Article
Immunology
Yinglan Cheng, Ichiro Manabe, Sumio Hayakawa, Yusuke Endo, Yumiko Oishi
Summary: It is discovered that mouse caspase-11 is a novel inflammatory activator of SREBP1a in macrophages, promoting the processing and activation of SREBP1 through site-1 protease (S1P). Caspase-11 directly interacts with S1P and cleaves it at a specific site. Deletion of the Casp4 gene impairs the activation of S1P and SREBP1, as well as alters the expression of SREBP1-regulated genes in macrophages.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Fei Luo, Chao Xing, Sumeet K. Asrani, Shili Li, Guosheng Liang, Helen H. Hobbs, Jonathan C. Cohen
Summary: This study identified a missense variant in the insulin receptor associated with fatty liver disease in a four generation family, but experiments in mice failed to show a causal relationship between this variant and the disease or any impact on hepatic triglyceride metabolism.
MOLECULAR METABOLISM
(2021)
Article
Agriculture, Dairy & Animal Science
Yiwei Zhu, Lin Lei, Xinghui Wang, Qianming Jiang, Juan J. Loor, Fanrong Kong, Linfang Chen, Jinxia Li, Chenchen Zhao, Menglin Liu, Guowen Liu, Xinwei Li
Summary: This study aims to investigate the potential role of the INSIG1-SCAP-SREBP-1c axis in the progression of fatty liver in dairy cows. It was found that cows with severe fatty liver had higher levels of β-hydroxybutyrate and free fatty acids and lower level of glucose in their blood. The liver of these cows also exhibited lower abundance of INSIG1 protein and higher abundance of SCAP and SREBP-1c proteins. Furthermore, in vitro experiments showed that decreased INSIG1 abundance contributed to enhanced SREBP-1c processing and triglyceride synthesis in hepatocytes. Therefore, the INSIG1-SCAP-SREBP-1c axis may serve as a potential target for the treatment of fatty liver in dairy cows.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Nutrition & Dietetics
Jui-Ting Yang, Yu-Jen Chen, Chao-Wei Huang, Ya-Chin Wang, Harry J. Mersmann, Pei-Hwa Wang, Shih-Torng Ding
Summary: The study demonstrates that DHA negatively regulates the adipogenic TN in both pigs in vivo and in humans/pigs in vitro, potentially through SREBP-1c or FoxO. This down-regulation of TN associated with fibrinolysis and adipogenesis could contribute to the beneficial effects of DHA on alleviating obesity-induced metabolic syndromes.
Article
Neurosciences
Shuang-Feng Xu, Zhong-Qiu Pang, Yong-Gang Fan, Yan-Hui Zhang, Yu-Han Meng, Chen-Yang Bai, Meng-Yu Jia, Yan-Hong Chen, Zhan-You Wang, Chuang Guo
Summary: There is growing evidence that circulating lactoferrin (Lf) is involved in peripheral cholesterol metabolism disorders. The distribution of Lf changes in astrocytes of aging brains and those with neurodegenerative diseases, but its role is not yet understood.
Article
Agriculture, Dairy & Animal Science
Chaochao Luo, Nan Li, Qingzhu Wang, Chunjiang Li
Summary: Short-chain fatty acids play a crucial role in regulating milk fat synthesis through the SREBP1 pathway. This study investigated the role of sodium acetate (SA) in milk fat synthesis in bovine mammary epithelial cells (BMECs). The results showed that SA supplementation increased the activation of the SREBP1 pathway and promoted milk fat synthesis.
Article
Agriculture, Dairy & Animal Science
Qiuya He, Jun Luo, Jiao Wu, Zhuang Li, Weiwei Yao, Saige Zang, Huimin Niu
Summary: The role of ELOVL6 gene in the synthesis of long-chain saturated and monounsaturated fatty acids is important. Studies have shown that SREBP1 regulates the transcription of ELOVL6 through the SRE elements in the ELOVL6 promoter.
JOURNAL OF DAIRY SCIENCE
(2021)
Review
Agriculture, Dairy & Animal Science
Meihong Han, Minghui Zhang
Summary: In this article, recent advances in the regulatory mechanism of amino acids on milk protein and fat synthesis in mammary epithelial cells (MECs) are reviewed. The mechanisms reflect the amino acid requirements of MECs and the current and future prospects for amino acid regulation in milk production are discussed.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Liang Chen, Andrea J. Lengi, Benjamin A. Corl
Summary: The conjugated linoleic acid t10,c12 plays a role in regulating SREBP1 activation by delaying Insig1 degradation, leading to reduced transcription of lipogenic genes in bovine mammary epithelial cells.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Zhendong Qiu, Wenhong Deng, Yupu Hong, Liang Zhao, Man Li, Yongjun Guan, Yingru Su, Chen Chen, Qiao Shi, Jia Yu, Weixing Wang
Summary: Research showed that the knockdown of ATP citrate lyase (ACLY) and Sterol regulatory element binding protein 1 (SREBP1) genes inhibits proliferation, migration, and invasion of colorectal cancer cells, while promoting apoptosis. These findings suggest potential new targets for treating colorectal cancer through modulation of lipid synthesis in cancer cells.
ONCOTARGETS AND THERAPY
(2021)
Article
Developmental Biology
Abi K. Funes, Layla Simon, Regina Colombo, Maria Virginia Avena, Maria Monclus, Julieta Crescitelli, Maria E. Cabrillana, Maria Ines Conte, Niubys Cayado, Paola Boarelli, Miguel W. Fornes, Tania E. Saez Lancellotti
Summary: Male fertility is dependent on cholesterol homeostasis, with fat consumption impacting the intracellular pathway regulating cholesterol levels in the testicle in the long term.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Genetics & Heredity
Ying Hu, Yanli Wang, Xuanjun Wang, Xiaoyun Wu, Lin Fu, Xiayu Liu, Yu Wen, Jun Sheng, Jingjing Zhang
Summary: The study found that the cation diffusion facilitators CDF-1 and SUR-7 regulate lipid metabolism in response to zinc, affecting the functionality of the SREBP-SCD axis.
