Article
Chemistry, Multidisciplinary
Na Yan, Bin Hu, Junchao Xu, Rong Cai, Zhenhai Liu, Dapeng Fu, Beibei Huo, Zhenhua Liu, Yuliang Zhao, Chunying Chen, Weihua Xu
Summary: Periodontitis poses a significant challenge in healthcare worldwide. Current treatment methods have limitations, but a novel stem cell-containing patch shows great potential in promoting periodontal regeneration and preventing epithelial invasion, offering a safe and effective strategy for repairing and protecting periodontal tissues.
Review
Biotechnology & Applied Microbiology
Zeqing Zhao, Jin Liu, Michael D. Weir, Abraham Schneider, Tao Ma, Thomas W. Oates, Hockin H. K. Xu, Ke Zhang, Yuxing Bai
Summary: This review article presents the recent advances in PDLSC-based bone regeneration and periodontal tissue regeneration. By combining PDLSCs with various materials and scaffolds, as well as applying different osteoinductive agents and strategies, PDLSCs demonstrate the potential for bone and periodontal tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Qiao Ruan, Shenglong Tan, Li Guo, Dandan Ma, Jun Wen
Summary: Prevascularization techniques have been proposed to solve the challenge of rapid vascularization in pulp regeneration. These techniques involve coculturing endothelial cells and pericytes to induce intercellular communication, and then introducing them into a customized artificial vascular bed or inducing self-assembly. However, there are still unresolved problems regarding cell sources, intercellular communication, and the construction of prevascularization systems for pulp regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shuntaro Yamada, Philipp Niklas Ockermann, Thomas Schwarz, Kamal Mustafa, Jan Hansmann
Summary: This review primarily focuses on the biophysical environment in bone and its application in 2D and 3D cell culture, including the impact of mechanical stimuli on bone cell growth and fate, as well as the use of dynamic cell culture platforms in bone tissue engineering.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Konstantinos Loukelis, Foteini Machla, Athina Bakopoulou, Maria Chatzinikolaidou
Summary: This study investigates the impact of kappa-carrageenan on dental pulp stem cells and reveals that its integration in scaffolds significantly enhances the odontogenic potential of DPSCs, supporting dentin-pulp regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nanoscience & Nanotechnology
Qi You, Minxun Lu, Zhuangzhuang Li, Yong Zhou, Chongqi Tu
Summary: Congenital or acquired bone defects present a challenge to the global healthcare system, and novel cell sheet technology shows promise for promoting bone regeneration. This review introduces and explores the application of cell sheet technology in bone regeneration, highlights the current state of research, and offers perspectives on translating this knowledge to clinical practice.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Multidisciplinary Sciences
Kengo Abe, Akihiro Yamashita, Miho Morioka, Nanao Horike, Yoshiaki Takei, Saeko Koyamatsu, Keisuke Okita, Shuichi Matsuda, Noriyuki Tsumaki
Summary: Allogeneic iPSC-derived cartilage organoids survive and integrate with surrounding native cartilage without immune reactions in a primate model of chondral defects in the knee joints, being remodeled and functioning as articular cartilage.
NATURE COMMUNICATIONS
(2023)
Article
Cell & Tissue Engineering
Che-Chang Tu, Nai-Chen Cheng, Jiashing Yu, Yi-Xuan Pan, Wei-Chiu Tai, Yin-Chuan Chen, Po-Chun Chang
Summary: This study evaluates the potential of self-assembled adipose-derived stem cell spheroids (ADsp) in microbial transglutaminase cross-linked gelatin hydrogel (mTG) for treating diabetic periodontal wounds and craniofacial defects. The results show that osteogenically pretreated ADsp-mTG can promote the regeneration of diabetic osseous defects. This suggests that ADsp-mTG can facilitate diabetic periodontal wound healing and craniofacial osseous defect regeneration.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Medicine, Research & Experimental
Mengyuan Wang, Ying Li, Hongqiao Wang, Meng Li, Xiaomin Wang, Rongzhen Liu, Daijun Zhang, Wenhua Xu
Summary: Corneal epithelial defects and excessive wound healing can cause severe complications. Stem cells offer a promising solution for regenerating the corneal epithelium and treating severe corneal epithelial injury. Biological scaffolds such as the amniotic membrane, fibrin, and hydrogels provide the necessary signals for stem cell proliferation and differentiation. Researchers have evaluated these scaffolds as potential therapeutic interventions for corneal disorders, identifying both benefits and drawbacks. This study provides a comprehensive overview of the history and use of stem cells in corneal repair, focusing on biological scaffolds used in stem cell transplantation and innovative materials under investigation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Chemistry, Multidisciplinary
Parinaz Abdollahiyan, Fatemeh Oroojalian, Maryam Hejazi, Miguel de la Guardia, Ahad Mokhtarzadeh
Summary: 3D bioprinting techniques in tissue engineering have shown great potential in constructing hard organs and tissues, such as bone and cartilage. However, the main challenge lies in replicating the complex structures of natural tissues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Polymer Science
Ali M. Alqahtani
Summary: This comprehensive review provides an in-depth analysis of the use of biomaterials in guided tissue and bone regeneration in dental therapeutic interventions. The review explores different types of membranes and biomaterials used in guided bone regeneration procedures, as well as the manufacturing technologies for the scaffold. The significance of guided bone regeneration and the critical role of membranes in successful bone and tissue regeneration are emphasized.
