Article
Plant Sciences
Yang Gao, Wenjing Ji, Man Lu, Zhiheng Wang, Xurui Jia, Dawei Wang, Peng Cao, Chunping Hu, Xiaoyan Sun, Zhigang Wang
Summary: Guizhi Fuling decoction (GZFL decoction) has a long history in treating endometriosis, but its exact mechanism remains unclear. This study explored the mechanism of GZFL decoction in treating endometriosis-associated pain. The results showed that GZFL decoction could reduce the volume of lesions, suppress inflammation, and decrease the sensitivity to pain in endometriosis rat models through inhibiting the PI3K/Akt pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Yang Gao, Wenjing Ji, Man Lu, Zhiheng Wang, Xurui Jia, Dawei Wang, Peng Cao, Chunping Hu, Xiaoyan Sun, Zhigang Wang
Summary: This study investigated the mechanism of Guizhi Fuling decoction in treating endometriosis-associated pain through system pharmacology and pharmacodynamic approaches. The results showed that the decoction could reduce lesion volume, suppress inflammation, and alleviate pain sensitivity by inhibiting the PI3K/Akt pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anthony Tucker-Bartley, Daryl J. Selen, Emma Golden, Raquel van Gool, David Ebb, Michael Mannstadt, Jaymin Upadhyay
Summary: Fibrous dysplasia (FD) is a rare non-inherited bone disease caused by a somatic gain-of-function mutation of the GNAS gene. The disease can manifest as a single FD lesion or with extraskeletal features, known as McCune-Albright Syndrome (MAS). Pain is a prominent and challenging aspect of FD/MAS, due to the heterogeneous nature of the disease, variable pain phenotypes, lack of pain mechanism studies, and limited validated analgesic strategies. Current pharmacotherapies, such as bisphosphonates and denosumab, are used to manage skeletal disease activity and pain in FD/MAS. However, there is a need for further research and randomized control trials to identify effective pain treatments and explore new pain pathways in this rare bone disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Pyrola Backe, Matteo Bruschettini, Greta Sibrecht, Ylva Thernstrom Blomqvist, Emma Olsson
Summary: This study aims to evaluate the effects of pharmacological interventions on pain and sedation management in newborn infants undergoing therapeutic hypothermia. However, no studies that meet the inclusion criteria were found, so there is no evidence to recommend or refute the use of pharmacological interventions.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Medicine, General & Internal
Mia Elena Koponen, Patrice Forget
Summary: This study aimed to investigate pharmacological interventions for opioid-induced hyperalgesia caused by different opioids. The majority of interventions were studied in only one trial, with the most common mechanism being the inhibition of N-methyl-D-aspartate (NMDA) receptors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nursing
Yo-Jen Liao, Jyotsana Parajuli, Ying-Ling Jao, Lisa Kitko, Diane Berish
Summary: This review systematically synthesized current evidence on non-pharmacological interventions to manage pain in people living with dementia. Various interventions were found to have a positive impact on pain, but most of them were only evaluated once, and the studies had similar sample characteristics and environment. More research with larger sample sizes, diverse populations, and rigorous designs are needed to validate the results.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Article
Pediatrics
Zhuowen Yu, Yiwen Zhou, Xiaofeng Xu, Lili Lin, Qian Le, Ying Gu
Summary: This study aimed to evaluate the effectiveness of three intervention methods for pediatric venipuncture. The results showed that all three interventions can decrease children's pain during venipuncture. Additionally, the distraction group had lower salivary cortisol levels compared to the combined group. No significant differences were observed among the three groups in self-reported pain, parent-reported pain, and observer-reported pain.
Review
Medicine, General & Internal
Mustafa Ali Kassim Kassim, Alexandru Cosmin Pantazi, Wassan Nori, Liliana Ana Tuta, Adriana Luminita Balasa, Cristina Maria Mihai, Larisia Mihai, Corina Elena Frecus, Vasile Valeriu Lupu, Ancuta Lupu, Antonio Andrusca, Andra Maria Iorga, Radu Mihai Litrin, Irina Ion, Elena Ciciu, Sergiu Ioachim Chirila, Tatiana Chisnoiu
Summary: This narrative review summarizes non-pharmacological interventions for pain management in hemodialysis patients, assesses their potential benefits and limitations, and highlights the need for further research. The existing evidence supports the potential benefits of interventions such as acupuncture, cognitive-behavioral therapy, and relaxation techniques in managing pain and improving the well-being of hemodialysis patients. However, more research is needed to confirm their effectiveness, establish implementation best practices, and assess long-term impact on patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Nasrin Aktar, Ahmed Moudud, Tingting Chen, Xiaoqing Gao, Hanhui Min, Meng Tang, Xiaohui Zhou
Summary: Chronic prostatitis/chronic pelvic pain syndrome type III is associated with irritative voiding, sexual dysfunction, and pelvic pain. Various pharmacological treatments are used clinically, but they mainly focus on symptom relief without addressing the root cause of the condition.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Medicine, General & Internal
Qiao Shen, Zixuan Huang, Hongyao Leng, Xufei Luo, Xianlan Zheng
Summary: This overview of systematic reviews synthesizes current evidence on the efficacy and safety of non-pharmacological interventions for preventing and treating pain in newborn infants. The analysis included 29 reviews and found that facilitated tucking, kangaroo care, sweet solutions, and familiar odour were effective and safe in reducing pain from medical procedures in neonates. However, sucrose alone was less effective than local anaesthesia or a combination of the two during circumcision. Further research is needed to identify the best non-pharmacological approaches for pain in neonates.
