Review
Medicine, Research & Experimental
Michael C. Ferrera, Wassim W. Labaki, MeiLan K. Han
Summary: COPD is a common respiratory disorder with high morbidity and mortality, often underdiagnosed until clinical advancement. Research focuses on early changes for better diagnosis and identifying patients for early intervention. Treatment options have significantly expanded in the past 20 years with new medications and procedures.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Article
Respiratory System
Vasiliy V. Polosukhin, Sergey S. Gutor, Rui-Hong Du, Bradley W. Richmond, Pierre P. Massion, Pingsheng Wu, Justin M. Cates, Kim L. Sandler, Stephen Rennard, Timothy S. Blackwell
Summary: In patients with COPD, thickening of epithelial and subepithelial tissue, mucus plugging, reduced collagen density in the airway wall, and loss of radial alveolar attachments were associated with airflow limitation. The major determinant of airflow limitation related to small airways was found to be the loss of alveolar attachments, which may be mediated by neutrophilic inflammation. Additionally, quantitative analysis of CT scans found an association between the extent of emphysema and loss of alveolar attachments.
Article
Respiratory System
Sonia Wing Mei Cheng, Jennifer Alison, Emmanuel Stamatakis, Sarah Dennis, Renae McNamara, Lissa Spencer, Zoe McKeough
Summary: This study found that a 6-week behavior change intervention did not reduce time spent in sedentary behavior compared with a sham intervention in people with stable moderate-to-severe COPD prior to pulmonary rehabilitation.
Article
Multidisciplinary Sciences
Jihye Yun, Young Hoon Cho, Sang Min Lee, Jeongeun Hwang, Jae Seung Lee, Yeon-Mok Oh, Sang-Do Lee, Li-Cher Loh, Choo-Khoon Ong, Joon Beom Seo, Namkug Kim
Summary: Deep radiomics from chest CT images can predict mortality in COPD patients by extracting features from CT images with a CNN model, achieving high predictive accuracy in both discovery and external validation cohorts.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Marija Gredic, Isabel Blanco, Gabor Kovacs, Zsuzsanna Helyes, Peter Ferdinandy, Horst Olschewski, Joan Albert Barbera, Norbert Weissmann
Summary: This article summarizes the pathophysiology and treatment options for PH in COPD patients, pointing out that current research still does not fully understand its underlying mechanisms, and some of the treatment methods tested in clinical settings have not been effective. Preclinical studies have proposed some treatment approaches.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Hematology
Peter G. Miller, Dandi Qiao, Joselyn Rojas-Quintero, Michael C. Honigberg, Adam S. Sperling, Christopher J. Gibson, Alexander G. Bick, Abhishek Niroula, Marie E. McConkey, Brittany Sandoval, Brian C. Miller, Weiwei Shi, Kaushik Viswanathan, Matthew Leventhal, Lillian Werner, Matthew Moll, Brian E. Cade, R. Graham Barr, Adolfo Correa, L. Adrienne Cupples, Sina A. Gharib, Deepti Jain, Stephanie M. Gogarten, Leslie A. Lange, Stephanie J. London, Ani Manichaikul, George T. O'Connor, Elizabeth C. Oelsner, Susan Redline, Stephen S. Rich, Jerome I. Rotter, Vasan Ramachandran, Bing Yu, Lynette Sholl, Donna Neuberg, Siddhartha Jaiswal, Bruce D. Levy, Caroline A. Owen, Pradeep Natarajan, Edwin K. Silverman, Peter van Galen, Yohannes Tesfaigzi, Michael H. Cho, Benjamin L. Ebert
Summary: Somatic mutations in blood cells are associated with the development and severity of chronic obstructive pulmonary disease (COPD), independent of age and smoking.
Article
Environmental Sciences
Humairat H. Rahman, Danielle Niemann, Stuart H. Munson-McGee
Summary: This study investigated the correlation between asthma, emphysema, chronic bronchitis, chronic obstructive lung disease (COPD) and lung cancer in the US adult population. The study found a significant correlation between emphysema, chronic bronchitis, COPD and lung cancer. However, no correlation was established between asthma and lung cancer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Praneeth Reddy Amudala Puchakayala, Venkata L. Sthanam, Arie Nakhmani, Muhammad F. A. Chaudhary, Abhilash Kizhakke Puliyakote, Joseph M. Reinhardt, Chengcui Zhang, Surya P. Bhatt, Sandeep Bodduluri
Summary: This study evaluated the performance of radiomics features in the diagnosis of COPD and found that a combination of features representing parenchymal texture and lung and airway shape on inspiratory CT scans can accurately detect COPD.