G3-GENES GENOMES GENETICS
(2021)
Article
Agriculture, Multidisciplinary
Sanna Hokkanen, Alexander D. Frey, Baoru Yang, Kaisa M. Linderborg
Summary: The similarity of infant formulas containing either bovine milk fat or vegetable oil to breastmilk was evaluated by analyzing their lipid composition. Formulas with milk fat were more similar to breastmilk compared to those with vegetable oil, with differences found in cholesterol, polar lipids, fatty acid distribution, and composition. Vegetable oil formulas showed higher similarity in n-6 polyunsaturated fatty acids.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Genetics & Heredity
Shobhana Rajasenan, Aysha H. Osmani, Stephen A. Osmani
Summary: Fungal biofilm founder cells undergo self-generated hypoxia, leading to changes in cell biology, including microtubule disassembly and modulation of cellular responses to gaseous signaling. The transcription factors SrbA and AtrR play crucial roles in regulating biofilm development and responding to environmental cues.
FUNGAL GENETICS AND BIOLOGY
(2022)
Article
Biology
Sahar Khateeb, Aishah Albalawi, Adel Alkhedaide
Summary: The study found that DG significantly reduced body weight gain, adjusted liver enzymes, and improved lipid levels in mice. Additionally, DG improved histopathological changes by reducing lipid vacuoles and hepatosteatosis, as well as downregulated SREBP-1c and FASN gene expression involved in fatty acid synthesis.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Veterinary Sciences
Jessica K. Suagee, Rebecca K. Splan, Kelcey L. Swyers, Raymond J. Geor, Benjamin A. Corl
JOURNAL OF EQUINE VETERINARY SCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Cristina Caldari-Torres, Michael L. McGilliard, Benjamin A. Corl
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2016)
Article
Agriculture, Dairy & Animal Science
Y. Yang, G. Ferreira, C. L. Teets, B. A. Corl, W. E. Thomason, C. A. Griffey
JOURNAL OF DAIRY SCIENCE
(2017)
Article
Agriculture, Dairy & Animal Science
Y. Yang, G. Ferreira, C. L. Teets, B. A. Corl, W. E. Thomason, C. A. Griffey
JOURNAL OF DAIRY SCIENCE
(2018)
Article
Agriculture, Dairy & Animal Science
Y. Yang, G. Ferreira, B. A. Corl, B. T. Campbell
JOURNAL OF DAIRY SCIENCE
(2019)
Article
Biotechnology & Applied Microbiology
Kayla Carey, Junghyun Ryu, Kyungjun Uh, Andrea J. Lengi, Sherrie Clark-Deener, Benjamin A. Corl, Kiho Lee
Article
Nutrition & Dietetics
D. E. Rico, J. E. Parales, B. A. Corl, A. Lengi, P. Y. Chouinard, R. Gervais
BRITISH JOURNAL OF NUTRITION
(2020)
Article
Agriculture, Dairy & Animal Science
G. Ferreira, L. L. Martin, C. L. Teets, B. A. Corl, S. L. Hines, G. E. Shewmaker, M. E. De Haro-Marti, M. Chahine
Summary: The study aimed to investigate the impact of drought stress on NDF and LIG concentrations, as well as IVDMD and IVNDFD of corn for silage. Drought stress increased NDF concentration, decreased IVDMD and IVNDFD, but had minimal effect on LIG concentration.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
H. Taga, M. P. Dallaire, R. Gervais, F. J. Richard, L. Ma, B. A. Corl, P. Y. Chouinard
Summary: The study aimed to characterize lipid raft microdomains in mammary gland tissue and investigate the effects of dietary fatty acids on lipid raft markers in mammary cells, as well as their relationships with lactation performance in dairy cows. The results indicated a positive relationship between the abundance of GM-1 and lipid raft markers in DRM fraction with milk yield, protein yield, and lactose yield.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
H. H. Hanling, M. L. McGilliard, B. A. Corl
Summary: Increasing milking frequency can boost milk yield, but different milking intervals did not significantly affect milk component yields. By using uneven milking intervals, labor efficiency can be improved while still optimizing milk production in early-lactation cows.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Liang Chen, Andrea J. Lengi, Benjamin A. Corl
Summary: The conjugated linoleic acid t10,c12 plays a role in regulating SREBP1 activation by delaying Insig1 degradation, leading to reduced transcription of lipogenic genes in bovine mammary epithelial cells.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Andrea J. Lengi, Jacob W. Stewart, Melissa Makris, Michelle L. Rhoads, Benjamin A. Corl
Summary: This study found that heat stress affects the composition and viability of somatic cells in milk, which has implications for milk production and the immunocompetence of dairy cows.
Meeting Abstract
Agriculture, Dairy & Animal Science
J. Suagee-Bedore, S. Hebrock, B. Corl, A. Lengi, O. Sundin, K. Cole, M. Worth
JOURNAL OF ANIMAL SCIENCE
(2018)
Proceedings Paper
Agriculture, Dairy & Animal Science
L. Chen, B. Corl
TRI-STATE DAIRY NUTRITION CONFERENCE, 2016
(2016)
Meeting Abstract
Agriculture, Dairy & Animal Science
H. Hanling, M. McGilliard, B. Corl
JOURNAL OF DAIRY SCIENCE
(2019)