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Role for proteases and HLA-G in the pathogenicity of influenza A viruses

JOURNAL OF CLINICAL VIROLOGY (2011)

Journal

JOURNAL OF CLINICAL VIROLOGY

Volume 51, Issue 3, Pages 155-159

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ELSEVIER

DOI: 10.1016/j.jcv.2011.04.013

Keywords

Influenza virus; HLA-G; Proteases-activated receptors; Inflammation; Host-virus relation; Therapeutic

Categories

Virology

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Abstract

Influenza is one of the most common infectious diseases in humans occurring as seasonal epidemic and sporadic pandemic outbreaks. The ongoing infections of humans with avian H5N1 influenza A viruses (IAV) and the past 2009 pandemic caused by the quadruple human/avian/swine reassortant (H1N1) virus highlights the permanent threat caused by these viruses. This review aims to describe the interaction between the virus and the host, with a particular focus on the role of proteases and HLA-G in the pathogenicity of influenza viruses. (C) 2011 Elsevier B.V. All rights reserved.

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Pritchard, Lucia Proenca, Oriane Puechal, Gregory Purcell, Luisa Quesada, Else Quist-Paulsen, Mohammed Quraishi, Indrek Ratsep, Bernhard Rossler, Christian Rabaud, Marie Rafiq, Gabrielle Ragazzo, Fernando Rainieri, Nagarajan Ramakrishnan, Kollengode Ramanathan, Blandine Rammaert, Christophe Rapp, Menaldi Rasmin, Cornelius Rau, Stanislas Rebaudet, Sarah Redl, Brenda Reeve, Liadain Reid, Renato Reis, Jonathan Remppis, Martine Remy, Hanna Renk, Liliana Resende, Anne-Sophie Resseguier, Matthieu Revest, Oleksa Rewa, Luis Felipe Reyes, David Richardson, Denise Richardson, Laurent Richier, Jordi Riera, Ana Lucia Rios, Asgar Rishu, Patrick Rispal, Karine Risso, Maria Angelica Rivera Nunez, Nicholas Rizer, Andre Roberto, Stephanie Roberts, David L. Robertson, Olivier Robineau, Ferran Roche-Campo, Paola Rodari, Simao Rodeia, Julia Rodriguez Abreu, Emmanuel Roilides, Amanda Rojek, Juliette Romaru, Roberto Roncon-Albuquerque, Melanie Roriz, Manuel Rosa-Calatrava, Michael Rose, Dorothea Rosenberger, Andrea Rossanese, Benedicte Rossignol, Patrick Rossignol, Carine Roy, Benoit Roze, Clark D. Russell, Steffi Ryckaert, Aleksander Rygh Holten, Xavier Sanchez Choez, Isabela Saba, Musharaf Sadat, Nadia Saidani, Leonardo Salazar, Gabriele Sales, Stephane Sallaberry, Helene Salvator, Angel Sanchez-Miralles, Olivier Sanchez, Vanessa Sancho-Shimizu, Gyan Sandhu, Oana Sandulescu, Marlene Santos, Shirley Sarfo-Mensah, Benjamine Sarton, Egle Saviciute, Parthena Savvidou, Joshua Scarsbrook, Tjard Schermer, Arnaud Scherpereel, Marion Schneider, Stephan Schroll, Michael Schwameis, James Scott-Brown, Janet T. Scott, Nicholas Sedillot, Tamara Seitz, Caroline Semaille, Malcolm G. Semple, Eric Senneville, Filipa Sequeira, Tania Sequeira, Ellen Shadowitz, Mohammad Shamsah, Pratima Sharma, Catherine A. Shaw, Victoria Shaw, Nisreen Shiban, Nobuaki Shime, Hiroaki Shimizu, Keiki Shimizu, Sally Shrapnel, Hoi Ping Shum, Nassima Si Mohammed, Louise Sigfrid, Catarina Silva, Maria Joao Silva, Wai Ching Sin, Vegard Skogen, Sue Smith, Benjamin Smood, Michelle Smyth, Morgane Snacken, Dominic So, Monserrat Solis, Joshua Solomon, Tom Solomon, Emily Somers, Agnes Sommet, Myung Jin Song, Rima Song, Tae Song, Michael Sonntagbauer, Edouard Soum, Maria Sousa Uva, Marta Sousa, Vicente Souza-Dantas, Alexandra Sperry, Shiranee Sriskandan, Thomas Staudinger, Stephanie-Susanne Stecher, Ymkje Stienstra, Birgitte Stiksrud, Adrian Streinu-Cercel, Anca Streinu-Cercel, Samantha Strudwick, Ami Stuart, David Stuart, Asfia Sultana, Charlotte Summers, Magdalena Surovcova, Andrey A. Svistunov, Konstantinos Syrigos, Jaques Sztajnbok, Konstanty Szuldrzynski, Francois Teoule, Shirin Tabrizi, Lysa Tagherset, Ewa Talarek, Sara Taleb, Jelmer Talsma, Le Van Tan, Hiroyuki Tanaka, Taku Tanaka, Hayato Taniguchi, Coralie Tardivon, Pierre Tattevin, M. Azhari Taufik, Richard S. Tedder, Joao Teixeira, Marie-Capucine Tellier, Pleun Terpstra, Olivier Terrier, Nicolas Terzi, Hubert Tessier-Grenier, Vincent Thibault, Simon-Djamel Thiberville, Benoit Thill, A. A. Roger Thompson, Shaun Thompson, David Thomson, Emma C. Thomson, Duong Bich Thuy, Ryan S. Thwaites, Peter S. Timashev, Jean-Francois Timsit, Bharath Kumar Tirupakuzhi Vijayaraghavan, Maria Toki, Kristian Tonby, Rosario Maria Torres Santos-Olmo, Antoni Torres, Margarida Torres, Theo Trioux, Huynh Trung Trieu, Cecile Tromeur, Ioannis Trontzas, Jonathan Troost, Tiffany Trouillon, Christelle Tual, Sarah Tubiana, Helen Tuite, Lance C. W. Turtle, Pawel Twardowski, Makoto Uchiyama, Roman Ullrich, Alberto Uribe, Asad Usman, Luis Val-Flores, Stijn Van de Velde, Marcel Van den Berge, Machteld Van der Feltz, Nicky Van der Vekens, Peter Van der Voort, Sylvie Van der Werf, Marlice Van Dyk, Laura Van Gulik, Jarne Van Hattem, Steven Van Lelyveld, Carolien Van Netten, Noemie Vanel, Henk Vanoverschelde, Charline Vauchy, Aurelie Veislinger, Jorge Velazco, Sara Ventura, Annelies Verbon, Cesar Vieira, Joy Ann Villanueva, Judit Villar, Pierre-Marc Villeneuve, Andrea Villoldo, Nguyen Van Vinh Chau, Benoit Visseaux, Hannah Visser, Aapeli Vuorinen, Fanny Vuotto, Chih-Hsien Wang, Jia Wei, Katharina Weil, Sanne Wesselius, Murray Wham, Bryan Whelan, Nicole White, Aurelie Wiedemann, Keith Wille, Evert-Jan Wils, Ioannis Xynogalas, Jacky Y. Suen, Sophie Yacoub, Masaki Yamazaki, Yazdan Yazdanpanah, Cecile Yelnik, Stephanie Yerkovich, Toshiki Yokoyama, Hodane Yonis, Paul Young, Saptadi Yuliarto, Marion Zabbe, Kai Zacharowski, Maram Zahran, Maria Zambon, Alberto Zanella, Konrad Zawadka, Hiba Zayyad, Alexander Zoufaly, David Zucman