Review
Cell Biology
Josefa Alarcon-Apablaza, Ruth Prieto, Mariana Rojas, Ramon Fuentes
Summary: Bone loss often occurs due to trauma, surgery, or congenital malformations. This review examines the potential of mesenchymal stromal cells (MSCs) from the oral cavity for bone regeneration. Different sources of MSCs, such as dental pulp, inflamed dental pulp, exfoliated deciduous teeth, periodontal ligament, periosteal cells, buccal fat pad, and bone-derived MSCs, have been used successfully for repairing bone defects. Additional scaffolds are needed for effective stem cell delivery.
Review
Dentistry, Oral Surgery & Medicine
Fabiana Divina Magalhaes, Giovanna Sarra, Giovanna Lopes Carvalho, Ana Clara Fagundes Pedroni, Marcia Martins Marques, Leandro Chambrone, Thais Gimenez, Maria Stella Moreira
Summary: The review of 33 studies indicates that cell sheets formed by mesenchymal stem cells derived from dental tissues have great potential for periodontal tissue regeneration in animal models, but the regeneration process is not always complete.
ARCHIVES OF ORAL BIOLOGY
(2021)
Review
Engineering, Biomedical
Woochan Kim, Yonghyun Gwon, Sunho Park, Hyoseong Kim, Jangho Kim
Summary: Three-dimensional stem cell culture systems have the potential to mimic complex interactions between cells and the extracellular matrix, and have unique properties that can be applied in therapeutics.
BIOACTIVE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Yangwang Jin, Weixin Zhao, Ming Yang, Wenzhuo Fang, Guo Gao, Ying Wang, Qiang Fu
Summary: Urethral tissue engineering provides a new approach to repair urethral strictures, but the source, selection, and application conditions of cells need further investigation and improvement.
Article
Dentistry, Oral Surgery & Medicine
F. J. Rodriguez-Lozano, A. Lozano, S. Lopez-Garcia, D. Garcia-Bernal, J. L. Sanz, J. Guerrero-Girones, C. Llena, L. Forner, M. Melo
Summary: The new tantalum oxide (Ta2O5)-containing material, NeoMTA 2, exhibited higher calcium release compared to other materials. All groups showed similar effects on hDPSC viability and migration, with substantial cell attachment and spreading. NeoMTA 2 upregulated osteo/odontogenic gene expression and promoted higher ROS production in hDPSCs, indicating its potential for vital pulp therapy.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Anatomy & Morphology
E. Dominguez-Sala, A. Andreu-Cervera, P. Martin-Climent, R. Murcia-Ramon, S. Martinez, Emilio Geijo-Barrientos
Summary: Dysfunction of the LIS1 gene leads to abnormal properties of epileptiform discharges and their propagation in the cortex.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Polymer Science
Frine Velazquez-Contreras, Camilo Zamora-Ledezma, Ivan Lopez-Gonzalez, Luis Meseguer-Olmo, Estrella Nunez-Delicado, Jose Antonio Gabaldon
Summary: The use of cyclodextrins in food packaging enhances solubility and protection of volatile or bioactive molecules. Emphasis is placed on sustainable and biodegradable packaging, including the incorporation of nanotechnologies. Discussion also includes risks to human health, legislation, patents, and future research challenges.
Article
Dentistry, Oral Surgery & Medicine
Julia Guerrero-Girones, Sergio Lopez-Garcia, Miguel R. Pecci-Lloret, Maria P. Pecci-Lloret, Francisco Javier Rodriguez Lozano, David Garcia-Bernal
Summary: This study assessed and compared the in vitro biocompatibility of different resins used for dental splints. The results showed that the 3D-printed resins and conventional resin had similar biocompatibility, except for Freeprint Splint, which was the most cytotoxic on hGFs.
JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Francisco Javier Rodriguez-Lozano, Sergio Lopez-Garcia, Sonia Sanchez-Bautista, Javier Perez-Lopez, Ariel J. Raigrodski, Marta Revilla-Leon
Summary: The purpose of this study was to compare the effects of milled and lithography-based AM zirconia on the biological properties of human osteoblasts, as well as to compare their chemical composition differences. The results showed that both types of zirconia had similar cytocompatibility with human osteoblasts, but there were slight differences in their chemical composition.
