Review
Pharmacology & Pharmacy
Hongying Shan, Renxin Luo, Xuanying Guo, Rong Li, Zhenhong Ye, Tianliu Peng, Fenting Liu, Zi Yang
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women, which is associated with infertility, menstrual irregularities, endometrial hyperplasia, and obesity. The disease and its complications are closely related to local oxidative stress imbalance in the endometrium, affecting endometrial receptivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Bulent Ayas, Seda Kirmizikan, Adem Kocaman, Bahattin Avci
Summary: The study aimed to investigate the effects of metformin treatment at different dosage levels on rat offspring ovaries and uteruses during the intrauterine period. The results showed that gestational exposure to high dose metformin may lead to decreased estradiol production in the offspring rats, resulting in reduced endometrial thickness.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Li Wang, Shulan Lv, Fen Li, E. Bai, Xiaofeng Yang
Summary: This study compared endometrial receptivity during implantation windows among letrozole, clomiphene citrate, and natural cycle in polycystic ovary syndrome (PCOS) patients. The results showed that letrozole had superior endometrial receptivity compared to clomiphene citrate, leading to higher clinical pregnancy and ongoing pregnancy rates. Endometrial flow index during the implantation window was found to have the highest predictive value for pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Zhi Wang, Kexin Nie, Hao Su, Yueheng Tang, Hongzhan Wang, Xiaohu Xu, Hui Dong
Summary: Berberine could improve ovulation in PCOS by reducing the number of cystic follicles, lowering serum luteinizing hormone and total cholesterol levels, and improving glucolipid metabolism, possibly through up-regulating LHCGR and CYP19A1. In addition, berberine could enhance endometrial receptivity by down-regulating alpha v beta 3 and LPAR3.
Article
Medicine, Research & Experimental
Can Wang, Yang-Xing Wen, Qing-Yun Mai
Summary: The present study investigated the expression of endometrial receptivity-related molecules in patients with polycystic ovary syndrome (PCOS) and examined the effects of androgen status, insulin resistance (IR), and body mass index (BMI) on pregnancy outcomes. The results showed that patients with PCOS and IR status, hyperandrogenemia (HA), and obesity had altered mRNA expression levels of several molecules related to endometrial receptivity, which may contribute to poorer embryo implantation and pregnancy outcomes.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Iwona Scheliga, Dunja M. Baston-Buest, Gereon Poschmann, Kai Stuehler, Jan-Steffen Kruessel, Alexandra P. Bielfeld
Summary: Endometrial scratching has been widely used in assisted reproductive technology to improve pregnancy rates, but its mechanism and benefits are still not fully understood or investigated. Proteomic analysis suggests that the scratching procedure may impact proteins involved in immune response pathways and cytoskeleton formation, potentially increasing endometrial receptivity and enhancing embryo implantation. This pilot study provides data that explain the possible benefits of endometrial scratching for patients in infertility treatment and highlights potential changes in the endometrium due to the procedure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Hon Yeung Chan, Ha M. Tran, James Breen, John E. Schjenken, Sarah A. Robertson
Summary: This study provides a comprehensive profile of the endometrial transcriptome in the peri-ovulatory and peri-implantation states, identifying genes, regulatory pathways, and upstream drivers involved in the transition to uterine receptivity that were not previously associated with implantation. Several upstream regulators, including cytokines, ovarian steroid hormones, prostaglandin E2, and vascular endothelial growth factor A, were found to be activated during this transition. The findings of this study will contribute to further research on the molecular mechanisms of uterine receptivity.
