Article
Oncology
Marla Lipsyc-Sharf, Fang-Shu Ou, Matthew B. Yurgelun, Douglas A. Rubinson, Deborah Schrag, Shaker R. Dakhil, Philip J. Stella, Douglas J. Weckstein, Donald B. Wender, Meredith Faggen, Tyler J. Zemla, Erica N. Heying, Samantha R. Schuetz, Stephanie Noble, Jeffrey A. Meyerhardt, Tanios Bekaii-Saab, Charles S. Fuchs, Kimmie Ng
Summary: The study investigated the efficacy of combining bevacizumab with irinotecan and cetuximab in patients with irinotecan-refractory metastatic colorectal cancer. Although there was no significant difference in progression-free survival between the two treatment groups, there was a statistically significant improvement in overall survival favoring the group that received bevacizumab in addition to irinotecan and cetuximab. Further investigation on this combination therapy is warranted.
Article
Oncology
Hiroya Taniguchi, Kentaro Yamazaki, Toshiki Masuishi, Takeshi Kawakami, Yusuke Onozawa, Kazunori Honda, Shigenori Kadowaki, Yukiya Narita, Takahiro Tsushima, Satoshi Hamauchi, Akiko Todaka, Tomoya Yokota, Masashi Ando, Keita Mori, Hiromichi Shirasu, Hirofumi Yasui, Kei Muro
Summary: In this phase Ib study, trifluridine/tipiracil, irinotecan, and bevacizumab were tested in patients with metastatic colorectal cancer. The treatment showed moderate antitumor activity but had a high risk of severe myelotoxicity.
Article
Oncology
Zhan Wang, Bao-Dong Qin, Chen-Yang Ye, Miao-Miao Wang, Ling-Yan Yuan, Wei-Ping Dai, Li Sun, Ke Liu, Wen-Xing Qin, Xiao-Dong Jiao, Xing-Nan Li, Yuan-Sheng Zang
Summary: This study evaluated the safety and efficacy of a new protocol using vemurafenib and cetuximab combined with FOLFIRI in patients with BRAF V600E-mutated colorectal cancer. The results showed promising antitumour activity and tolerable toxicity with this combination therapy.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Ji Hyun Park, Hyun Seok Lee, Jin Woo Choi, So Dug Lim, Hyeon Kang Koh, Kyung Rae Cho, Joon Cho, Young-Cho Koh, So Young Yoon
Summary: The study found that salvage treatment with BEV+IRI in r/rGBM conferred comparable clinical benefit, with ECOG PS >= 3, TP53 loss, and lack of prompt clinical improvement after the treatment significantly associated with an unfavorable overall survival. The efficacy of BEV+IRI and its potential biomarker in r/rGBM patients warrant further investigation.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Hans-Joachim Schmoll, Julia Mann, Fabian Meinert, Benjamin Garlipp, Kersten Borchert, Arndt Vogel, Eray Goekkurt, Ulrich Kaiser, Heinz-Gert Hoeffkes, Joern Ruessel, Stephan Kanzler, Thomas Edelmann, Helmut Forstbauer, Thomas Goehler, Carla Hannig, Bert Hildebrandt, Carsten Roll, Carsten Bokemeyer, Joerg Steighardt, Franziska Cygon, Stefan Ibach, Alexander Stein, Joseph Tintelnot
Summary: The study confirms the effectiveness and tolerability of FOLFOXIRI plus bevacizumab as a first-line treatment for mCRC, but challenges remain in its clinical implementation.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Angeline Ginzac, Emilie Thivat, Caroline Petorin, Damien Richard, Pauline Herviou, Ioana Molnar, Herve Devaud, Isabelle Creveaux, Florent Ferrer, Nicolas Authier, Marine Jary, Denis Pezet, Xavier Durando
Summary: The study aimed to assess the safety and efficacy of irinotecan dosage adjusted according to UGT1A1 polymorphism in mCRC patients. The results showed that mCRC patients can tolerate a higher dose of irinotecan based on their UGT1A1 genotype without increased toxicities.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Article
Oncology
Stefanie Noepel-Duennebacke, Hendrik Juette, Karsten Schulmann, Ulrich Graeven, Rainer Porschen, Jan Stoehlmacher, Susanna Hegewisch-Becker, Arne Raulf, Dirk Arnold, Anke Reinacher-Schick, Aandrea Tannapfel
Summary: High microsatellite instability (MSI-H) tumors were more frequent in right-sided tumors and correlated with mutant BRAF. PD-L1 expression was not correlated with MSI-H status, but in MSI-H tumors the percentage of PD-L1 positive tumors was higher than in MSS tumors.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Toshiki Masuishi, Soshi Nagaoka, Long Jin, Kenichi Yoshizawa
Summary: This study assessed the safety of ramucirumab plus FOLFIRI in patients with metastatic colorectal cancer, finding that the safety profile was similar regardless of patient age and initial irinotecan dose.