INFECTION (2021)

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Article Immunology

Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs

Jonathan Lopez, Marine Mommert, William Mouton, Andres Pizzorno, Karen Brengel-Pesce, Mehdi Mezidi, Marine Villard, Bruno Lina, Jean-Christophe Richard, Jean-Baptiste Fassier, Valerie Cheynet, Blandine Padey, Victoria Duliere, Thomas Julien, Stephane Paul, Paul Bastard, Alexandre Belot, Antonin Bal, Jean-Laurent Casanova, Manuel Rosa-Calatrava, Florence Morfin, Thierry Walzer, Sophie Trouillet-Assant

Summary: The nasal IFN-I/III signature in mildly symptomatic COVID-19 patients correlates with serum IFN-a(2) levels, while critically ill patients with autoantibodies against IFN-I showed low nasal IFN-I/III scores despite high viral loads. Functional assays confirmed the role of autoantibodies in compromising the antiviral effects of IFN-I at the early stages of SARS-CoV-2 infection.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Correction Immunology

Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs (vol 218, e20211211, 2021)

Jonathan Lopez, Marine Mommert, William Mouton, Andres Pizzorno, Karen Brengel-Pesce, Mehdi Mezidi, Marine Villard, Bruno Lina, Jean-Christophe Richard, Jean-Baptiste Fassier, Valerie Cheynet, Blandine Padey, Victoria Duliere, Thomas Julien, Stephane Paul, Paul Bastard, Alexandre Belot, Antonin Bal, Jean-Laurent Casanova, Manuel Rosa-Calatrava, Florence Morfin, Thierry Walzer, Sophie Trouillet-Assant

