Intranasal therapeutic strategies for management of Alzheimer’s disease

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Modulation of cerebral malaria by curcumin as an adjunctive therapy

(2013) Kunal Jain et al.   Brazilian Journal of Infectious Diseases

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2013) Jessica Freiherr et al.   CNS DRUGS

Optimization of curcumin nanoemulsion for intranasal delivery using design of experiment and its toxicity assessment

(2013) Sumeet Sood et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Enhanced brain targeting of curcumin by intranasal administration of a thermosensitive poloxamer hydrogel

(2013) Xi Chen et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Development of buccal tablets for curcumin using Anacardium occidentale gum

(2012) K. Gowthamarajan et al.   CARBOHYDRATE POLYMERS

Tissue Distribution and Pharmacodynamics of Rivastigmine after Intranasal and Intravenous Administration in Rats

(2012) Zhen-zhen Yang et al.   Current Alzheimer Research

Herbal Medicines for the Prevention and Treatment of Alzheimer's Disease

(2012) Hyo Geun Kim et al.   CURRENT PHARMACEUTICAL DESIGN

Immunopathogenesis of Neurodegenerative Diseases: Current Therapeutic Models of Neuroprotection with Special Reference to Natural Products

(2012) T. Magrone et al.   CURRENT PHARMACEUTICAL DESIGN

Resveratrol, A Neuroprotective Supplement for Alzheimer's Disease

(2012) Fei Li et al.   CURRENT PHARMACEUTICAL DESIGN

Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans

(2012) K. Jauch-Chara et al.   DIABETES

Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting

(2012) Mohammad Fazil et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

(2012) Chuang Guo et al.   NEUROBIOLOGY OF AGING

Intranasal administration of TAT-haFGF14–154 attenuates disease progression in a mouse model of Alzheimer’s disease

(2012) G. Lou et al.   NEUROSCIENCE

Intranasal delivery of siRNA to the olfactory bulbs of mice via the olfactory nerve pathway

(2012) Dan B. Renner et al.   NEUROSCIENCE LETTERS

Correction: Intranasal “painless” Human Nerve Growth Factors Slows Amyloid Neurodegeneration and Prevents Memory Deficits in App X PS1 Mice

(2012) Simona Capsoni et al.   PLoS One

Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice

(2012) J. M. Fine et al.   EXPERIMENTAL BRAIN RESEARCH

Intranasal delivery of deferoxamine reduces spatial memory loss in APP/PS1 mice

(2012) Leah R. Hanson et al.   Drug Delivery and Translational Research

Intranasal delivery of biologics to the central nervous system

(2011) Jeffrey J. Lochhead et al.   ADVANCED DRUG DELIVERY REVIEWS

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Albumin nanoparticles carrying cyclodextrins for nasal delivery of the anti-Alzheimer drug tacrine

(2011) Barbara Luppi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A novel small Odorranalectin-bearing cubosomes: Preparation, brain delivery and pharmacodynamic study on amyloid-β25–35-treated rats following intranasal administration

(2011) Hongbing Wu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Nose-to-brain transport of melatonin from polymer gel suspensions: a microdialysis study in rats

(2011) R. Jayachandra Babu et al.   JOURNAL OF DRUG TARGETING

Brain Insulin Signaling and Alzheimer's Disease: Current Evidence and Future Directions

(2011) Helgi B. Schiöth et al.   MOLECULAR NEUROBIOLOGY

Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues

(2011) Davide Brambilla et al.   Nanomedicine-Nanotechnology Biology and Medicine

Chronic Intranasal Treatment with an Anti-Aβ30-42 scFv Antibody Ameliorates Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) Susann Cattepoel et al.   PLoS One

REVIEW: Curcumin and Alzheimer's Disease

(2010) Tsuyoshi Hamaguchi et al.   CNS Neuroscience & Therapeutics

The application of mucoadhesive polymers in nasal drug delivery

(2010) Lingmin Jiang et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Intranasal insulin as a therapeutic option in the treatment of cognitive impairments