DRUGS-REAL WORLD OUTCOMES
(2023)
Review
Pharmacology & Pharmacy
Marta Miarons, Pau Riera, Sara Garcia-Gil, Fernando Gutierrez-Nicolas
Summary: This systematic review analyzes the efficacy and safety of using higher doses of irinotecan in metastatic colorectal cancer patients with UGT1A1*1/*1 or *1/*28 genotypes who are treated with the FOLFIRI regimen. The results suggest that increasing irinotecan dose can improve the objective response rate and progression-free survival. Safety studies indicate that doses higher than 180 mg/m2 are well-tolerated by most UGT1A1*1/*1 and *1/*28 patients.
FARMACIA HOSPITALARIA
(2022)
Article
Pharmacology & Pharmacy
Naoko Takebe, Jan H. Beumer, Shivaani Kummar, Brian F. Kiesel, Afshin Dowlati, Geraldine O'Sullivan Coyne, Richard Piekarz, Lawrence Rubinstein, Laura K. Fogli, Ulka Vaishampayan, Sanjay Goel, Cindy L. O'Bryant, Bassel F. El-Rayes, Vincent Chung, Heinz-Josef Lenz, Richard Kim, Chandra P. Belani, Joseph M. Tuscano, William Schelman, Nancy Moore, James H. Doroshow, Alice P. Chen
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Article
Biology
Anna Shemorry, Jonathan M. Harnoss, Ofer Guttman, Scot A. Marsters, Liszlo G. Komuves, David A. Lawrence, Avi Ashkenazi
Article
Biology
Mable Lam, Scot A. Marsters, Avi Ashkenazi, Peter Walter
Article
Oncology
Catherine Michelle Laird, Ashley E. Glode, Kerry Schwarz, Elaine T. Lam, Cindy L. O'Bryant
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2020)
Article
Oncology
Jonathan M. Harnoss, Adrien Le Thomas, Mike Reichelt, Ofer Guttman, Thomas D. Wu, Scot A. Marsters, Anna Shemorry, David A. Lawrence, David Kan, Ehud Segal, Mark Merchant, Klara Totpal, Lisa M. Crocker, Kathryn Mesh, Monika Dohse, Margaret Solon, Zora Modrusan, Joachim Rudolph, Hartmut Koeppen, Peter Walter, Avi Ashkenazi
Article
Oncology
S. Lindsey Davis, Anastasia A. Ionkina, Stacey M. Bagby, James D. Orth, Brian Gittleman, Joshua M. Marcus, Elaine T. Lam, Bradley R. Corr, Cindy L. O'Bryant, Ashley E. Glode, Aik-Choon Tan, Jihye Kim, John J. Tentler, Anna Capasso, Kyrie L. Lopez, Daniel L. Gustafson, Wells A. Messersmith, Stephen Leong, S. Gail Eckhardt, Todd M. Pitts, Jennifer R. Diamond
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Mehmet Akce, Anthony El-Khoueiry, Sarina A. Piha-Paul, Emeline Bacque, Peng Pan, Zhi-Yi Zhang, Reginald Ewesuedo, Divya Gupta, Yongqiang Tang, Ashley Milton, Stefan Zajic, Patricia L. Judson, Cindy L. O'Bryant
Summary: This study aimed to characterize the pharmacokinetics and safety of niraparib in patients with normal hepatic function (NHF) versus moderate hepatic impairment (MHI). The results showed that MHI patients had increased plasma exposure to niraparib compared to NHF patients, but this did not affect tolerability. Adjusting the starting dose of niraparib from 300 mg to 200 mg QD in MHI patients is recommended based on these findings. Safety profiles were consistent across both patient groups.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Biology
Mor Levi-Ferber, Rewayd Shalash, Adrien Le-Thomas, Yehuda Salzberg, Maor Shurgi, Jennifer Ic Benichou, Avi Ashkenazi, Sivan Henis-Korenblit
Summary: The study reveals how ER stress enhances ectopic germline differentiation through regulating a specific neuronal circuit in Caenorhabditis elegans. The neuronal circuit communicates with the gonad via the neurotransmitter serotonin to limit somatic differentiation of tumorous germline cells. Regulated Ire1-dependent decay of transcripts encoding the neuropeptide FLP-6 plays a crucial role in controlling the integrity of the circuit and preventing somatic-fate acquisition by germline tumor cells.
