☆ 4.2 Article

High-Resolution Computed Tomographic Imaging of Airways in Sarcoidosis Patients With Airflow Obstruction

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY (2008)

Journal

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY

Volume 32, Issue 6, Pages 905-912

Publisher

LIPPINCOTT WILLIAMS & WILKINS

DOI: 10.1097/RCT.0b013e31815b63dd

Keywords

airflow obstruction; airways; computed tomography; sarcoidosis

Categories

Radiology, Nuclear Medicine & Medical Imaging

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Abstract

Objective: To investigate airway involvement in patients with pulmonary sarcoidosis and airflow obstruction (AO) using high-resolution computed tomography Methods: Forty-two sarcoidosis patients with AO and 42 matched sarcoidosis patients Without AO were retrospectively analyzed. High-resolution Computed tomographic patterns of airway involvement were bronchial distortion, peribronchovascular thickening, small airway obstruction, and bronchial compression by enlarged lymph nodes. Results: Interobserver agreement was good (kappa > 0.8). High-resolution computed tomographic patterns of airway involvement were found more frequently, scored higher, and were more often multiple (P < 0.05) in patients with AO than those without. Functional improvement tinder treatment was observed more frequently in patients with predominant peribronchovascular thickening compared with patients with predominant bronchial distortion (P < 0.03). Conclusions: In pulmonary sarcoidosis patients with AO, high-resolution computed tomography is a reliable tool to identify underlying airways involvements, which are often Multiple, and enables prediction of the therapeutic response.

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