Article
Polymer Science
Estefania Tiburcio, Eduardo Garcia-Junceda, Leoncio Garrido, Alfonso Fernandez-Mayoralas, Julia Revuelta, Agatha Bastida
Summary: A novel chitosan gel beads were synthesized using a double ionic co-crosslinking mechanism, showing good antibacterial properties. The release mechanism of streptomycin and kanamycin A was bimodal, with an initial burst followed by sustained release.
Article
Biochemistry & Molecular Biology
Mostafa Saeedi, Mohammad Reza Moghbeli, Omid Vahidi
Summary: In this study, chitosan was crosslinked using glycyrrhizic acid as a new crosslinking agent, and the obtained hydrogels showed biocompatibility for controlled release of gallic acid in transdermal therapy. The crosslinking of chitosan with glycyrrhizic acid formed a covalent amide linkage, resulting in the formation of a crosslinked hydrogel network structure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Olimpia Daniela Frent, Narcis Duteanu, Alin Cristian Teusdea, Stefania Ciocan, Laura Vicas, Tunde Jurca, Mariana Muresan, Annamaria Pallag, Paula Ianasi, Eleonora Marian
Summary: The aim of this study was to prepare microspheres based on biodegradable polymers and load them with a water-insoluble and environmentally sensitive active drug. The experimental results showed that the prepared microspheres had a high drug entrapment rate and could achieve controlled release of the active drug at the intestinal level. Furthermore, the microspheres exhibited good thermal stability, making them suitable for drug delivery systems.
Article
Biochemistry & Molecular Biology
Enchao Liu, Shenghan Zhao, Xiao Li, Xianghong Meng, Bingjie Liu
Summary: In this study, a novel DHA-loaded nanoparticle (PCSDNP) with PLGA and chitosan was successfully prepared. The particle structure and interactions were analyzed through various microscopy techniques and FTIR spectroscopy. PCSDNP showed better stability and controlled release properties under different environmental conditions, mainly attributed to hydrogen bonds and electrostatic interactions between PLGA and chitosan, demonstrating potential for biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Emine Bulut, Yakup Turhan
Summary: This study focuses on the preparation of temperature-sensitive CS/HPC-g-PAAm blend microspheres for controlled drug release, showing that the microspheres have temperature sensitivity and the release of AMX is slightly more controlled by increasing graft yield.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Bingren Tian, Jianhua Cheng, Tianping Zhang, Yumei Liu, Dejun Chen
Summary: This study focused on creating a chitosan-based hydrogel film loaded with hops beta-acids by introducing silane, which showed improved tensile strength and antibacterial properties against E. coli and S. aureus. The nanosilica in the film promoted the delayed release of beta-acids, leading to disruption of membrane integrity and cell death. Additionally, the film displayed UV-blocking capabilities and the potential for applications in the food industry as an antiseptic material.
FOOD HYDROCOLLOIDS
(2022)
Review
Biochemistry & Molecular Biology
Wei Shi, Yern Chee Ching, Cheng Hock Chuah
Summary: This review focuses on the preparation and application of spherical aerogels for drug delivery, with a specific emphasis on their potential as drug carriers. Various innovative approaches and future prospects are proposed to inspire readers in creating novel drug release systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
X. Luo, K. -Y Tang, Y. -Y Wang
Summary: The study concludes that the kaolin/chitosan composite microspheres prepared by the emulsification-crosslinking method are excellent drug-loading materials, with good drug loading rate and encapsulation efficiency, and can achieve sustained-release performance.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
W. Ramos-Torres, Rocio Borges-Argaez, P. Gonzalez-Chi
Summary: Hybrid microspheres composed of PAL nanoclay and crosslinked QS were prepared to trap and control the release of TIM. The hybrid microspheres showed higher encapsulation efficiency and more uniform size distribution compared to pristine chitosan microspheres, and the thymol release kinetics was modified by the palygorskite content.