Article
Oncology
Kushal Kandhari, Sandeep Paudel, Komal Raina, Chapla Agarwal, Rama Kant, Michael F. Wempe, Cindy O'Bryant, Rajesh Agarwal
Summary: Comparative pre-clinical studies showed that Chinese and Indian bitter melon varieties exhibit comparable efficacy in inhibiting pancreatic cancer cell proliferation, inducing cell death, suppressing tumor growth, and decreasing angiogenesis. The geographical availability of a particular cultivar should not be a limiting factor in selecting a variant for clinical trials.
JOURNAL OF CANCER PREVENTION
(2021)
Article
Cell Biology
Riccardo Guidi, Daqi Xu, David F. Choy, Thirumalai R. Ramalingam, Wyne P. Lee, Zora Modrusan, Yuxin Liang, Scot Marsters, Avi Ashkenazi, Alison Huynh, Jessica Mills, Sean Flanagan, Shannon Hambro, Victor Nunez, Laurie Leong, Ashley Cook, Tiffany Hao Tran, Cary D. Austin, Yi Cao, Christine Clarke, Reynold A. Panettieri, Cynthia Koziol-White, William F. Jester, Fen Wang, Mark S. Wilson
Summary: Asthma and inflammatory airway diseases restrict lung airflow and function. Inhaled corticosteroids (ICSs) can reduce inflammation and improve symptoms, but some severe asthma patients do not benefit from ICS. This study identified a corticosteroid-driven fibroblast growth factor (FGF)-dependent inflammatory axis and found that combination therapy with pan-FGF receptor inhibitors and corticosteroids can prevent both eosinophilic and steroid-induced neutrophilic inflammation.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biology
Vladislav Belyy, Iratxe Zuazo-Gaztelu, Andrew Alamban, Avi Ashkenazi, Peter Walter
Summary: Protein folding homeostasis in the endoplasmic reticulum is regulated by the unfolded protein response (UPR), with Inositol-requiring enzyme 1 (IRE1) playing a key role in signal transmission. This study used a two-color single-molecule tracking approach to investigate the oligomerization of IRE1 in live cells. The results suggest that IRE1 exists as a constitutive homodimer and assembles into small oligomers upon ER stress, with its lumenal domain governing the formation of inactive dimers and stress-dependent oligomers.
Meeting Abstract
Oncology
S. Lindsey Davis, Alexis Diane Leal, Wells A. Messersmith, Christopher Hanyoung Lieu, Elaine T. Lam, Bradley Corr, Cindy L. O'Bryant, Natalie Julie Serkova, Todd Pitts, Jennifer Robinson Diamond
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Joanna Q. Huang, Emmeline Academia, Daniel Aaron Pollyea, Jonathan Aaron Gutman, Andrew Hammes, Stephanie Chase, Cindy L. O'Bryant, Jeff Kaiser
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Toxicology
Blessy George, Xia Wen, Nickie Mercke, Madeleine Gomez, Cindy O'Bryant, Daniel W. Bowles, Yichun Hu, Susan L. Hogan, Melanie S. Joy, Lauren M. Aleksunes
TOXICOLOGY REPORTS
(2020)
Meeting Abstract
Oncology
Mehmet Akce, Anthony B. El-Khoueiry, Sarina Anne Piha-Paul, Emeline Bacque, Peng Pan, Zhi-Yi Zhang, Reginald Ewesuedo, Divya Gupta, Ashley Milton, Patricia Judson, Cindy L. O'Bryant
JOURNAL OF CLINICAL ONCOLOGY
(2020)