Review
Nursing
Zhuming Bao, Margaret Landers
Summary: This study aimed to systematically review evidence on non-pharmacological interventions for pain management in patients with dementia, identifying various interventions such as massage and play activities program. The majority of studies showed that non-pharmacological interventions have positive effects on pain management in patients with dementia.
JOURNAL OF CLINICAL NURSING
(2022)
Review
Biochemistry & Molecular Biology
Liang-Hsuan Chen, Wei-Che Lo, Hong-Yuan Huang, Hsien-Ming Wu
Summary: Endometriosis is a chronic inflammatory disease that causes bothersome symptoms and long-term systemic impacts. It is characterized by the presence of endometrial-like tissue outside the uterus, leading to menstrual disorders, chronic pelvic pain, and infertility. The disease can also spread to extra-pelvic sites and cause systemic effects such as metabolic disorder, immune dysregulation, and cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nursing
Yinchu Hu, Hong Lu, Jing Huang, Yu Zang
Summary: This study demonstrates that non-pharmacological interventions are effective and safe for managing labour pain in low-risk pregnant women. Acupressure, aromatherapy, and massage therapy show significant positive effects in alleviating labour pain.
JOURNAL OF CLINICAL NURSING
(2021)
Review
Endocrinology & Metabolism
L. Maulitz
Summary: Endometriosis patients often have comorbid mental disorders, potentially requiring psychological treatment. Neuroimaging studies on endometriosis patients show that brain regions related to pain processing as well as emotion, cognition, self-regulation, and reward may constitute the "endometriosis brain." However, it is unclear whether the observed neurobiological changes are caused by chronic pain, mental comorbidities, or endometriosis itself.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Review
Dermatology
Ramyar Farzan, Arman Parvizi, Soudabeh Haddadi, Mansooreh Sadeh Tabarian, Amirreza Jamshidbeigi, Pirouz Samidoust, Pooyan Ghorbani Vajargah, Amirabbas Mollaei, Poorya Takasi, Samad Karkhah, Mahbobeh Firooz, Seyed Javad Hosseini
Summary: This study found that non-pharmacological interventions significantly reduced pain intensity in children with burns, with non-virtual reality interventions showing better effects. Future research should compare virtual reality interventions with non-virtual reality interventions and single versus multi-modal distraction to clarify their effectiveness.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Endocrinology & Metabolism
Anas Zakarya Nourelden, Alaa Ahmed Elshanbary, Loalo'a El-Sherif, Amira Yasmine Benmelouka, Hagar Ismail Rohim, Sara Kamel Helmy, Merhan Kamal Sayed, Ammar Ismail, Ahmed Said Ali, Khaled Mohamed Ragab, Mohamed Sayed Zaazouee
Summary: Teplizumab is associated with lower insulin use and higher AUC of C-peptide in type 1 diabetic patients with no significant effect on Hb1c levels. However, teplizumab has shown some adverse effects such as lymphopenia and skin disorders.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Letter
Obstetrics & Gynecology
Ahmed S. A. Ashour, Ahmed S. Ali
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Nansy Mohamed Ali Rund, Hossam El Shenoufy, Bassem Aly Islam, Tarek El Husseiny, Salma Ashraf Nassar, Reham A. Mohsen, Doaa Alaa, Sherine H. Gad Allah, Ahmed Bakry, Rania Refaat, Mahmoud Ahmed Gehad, Mohamed Mahmoud Mohamed Kotb, Omneya M. Osman, Ahmed S. A. Ashour, Ahmed Said Ali, Ayman Taher, Khaled Kholaif, Ahmed T. Hashem, Ayman Aly Hamed Elsallamy, Dalia Adel Nour, Sherif Dahab, Bassem Talaat, Maged Almohammady
Summary: This study aimed to determine the optimal timing of vaginal dinoprostone administration before office hysteroscopy in nulliparous women. The results showed that administering dinoprostone vaginally 12 hours before the procedure was more effective in reducing pain during hysteroscopy compared to administering it 3 hours before. It also resulted in easier hysteroscope insertion, shorter procedure duration, and higher patient satisfaction.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Yomna Ali Bayoumi, Mahmoud Alalfy, Mohamed Sharkawy, Ahmed S. Ali, Hisham Mohamed Gouda, Dina Latif Hatem
