Review
Biochemistry & Molecular Biology
Sandra Santos-Sierra
Summary: Inflammatory arthritis is a group of diseases caused by dysregulated immune system activity, and various medications are used to control the excessive immune response. However, drug resistances, flare-reactions, and adverse effects to current therapies are common in affected patients.
Review
Pharmacology & Pharmacy
Zhen Zhang, Hong Zhao, Chu Chu, Xiaoxiao Fu, Yonglin Liu, Li Wang, Ran Wei, Ke Xu, Lihua Li, Xia Li
Summary: Ovarian cancer is fatal to women with a high mortality rate, and efforts to identify diagnostic and intervention strategies are ongoing with limited success. Inflammation plays a crucial role in the initiation and progression of ovarian cancer, triggered by various stimuli and innate immune system related receptors like Toll-like receptors and cyclic GMP-AMP synthase. The complexity of pathogenesis poses challenges in effectively managing ovarian cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Wenxue Hou, Xiaomin Xia, Ying Li, Hanlin Lv, Jie Liu, Xue Li
Summary: Periodontitis is a common oral disease that may not only affect tooth structures but also have implications for overall health. Studies have suggested a potential connection between periodontitis and hyperuricemia.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiaoqin Tang, Qian Xu, Shuo Yang, Xinwu Huang, Long Wang, Feihong Huang, Jiesi Luo, Xiaogang Zhou, Anguo Wu, Qibing Mei, Chunling Zhao, Jianming Wu
Summary: Platelets, as the second most abundant blood component, play a crucial role in various physiological and pathological functions. In addition to its traditional role in hemostasis and thrombosis, platelets also have an indispensable role in inflammatory diseases. Thrombocytopenia, a common hematologic problem, is closely related to the fatality of many diseases, highlighting the significance of its prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Gesa M. Richter, Jochen Kruppa, H. Gencay Keceli, Emel Tugba Ataman-Duruel, Christian Graetz, Nicole Pischon, Gunar Wagner, Carsten Rendenbach, Yvonne Jockel-Schneider, Orlando Martins, Corinna Bruckmann, Ingmar Staufenbiel, Andre Franke, Rahime M. Nohutcu, Soren Jepsen, Henrik Dommisch, Arne S. Schaefer
Summary: This study identified significant differences in gene methylation levels between inflamed and uninflamed oral mucosa in periodontitis patients, indicating specific adaptations of the mucosa to persistent inflammatory environments involving wound repair, barrier integrity, and innate immune defense.
CLINICAL EPIGENETICS
(2021)
Article
Immunology
Maria Jose Bordagaray, Alejandra Fernandez, Jessica Astorga, Mauricio Garrido, Patricia Hernandez, Alejandra Chaparro, Maria Jesus Lira, Peter Gebicke-Haerter, Marcela Hernandez
Summary: PBMCs from individuals with AP exhibit a proinflammatory phenotype and upregulation of TLR2, associated with CpG site methylation in the promoter region of the TLR2 gene.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Felix I. L. Clanchy, Federica Borghese, Jonas Bystrom, Attila Balog, Henry Penn, Dobrina N. Hull, Graham M. A. Wells, Serafim Kiriakidis, Peter C. Taylor, Sandra M. Sacre, Lynn M. Williams, Trevor W. Stone, Rizgar A. Mageed, Richard O. Williams
Summary: The role of Toll-like receptor (TLR) gene expression in disease status, particularly its increase in the blood before clinical manifestation, has been strongly associated with disease status.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Cristina Vazquez-Carballo, Melania Guerrero-Hue, Cristina Garcia-Caballero, Sandra Rayego-Mateos, Lucas Opazo-Rios, Jose Luis Morgado-Pascual, Carmen Herencia-Bellido, Mercedes Vallejo-Mudarra, Isabel Cortegano, Maria Luisa Gaspar, Belen de Andres, Jesus Egido, Juan Antonio Moreno
Summary: Acute kidney injury (AKI) is a significant health issue, particularly in low- and middle-income countries. Studies suggest that inflammation plays a crucial role in the development of AKI, and anti-inflammatory agents targeting Toll-like receptors may help reduce kidney damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Mei Jin, Jian Fang, Jiao-jiao Wang, Xin Shao, Suo-wen Xu, Pei-qing Liu, Wen-cai Ye, Zhi-ping Liu
Summary: Atherosclerosis, a life-threatening cardiovascular disease, is associated with chronic inflammation and immune processes. Toll-like receptors (TLRs) play a vital role in the occurrence and development of atherosclerosis. Targeting TLRs and their regulated inflammatory events could be a promising new strategy for the treatment of atherosclerotic CVDs.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Biochemistry & Molecular Biology
Ali Keshavarz, Atieh Pourbagheri-Sigaroodi, Parisa Zafari, Nader Bagheri, Seyed H. Ghaffari, Davood Bashash
Summary: TLRs play a crucial role in immune system, but misregulation is linked to cancer development. Aberrant expression of TLRs allows cancer cells to escape immune surveillance and promotes proliferation and angiogenesis.