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Immunology

Autoantibodies neutralizing type I IFNs are present in ∼4% of uninfected individuals over 70 years old and account for ∼20% of COVID-19 deaths

Paul Bastard, Adrian Gervais, Tom Le Voyer, Jeremie Rosain, Quentin Philippot, Jeremy Manry, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Shohei Eto, Marina Garcia-Prat, Lucy Bizien, Alba Parra-Martinez, Rui Yang, Liis Haljasmagi, Melanie Migaud, Karita Sarekannu, Julia Maslovskaja, Nicolas de Prost, Yacine Tandjaoui-Lambiotte, Charles-Edouard Luyt, Blanca Amador-Borrero, Alexandre Gaudet, Julien Poissy, Pascal Morel, Pascale Richard, Fabrice Cognasse, Jesus Troya, Sophie Trouillet-Assant, Alexandre Belot, Kahina Saker, Pierre Garcon, Jacques G. Riviere, Jean-Christophe Lagier, Stephanie Gentile, Lindsey B. Rosen, Elana Shaw, Tomohiro Morio, Junko Tanaka, David Dalmau, Pierre-Louis Tharaux, Damien Sene, Alain Stepanian, Bruno Megarbane, Vasiliki Triantafyllia, Arnaud Fekkar, James R. Heath, Jose Luis Franco, Juan-Manuel Anaya, Jordi Sole-Violan, Luisa Imberti, Andrea Biondi, Paolo Bonfanti, Riccardo Castagnoli, Ottavia M. Delmonte, Yu Zhang, Andrew L. Snow, Steven M. Holland, Catherine M. Biggs, Marcela Moncada-Velez, Andres Augusto Arias, Lazaro Lorenzo, Soraya Boucherit, Boubacar Coulibaly, Dany Anglicheau, Anna M. Planas, Filomeen Haerynck, Sotirija Duvlis, Robert L. Nussbaum, Tayfun Ozcelik, Sevgi Keles, Ahmed A. Bousfiha, Jalila El Bakkouri, Carolina Ramirez-Santana, Stephane Paul, Qiang Pan-Hammarstrom, Lennart Hammarstrom, Annabelle Dupont, Alina Kurolap, Christine N. Metz, Alessandro Aiuti, Giorgio Casari, Vito Lampasona, Fabio Ciceri, Lucila A. Barreiros, Elena Dominguez-Garrido, Mateus Vidigal, Mayana Zatz, Diederik van de Beek, Sabina Sahanic, Ivan Tancevski, Yurii Stepanovskyy, Oksana Boyarchuk, Yoko Nukui, Miyuki Tsumura, Loreto Vidaur, Stuart G. Tangye, Sonia Burrel, Darragh Duffy, Lluis Quintana-Murci, Adam Klocperk, Nelli Y. Kann, Anna Shcherbina, Yu-Lung Lau, Daniel Leung, Matthieu Coulongeat, Julien Marlet, Rutger Koning, Luis Felipe Reyes, Angelique Chauvineau-Grenier, Fabienne Venet, Guillaume Monneret, Michel C. Nussenzweig, Romain Arrestier, Idris Boudhabhay, Hagit Baris-Feldman, David Hagin, Joost Wauters, Isabelle Meyts, Adam H. Dyer, Sean P. Kennelly, Nollaig M. Bourke, Rabih Halwani, Narjes Saheb Sharif-Askari, Karim Dorgham, Jerome Sallette, Souad Mehlal Sedkaoui, Suzan AlKhater, Raul Rigo-Bonnin, Francisco Morandeira, Lucie Roussel, Donald C. Vinh, Sisse Rye Ostrowski, Antonio Condino-Neto, Carolina Prando, Anastasiia Bondarenko, Andras N. Spaan, Laurent Gilardin, Jacques Fellay, Stanislas Lyonnet, Kaya Bilguvar, Richard P. Lifton, Shrikant Mane, Mark S. Anderson, Bertrand Boisson, Vivien Beziat, Shen-Ying Zhang, Evangelos Andreakos, Olivier Hermine, Aurora Pujol, Part Peterson, Trine H. Mogensen, Lee Rowen, James Mond, Stephanie Debette, Xavier de Lamballerie, Xavier Duval, France Mentre, Marie Zins, Pere Soler-Palacin, Roger Colobran, Guy Gorochov, Xavier Solanich, Sophie Susen, Javier Martinez-Picado, Didier Raoult, Marc Vasse, Peter K. Gregersen, Lorenzo Piemonti, Carlos Rodriguez-Gallego, Luigi D. Notarangelo, Helen C. Su, Kai Kisand, Satoshi Okada, Anne Puel, Emmanuelle Jouanguy, Charles M. Rice, Pierre Tiberghien, Qian Zhang, Aurelie Cobat, Laurent Abel, Jean-Laurent Casanova

Summary: Autoantibodies neutralizing interferons are present in a significant percentage of critical COVID-19 patients, especially in older individuals, and their prevalence increases with age.

