Clopidogrel, CYP2C19 and proton pump inhibitors: What we know and what it means

Effect of Esomeprazole With/Without Acetylsalicylic Acid, Omeprazole and Lansoprazole on Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Volunteers

(2014) Tommy Andersson et al.   American Journal of Cardiovascular Drugs

Grapefruit Juice Inhibits the Metabolic Activation of Clopidogrel

(2013) M T Holmberg et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Contributions of Intestine and Plasma to the Presystemic Bioconversion of Vicagrel, an Acetate of Clopidogrel

(2013) Zhixia Qiu et al.   PHARMACEUTICAL RESEARCH

The paraoxonase-1 pathway is not a major bioactivation pathway of clopidogrel in vitro

(2012) V Ancrenaz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of the CYP2C19*2 and *3 genotypes, ABCB1 C3435T and PON1 Q192R alleles on the pharmacodynamics and adverse clinical events of clopidogrel in Chinese people after percutaneous coronary intervention

(2012) Xiao-Fang Tang et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

A Randomized, 2-Period, Crossover Design Study to Assess the Effects of Dexlansoprazole, Lansoprazole, Esomeprazole, and Omeprazole on the Steady-State Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Volunteers

(2012) Andrew L. Frelinger et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis

(2012) J.-L. RENY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Cytochromes P450 Catalyze Both Steps of the Major Pathway of Clopidogrel Bioactivation, whereas Paraoxonase Catalyzes the Formation of a Minor Thiol Metabolite Isomer

(2011) Patrick M. Dansette et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Genetic Polymorphisms and the Impact of a Higher Clopidogrel Dose Regimen on Active Metabolite Exposure and Antiplatelet Response in Healthy Subjects

(2011) T Simon et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Proton Pump Inhibitor, Omeprazole, but Not Lansoprazole or Pantoprazole, Is a Metabolism-Dependent Inhibitor of CYP2C19: Implications for Coadministration with Clopidogrel

(2011) B. W. Ogilvie et al.   DRUG METABOLISM AND DISPOSITION

Clopidogrel and Proton Pump Inhibitors

(2011) Udaya S. Tantry et al.   JACC-Cardiovascular Interventions

Impact of genetic variants on post-clopidogrel platelet reactivity in patients after elective percutaneous coronary intervention

(2011) Orsolya Rideg et al.   PHARMACOGENOMICS

An improved method for specific and quantitative determination of the clopidogrel active metabolite isomers in human plasma

(2011) Sebastien Roy et al.   THROMBOSIS AND HAEMOSTASIS

Omeprazole and clopidogrel: Should clinicians be worried?

(2010) J. P. DEPTA et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Differential Effects of Omeprazole and Pantoprazole on the Pharmacodynamics and Pharmacokinetics of Clopidogrel in Healthy Subjects: Randomized, Placebo-Controlled, Crossover Comparison Studies

(2010) D J Angiolillo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Paraoxonase-1 is a major determinant of clopidogrel efficacy

(2010) Heleen J Bouman et al.   NATURE MEDICINE

Interaction of Clopidogrel and Omeprazole

(2010) Mary Ross Southworth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clopidogrel with or without Omeprazole in Coronary Artery Disease

(2010) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite

(2009) M. Kazui et al.   DRUG METABOLISM AND DISPOSITION

Effect of Cytochrome P450 Polymorphisms on Platelet Reactivity After Treatment With Clopidogrel in Acute Coronary Syndrome

(2008) Corinne Frere et al.   AMERICAN JOURNAL OF CARDIOLOGY

Cytochrome P-450 Polymorphisms and Response to Clopidogrel

(2008) Jessica L. Mega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Determinants of Response to Clopidogrel and Cardiovascular Events

(2008) Tabassome Simon et al.   NEW ENGLAND JOURNAL OF MEDICINE