Journal
LEUKEMIA RESEARCH
Volume 37, Issue 5, Pages 556-560Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2013.01.001
Keywords
Acute myeloid leukemia; Chemotherapy; Consolidation; Cytarabine
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We evaluated outcomes in two consecutive groups of AML patients age > 60 years in CR after 7 + 3 induction therapy. Group 1 received consolidation with cytarabine 1.5 g/m(2) q12 h x 6 + daunorubicin for two cycles, while group 2 received consolidation with 7 + 3 followed by mitoxantrone + etoposide. For patients with intermediate-risk cytogenetics, group 1 had a significantly superior DFS (p = 0.046), and a trend toward better OS (p = 0.087). The treatment group remained a significant predictor of DFS on multivariate analysis. The results indicate that a high-dose cytarabine-containing consolidation regimen produces superior outcomes in AML patients age > 60 years with intermediate-risk cytogenetics. (C) 2013 Elsevier Ltd. All rights reserved.
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