Summary: The study found that castor oil can effectively initiate labor in women with a history of one previous cesarean section, increasing the rate of successful VBAC deliveries and providing a low-cost and harmless option to avoid ERCS.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Ahmed T. Hashem, Mostafa Mahmoud, Bassem Aly Islam, Mohamed Ibrahem Eid, Nancy Ahmed, Ahmed Mohamed Mamdouh, Rasha Elkomy, Amira Fouad Elgamel, A. A. Ali Hamada, Eman M. Khalil, Ahmed S. A. Ashour, Ahmed Said Ali, Ayman Taher, Amr Hasan Hussein, Iman Elzahaby, Mohamed Hafez Mohamed Younes, Emad Salah, Eman M. Mojahed, Bassem Talaat, Mohamed ElHodiby, Nada Kamal Osman, Dalia Adel Nour, Yasser Khamis, Ayman Aly Hamed Elsallamy, Mahmoud Ahmed Gehad, Mohamed Mahmoud Mohamed Kotb, Sherine H. Gad Allah
Summary: In parous women delivered only by elective cesarean delivery, lidocaine-prilocaine cream and 200 micrograms of vaginal misoprostol effectively reduced pain during and 10 minutes after LNG-IUD insertion, with easier insertions, high patient satisfaction, and tolerable side effects.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Review
Obstetrics & Gynecology
Ahmed Abu-Zaid, Yasmine Adel Mohammed, Saeed Baradwan, Reem Sayad, Esraa Faraag, Eman Reda Mohammed, Suhaila Mamdouh Mohammed, Ahmed Samy Ashour
Summary: This meta-analysis examined the efficacy and safety of preoperative misoprostol compared to placebo in abdominal hysterectomy. The results showed that misoprostol significantly reduced intraoperative blood loss, hemoglobin drop, and length of hospital stay compared to placebo. However, there were no significant differences between the two groups in operative time, rate of perioperative blood transfusion, and drug-related adverse events.
REPRODUCTIVE SCIENCES
(2023)
Correction
Peripheral Vascular Disease
Amjaad Ibrahim Almarjan, Sara Abdulaziz Almarjan, Ahmed Taher Masoud
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2023)
Review
Peripheral Vascular Disease
Amjaad Ibrahim Almarjan, Sara Abdulaziz Almarjan, Ahmed Taher Masoud
Summary: This study compares the efficacy and safety of sacubitril/valsartan with olmesartan in patients with hypertension. The results show that sacubitril/valsartan is more effective in lowering blood pressure and has a higher safety profile compared to olmesartan.
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2023)
Review
Obstetrics & Gynecology
Ebraheem Albazee, Reem Sayad, Mohammad Alnifise, Abdulrahman Al-Anzi, Faisal Alshammari, Gheith Rasheed, Ahmed Samy, Haifa Al-Jundy, Marwah Ghazi Bintalib, Ahmed Abu-Zaid
Summary: This study evaluated the efficacy of lidocaine local analgesia in reducing maternal pain during amniocentesis. The results showed no significant difference in pain perception between the lidocaine group and the control group.
TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Ahmed Masoud, Fatma Elsayed, Ahmed Abu-Zaid, Greg Marchand, Rachel Lowe, Belle Liang, Manar Jallad
Summary: This study conducted a comprehensive analysis on the effectiveness and safety of acupuncture as an adjunct therapy to IVF cycles. The results showed that acupuncture had lower clinical and ongoing pregnancy rates in China compared to placebo, while outside of China acupuncture increased both clinical and ongoing pregnancy rates. The overall analysis did not show a statistically significant increase in clinical pregnancy rates worldwide when using acupuncture as an adjunct therapy to IVF.
TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Peripheral Vascular Disease
Shady Habboush, Ahmed Adel Sofy, Ahmed Taher Masoud, Omar Cherfaoui, Abdullah Mohamed Farhat, Ahmed Taha Abdelsattar, Ahmed Elmoursi
Summary: The aim of this study is to evaluate the efficacy of perindopril/indapamide/amlodipine single-pill combination in patients with uncontrolled hypertension. Based on the analysis of six clinical trials, the triple therapy significantly reduces systolic and diastolic blood pressures, as well as 24-hour ambulatory blood pressure monitoring values.
HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
(2022)
Review
Obstetrics & Gynecology
Mohammad Abrar Shareef, Ahmed Adel Sofy, Ahmed Taha Abdelsattar, Ahmed Taher Masoud, Abdullah Mohamed Farhat, Hiba Maarouf
Summary: This systematic review and meta-analysis evaluated the efficacy of metformin in patients with endometrial carcinoma. The results demonstrate that metformin effectively reduces Ki-67 expression, as well as blood glucose and insulin levels.
TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
