Article
Neurosciences
Elena Cesnaite, Paul Steinfath, Mina Jamshidi Idaji, Tilman Stephani, Deniz Kumral, Stefan Haufe, Christian Sander, Tilman Hensch, Ulrich Hegerl, Steffi Riedel-Heller, Susanne Roehr, Matthias L. Schroeter, A. Veronica Witte, Arno Villringer, Vadim V. Nikulin
Summary: While previous studies have found structural and biochemical changes in the aging brain, the functional properties of neuronal networks, as reflected in their electrophysiological signatures, remain controversial. This study used a large dataset to investigate age-related alterations in multiple EEG biomarkers and their contributions to cognitive performance. The findings suggest that the interplay between individual alpha peak frequency (IAF) decline, power in the theta frequency range, 1/f slope, and alpha power measures may explain inconsistencies reported in previous literature. Multiple electrophysiological features and their interactions should be considered for a comprehensive assessment of the association between age, neuronal activity, and cognitive performance.
Article
Biochemistry & Molecular Biology
Miral Abdalaziz, Zach Redding, Ian C. Fiebelkorn
Summary: Selective attention is characterized by alternating states that isolate function-specific neural activity in time. We tested the hypothesis that rhythmic temporal coordination can also prevent representational conflicts during working memory. The results support the idea that rhythmic temporal coordination is a general mechanism for preventing conflicts and inform models of working memory organization.
Review
Neurosciences
S. M. Courtney, T. Hinault
Summary: Brain activity and communication are complex phenomena, but research on temporal dynamics of neural activity is limited. Current studies focus on MEG and EEG to understand the effects of healthy and pathological aging on neural dynamics, with implications for clinical practice and theory. Insights into these dynamics could lead to new theoretical frameworks and biomarker development for age-related cognitive changes.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Geriatrics & Gerontology
Eiki Akatsuka, Etsuko Tadaka
Summary: A resilience scale for oldest-old age (RSO) was developed and validated, showing reliable and valid results for assessing individual resilience among oldest-old individuals. The scale has the potential to promote health and well-being in this population.
Article
Clinical Neurology
Ji Yeoun Yoo, Nathalie Jette, Churl-Su Kwon, James Young, Lara Marcuse, Madeline C. Fields, Nicolas Gaspard, Lawrence J. Hirsch
Summary: The study found that BIRDs and PFA in EEG are closely related to the clinical significance of seizures. The location of patients, regardless of frequency, colocalized with the seizure onset zone on the scalp.
Article
Neurosciences
Hui Tang, Tao Liu, Hao Liu, Jiyang Jiang, Jian Cheng, Haijun Niu, Shuyu Li, Henry Brodaty, Perminder Sachdev, Wei Wen
Summary: This study measured the brain morphology of elderly individuals and found that most sulci widened with age, but at a slower rate in the oldest old group. The pattern of cortical thinning corresponded partly with sulcal widening, with males having wider sulci compared to females.
Article
Neurosciences
Jonathan Daume, Peng Wang, Alexander Maye, Dan Zhang, Andreas K. Engel
Summary: The study found that phase alignments of neural oscillations are stronger in sensory, parietal, and frontal brain areas when participants are engaged in a temporal prediction task. This alignment correlates with prediction performance in the cerebellum and visual cortex, suggesting that low-frequency neural oscillations underlie temporal predictions in a non-rhythmic visual and crossmodal context.
Article
Nutrition & Dietetics
Ashley C. C. Flores, Gordon L. L. Jensen, Diane C. C. Mitchell, Muzi Na, G. Craig Wood, Christopher D. D. Still, Xiang Gao
Summary: This study examined the association between diet quality and dementia risk in the oldest old in a rural cohort. The study included 2232 participants aged ≥80 years without dementia at baseline. Diet quality was assessed using a validated screening tool in 2009, and dementia cases were identified using diagnosis codes. Cox proportional hazards models were used to estimate associations, adjusted for potential confounders. After an average follow-up of 6.90 years, there were 408 incident cases of all-cause dementia. Higher diet quality was not significantly associated with a lower risk of dementia in this population.
Article
Geriatrics & Gerontology
Kiyoaki Matsumoto, Yasuyuki Gondo, Yukie Masui, Saori Yasumoto, Yuko Yoshida, Kazunori Ikebe, Yasumichi Arai, Mai Kabayama, Kei Kamide, Hiroshi Akasaka, Tatsuro Ishizaki
Summary: This study aimed to establish reference values for physical performance measures among 90-year-olds and compare them with those of older age groups. By analyzing hand grip strength and Short Physical Performance Battery, it was found that the physical performance measures of 90-year-olds were significantly different from those of younger age groups.