Article
Oncology
Bing Zhuan, Hong-Hong Ma, Bo-Chao Zhang, Ping Li, Xi Wang, Qun Yuan, Zhao Yang, Jun Xie
Summary: This study aimed to develop and compare machine learning models to identify future diagnoses of chronic obstructive pulmonary disease (COPD) combined with non-small cell lung cancer (NSCLC) based on the patient's disease and routine clinical data. The results showed that pulmonary function and emphysema were important risk factors and that the support vector machine-based identification model showed optimal performance.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Caspar Schiffers, Cheryl van de Wetering, Robert A. Bauer, Aida Habibovic, Milena Hristova, Christopher M. Dustin, Sara Lambrichts, Pamela M. Vacek, Emiel F. M. Wouters, Niki L. Reynaert, Albert van der Vliet
Summary: The downregulation of DUOX1 in the airways of patients with Chronic Obstructive Pulmonary Disease (COPD) may contribute to the pathogenesis of COPD, leading to airway remodeling and emphysema. Animal studies also demonstrate that Duox1 deficiency exacerbates lung pathology induced by smoke exposure.
Article
Biochemistry & Molecular Biology
Danushki Herath, Benjamin Even, Mathilde Oranger, Roberta Foresti, Dulce Papy, Laurent Boyer, Jorge Boczkowski, Maylis Dagouassat
Summary: This study reveals that lung fibroblast senescence is involved in the pathophysiology of COPD, but the specific mechanisms are poorly understood. The researchers found that secreted phospholipases (sPLA2) are released by senescent cells and can induce cell senescence. However, the role of sPLA2 in fibroblast senescence in COPD is still unknown.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Physiology
Haifeng Wang, Xiaojuan Ye, Yafeng Zhang, Shiliang Ling
Summary: The incidence, mortality, and DALYs of chronic obstructive pulmonary disease (COPD) have increased globally, despite a decrease in the overall burden of COPD. However, in certain regions such as those with high SDI, high-income North America, Southern Latin America, North Africa, and the Middle East, the incidence of COPD has increased.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Xia Xu, Ke Huang, Fen Dong, Shiwei Qumu, Qichao Zhao, Hongtao Niu, Xiaoxia Ren, Xiaoying Gu, Tao Yu, Lin Pan, Ting Yang, Chen Wang
Summary: COPD is a heterogeneous disease with eosinophils potentially associated with emphysema, different from neutrophilic inflammation-related emphysema in small airway disease. The characterization of heterogeneity in COPD-associated inflammation may pave the way for personalized medicine and new therapeutic approaches.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cell Biology
Ariel Jaitovich
Summary: This article provides an overview of the association between locomotor skeletal muscle dysfunction and chronic obstructive pulmonary disease (COPD), and discusses the mechanisms of muscle deterioration caused by COPD and the regulatory role of mitochondrially driven metabolic signals in muscle regeneration.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Stephanie A. Christenson, Benjamin M. Smith, Mona Bafadhel, Nirupama Putcha
Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.
Article
Cardiac & Cardiovascular Systems
Janet L. Larson, Katelyn E. Webster
Article
Nursing
Innah Park, Philip T. Veliz, Berit Ingersoll-Dayton, Laura M. Struble, Nancy A. Gallagher, Bonnie M. Hagerty, Janet L. Larson
WESTERN JOURNAL OF NURSING RESEARCH
(2020)
Review
Nursing
Weijiao Zhou, Seoyoon Woo, Janet L. Larson
JOURNAL OF CLINICAL NURSING
(2020)
Article
Oncology
Grace A. Kanzawa-Lee, Robert J. Ploutz-Snyder, Janet L. Larson, John C. Krauss, Kenneth Resnicow, Ellen M. Lavoie Smith
Summary: This pilot study aimed to explore the effects of an 8-week home-based brisk walking intervention on oxaliplatin-induced peripheral neuropathy (OIPN) severity and quality of life (QOL) in adults with gastrointestinal cancer. The results showed that the intervention did not have a significant effect on OIPN severity and QOL. However, aerobic walking may partially alleviate OIPN. Further research is needed to confirm these findings.
Article
Biophysics
Katelyn E. Webster, Natalie Colabianchi, Robert Ploutz-Snyder, Neha Gothe, Ellen Lavoie Smith, Janet L. Larson
Summary: This study examined different techniques for processing ActiGraph data in sedentary adults with COPD and found that the best technique was using vector magnitude data with LFE filter, 120 min non-wear algorithm, and <40 counts/15 s SB cut-point. The results suggest that these findings can guide future decisions on data processing for ActiGraph.