Article
Biology
Haley E. Hanson, Cedric Zimmer, Bilal Koussayer, Aaron W. Schrey, J. Dylan Maddox, Lynn B. Martin
Summary: The study reveals that house sparrows with high EP express more TLR4 in various physiological tissues, especially in the blood, compared to those with low EP. Additionally, only females with high EP exhibit reversibility in gene expression. The effect of EP varies between sexes and among tissues.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Adam J. Wolpaw, Liron D. Grossmann, Jessica L. Dessau, May M. Dong, Bailey J. Aaron, Patricia A. Brafford, Darya Volgina, Guillem Pascual-Pasto, Alba Rodriguez-Garcia, Yasin Uzun, Marie Arsenian-Henriksson, Daniel J. Powell, Kristopher R. Bosse, Andrew Kossenkov, Kai Tan, Michael D. Hogarty, John M. Maris, Chi V. Dang
Summary: By investigating inflammatory signaling pathways in neuroblastoma, researchers have identified heterogeneity in dsRNA sensing and intratumoral inflammatory signaling, which has significant implications for immunotherapeutic strategies in this aggressive childhood cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Yuta Takahashi, Mariana Morales Valencia, Yang Yu, Yasuo Ouchi, Kazuki Takahashi, Maxim Nikolaievich Shokhirev, Kathryn Lande, April E. Williams, Chiara Fresia, Masakazu Kurita, Tomoaki Hishida, Kensaku Shojima, Fumiyuki Hatanaka, Estrella Nunez-Delicado, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmonte
Summary: Research demonstrates that DNA methylation can be transmitted from parents to offspring in mice, and this trans-generational inheritance can persist across multiple generations. This finding is significant in understanding trans-generational epigenetic inheritance in mammals and may have implications in evolutionary biology as well as the etiology, diagnosis, and prevention of non-genetically inherited human diseases.
Review
Medicine, General & Internal
Adam Li, Zane Koch, Trey Ideker
Summary: Numerous studies have shown that epigenetic age is associated with various factors and can be computed based on DNA methylation patterns. The focus of research needs to shift from accurate age prediction to understanding the links between the epigenome and aging mechanisms. Current research areas include epigenetic clocks and investigation of the epigenome to build a mechanistic theory of aging and inform clinical practice.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Antonios Lazaridis, Eleni Gavriilaki, Stella Douma, Eugenia Gkaliagkousi
Summary: Essential hypertension is a highly heterogeneous disease with a complex etiology, where subclinical inflammation and abnormal activation of TLR signaling play crucial roles in its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Rogerio S. Ferreira, Rahyza I. F. Assis, Georgia da S. Feltran, Iasmin Caroline do Rosario Palma, Beatriz G. Francoso, Willian F. Zambuzzi, Denise C. Andia, Rodrigo A. da Silva
Summary: The study investigated the impact of individual epigenetic and transcriptional profiles on osteogenic potential using mesenchymal cells from periodontal ligament. Results showed distinct epigenetic and transcriptional differences among PDLCs, which were maintained after osteogenic induction. These findings suggest that individual donor characteristics have a significant impact on the acquisition of the osteogenic phenotype.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Willian Peter Boelcke, Isadora Ferrari Teixeira, Iara Gonalves Aquino, Amanda Ramos Mazzaro, Florence Juana Maria Cuadra-Zelaya, Ana Paula de Souza, Tuula Salo, Ricardo Della Coletta, Edgard Graner, Debora Campanella Bastos
Summary: This study suggests that C75, triclosan, and orlistat have different effects on SCC-9 cells, with triclosan showing superior interference in tumorigenic phenotypes.