SCIENCE IMMUNOLOGY (2021)

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Article Immunology

X-linked recessive TLR7 deficiency in ∼1% of men under 60 years old with life-threatening COVID-19

Takaki Asano, Bertrand Boisson, Fanny Onodi, Daniela Matuozzo, Marcela Moncada-Velez, Majistor Raj Luxman Maglorius Renkilaraj, Peng Zhang, Laurent Meertens, Alexandre Bolze, Marie Materna, Sarantis Korniotis, Adrian Gervais, Estelle Talouarn, Benedetta Bigio, Yoann Seeleuthner, Kaya Bilguvar, Yu Zhang, Anna-Lena Neehus, Masato Ogishi, Simon J. Pelham, Tom Le Voyer, Jeremie Rosain, Quentin Philippot, Pere Soler-Palacin, Roger Colobran, Andrea Martin-Nalda, Jacques G. Riviere, Yacine Tandjaoui-Lambiotte, Khalil Chaibi, Mohammad Shahrooei, Ilad Alavi Darazam, Nasrin Alipour Olyaei, Davood Mansouri, Figen Palabiyik, Tayfun Ozcelik, Giuseppe Novelli, Antonio Novelli, Giorgio Casari, Alessandro Aiuti, Paola Carrera, Simone Bondesan, Federica Barzaghi, Patrizia Rovere-Querini, Cristina Tresoldi, Jose Luis Franco, Julian Rojas, Luis Felipe Reyes, Ingrid G. Bustos, Andres Augusto Arias, Guillaume Morelle, Christele Kyheng, Jesus Troya, Laura Planas-Serra, Agatha Schluter, Marta Gut, Aurora Pujol, Luis M. Allende, Carlos Rodriguez-Gallego, Carlos Flores, Oscar Cabrera-Marante, Daniel E. Pleguezuelo, Rebeca Perez de Diego, Sevgi Keles, Gokhan Aytekin, Ozge Metin Akcan, Yenan T. Bryceson, Peter Bergman, Petter Brodin, Daniel Smole, C. I. Edvard Smith, Anna-Carin Norlin, Tessa M. Campbell, Laura E. Covill, Lennart Hammarstrom, Qiang Pan-Hammarstrom, Hassan Abolhassani, Shrikant Mane, Nico Marr, Manar Ata, Fatima Al Ali, Taushif Khan, Andras N. Spaan, Clifton L. Dalgard, Paolo Bonfanti, Andrea Biondi, Sarah Tubiana, Charles Burdet, Robert Nussbaum, Amanda Kahn-Kirby, Andrew L. Snow, Jacinta Bustamante, Anne Puel, Stephanie Boisson-Dupuis, Shen-Ying Zhang, Vivien Beziat, Richard P. Lifton, Paul Bastard, Luigi D. Notarangelo, Laurent Abel, Helen C. Su, Emmanuelle Jouanguy, Ali Amara, Vassili Soumelis, Aurelie Cobat, Qian Zhang, Jean-Laurent Casanova

Summary: A study revealed that rare X-linked TLR7 variants were found in 16 unrelated male individuals with critical COVID-19 pneumonia out of a cohort of 1202 male patients. No such variants were detected in 331 asymptomatic or mildly infected male individuals.

SCIENCE IMMUNOLOGY (2021)

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Article Pharmacology & Pharmacy

Treatments for COVID-19: Lessons from 2020 and new therapeutic options

Fanny Salasc, Thomas Lahlali, Emilie Laurent, Manuel Rosa-Calatrava, Andres Pizzorno

Summary: This review examines the main drug repurposing strategies and achievements made during the first 18 months of the COVID-19 pandemic, and discusses potential antivirals, immunomodulators, and drug combinations for future treatment.