PHYSIOLOGICAL MEASUREMENT
(2021)
Review
Respiratory System
Seoyoon Woo, Weijiao Zhou, Janet L. Larson
Summary: The study synthesized relevant scientific literature exploring stigma experiences and their impacts on COPD patients. It found that social stigma can lead to emotional distress, limited social interactions, and negative effects on medication adherence and help-seeking behaviors.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Review
Public, Environmental & Occupational Health
Katelyn E. Webster, Weijiao Zhou, Nancy A. Gallagher, Ellen M. Lavoie Smith, Neha P. Gothe, Robert Ploutz-Snyder, Natalie Colabianchi, Janet L. Larson
Summary: The study found that older adults aged 80 and older tend to have high levels of sedentary behavior, with male gender and age over 85 possibly contributing to increased sedentary behavior. Factors associated with sedentary behavior include older age, male gender, non-Hispanic white race/ethnicity, social disadvantage, and declining cognitive function.
PREVENTIVE MEDICINE REPORTS
(2021)
Article
Environmental Sciences
Weiyun Chen, Zhanjia Zhang, Bruno Giordani, Janet L. Larson
Summary: This study used the social ecological model to design the two-level 4Active intervention, combining group exercises and personal activity trackers, aiming to improve psychological well-being and physical activity participation in older adults. The results showed that the two-level 4Active intervention group was more effective in reducing negative affect and increasing moderate physical activity time.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Oncology
Weijiao Zhou, Katelyn E. Webster, Ellen Lavoie Smith, Weiyun Chen, Philip T. Veliz, Rishindra M. Reddy, Janet L. Larson
Summary: The review indicates that physical activity is low among surgical lung cancer patients and may not recover within 3 months after surgery. Physical activity is associated with postoperative outcomes and has the potential to improve them.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Nursing
Carol M. Vos, Nancy Ambrose-Gallagher, Katelyn E. Webster, Janet L. Larson
Summary: Residents in assisted living have low physical activity levels and spend a significant amount of time being sedentary. Depression, use of assistive devices, fatigue, and tendency to make social comparisons are associated with sedentary behavior, highlighting the need for further research on factors influencing physical activity and sedentary behavior.
RESEARCH IN GERONTOLOGICAL NURSING
(2022)
Article
Nursing
Katelyn E. Webster, Julia S. Seng, Nancy A. Gallagher, Neha P. Gothe, Natalie Colabianchi, Ellen M. Lavoie Smith, Robert Ploutz-Snyder, Janet L. Larson
Summary: This qualitative study interviewed assisted living (AL) residents to gather their recommendations for a self-efficacy enhancing intervention aimed at replacing sedentary behavior with light physical activity. The study found that residents suggested shorter intervention sessions and framing the intervention as increasing light physical activity. The analysis also identified various factors that could influence intervention implementation, such as motivation, safety concerns, ageist attitudes, residents' abilities, social influences, and limited opportunities for physical activity.
WESTERN JOURNAL OF NURSING RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Katelyn E. Webster-Dekker, Weijiao Zhou, Seoyoon Woo, Jung Yoen Son, Robert Ploutz-Snyder, Janet L. Larson
Summary: This study aimed to describe patterns of sedentary behavior (SB) in individuals with chronic obstructive pulmonary disease (COPD) and identify factors associated with prolonged bouts of SB. The results showed that COPD patients engage in extensive SB, with more than half of the time spent in bouts lasting over 60 minutes. Self-efficacy, balance, and lower body strength were found to be modifiable variables associated with SB, suggesting potential targets for interventions.
Article
Geriatrics & Gerontology
Weijiao Zhou, Katelyn E. Webster, Philip T. Veliz, Janet L. Larson
Summary: This study identified distinct subgroups of oldest old adults based on sedentary behavior profiles and found that both total sedentary time and sedentary behavior pattern were associated with health outcomes. Participants with less total sedentary time and mentally active sedentary patterns had better health outcomes.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Review
Oncology
Grace A. Kanzawa-Lee, Janet L. Larson, Kenneth Resnicow, Ellen Marie Lavoie Smith
Article
Nursing
Carol M. Vos, Nancy Ambrose-Gallagher, Katelyn E. Webster, Janet L. Larson
Summary: Residents in assisted living facilities are found to have low levels of physical activity and high sedentary behavior, with factors such as depression, fatigue, and tendency to make social comparisons influencing their activity levels.
RESEARCH IN GERONTOLOGICAL NURSING
(2022)