Evaluating the potential for undesired genomic effects of the piggyBac transposon system in human cells

Pseudo attP sites in favor of transgene integration and expression in cultured porcine cells identified by streptomyces phage phiC31 integrase

(2013) Yanzhen Bi et al.   BMC MOLECULAR BIOLOGY

Minimal piggyBac vectors for chromatin integration

(2013) V Solodushko et al.   GENE THERAPY

A new approach to gene therapy usingSleeping Beautyto genetically modify clinical-grade T cells to target CD19

(2013) Harjeet Singh et al.   IMMUNOLOGICAL REVIEWS

The piggyBac Transposon Displays Local and Distant Reintegration Preferences and Can Cause Mutations at Noncanonical Integration Sites

(2013) M. A. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcription activator like effector (TALE)-directed piggyBac transposition in human cells

(2013) Jesse B. Owens et al.   NUCLEIC ACIDS RESEARCH

DNA transposition by protein transduction of the piggyBac transposase from lentiviral Gag precursors

(2013) Yujia Cai et al.   NUCLEIC ACIDS RESEARCH

Evaluation of Long-term Transgene Expression in piggyBac-Modified Human T Lymphocytes

(2012) Yozo Nakazawa et al.   JOURNAL OF IMMUNOTHERAPY

Chimeric piggyBac transposases for genomic targeting in human cells

(2012) Jesse B. Owens et al.   NUCLEIC ACIDS RESEARCH

The Impact of cHS4 Insulators on DNA Transposon Vector Mobilization and Silencing in Retinal Pigment Epithelium Cells

(2012) Nynne Sharma et al.   PLoS One

Comparative Analysis of the Recently Discovered hAT Transposon TcBuster in Human Cells

(2012) Lauren E. Woodard et al.   PLoS One

A resurrected mammalian hAT transposable element and a closely related insect element are highly active in human cell culture

(2012) X. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperactive piggyBac Gene Transfer in Human Cells and In Vivo

(2011) Joseph E. Doherty et al.   HUMAN GENE THERAPY

Manipulating piggyBac Transposon Chromosomal Integration Site Selection in Human Cells

(2011) Claudia Kettlun et al.   MOLECULAR THERAPY

PiggyBac-mediated Cancer Immunotherapy Using EBV-specific Cytotoxic T-cells Expressing HER2-specific Chimeric Antigen Receptor

(2011) Yozo Nakazawa et al.   MOLECULAR THERAPY

Combining mTor Inhibitors With Rapamycin-resistant T Cells: A Two-pronged Approach to Tumor Elimination

(2011) Leslie E Huye et al.   MOLECULAR THERAPY

Mobilization of giant piggyBac transposons in the mouse genome

(2011) Meng Amy Li et al.   NUCLEIC ACIDS RESEARCH

A hyperactive piggyBac transposase for mammalian applications

(2011) K. Yusa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Transposon and Transposase System for Human Application

(2010) Perry B Hackett et al.   MOLECULAR THERAPY

Differential Contribution of Rod and Cone Circadian Clocks in Driving Retinal Melatonin Rhythms in Xenopus

(2010) Naoto Hayasaka et al.   PLoS One

Multiplexed transposon-mediated stable gene transfer in human cells

(2010) K. M. Kahlig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Helper-independent piggyBac plasmids for gene delivery approaches: Strategies for avoiding potential genotoxic effects

(2010) J. Urschitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells

(2009) T. VandenDriessche et al.   BLOOD

piggyBac Transposon/Transposase System to Generate CD19-Specific T Cells for the Treatment of B-Lineage Malignancies

(2009) Pallavi V. Raja Manuri et al.   HUMAN GENE THERAPY

Optimization of the PiggyBac Transposon System for the Sustained Genetic Modification of Human T Lymphocytes

(2009) Yozo Nakazawa et al.   JOURNAL OF IMMUNOTHERAPY

PiggyBac Transposon-based Inducible Gene Expression In Vivo After Somatic Cell Gene Transfer

(2009) Sai K Saridey et al.   MOLECULAR THERAPY

Virus-free induction of pluripotency and subsequent excision of reprogramming factors

(2009) Keisuke Kaji et al.   NATURE

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

(2009) Knut Woltjen et al.   NATURE

Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon

(2009) Kosuke Yusa et al.   NATURE METHODS

Chromosomal transposition of PiggyBac in mouse embryonic stem cells

(2008) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA