Article
Agriculture, Dairy & Animal Science
X. P. Jing, W. J. Wang, A. A. Degen, Y. M. Guo, J. P. Kang, P. P. Liu, L. M. Ding, Z. H. Shang, J. W. Zhou, R. J. Long
Summary: This study compared the energy substrate metabolism of Tibetan sheep and Small-tailed Han sheep under different dietary energy densities, revealing that Tibetan sheep have advantages in coping with low energy intake and regulating whole-body energy homeostasis in the harsh environment of the Qinghai-Tibetan Plateau.
Review
Pharmacology & Pharmacy
Coen C. Paulusma, Wouter H. Lamers, Stefan Broer, Stan F. J. van de Graaf
Summary: The liver controls the exposure of amino acids entering via the gastrointestinal tract, but it is still unclear which transporters are involved in hepatocellular amino acid transport.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Jin Zhang, Rui Chi, Yunpeng Zhang, Yi Xie, Yunxia Liu, Qun Bao, Hengyu Lv, Bo Han, Haipeng Sun, Peng Sun
Summary: This study demonstrates that preoperative supplementation of BCAA can lower blood glucose levels by reducing liver gluconeogenesis without significant elevation of insulin levels. This provides a novel approach for preventing postoperative insulin resistance.
NUTRITION & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Katrin Panzitt, Martin Wagner
Summary: The liver serves as a central metabolic hub that coordinates nutritional inputs and metabolic outputs. FXR in the liver and intestine plays a crucial role in regulating postprandial nutrient disposal. Aside from classical roles, FXR also has effects on amino acid, protein metabolism, autophagic turnover, and inflammation, which are less studied. Additionally, understanding of how FXR signaling is affected by posttranslational modifications and different isoforms is important for potential pharmaceutical targeting in clinical applications.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Liangkui Li, Haoyu Zhou, Jinhui Wang, Jiaxin Li, Xuchao Lyu, Wenshan Wang, Chengting Luo, He Huang, Dawang Zhou, Xiaowei Chen, Li Xu, Peng Li
Summary: This study reveals that the liver functions as an energy conversion center to maintain blood glucose homeostasis in neonates. Glucose is found to be the universal fuel essential for neonatal life. The limitation of lipid supply in milk leads to severe hypoglycemia and neonatal lethality.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Javier Andres Moreno Meneses, Karolina Batista Nascimento, Matheus Castilho Galvao, German Dario Ramirez-Zamudio, Tathyane Ramalho Santos Gionbelli, Marcio Machado Ladeira, Marcio de Souza Duarte, Daniel Rume Casagrande, Mateus Pies Gionbelli
Summary: During the 100 to 200 days of gestation, giving cows protein supplements can improve blood glucose and insulin levels, increase non-esterified fatty acid concentration, and enhance the expression of protein synthesis markers while reducing the expression of protein degradation markers. This study highlights the importance of alleviating restriction overload on maternal metabolism.
Review
Nutrition & Dietetics
Md Shahjalal Khan, Redin A. Spann, Heike Munzberg, Sangho Yu, Vance L. Albaugh, Yanlin He, Hans-Rudolf Berthoud, Christopher D. Morrison
Summary: Feeding behavior in animals is guided by various physiological needs, with dietary protein intake being a specific and crucial nutritional requirement. Animals are able to sense restricted protein intake and adaptively alter their feeding behavior to increase protein intake, indicating a strong body of literature supporting the defense of protein intake.