CURRENT OPINION IN PHARMACOLOGY (2022)

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Editorial Material Infectious Diseases

The value of open-source clinical science in pandemic response: lessons from ISARIC

LANCET INFECTIOUS DISEASES (2021)

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Article Immunology

Flagellin From Pseudomonas aeruginosa Modulates SARS-CoV-2 Infectivity in Cystic Fibrosis Airway Epithelial Cells by Increasing TMPRSS2 Expression

Manon Ruffin, Jeanne Bigot, Claire Calmel, Julia Mercier, Maelle Givelet, Justine Oliva, Andres Pizzorno, Manuel Rosa-Calatrava, Harriet Corvol, Viviane Balloy, Olivier Terrier, Loic Guillot

Summary: In this study, it was found that Pseudomonas aeruginosa increases the expression of TMPRSS2 in airway epithelial cells and Calu-3 cells, potentially enhancing susceptibility to SARS-CoV-2 infection. The mechanism is through the activation of Toll-like receptor-5 and p38 MAPK. This result may have clinical significance for cystic fibrosis patients who are frequently infected with P. aeruginosa.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Avian Cell Line DuckCelt(R)-T17 Is an Efficient Production System for Live-Attenuated Human Metapneumovirus Vaccine Candidate Metavac(R)

Caroline Chupin, Andres Pizzorno, Aurelien Traversier, Pauline Brun, Daniela Ogonczyk-Makowska, Blandine Padey, Cedrine Milesi, Victoria Duliere, Emilie Laurent, Thomas Julien, Marie Galloux, Bruno Lina, Jean-Francois Eleouet, Karen Moreau, Marie-Eve Hamelin, Olivier Terrier, Guy Boivin, Julia Dubois, Manuel Rosa-Calatrava

Summary: This study investigated the potential of using the DuckCelt(R)-T17 avian cell line as a production system for the HMPV LAV candidate vaccine. The results indicated that this cell line is permissive and well-adapted for efficient production of the vaccine candidate, showcasing promising scalability for large-scale production.

VACCINES (2021)

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Article Medicine, Research & Experimental

Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro

Hulda R. Jonsdottir, Denise Siegrist, Thomas Julien, Blandine Padey, Mendy Bouveret, Olivier Terrier, Andres Pizzorno, Song Huang, Kirandeep Samby, Timothy N. C. Wells, Bernadett Boda, Manuel Rosa-Calatrava, Olivier B. Engler, Samuel Constant

Summary: The SARS-CoV-2 virus has caused a global pandemic with significant economic and societal impact. While vaccines are available, there are disparities in access worldwide. Development of effective antiviral treatments is crucial due to the emergence of new variants and short immunity duration. Researchers evaluated the antiviral activity of single compounds and combinations using a standardized in vitro model. They found that selected drug combinations containing molnupiravir showed enhanced antiviral activity compared to single compound treatments, suggesting their potential as treatment strategies for COVID-19.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Immunology

Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2

Cyril Planchais, Ignacio Fernandez, Timothee Bruel, Guilherme Dias de Melo, Matthieu Prot, Maxime Beretta, Pablo Guardado-Calvo, Jeremy Dufloo, Luis M. Molinos-Albert, Marija Backovic, Jeanne Chiaravalli, Emilie Giraud, Benjamin Vesin, Laurine Conquet, Ludivine Grzelak, Delphine Planas, Isabelle Staropoli, Florence Guivel-Benhassine, Thierry Hieu, Mikael Boulle, Minerva Cervantes-Gonzalez, Marie-Noelle Ungeheuer, Pierre Charneau, Sylvie van Der Werf, Fabrice Agou, Jordan D. Dimitrov, Etienne Simon-Loriere, Herve Bourhy, Xavier Montagutelli, Felix A. Rey, Olivier Schwartz, Hugo Mouquet

Summary: This study reveals the contribution of memory B cells and antibodies targeting the SARS-CoV-2 spike protein to long-term immune protection against severe COVID-19. It also identifies potent IgA antibodies that can neutralize the virus, highlighting their potential for COVID-19 prevention and treatment.

JOURNAL OF EXPERIMENTAL MEDICINE (2022)

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Article Chemistry, Physical

Antiviral Activity of Active Materials: Standard and Finger-Pad-Based Innovative Experimental Approaches

Lea Szpiro, Clara Bourgeay, Alexandre Loic Hoareau, Thomas Julien, Camille Menard, Yana Marie, Manuel Rosa-Calatrava, Vincent Moules

Summary: Environmental surfaces, especially high-touch surfaces, pose a high risk of becoming carriers of viruses and transmitting them to other individuals through direct contact. Consequently, there has been a growing interest in developing self-decontaminating materials to prevent viral transmission. This study compared the antiviral activities of three different experimental procedures on a reference surface and three active materials, highlighting the need for standardized testing conditions. Furthermore, an innovative approach based on finger-pad transfer was developed to evaluate the antiviral activity of high-touch surfaces under conditions resembling real-life exposure.

MATERIALS (2023)

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