MATERIALS RESEARCH EXPRESS
(2021)
Article
Agriculture, Multidisciplinary
Meiyi Wang, Jiayu Lou, Yapeng Chen, Leiyu Yang, Huashan Wang
Summary: A novel photoresponsive herbicide delivery system was developed by functionalizing silica microsphere surfaces and encapsulating them with gamma-cyclodextrin. The microspheres showed remarkable loading capacity for pendimethalin and displayed excellent photoresponsiveness and controlled release. They exhibited longer duration weed control and lower genotoxicity than traditional pendimethalin, making them an environmentally friendly herbicidal formulation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Meiyi Wang, Jiayu Lou, Yapeng Chen, Leiyu Yang, Huashan Wang
Summary: A novel photoresponsive herbicide delivery system was developed by functionalizing silica microspheres with cinnamamide and encapsulating them with gamma-cyclodextrin to form a double-layered microsphere shell loaded with pendimethalin. The microspheres showed excellent photoresponsiveness and controlled release, with over 80% cumulative drug release rate under UV or sunlight irradiation. They exhibited similar herbicidal activity as pendimethalin and longer duration weed control compared to commercial pendimethalin. The microspheres also demonstrated lower genotoxicity than pendimethalin, making them an environmentally friendly herbicidal formulation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jian Xu, Wei Song, Nan Wu, Jin Tong, Lili Ren
Summary: By controlling the content of added polyvinyl alcohol (PVA), the structure and properties of chitosan/polyvinyl alcohol (CS/PVA) porous aerogel microspheres can be manipulated to enhance their physicochemical characteristics. This study demonstrates the potential to improve the structure and performance of hybrid aerogel microspheres by adjusting the content of PVA.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Nafiseh Hosseini-Ashtiani, Azadeh Tadjarodi, Rouholah Zare-Dorabei
Summary: This study aimed to develop a safe nano-drug carrier using chitosan and cyanocobalamin for enhanced oral delivery of ciprofloxacin hydrochloride. The optimized drug loading efficiency and controlled release patterns demonstrated the potential of this chitosan-based nano-drug delivery system for oral administration of CIP.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Soha Habibi, Toraj Mohammadi, Romina HMTShirazi, Fatemeh Atyabi, Melika Kiani, Amir Atabak Asadi
Summary: In this study, double-layer CS/PVA/mupirocin (CPM) + CS/PVA/bupivacaine (CPB) electrospun nanofiber mats were prepared and crosslinked to optimize their water-resistant and biodegradation properties. The mats exhibited defect-free and interconnected nanofibers, providing a moist environment for efficient wound breathing and repairing. The highly porous mat absorbed wound exudates and allowed air permeability, reducing the chance of bacterial infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Shu-ji Wang, Di Wang, Peng Chen, Shi Yan, Qing-jie Jiao, Xue-yong Guo
Summary: Electrostatic spray drying method was used to prepare Al@TKX-50@NC composite microspheres, which showed excellent mechanical properties. The structure and composition of the composite were characterized, and its thermal decomposition kinetics and thermodynamics were calculated and analyzed. The ignition and combustion performance of the composite were also tested. The results demonstrated that the electrostatic spray method is highly effective in improving the energy release of composite energetic materials.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Applied
Ernesto Doncel-Perez, Inmaculada Aranaz, Agatha Bastida, Julia Revuelta, Celia Camacho, Niuris Acosta, Leoncio Garrido, Concepcion Civera, Eduardo Garcia-Junceda, Angeles Heras, Alfonso Fernandez-Mayoralas
CARBOHYDRATE POLYMERS
(2018)
Article
Biochemistry & Molecular Biology
Inmaculada Aranaz, Andres R. Alcantara, Angeles Heras, Niuris Acosta
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Biochemistry & Molecular Biology
Sawsan Affes, Inmaculada Aranaz, Marwa Hamdi, Niuris Acosta, Olfa Ghorbel-Bellaaj, Angeles Heras, Moncef Nasri, Hana Maalej