Article
Nutrition & Dietetics
Cristina Galarregui, Irene Cantero, Bertha Araceli Marin-Alejandre, J. Ignacio Monreal, Mariana Elorz, Alberto Benito-Boillos, Jose Ignacio Herrero, de la O. Victor, Miguel Ruiz-Canela, Helen Hermana M. Hermsdorff, Josefina Bressan, Josep A. Tur, J. Alfredo Martinez, M. Angeles Zulet, Itziar Abete
Summary: The study found that higher consumption of specific dietary amino acids was associated with poorer liver health, as indicated by liver fat content, liver iron concentration, and ferritin levels. The intake of these amino acids was positively correlated with markers of glucose metabolism.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Environmental Sciences
Linchen He, Xinyan Hu, Drew B. Day, Meilin Yan, Yanbo Teng, Xing (Lucy) Liu, Erik Yan, Jianbang Xiang, Xinghua Qiu, Jinhan Mo, Yinping Zhang, Junfeng (Jim) Zhang, Jicheng Gong
Summary: Exposure to certain nitro-PAHs may affect glucose homeostasis, partly resulting from the depletion of insulin-stimulating amino acids.
ENVIRONMENTAL POLLUTION
(2021)
Review
Pharmacology & Pharmacy
Hao Chen, Lan-Lan Li, Yan Du
Summary: Liver diseases, characterized by metabolic disorder, have become a global public health problem with high morbidity and mortality. Kruppel-like factor 15 (KLF15), a zinc-finger transcription factor mainly enriched in liver, is rapidly activated during fasting and regulates various metabolic processes in the liver. This review summarizes the latest advances of KLF15 in metabolic reprogramming and its role in acute liver injury, hepatitis B virus, and autoimmune hepatitis, aiming to assess the potential of KLF15 as a therapeutic target and prognostic biomarker for liver diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Justine Lallement, Ilyes Raho, Gregory Merlen, Dominique Rainteau, Mikael Croyal, Melody Schiffano, Nadim Kassis, Isabelle Doignon, Maud Soty, Floriane Lachkar, Michel Krempf, Matthias Van Hul, Patrice D. Cani, Fabienne Foufelle, Chloe Amouyal, Herve Le Stunff, Christophe Magnan, Thierry Tordjmann, Celine Cruciani-Guglielmacci
Summary: This study aimed to determine the role of de novo hepatic ceramide synthesis in energy and liver homeostasis. The results showed that mice lacking the Sptlc2 gene were protected against obesity induced by high fat diet and displayed a defect in lipid absorption. In addition, the deficiency enhanced glucose tolerance and attenuated hepatic glucose production, while the latter effect was dampened in presence of nSMase2 inhibitor. Furthermore, Sptlc2 disruption promoted apoptosis, inflammation, and progressive development of hepatic fibrosis. These findings highlight the importance of ceramides in liver homeostasis and metabolic functions.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Multidisciplinary Sciences
Azadehalsadat Hosseini Dastgerdi, Mohammadreza Sharifi, Nepton Soltani
Summary: The study found that GABA can reduce liver insulin resistance in both parents with type 2 diabetes and their offspring by improving insulin sensitivity, increasing liver glycogen levels, and decreasing lipid profile and blood glucose levels.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Mais Jubouri, Giancarlo G. M. Talarico, Jean-Michel Weber, Jan A. Mennigen
Summary: The study demonstrates that alanine inhibits glucose metabolism in rainbow trout, leading to a reduction in blood glucose levels. This effect is likely mediated through stimulation of insulin secretion and involves specific gene expression changes in muscle, differing from the mechanisms observed in mammals.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Xiaoming Hu, Feifan Guo
Summary: The body's ability to sense and respond to changes in nutrient levels, particularly amino acids, is crucial for survival. Amino acids play dual roles as building blocks for proteins and peptides, as well as important bioactive molecules involved in signaling pathways and metabolic regulation. Imbalance in amino acid sensing signals may be linked to metabolic disorders, highlighting their potential as therapeutic targets.
