Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function
Authors
Keywords
-
Journal
NUCLEIC ACIDS RESEARCH
Volume 43, Issue 7, Pages 3524-3545
Publisher
Oxford University Press (OUP)
Online
2015-03-14
DOI
10.1093/nar/gkv188
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A Chemical Biology Approach to Developing STAT Inhibitors: Molecular Strategies for Accelerating Clinical Translation
- (2015) Erik A. Nelson et al. Oncotarget
- The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse
- (2014) O. R. Bandapalli et al. HAEMATOLOGICA
- Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia
- (2014) M Kontro et al. LEUKEMIA
- Targeting STAT5 in Hematologic Malignancies through Inhibition of the Bromodomain and Extra-Terminal (BET) Bromodomain Protein BRD2
- (2014) S. Liu et al. MOLECULAR CANCER THERAPEUTICS
- Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor against Human Acute Myelogenous Leukemia Cells
- (2014) W. Fiskus et al. MOLECULAR CANCER THERAPEUTICS
- BET Protein Antagonist JQ1 Is Synergistically Lethal with FLT3 Tyrosine Kinase Inhibitor (TKI) and Overcomes Resistance to FLT3-TKI in AML Cells Expressing FLT-ITD
- (2014) W. Fiskus et al. MOLECULAR CANCER THERAPEUTICS
- The Synthetic α-Bromo-2′,3,4,4′-Tetramethoxychalcone (α-Br-TMC) Inhibits the JAK/STAT Signaling Pathway
- (2014) Sophia Pinz et al. PLoS One
- The Natural Chemopreventive Agent Sulforaphane Inhibits STAT5 Activity
- (2014) Sophia Pinz et al. PLoS One
- JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia
- (2013) W. Warsch et al. BLOOD
- Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia
- (2013) H. L. M. Rajala et al. BLOOD
- Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance
- (2013) A. Quintas-Cardama et al. CLINICAL CANCER RESEARCH
- JAK1/2 and Pan-Deacetylase Inhibitor Combination Therapy Yields Improved Efficacy in Preclinical Mouse Models of JAK2V617F-Driven Disease
- (2013) E. Evrot et al. CLINICAL CANCER RESEARCH
- The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing
- (2013) Jarmila Hnilicová et al. MOLECULAR BIOLOGY OF THE CELL
- Acetylation modulates the STAT signaling code
- (2012) Martin Wieczorek et al. CYTOKINE & GROWTH FACTOR REVIEWS
- The HAT/HDAC interplay: Multilevel control of STAT signaling
- (2012) Laura Icardi et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed
- (2012) Berkley E Gryder et al. Future Medicinal Chemistry
- Critical Role of STAT5 Transcription Factor Tetramerization for Cytokine Responses and Normal Immune Function
- (2012) Jian-Xin Lin et al. IMMUNITY
- Bromodomain Protein Brd4 Associated with Acetylated Chromatin Is Important for Maintenance of Higher-order Chromatin Structure
- (2012) Ranran Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition
- (2012) Reecha D. Shah et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Breakdown of the FLT3-ITD/STAT5 Axis and Synergistic Apoptosis Induction by the Histone Deacetylase Inhibitor Panobinostat and FLT3-Specific Inhibitors
- (2012) K. Pietschmann et al. MOLECULAR CANCER THERAPEUTICS
- SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation
- (2012) Thang Van Nguyen et al. MOLECULAR CELL
- The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors
- (2011) E. A. Nelson et al. BLOOD
- HDAC Inhibitors Potentiate the Activity of the BCR/ABL Kinase Inhibitor KW-2449 in Imatinib-Sensitive or -Resistant BCR/ABL+ Leukemia Cells In Vitro and In Vivo
- (2011) T. Nguyen et al. CLINICAL CANCER RESEARCH
- The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3
- (2011) S. Rahman et al. MOLECULAR AND CELLULAR BIOLOGY
- Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range
- (2011) J. Bachmann et al. Molecular Systems Biology
- Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2
- (2011) Malay Mandal et al. NATURE IMMUNOLOGY
- p300-mediated Acetylation of Histone H3 Lysine 56 Functions in DNA Damage Response in Mammals
- (2010) Rahul K. Vempati et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Acetylation modulates prolactin receptor dimerization
- (2010) L. Ma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells
- (2009) Y. Wang et al. BLOOD
- HDACi – Targets beyond chromatin
- (2009) Marc Buchwald et al. CANCER LETTERS
- A phosphorylation-acetylation switch regulates STAT1 signaling
- (2009) O. H. Kramer et al. GENES & DEVELOPMENT
- STAT5 Activation Is Critical for the Transformation Mediated by Myeloproliferative Disorder-associated JAK2 V617F Mutant
- (2009) Megumi Funakoshi-Tago et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphorylation–acetylation switch in the regulation of STAT1 signaling
- (2009) Oliver H. Krämer et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- STAT3 inhibition of gluconeogenesis is downregulated by SirT1
- (2009) Yongzhan Nie et al. NATURE CELL BIOLOGY
- Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
- (2009) C. Choudhary et al. SCIENCE
- HDAC2: a critical factor in health and disease
- (2009) Oliver H. Krämer TRENDS IN PHARMACOLOGICAL SCIENCES
- Histone acetyltransferase-1 regulates integrity of cytosolic histone H3–H4 containing complex
- (2008) Hirak Kumar Barman et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- HDAC family: What are the cancer relevant targets?
- (2008) Olaf Witt et al. CANCER LETTERS
- Discovery of Chromone-Based Inhibitors of the Transcription Factor STAT5
- (2008) Judith Müller et al. CHEMBIOCHEM
- The LIM-homeodomain transcription factor LMX1B regulates expression of NF-kappa B target genes
- (2008) Anne Rascle et al. EXPERIMENTAL CELL RESEARCH
- The STAT3 NH2-terminal Domain Stabilizes Enhanceosome Assembly by Interacting with the p300 Bromodomain
- (2008) Tieying Hou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo
- (2008) M. Fournel et al. MOLECULAR CANCER THERAPEUTICS
- The Double Bromodomain Proteins Brd2 and Brd3 Couple Histone Acetylation to Transcription
- (2008) Gary LeRoy et al. MOLECULAR CELL
- The many roles of histone deacetylases in development and physiology: implications for disease and therapy
- (2008) Michael Haberland et al. NATURE REVIEWS GENETICS
- In vivo identification of novel STAT5 target genes
- (2008) B. Basham et al. NUCLEIC ACIDS RESEARCH
- Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution
- (2008) S. Ray et al. NUCLEIC ACIDS RESEARCH
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now