(2010) Christian Benedict et al.   EXPERIMENTAL GERONTOLOGY

Neurotherapeutic applications of nanoparticles in Alzheimer's disease

(2010) Jasjeet Kaur Sahni et al.   JOURNAL OF CONTROLLED RELEASE

Brain targeting of risperidone-loaded solid lipid nanoparticles by intranasal route

(2010) Sonal Patel et al.   JOURNAL OF DRUG TARGETING

Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

(2010) Lusine Danielyan et al.   REJUVENATION RESEARCH

Regulation of P-glycoprotein and other ABC drug transporters at the blood–brain barrier

(2010) David S. Miller   TRENDS IN PHARMACOLOGICAL SCIENCES

Human and rodent amyloid-β peptides differentially bind heme: Relevance to the human susceptibility to Alzheimer’s disease

(2009) Hani Atamna et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin

(2009) Balmiki Ray et al.   CURRENT OPINION IN PHARMACOLOGY

Intranasal Insulin Ameliorates Experimental Diabetic Neuropathy

(2009) G. Francis et al.   DIABETES

FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer’s disease

(2009) Lisa Mosconi et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Nanoparticles for direct nose-to-brain delivery of drugs

(2009) Alpesh Mistry et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Formulation of intranasal mucoadhesive temperature-mediatedin situgel containing ropinirole and evaluation of brain targeting efficiency in rats

(2009) Shagufta Khan et al.   JOURNAL OF DRUG TARGETING

Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS

(2009) Sandra R. Alcalá-Barraza et al.   JOURNAL OF DRUG TARGETING

Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles

(2009) Kamila B. Kurakhmaeva et al.   JOURNAL OF DRUG TARGETING

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Intranasal delivery to the central nervous system: Mechanisms and experimental considerations

(2009) Shyeilla V. Dhuria et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke

(2009) L. R. Hanson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Nanoparticle–chelator conjugates as inhibitors of amyloid-β aggregation and neurotoxicity: A novel therapeutic approach for Alzheimer disease

(2009) Gang Liu et al.   NEUROSCIENCE LETTERS

Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat

(2009) Rahul Agrawal et al.   PHARMACOLOGICAL RESEARCH

A study of rivastigmine liposomes for delivery into the brain through intranasal route

(2008) Karthik Arumugam et al.   ACTA PHARMACEUTICA

Intranasal Mucoadhesive Microemulsion of Tacrine to Improve Brain Targeting

(2008) Viral V. Jogani et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Disease-modifying therapies in Alzheimer’s disease

(2008) Stephen Salloway et al.   Alzheimers & Dementia

Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease

(2008) Wei-Qin Zhao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Surface Charge of Nanoparticles Determines Their Endocytic and Transcytotic Pathway in Polarized MDCK Cells

(2008) Oshrat Harush-Frenkel et al.   BIOMACROMOLECULES

Intranasal administration of acetylcholinesterase inhibitors

(2008) Henry R Costantino et al.   BMC NEUROSCIENCE

RETRACTED: Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy

(2008)   BRAIN

Metals in Alzheimer's and Parkinson's Diseases

(2008) Kevin J Barnham et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The role of glycogen synthase kinase 3 in the early stages of Alzheimers’ disease

(2008) Félix Hernández et al.   FEBS LETTERS

Gateways and tools for drug delivery: Endocytic pathways and the cellular dynamics of cell penetrating peptides

(2008) Arwyn T. Jones   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Intranasal nanoemulsion based brain targeting drug delivery system of risperidone

(2008) Mukesh Kumar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mucoadhesive nanoemulsion-based intranasal drug delivery system of olanzapine for brain targeting

(2008) Mukesh Kumar et al.   JOURNAL OF DRUG TARGETING

Linking vascular disorders and Alzheimer's disease: Potential involvement of BACE1

(2008) Sarah L. Cole et al.   NEUROBIOLOGY OF AGING

Delivery of interferon-β to the monkey nervous system following intranasal administration

(2008) R.G. Thorne et al.   NEUROSCIENCE