Article
Biochemistry & Molecular Biology
Jose M. Horcas-Nieto, Christian J. Versloot, Miriam Langelaar-Makkinje, Albert Gerding, Tjasso Blokzijl, Mirjam H. Koster, Mirjam Baanstra, Ingrid A. Martini, Robert P. Coppes, Celine Bourdon, Sven C. D. van Ijzendoorn, Peter Kim, Robert H. J. Bandsma, Barbara M. Bakker
Summary: Hospitalized children with severe malnutrition often suffer from hepatic and intestinal dysfunction, leading to high mortality rates. Our study has established organoid models of severe malnutrition in the liver and intestine, which recapitulate the expected functional changes and protein alterations seen in these organs. By re-supplementing amino acids or using specific drugs, we observed partial recovery of organoid function. These organoid models serve as valuable tools for understanding the underlying mechanisms and testing potential treatments for intestinal and hepatic dysfunction in severe malnutrition.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Nutrition & Dietetics
Jinyoung Kim, Kathryn J. Burton-Pimentel, Charlotte Fleuti, Carola Blaser, Valentin Scherz, Rene Badertscher, Corinne Marmonier, Noelle Lyon-Belgy, Aurelie Caille, Veronique Pidou, Adeline Blot, Claire Bertelli, Jeremie David, Ueli Buetikofer, Gilbert Greub, Dominique Dardevet, Sergio Polakof, Guy Vergeres
Summary: This study found that excluding dairy products and limiting fermented food consumption for 19 days had significant effects on gut microbiota composition and blood metabolites in both young and older adult men, with changes such as increased levels of Akkermansia muciniphila and decreased levels of bacteria in the Clostridiales order. The intervention also resulted in lower fasting levels of glucose and insulin, as well as decreased HDL and LDL cholesterol levels, with dairy fat intake being positively associated with changes in HDL cholesterol. The impact of the dietary restrictions on these outcomes was more pronounced than the effect of age.
Article
Nutrition & Dietetics
Ahmed Ben Mohamed, Didier Remond, Andreu Gual-Grau, Annick Bernalier-Donnadille, Frederic Capel, Marie-Caroline Michalski, Fabienne Laugerette, Benoit Cohade, Noureddine Hafnaoui, Daniel Bechet, Cecile Coudy-Gandilhon, Marine Gueugneau, Jerome Salles, Carole Migne, Dominique Dardevet, Jeremie David, Sergio Polakof, Isabelle Savary-Auzeloux
Summary: This study found that supplemented bread with fermentable fibers can modulate muscle energy metabolism, reduce muscle fiber cross sectional area, and prevent the occurrence of muscle obesity in the context of overfeeding.
Article
Nutrition & Dietetics
Dorothee Volkert, Clare A. Corish, Dominique Dardevet, Giuseppe De Vito, Christelle Guillet, Stephanie Bader-Mittermaier, Sian Robinson, Helen M. Roche, Avan A. Sayer, Marjolein Visser
Summary: The APPETITE project aims to develop interventions to enhance protein and fiber intake in older adults with poor appetite, in order to address undernutrition. It will involve developing innovative plant-based protein and fiber products, examining their impact on metabolism, and conducting a randomized intervention trial to evaluate their effectiveness in improving quality of life for older Europeans.
NUTRITION BULLETIN
(2021)
Article
Nutrition & Dietetics
Dominique Dardevet, Laurent Mosoni, Isabelle Savary-Auzeloux, Marie-Agnes Peyron, Sergio Polakof, Didier Remond
Summary: Aging leads to anabolic resistance in skeletal muscle towards dietary amino acids, which can be overcome by increasing protein intake above recommended levels. Quality of dietary protein is crucial, covering all essential amino acids at recommended intake levels. Other determinants affecting protein quality include digestion speed, specific amino acids presence, food matrix, food production processes, energy supply, and nutrient interactions. Timing of protein intake and its relation to energy nutrient intake is also important for muscle health.