Review
Endocrinology & Metabolism
Huamin Zeng, Ying Zhang, Sikai Huang, Jinghua Wu, Wenrui Ren, Lingru Zhou, Leneng Huang, Yuyin Ye
Summary: Metformin combined with spironolactone therapy may be more effective in reducing BMI and serum androgen levels in PCOS patients. However, it does not have a significant effect on hirsutism score or gonadotropin hormone levels, and is not associated with an elevation in side-effects. When the treatment course is greater than 6 months, combination therapy can effectively reduce FBG and improve insulin resistance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Reproductive Biology
Leandro M. Velez, Marcus Seldin, Alicia B. Motta
Summary: PCOS is a common endocrinopathy affecting 5-10% of women of reproductive age, characterized by ovarian cysts, ovulation disorders, and hyperandrogenism, along with metabolic abnormalities. Chronic inflammation may play a pivotal role in the pathogenesis of PCOS.
BIOLOGY OF REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Elizabeth Garcia-Gomez, Yadira Ines Gomez-Viais, Martin Mizael Cruz-Aranda, Luis Daniel Martinez-Razo, Christian Reyes-Mayoral, Lizeth Ibarra-Gonzalez, Araceli Montoya-Estrada, Mauricio Osorio-Caballero, Otilia Perichart-Perera, Ignacio Camacho-Arroyo, Marco Cerbon, Enrique Reyes-Munoz, Edgar Ricardo Vazquez-Martinez
Summary: This study investigated the expression and DNA methylation levels of eight genes related to endometrial function in the endometrium of PCOS patients and control group. The results showed decreased expression of HOXA10, GAB1, and SLC2A4 genes and increased DNA methylation levels of the HOXA10 promoter in PCOS patients. After metformin and nutritional intervention, improvements were observed in metabolic and clinical variables, accompanied by increased expression of HOXA10, ESR1, GAB1, and SLC2A4 genes and reduced DNA methylation levels of the HOXA10 promoter in PCOS women. These findings suggest that metformin and a carbohydrate-controlled diet can improve endometrial function in PCOS patients by modulating DNA methylation and gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xiao Ma, Jing Wang, Likai Wang, Laiqing Yan, Yunjie Liu, Wenkui Ma, Pengyun Ji, Lu Zhang, Guoshi Liu
Summary: Using Aanat and Mt2 KO mice, this study found that the melatonergic system plays a crucial role in early pregnancy in mice. The deficiency of AANAT and MT2 resulted in reduced implantation sites and abnormal endometrium morphology. Mechanistically, the melatonergic system is essential for normal endometrial receptivity and functions by activating the STAT signaling pathway. Melatonin production reduction and signal transduction impairment led to hyperproliferative endometrium and increased local immunoinflammatory reaction, causing early abortion in Mt2 KO mice. These findings might have implications in other animals, including humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Xue Ke, Xue-fei Liang, Yong-hong Lin, Fang Wang
Summary: This study aimed to evaluate the predictive value of endometrial blood flow branches on pregnancy outcomes after hormone replacement therapy-frozen embryo transfer (HRT-FET). The results showed that there were differences in endometrial blood flow branches between pregnant and non-pregnant patients, and the endometrial blood flow branches on the day before embryo transfer were found to be an independent factor influencing the chance of clinical pregnancy. These findings suggest that evaluating endometrial branches using power Doppler ultrasound is a simple and effective approach for predicting pregnancy outcomes during the HRT-FET cycle.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Can Turkler, Tunay Kiremitli, Taylan Onat, Engin Yildirim, Gulce N. Yazici, Renad Mammadov, Mukadder Sunar
Summary: Pycnogenol pretreatment alleviates cisplatin-induced uterine and ovarian injury in rats by reducing oxidative damage. The levels of tGSH and SOD increased, while MDA levels decreased in the PCG group, compared to the CG group.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Genetics & Heredity
Yanjun Liu, Yang Wang, Dan Yao, Xing Chen, Feifei Zhang, Yi Feng, Xin Li
Summary: The combination therapy of Diane-35 and metformin significantly inhibits the progression of endometrial carcinoma (EC) in women with polycystic ovary syndrome (PCOS). The therapy suppresses androgen receptor (AR) expression and promotes GLUT4 expression, induces cell autophagy through the regulation of the mTORC pathway, and inhibits the development of EC via the activation of the PI3K/mTORC pathway.