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Review
Chemistry, Physical
Veymar G. Tacias-Pascacio, Claudia Ortiz, Nazzoly Rueda, Angel Berenguer-Murcia, Niuris Acosta, Inmaculada Aranaz, Concepcion Civera, Roberto Fernandez-Lafuente, Andres R. Alcantara
Article
Biochemistry & Molecular Biology
Sawsan Affes, Hana Maalej, Inmaculada Aranaz, Niuris Acosta, Angeles Heras, Moncef Nasri
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Nanoscience & Nanotechnology
Julia Revuelta, Inmaculada Aranaz, Niuris Acosta, Concepcion Civera, Agatha Bastida, Nerea Pena, Dianelis T. Monterrey, Ernesto Doncel-Perez, Leoncio Garrido, Angeles Heras, Eduardo Garcia-Junceda, Alfonso Fernandez-Mayoralas
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Applied
Sawsan Affes, Hana Maalej, Inmaculada Aranaz, Hela Kchaou, Niuris Acosta, Angeles Heras, Moncef Nasri
CARBOHYDRATE POLYMERS
(2020)
Article
Biochemistry & Molecular Biology
Sawsan Affes, Inmaculada Aranaz, Niuris Acosta, Angeles Heras, Moncef Nasri, Hana Maalej
Summary: This study developed Ch/CDP-based films with varying molecular weight and acetylation degree, showing improved optical and antioxidant properties, as well as enhanced water resistance, mechanical properties, and anti-bacterial properties. The films also exhibited controlled release of ciprofloxacin, making them promising drug delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Polymer Science
Inmaculada Aranaz, Andres R. Alcantara, Maria Concepcion Civera, Concepcion Arias, Begona Elorza, Angeles Heras Caballero, Niuris Acosta
Summary: Chitosan, a polymer with diverse properties and potential applications, is facing challenges such as poor solubility, complex molecular structure, and varied biological properties. Researchers are exploring the chemistry of chitosan to improve its solubility and enhance its properties, focusing on its biological and technological performance. Additionally, applications of chitosan in green processes, such as the synthesis of metallic nanoparticles and support for biocatalysts, are being investigated for their potential in drug delivery systems.
Article
Polymer Science
Sara Garcinuno, Inmaculada Aranaz, Concepcion Civera, Concepcion Arias, Niuris Acosta
Summary: This work produces and characterizes two chitosan samples from cuttlebone and squid pen, and investigates the formation of thermoresponsive hydrogels with beta-glycerol phosphate. Different formulations are required for gel formation depending on the chitosan source. The study also develops risperidone formulations for controlled drug delivery using noncommercial chitosan sources combined with beta-glycerol phosphate.
Article
Biochemistry & Molecular Biology
Daniel Fernandez-Villa, Rosa Ana Ramirez-Jimenez, Inmaculada Aranaz, Niuris Acosta, Blanca Vazquez-Lasa, Luis Rojo
Summary: This study synthesized a series of MTX complexes and characterized their physicochemical properties. The complexes showed new bioactive properties, such as increased deposition of GAGs and alternative anti-inflammatory capacities. Furthermore, the complexes were successfully loaded into spray-dried chitosan microparticles, enabling their encapsulation and localized delivery to rheumatoid arthritis-affected joints.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Isabel Rodriguez-Veiga, Niuris Acosta, Inmaculada Aranaz, Aldona Dobrzycka-Krahel
Summary: The demand for chitin and chitosan is increasing rapidly in various industries. This paper evaluates Saduria entomon as a source for chitin and chitosan isolation and finds that it has promising antimicrobial and antioxidant properties, making it a potential source for biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Multidisciplinary
Inmaculada Aranaz, Carolina Castro, Angeles Heras, Niuris Acosta
Review
Biochemistry & Molecular Biology
I. Aranaz, N. Acosta, A. Heras
BIOCATALYSIS AND BIOTRANSFORMATION
(2018)
Article
Biochemistry & Molecular Biology
P. Santos-Moriano, L. Fernandez-Arrojo, M. Mengibar, E. Belmonte-Reche, P. Penalver, F. N. Acosta, A. O. Ballesteros, J. C. Morales, P. Kidibule, M. Fernandez-Lobato, F. J. Plou
BIOCATALYSIS AND BIOTRANSFORMATION
(2018)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
