Article
Medicine, Research & Experimental
Lei Shen, Michael R. Dashwood, Carlo Casale, Nelson N. Orie, Ian M. Evans, Pratik Sufi, Rosaire Gray, Vidya Mohamed -Ali
Summary: In obese non-diabetic patients, omental adipose tissue (OAT) exhibits higher levels of norepinephrine (NE) concentration, tyrosine hydroxylase (TH) density, angiogenesis and maximal vasoconstriction compared to subcutaneous adipose tissue (SAT). However, OAT arterioles show lower sensitivity to NE and higher collagen deposition. In diabetic patients, NE sensitivity is reduced in SAT arterioles.
Article
Biochemical Research Methods
Min Yan, Mei X. Wu
Summary: This study demonstrates that pre-treatment with low-level light therapy can significantly enhance myotube formation and myoblast differentiation by increasing mitochondrial mass, myogenin expression, and reducing lactate production under hypoxic conditions, providing valuable insights for the timing and potential effects of LLLT on muscle strength in conjunction with anaerobic exercise.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Oncology
Roberta Giordo, Zena Wehbe, Panagiotis Paliogiannis, Ali H. Eid, Arduino A. Mangoni, Gianfranco Pintus
Summary: Tumor growth and progression are dependent on adequate blood supply. Tumor cells drive the formation of new blood vessels through the release of pro-angiogenic molecules. The processes involved in tumor angiogenesis are similar to normal vascular development, but with less control mechanisms. Targeting tumor blood vessels has been a focus of research, and nanomedicine offers advantages in specific drug delivery. This review comprehensively assesses key modulators of tumor vascular biology, promising nano-strategies, and future directions.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ruoyu Shen, Lijun Peng, Wentao Zhou, Ding Wang, Qi Jiang, Jian Ji, Fuqiang Hu, Hong Yuan
Summary: Abnormal tumor vasculature leads to malignant tumor microenvironment and affects tumor progression. We developed a nano-delivery system that sustains the release of anti-angiogenic agents to stabilize tumor vascular normalization, improving tumor perfusion and reversing abnormalities in the tumor microenvironment, ultimately inhibiting tumor progression.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Lisa Claire du Toit, Yahya Essop Choonara, Viness Pillay
Summary: This study developed an injectable nano-thermogel system for controlled delivery of the p11 anti-angiogenic peptide to prevent neovascularization in ocular disorders. The system showed potential efficacy and biocompatibility through various characterizations and evaluations.
Article
Chemistry, Multidisciplinary
Jiayu Chen, Xingzhi Zhou, Wenquan Sun, Zengjie Zhang, Wangsiyuan Teng, Fangqian Wang, Hangxiang Sun, Wei Zhang, Jianwei Wang, Xiaohua Yu, Zhaoming Ye, Weixu Li
Summary: This study demonstrates the successful development of a hybrid hydrogel delivery system using vascular derived extracellular matrix (vECM) and growth factors for promoting angiogenesis and osteogenesis in bone healing.
Article
Cell Biology
Suya Wang, Felix Umrath, Wanjing Cen, Antonio Jose Salgado, Siegmar Reinert, Dorothea Alexander
Summary: iPSC-derived MSC secretome pre-conditioned under inflammatory and hypoxic conditions shows higher angiogenic properties, making it a suitable cell source for collagen/hydroxyapatite with angiogenic properties.