ARCHIVES OF ORAL BIOLOGY
(2022)
Review
Immunology
Juliana Ramalho Guimaraes, Marina de Castro Coelho, Naila Francis Paulo de Oliveira
Summary: Sjogren's syndrome (SS) is a chronic disease characterized by dysfunction of salivary and lacrimal glands. Genetic, environmental, and epigenetic factors are important contributors to its pathogenesis. DNA methylation has been found to play a role in SS, and these findings may lead to the development of new diagnostic and therapeutic approaches.
Article
Cell Biology
Catharina Marques Sacramento, Rahyza Inacio Freire Assis, Miki Taketomi Saito, Ricardo Della Coletta, Mauricio da Rocha Dourado, Enilson A. Sallum, Francisco H. Nociti Jr, Renato Correa Viana Casarin, Denise Carleto Andia, Karina Gonzales Silverio
Summary: This study investigates the effect of 5-aza-2'-deoxycytidine on the differentiation of periodontal ligament mesenchymal progenitor cells towards osteoblast/cementoblast phenotype. The results show that 5-aza-dC improves osteoblast/cementoblast differentiation through BMP-2 secretion, particularly when ASPN expression is low.
Article
Dentistry, Oral Surgery & Medicine
Maria Eduarda Scordamaia Lopes, Camila Chierici Marcantonio, Rafael Scaf de Molon, Paulo Sergio Cerri, Cristiane Ribeiro Salmon, Luciana Souto Mofatto, Francisco Humberto Nociti Junior, James Deschner, Joni Augusto Cirelli, Andressa Vilas Boas Nogueira
Summary: The study found that obesity did not significantly impact bone loss resulting from periodontitis, but did affect the proteome of periodontal ligament tissues in experimental periodontitis, potentially identifying targets for personalized approaches.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Henrique B. Abdalla, Rayssa R. Marchioro, Karen Elizabeth A. Galvao, Lucas N. Teixeira, Kamila R. Kantovitz, Ana Luiza G. M. Millas, Francisco H. Nociti Jr
Summary: The study demonstrated that PCL scaffolds have the potential to promote mineralization by supporting cementoblast adhesion, proliferation, and modulating the expression of key markers. This suggests a potential clinical application of PCL scaffolds in promoting new cementum formation.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jose Maria Chagas Viana Filho, Beatriz Fernandes de Souza, Marina de Castro Coelho, Ana Maria Gondim Valenca, Darlene Camati Persuhn, Naila Francis Paulo de Oliveira
Summary: The study aimed to investigate the relationship between VDR gene polymorphisms and DNA methylation status with oral mucositis in oncopaediatric patients treated with methotrexate. Results showed a high prevalence of OM in the studied population, with lower leukocyte and platelet counts associated with the condition. Severe oral mucositis was found to be linked to specific genetic polymorphisms in the VDR gene.
Article
Biochemistry & Molecular Biology
Andressa V. B. Nogueira, Maria Eduarda S. Lopes, Camila C. C. Marcantonio, Cristiane R. R. Salmon, Luciana S. S. Mofatto, James Deschner, Francisco H. H. Nociti-Junior, Joni A. A. Cirelli
Summary: This study aimed to evaluate the effects of obesity on the proteomic profile of the periodontal ligament in rats induced with a high-fat diet. The results showed differential expression of proteins between the obese and control groups, which were associated with obesity, suggesting that the periodontal ligament is responsive to obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Caroline Pessoa-Lima, Jonas Tostes-Figueiredo, Natalia Macedo-Ribeiro, Annie Schmaltz Hsiou, Fellipe Pereira Muniz, Jose Augusto Maulin, Vinicius H. Franceschini-Santos, Frederico Barbosa de Sousa, Fernando Barbosa Jr, Sergio Roberto Peres Line, Raquel Fernanda Gerlach, Max Cardoso Langer
Summary: This study compared the morphological features and chemical composition of dental enamel between extinct and extant species of alligators and rodents. Results showed that major physical, chemical, and morphological features of dental enamel were present in both extant and extinct fossil tooth enamel (>8.5 Ma) in both taxa.