CAHIERS DE NUTRITION ET DE DIETETIQUE
(2021)
Review
Geriatrics & Gerontology
Muriel Giron, Muriel Thomas, Dominique Dardevet, Christophe Chassard, Isabelle Savary-Auzeloux
Summary: Evidence suggests that gut microbiota composition and diversity can have an impact on skeletal muscle metabolism and functionality. The signals generated by the gut microbiome can regulate muscle functionality via modulation of inflammation and insulin sensitivity. More studies are needed to identify specific strains of bacteria that can optimize muscle mass and function. Personalized nutrition and testing the efficiency of probiotics in different populations are essential. The combination of bacteria, prebiotics, and other supplements may be the best approach to preserve muscle functionality in individuals of all ages.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Nutrition & Dietetics
Jinyoung Kim, Carola Blaser, Reto Portmann, Rene Badertscher, Corinne Marmonier, Adeline Blot, Jeremie David, Helena Stoffers, Ueli von Ah, Ueli Butikofer, Guy Vergeres, Dominique Dardevet, Sergio Polakof
Summary: The identification and validation of biomarkers of food intake is a promising approach to develop more objective and complementary tools to the traditional dietary assessment methods. This study identified and compared the biomarkers of milk and yogurt intake through metabolomics analysis. The findings suggest that these biomarkers could be used as potential indicators of food intake, and population specificities, such as aging, should be considered in future studies.
FRONTIERS IN NUTRITION
(2022)
Review
Food Science & Technology
Dragan Milenkovic, Frederic Capel, Lydie Combaret, Blandine Comte, Dominique Dardevet, Bertrand Evrard, Christelle Guillet, Laurent-Emmanuel Monfoulet, Alexandre Pinel, Sergio Polakof, Estelle Pujos-Guillot, Didier Remond, Yohann Wittrant, Isabelle Savary-Auzeloux
Summary: Impairment of gut function is a mechanism for the decline in health status in the elderly, involving declines in digestive physiology, metabolism, and immune status. This is associated with changes in the composition and function of the gut microbiota. These alterations can be targeted through nutritional strategies to prevent or delay the occurrence of age-related pathologies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Gastroenterology & Hepatology
Marijana Basic, Dominique Dardevet, Peter Michael Abuja, Silvia Bolsega, Stephanie Bornes, Robert Caesar, Francesco Maria Calabrese, Massimo Collino, Maria De Angelis, Philippe Gerard, Miguel Gueimonde, Francois Leulier, Eva Untersmayr, Evelien Van Rymenant, Paul De Vos, Isabelle Savary-Auzeloux
Summary: Our understanding of the roles of gut microorganisms in host metabolism and immunity has greatly improved in the past 20 years. Microbiome studies are now focusing on demonstrating causality and identifying molecular mechanisms behind these interactions. Animal models are commonly used to evaluate the causal role of microbiota due to challenges in conducting mechanistic studies in humans. This review provides an overview of approaches that can be used to study host-microbe interactions and the impact of gut morphology, physiology, and diet on microbiota composition in major animal model organisms.
Article
Nutrition & Dietetics
Muriel Giron, Muriel Thomas, Marianne Jarzaguet, Camille Mayeur, Gladys Ferrere, Marie-Louise Noordine, Stephanie Bornes, Dominique Dardevet, Christophe Chassard, Isabelle Savary-Auzeloux
Summary: This study aimed to identify a probiotic-based strategy to maintain muscle anabolism in the elderly. By evaluating gut bacterial strains in a nematode model and a frail rat model, the researchers found that supplementing with Lacticaseibacillus casei strains could potentially promote muscle protein synthesis and alleviate sarcopenia in elderly individuals with low food intake.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
F. Rul, C. Bera-Maillet, M. C. Champomier-Verges, K. E. El-Mecherfi, B. Foligne, M. C. Michalski, D. Milenkovic, I. Savary-Auzeloux
Summary: Fermented foods have a long history and diverse origins, but current research does not definitively support the idea that they generally have health benefits. Some studies suggest specific health benefits in certain situations, but others do not show clear effects. This review explores why testing the health effects of fermented foods is complex and suggests ways to improve knowledge in this field.