Article
Multidisciplinary Sciences
Myrofora Panagi, Fotios Mpekris, Pengwen Chen, Chrysovalantis Voutouri, Yasuhiro Nakagawa, John D. Martin, Tetsuro Hiroi, Hiroko Hashimoto, Philippos Demetriou, Chryso Pierides, Rekha Samuel, Andreas Stylianou, Christina Michael, Shigeto Fukushima, Paraskevi Georgiou, Panagiotis Papageorgis, Petri Ch Papaphilippou, Laura Koumas, Paul Costeas, Genichiro Ishii, Motohiro Kojima, Kazunori Kataoka, Horacio Cabral, Triantafyllos Stylianopoulos
Summary: By utilizing the reprogramming capabilities of tranilast, researchers developed tranilast-loaded micelles that enhanced the reprogramming of cancer-associated fibroblasts. Combining these micelles with immunotherapy resulted in cures and immunological memory in immunotherapy-resistant breast cancer mice. Additionally, shear wave elastography (SWE) was able to monitor tumor stiffness caused by the micelles and predict response to nano-immunotherapy.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Nezar Boreak, Noor Mohammed Abu Khayrat, Ahmed Omar Shami, Haitham Jameel Mohammed Zaylaee, Aeshah Ali Hanbashi, Sara Abdulhamed Souri, Hala Mohammed Otayf, Rafif Essam Bakri, Mohammad Eissa Mansoor Ajeely, Alwaleed Essam Hassan Bakri, Mohammed Abdurabu Jafer, A. Thirumal Raj, Hosam Ali Baeshen, Shankargouda Patil
Summary: The study demonstrated that treatment with metformin enhances the angiogenic potential of dental pulp stem cell secretome, potentially aiding in regeneration.
SAUDI PHARMACEUTICAL JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Zhenjiang Zheng, Dingchuan Peng, Mengfei Li, Xuehan Lu, Songlin Gong, Yuan Yuan, Epiphane K. Silli, Jiali Tang, Qiaoyun Zhao, Haoyun Xu, Yufei Lan, Chunlu Tan, Ying Wang
Summary: By developing a novel nanoliposome, this study effectively inhibited the proliferation and promoted apoptosis of pancreatic tumor cells, while reducing collagen synthesis, providing a promising therapeutic strategy for pancreatic cancer.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elnaz Shaabani, Maryam Sharifiaghdam, Joris Lammens, Herlinde De Keersmaecker, Chris Vervaet, Thomas De Beer, Elahe Motevaseli, Mohammad Hossein Ghahremani, Parvin Mansouri, Stefaan De Smedt, Koen Raemdonck, Reza Faridi-Majidi, Kevin Braeckmans, Juan C. Fraire
Summary: Impaired wound healing in people with diabetes is caused by multiple factors, with lack of new blood vessel formation being one of the most important. Stabilization of HIF-1 alpha by downregulating PHD-2 can upregulate pro-angiogenic factors, improving diabetic wound healing. Gold nanoparticles loaded with siRNA and coated with a Poly L-arginine outer layer showed enhanced endosomal escape and transfection efficiency compared to other formulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Mohammad Kiani Shahvandi, Mohammad Souri, Shaghayegh Tavasoli, Farshad Moradi Kashkooli, Saptarshi Kar, M. Soltani
Summary: Delivery of chemotherapeutic medicines to solid tumors is critical for optimal therapeutic success and minimal adverse effects. In this study, a delivery method using thermosensitive nanocarriers activated by light irradiation was developed and compared to bolus and continuous infusions of doxorubicin. The efficacy of the delivery method was assessed using a pharmacodynamics model and a microvascular network. The study found that continuous infusion improved therapeutic response due to improved bioavailability, and multiple injections increased cancer cell death compared to single injections. Responsive nanocarriers supplied more drug than traditional chemotherapy in extracellular space, suppressing tumor development longer and reducing systemic side effects.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Materials Science, Biomaterials
Tauseef Ahmad, Sean McGrath, Catherine Sirafim, Ronaldo J. F. C. do Amaral, Shin-Loong Soong, Renuka Sitram, Shifa'a Turkistani, Francesco Santarella, Cathal J. Kearney
Summary: This study demonstrated successful on-demand delivery of therapeutic nanoparticles within a collagen-based scaffold through ultrasound-triggered release of multiple therapeutic drugs. These platforms offer a precise and versatile way to deliver therapeutic nanoparticles within a proven regenerative template, and can be used for wound healing and other tissue engineering applications.