Article
Genetics & Heredity
Beatriz Fernandes de Souza, Jose Maria Chagas Viana Filho, Jose Nunes de Queiroz Neto, Marina de Castro Coelho, Ana Maria Gondim Valenca, Darlene Camati Persuhn, Naila Francis Paulo de Oliveira
Summary: The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) and the DNA methylation profiles of the DNA methyltransferase (DNMT) gene family with oral mucositis in children and adolescents with hematologic malignancies treated with methotrexate (MTX). The results showed that there were no differences in the allele and genotypic frequencies of SNPs between patients with or without oral mucositis. However, an increase in the methylation frequency for DNMT1 was detected in patients recovered from mucositis. The genetic and epigenetic profiles of DNMT3A and DNMT3B were found to be associated with creatinine levels.
Article
Dentistry, Oral Surgery & Medicine
Rogerio S. Ferreira, Rodrigo A. da Silva, Georgia Da S. Feltran, Ericka Patricia da Silva, Rahyza I. F. de Assis, Emanuel Silva Rovai, Willian F. Zambuzzi, Denise C. Andia
Summary: The results of this study demonstrate the crucial role of JARID1B in repressing the osteogenic phenotype of PDLCs, suggesting its potential as a therapeutic target in pre-clinical protocols.
Article
Dentistry, Oral Surgery & Medicine
Ana Mara da Silva Morais, Ysadora Mayara Reali Pereira, Isaac Jordao de Souza-Araujo, Daniel Furtado Silva, Vanessa Gallego Arias Pecorari, Orisson Ponce Gomes, Francisco Humberto Nociti-Junior, Regina Maria Puppin-Rontani, Waldemir Francisco Vieira-Junior, Paulo Noronha Lisboa-Filho, Kamila Rosamilia Kantovitz
Summary: This in vitro study investigated the potential impact of titanium dioxide nanotubes (TiO2-nts) on the performance of glass ionomer cement (GIC). The results showed that GIC reinforced with TiO2-nts had similar elemental composition to unblended GIC, but significantly reduced the release rate of aluminum. These findings contribute to our understanding of the effects of TiO2-nts on conventional GICs.
BRAZILIAN ORAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Larissa Nadine da Silva Dias, Marina de Castro Coelho, Darlene Camati Persuhn, Isabella Lima Arrais Ribeiro, Eutilia Andrade Medeiros Freire, Naila Francis Paulo de Oliveira, Sabrina Garcia de Aquino
Summary: This study found a possible association between periodontitis and systemic lupus erythematosus (SLE), and it is related to the polymorphisms of DNA methylation-related genes.
JOURNAL OF APPLIED ORAL SCIENCE
(2022)
Article
Oncology
Dieila Giomo Lima, Guilherme Castro Lima Silva do Amaral, Aline Cristiane Planello, Gabriell Bonifacio Borgato, Gustavo Narvaes Guimaraes, Ana Paula de Souza
Summary: The effects of combination therapy using 5-aza-2CdR and cisplatin on DNA repair genes in oral squamous cell carcinoma were investigated in this study. The results showed that the treatments reduced cell viability and in some cases, 5-aza-2CdR sensitized cells to the cytotoxic effect of cisplatin. Additionally, changes in the methylation status and expression of MGMT and MLH1 genes were observed.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Marina Castro Coelho, Jose Maria Chagas Viana Filho, Beatriz Fernandes de Souza, Ana Maria Gondim Valenca, Darlene Camati Persuhn, Naila Francis Paulo de Oliveira
Summary: This study investigated the associations between gene polymorphisms and the occurrence and severity of oral mucositis (OM) in pediatric oncology patients undergoing chemotherapy. The results showed that gender and certain gene polymorphisms were related to the occurrence and severity of OM.
JOURNAL OF APPLIED ORAL SCIENCE
(2022)
