte Mineralocorticoid Receptor Ameliorates Adverse Remodeling After Myocardial Infarction

(2011) Daniela Fraccarollo et al.   CIRCULATION

Common Variation at the 11-β Hydroxysteroid Dehydrogenase Type 1 Gene Is Associated With Left Ventricular Mass

(2011) Thahira J. Rahman et al.   Circulation-Cardiovascular Genetics

Association of Diurnal Patterns in Salivary Cortisol with All-Cause and Cardiovascular Mortality: Findings from the Whitehall II Study

(2011) Meena Kumari et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Tissue-specific modulation of mineralocorticoid receptor function by 11β-hydroxysteroid dehydrogenases: An overview

(2011) Alex Odermatt et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Aldosterone and mineralocorticoid receptors: A personal reflection

(2011) John W. Funder   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation

(2011) Andrew C. Newman et al.   MOLECULAR BIOLOGY OF THE CELL

Improved heart function follows enhanced inflammatory cell recruitment and angiogenesis in 11βHSD1-deficient mice post-MI

(2010) Sara J. McSweeney et al.   CARDIOVASCULAR RESEARCH

Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice

(2010) Michael G. Usher et al.   JOURNAL OF CLINICAL INVESTIGATION

Steroidogenesis vs. steroid uptake in the heart: do corticosteroids mediate effects via cardiac mineralocorticoid receptors?

(2010) Wenxia Chai et al.   JOURNAL OF HYPERTENSION

Localization, Age- and Site-Dependent Expression, and Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 in Skin

(2010) Ana Tiganescu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms

(2010) Faiez Zannad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dilated Cardiomyopathy as the Predominant Feature of Cushing’s Syndrome

(2009) Melpomeni Peppa et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss

(2009) K. Kaur et al.   ANNALS OF THE RHEUMATIC DISEASES

Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease

(2009) Patrick W.F. Hadoke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chronic Intermittent Hypoxia Induces 11β-Hydroxysteroid Dehydrogenase in Rat Heart

(2009) Petra Klusoňová et al.   ENDOCRINOLOGY

Glucocorticoids Activate Cardiac Mineralocorticoid Receptors During Experimental Myocardial Infarction

(2009) Anastasia S. Mihailidou et al.   HYPERTENSION

Cardiac fibroblasts: At the heart of myocardial remodeling

(2009) Karen E. Porter et al.   PHARMACOLOGY & THERAPEUTICS

Genome-wide mechanisms of nuclear receptor action

(2009) Simon C. Biddie et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Direct protein–protein interaction of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase in the endoplasmic reticulum lumen

(2008) Atanas G. Atanasov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Serum Potassium and Clinical Outcomes in the Eplerenone Post–Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS)

(2008) Bertram Pitt et al.   CIRCULATION

Long-Term Trends in the Incidence of Heart Failure After Myocardial Infarction

(2008) Raghava S. Velagaleti et al.   CIRCULATION

Preadipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Keto-Reductase and Contributes to Diet-Induced Visceral Obesityin Vivo

(2008) R. A. De Sousa Peixoto et al.   ENDOCRINOLOGY

11-Beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors in Type 2 diabetes mellitus and obesity

(2008) Katherine A Hughes et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Immediate Mineralocorticoid Receptor Blockade Improves Myocardial Infarct Healing by Modulation of the Inflammatory Response

(2008) Daniela Fraccarollo et al.   HYPERTENSION

Expression profiles of human 11β-hydroxysteroid dehydrogenases type 1 and type 2 in inflammatory bowel diseases

(2008) J.P. Stegk et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Glucocorticoid Regulation of the Promoter of 11β-Hydroxysteroid Dehydrogenase Type 1 Is Indirect and Requires CCAAT/Enhancer-Binding Protein-β

(2008) Shuji Sai et al.   MOLECULAR ENDOCRINOLOGY

Hexose-6-Phosphate Dehydrogenase and 11β-Hydroxysteroid Dehydrogenase-1 Tissue Distribution in the Rat

(2007) Elise P. Gomez-Sanchez et al.   ENDOCRINOLOGY