Article
Medicine, General & Internal
Augustina Gyliene, Vestina Straksyte, Inga Zaboriene
Summary: Polycystic ovary syndrome (PCOS) is a common endocrinopathy among women of reproductive age associated with hyperandrogenism, oligo-amenorrhea, and infertility. Ultrasonographic assessment is a non-invasive, cheap, and effective tool for diagnosing PCOS.
Article
Obstetrics & Gynecology
Ghada Abdel Fattah Abdel Moety, Eman Abdel Monem El Kattan
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2016)
Article
Oncology
Mohamed A. Youssef, Lobna Abdelsalam, Reem Abdelhameed Harfoush, Iman Mamdouh Talaat, Eman Elkattan, Abeer Mohey, Rana M. A. Abdella, Marwa Salah Farhan, Hany Ahmed Foad, Abeer Mostafa Elsayed, Naglaa A. Elkinaai, Doaa Ghaith, Mohamed Elsayed Rashed, Mohamed Abd-El Ghafar, Yasser Khamis, Ahmed N. Hosni
INFECTIOUS AGENTS AND CANCER
(2016)
Article
Obstetrics & Gynecology
Eman F. Omran, Hadeer Meshaal, Sarah M. Hassan, Amira S. Dieb, Hala Nabil, Hani Saad
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2019)
Article
Obstetrics & Gynecology
M. MacKintosh, E. Elkattan, M. Mahendran, F. Basama
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2010)
Review
Obstetrics & Gynecology
Ahmed Samy, Ayman Taher, Sileem A. Sileem, Ahmed Mohamed Abdelhakim, Mohamed Fathi, Hisham Haggag, Khaled Ashour, Shady Abdelsattar Ahmed, Mohammad Abrar Shareef, Abdulhadi A. AlAmodi, Nawal Hamdy Ahmed Keshta, Hanan Barakat Abu Elyazid Shatat, Doaa M. Salah, Ahmed Said Ali, Eman Abdel Monem El Kattan, Moutaz Elsherbini
Summary: This study assessed and ranked different pharmacological interventions for relieving endometriosis-related pain, with CHCs, GnRH analogues, progesterone, and elagolix identified as the best approaches in reducing pain.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ahmed Hesham Said, Eman El-Kattan, Ahmed K. Abdel-Hakeem, Sahar Saleem
EGYPTIAN JOURNAL OF RADIOLOGY AND NUCLEAR MEDICINE
(2016)
Article
Reproductive Biology
Eman Elkattan, Rasha Kamel, Hesham Elghazaly, Ebtsam ElAriki
MIDDLE EAST FERTILITY SOCIETY JOURNAL
(2016)
Article
Obstetrics & Gynecology
Maged Al Mohamady, Ghada Abdel Fattah, Eman Elkattan, Rasha Bayoumy, Dalia Ahmed Hamed
INTERNATIONAL JOURNAL OF FERTILITY & STERILITY
(2016)
Article
Obstetrics & Gynecology
Eman Elkattan, Mona Abdelbadei, Hatem Abdelmoaty, Eman Ali, Dalia Samir, Hala Kheidr
JOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATION
(2015)
Article
Reproductive Biology
Eman Elkattan, Mona AbdElBadei, Hatem Hettow, Eman Hussein, Jina Assaad
MIDDLE EAST FERTILITY SOCIETY JOURNAL
(2014)
Article
Reproductive Biology
Eman ElKattan
MIDDLE EAST FERTILITY SOCIETY JOURNAL
(2013)
Article
Rheumatology
Tamer A. Gheita, Sherif M. Gamal, Eman El-Kattan
EGYPTIAN RHEUMATOLOGIST
(2011)
Article
Reproductive Biology
Eman ElKattan, Eman Omran, Hisham Al Inany
MIDDLE EAST FERTILITY SOCIETY JOURNAL
(2010)