JOURNAL OF PROSTHETIC DENTISTRY
(2023)
Article
Environmental Sciences
Maria Melo, Jose Luis Sanz, Leopoldo Forner, Francisco Javier Rodriguez-Lozano, Julia Guerrero-Girones
Summary: This study conducted a bibliometric analysis on research related to caries diagnosis, including the contributing researchers, organizations, countries or regions, and journals involved. The results showed that the majority of caries diagnosis research is conducted in the Dentistry Oral Surgery & Medicine category. Mendes FM and Braga MM were identified as the most productive authors, and Caries Research published the most articles on caries diagnosis. The keyword co-occurrence analysis revealed that the validity of diagnostic methods, tools or principles, as well as general aspects of caries detection and diagnosis, are the major focuses of this research.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Omer Sefvan Janjua, Sana Mehmood Qureshi, Muhammad Saad Shaikh, Ahmad Alnazzawi, Francisco J. Rodriguez-Lozano, Maria Pilar Pecci-Lloret, Muhammad Sohail Zafar
Summary: Autogenous tooth graft is an innovative technique using human teeth as a source of bone graft, which shows promise for maxillary and mandibular defect regeneration and can be used in sinus and ridge augmentations.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Maria Pilar Pecci-Lloret, Sergio Lopez-Garcia, Francisco Javier Rodriguez-Lozano, Pablo Alvarez-Novoa, David Garcia-Bernal
Summary: This study compared the cytotoxicity of five commonly used children's toothpastes on human gingival fibroblasts (hGFs) and found that Oral B toothpaste exhibited the lowest cytotoxicity and had the highest fluoride ion release. Further research is needed to confirm the biocompatibility of toothpastes containing sodium lauryl sarcosinate and sodium lauryl sulfate.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Jose Manuel Hernandez-Lopez, Cristina Hernandez-Medina, Cristina Medina-Corvalan, Monica Rodenas, Almagro Francisca, Claudia Perez-Garcia, Diego Echevarria, Francisco Carratala, Emilio Geijo-Barrientos, Salvador Martinez
Summary: The SARS-CoV-2 virus has the capacity to spread among humans and poses a threat to global public health. The expression of ACE2 in neuronal precursors and migratory neuroblasts in the fetal brain suggests that infection with this virus during the fetal period may impact brain development, memory generation, and increase the risk of cognitive and mental health issues throughout life.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Cell Biology
Ana Pombero, Raquel Garcia-Lopez, Salvador Martinez
Summary: Multiple biological processes, including embryonic development and cancer progression, rely on direct intercellular interactions to regulate cell proliferation and migration. Understanding the molecular and cellular mechanisms underlying the physical interactions between cancer cells and surrounding cells is of great importance for studying tumor development and growth.
Review
Microbiology
Alejandro Mora-Martinez, Laura Murcia, Francisco Javier Rodriguez-Lozano
Summary: Mucormycosis is a rare, opportunistic, and emerging fungal infection that becomes pathogenic when the host's immune system is compromised. The most common oral manifestations include bone exposures and oral ulcers, halitosis, pus discharge, gingival thickening, and periodontitis. However, more research is needed to understand the oral manifestations of mucormycosis.
Article
Dentistry, Oral Surgery & Medicine
Sergio Lopez-Garcia, Francisco J. Rodriguez-Lozano, Jose Luis Sanz, Leopoldo Forner, Maria Pilar Pecci-Lloret, Adrian Lozano, Laura Murcia, Sonia Sanchez-Bautista, Ricardo E. Onate-Sanchez
Summary: This study compared the cytocompatibility and bioactive potential of the new calcium silicate-based cement Ceraputty with Biodentine and Endosequence BC root repair material (ERRM) on human periodontal ligament stem cells (hPDLSCs). The results showed that Ceraputty exhibited reduced cytocompatibility towards hPDLSCs, while Biodentine and ERRM promoted mineralization and expression of osteo/cementogenic markers.
CLINICAL ORAL INVESTIGATIONS
(2023)
Review
Environmental Sciences
Miguel Ramon Pecci-Lloret, Maria Pilar Pecci-Lloret, Francisco Javier Rodriguez-Lozano
Summary: Due to the difficulty in dental management for individuals with special needs, it is important to analyze the prevalence of tooth decay in this group. A systematic review found that patients with intellectual disabilities had the highest prevalence of tooth decay, with no differences between genders. However, more research with standardized methods for diagnosis is needed to further investigate the prevalence of tooth decay in permanent teeth in patients with special needs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ana Lozano-Guillen, Sergio Lopez-Garcia, Francisco Javier Rodriguez-Lozano, Jose Luis Sanz, Adrian Lozano, Carmen Llena, Leopoldo Forner
Summary: The cytocompatibility of NeoPutty, NeoMTA Plus, and MTA Angelus with human dental pulp cells was evaluated in this study. The results demonstrated that these materials exhibited adequate cytocompatibility with human dental pulp cells.
CLINICAL ORAL INVESTIGATIONS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Julia Guerrero-Girones, Leopoldo Forner, Jose Luis Sanz, Francisco Javier Rodriguez-Lozano, James Ghilotti, Carmen Llena, Adrian Lozano, Maria Melo
Summary: The research on silicate-based endodontic materials has shown exponential growth between 1995 and 2020. The major co-authorship networks are led by Gandolfi MG, Prati C, Rodriguez-Lozano FJ, and Forner L. The most commonly used terms include mineral trioxide aggregate (MTA), biocompatibility, biodentine, and in vitro. The predominance of laboratory studies in this field highlights the need for more clinical studies to validate the findings.
CLINICAL ORAL INVESTIGATIONS
(2022)