BIOMATERIALS SCIENCE
(2021)
Article
Materials Science, Biomaterials
Yajing Ye, Yaqing Zhou, Zhuoyuan Jing, Yifan Xu, Dachuan Yin
Summary: The application of heparin-loaded sutures made of electrospun nanofibers is an effective strategy for improving tendon healing and health, surpassing traditional commercial sutures. Improving blood supply is crucial for tendon healing, presenting a promising approach for clinical treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Luyao Yi, Hongling Wu, Yue Xu, Jian Yu, Yaning Zhao, Hongye Yang, Cui Huang
Summary: This study developed a multifunctional nanocomposite for treating dentin hypersensitivity. The nanocomposite can immediately occlude dentinal tubules, exhibit acid and mechanical resistance, induce dentin remineralization, and promote odontogenic differentiation. By reconstructing the hierarchical structure of dentin and introducing newly formed minerals, it achieves superior long-term sealing effects.
Article
Cell & Tissue Engineering
Neil R. W. Martin, Samantha L. Passey, Darren J. Player, Vivek Mudera, Keith Baar, Linda Greensmith, Mark P. Lewis
TISSUE ENGINEERING PART A
(2015)
Review
Nanoscience & Nanotechnology
Ensanya Ali Abou Neel, Anas Aljabo, Adam Strange, Salwa Ibrahim, Melanie Coathup, Anne M. Young, Laurent Bozec, Vivek Mudera
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2016)
Review
Pharmacology & Pharmacy
Ensanya A. Abou Neel, Laurent Bozec, Jonathan C. Knowles, Omaer Syed, Vivek Mudera, Richard Day, Jung Keun Hyun
ADVANCED DRUG DELIVERY REVIEWS
(2013)
Article
Engineering, Biomedical
Neil R. W. Martin, Samantha L. Passey, Darren J. Player, Alastair Khodabukus, Richard A. Ferguson, Adam P. Sharples, Vivek Mudera, Keith Baar, Mark P. Lewis
Article
Biotechnology & Applied Microbiology
D. J. Player, N. R. W. Martin, S. L. Passey, A. P. Sharples, V. Mudera, M. P. Lewis
BIOTECHNOLOGY LETTERS
(2014)
Correction
Biotechnology & Applied Microbiology
D. J. Player, N. R. W. Martin, S. L. Passey, A. P. Sharples, V. Mudera, M. P. Lewis
BIOTECHNOLOGY LETTERS
(2014)
Article
Oncology
Katerina Stamati, John V. Priestley, Vivek Mudera, Umber Cheema
EXPERIMENTAL CELL RESEARCH
(2014)
Article
Engineering, Biomedical
Dan Deng, Wei Liu, Umber Cheema, Vivek Mudera, Ektoras Hadjipanayi, Robert A. Brown
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2014)
Article
Biochemistry & Molecular Biology
A. S. T. Smith, S. Passey, L. Greensmith, V. Mudera, M. P. Lewis
JOURNAL OF CELLULAR BIOCHEMISTRY
(2012)
Article
Engineering, Biomedical
Harvey Rich, Marianne Odlyha, Umber Cheema, Vivek Mudera, Laurent Bozec
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2014)
Article
Orthopedics
Jennifer S. N. Verhoekx, Kate S. Beckett, Marcus A. Bisson, Duncan A. McGrouther, Adriaan O. Grobbelaar, Vivek Mudera
JOURNAL OF ORTHOPAEDIC RESEARCH
(2013)
Article
Neurosciences
Liron S. Duraku, Mehdi Hossaini, Sieske Hoendervangers, Lukas L. Falke, Shoista Kambiz, Vivek C. Mudera, Joan C. Holstege, Erik T. Walbeehm, Tom J. H. Ruigrok
Article
Surgery
Jennifer S. N. Verhoekx, Vivek Mudera, Erik T. Walbeehm, Steven E. R. Hovius
PLASTIC AND RECONSTRUCTIVE SURGERY
(2013)
Editorial Material
Cell & Tissue Engineering
Prasad Sawadkar, Susan Alexander, Vivek Mudera
REGENERATIVE MEDICINE
(2014)
Article
Biochemistry & Molecular Biology
Esen Sayin, Erkan Turker Baran, Ahmed Elsheikh, Vivek Mudera, Umber Cheema, Vasif Hasirci
Summary: It was found that the 3D culture of MSCs in collagen/silk fibroin scaffolds could significantly enhance the expressions of OSX and VEGFA, and result in improved tensile mechanical properties compared to 2D culture, with different effects observed under different oxygen environments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)