Article
Neurosciences
Grigoriy Radchenko, Valeriia Demareva, Kirill Gromov, Irina Zayceva, Artem Rulev, Marina Zhukova, Andrey Demarev
Summary: Music is used as a therapeutic tool in rehabilitation medicine and psychophysiology. This study examined the neurocognitive processes during music perception of meter in different tempo variations. The results showed that the detection of stimuli change was influenced by the type of metric structure, with N200 wave occurring faster for stimuli with duple meter and fast tempo, and slower for stimuli with triple meter and fast pace.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Tomas Tanskanen, Karri J. M. Seppa, Anni Virtanen, Nea K. Malila, Janne M. Pitkaniemi
Summary: The increasing cancer burden in the oldest old poses a major challenge for health care in Finland, with nearly 1 in 10 cancers diagnosed in individuals aged 85 and above. Excess cancer mortality can be proposed as a measure of cancer-related mortality in older populations with competing risks of death.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Engineering, Biomedical
Yazeed K. Musallam, Nasser I. AlFassam, Ghulam Muhammad, Syed Umar Amin, Mansour Alsulaiman, Wadood Abdul, Hamdi Altaheri, Mohamed A. Bencherif, Mohammed Algabri
Summary: In this paper, a fixed hyperparameter-based CNN model named TCNet-Fusion is proposed, achieving high accuracy in decoding MI-EEG signals compared to variable hyperparameter networks and fixed networks.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Neurosciences
Jorge Bosch-Bayard, Fuleah Abdul Razzaq, Carlos Lopez-Naranjo, Ying Wang, Min Li, Lidice Galan-Garcia, Ana Calzada-Reyes, Trinidad Virues-Alba, Arielle G. Rabinowitz, Carlos Suarez-Murias, Yanbo Guo, Manuel Sanchez-Castillo, Kassandra Roger, Anne Gallagher, Leslie Prichep, Simon G. Anderson, Christoph M. Michel, Alan C. Evans, Maria L. Bringas-Vega, Janina R. Galler, Pedro A. Valdes-Sosa
Summary: Protein Energy Malnutrition (PEM) has lifelong consequences on brain development and cognitive function. A study found that individuals with histories of PEM in childhood showed abnormalities in resting-state EEG activity, which may be correlated with cognitive decline.
Article
Neurosciences
Anna E. Karlsson, Ulman Lindenberger, Myriam C. Sander
Summary: Episodic memory declines with advancing age, especially when forming associations between items and their contexts. This decline is associated with compromised theta-gamma coupling, which is more pronounced in older adults. Theta-gamma coupling closer to the peak of the theta rhythm is beneficial for associative memory formation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Jasmine Leahy, Seung-Goo Kim, Jie Wan, Tobias Overath
Summary: In this study, a linearized encoding analysis framework was used to investigate the rapid cortical encoding of tonal and rhythmic hierarchies in natural music. The results revealed a differential spatiotemporal neural encoding of beat and meter, but not of tonal stability and key clarity. This framework can uncover associations of ongoing brain activity with relevant musical features, which could be further extended to other relevant measures such as time-resolved emotional responses in future studies.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Peter T. Nelson, Carol Brayne, Margaret E. Flanagan, Erin L. Abner, Sonal Agrawal, Johannes Attems, Rudolph J. Castellani, Maria M. Corrada, Matthew D. Cykowski, Jing Di, Dennis W. Dickson, Brittany N. Dugger, John F. Ervin, Jane Fleming, Jonathan Graff-Radford, Lea T. Grinberg, Suvi R. K. Hokkanen, Sally Hunter, Alifiya Kapasi, Claudia H. Kawas, Hannah A. D. Keage, C. Dirk Keene, Mia Kero, David S. Knopman, Naomi Kouri, Gabor G. Kovacs, Sydney A. Labuzan, Eric B. Larson, Caitlin S. Latimer, Renata E. P. Leite, Billie J. Matchett, Fiona E. Matthews, Richard Merrick, Thomas J. Montine, Melissa E. Murray, Liisa Myllykangas, Sukriti Nag, Ruth S. Nelson, Janna H. Neltner, Aivi T. Nguyen, Ronald C. Petersen, Tuomo Polvikoski, R. Ross Reichard, Roberta D. Rodriguez, Claudia K. Suemoto, Shih-Hsiu J. Wang, Stephen B. Wharton, Lon White, Julie A. Schneider
Summary: Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and Alzheimer's disease neuropathologic change (ADNC) are both associated with cognitive impairment in aging populations, with LATE-NC being present in approximately 40% of participants and more commonly in cases with poorer cognitive abilities.
ACTA NEUROPATHOLOGICA
(2022)
Article
Neurosciences
Steven J. Granger, Luis Colon-Perez, Myra Sarai Larson, Michael Phelan, David B. Keator, John T. Janecek, Mithra T. Sathishkumar, Anna P. Smith, Liv McMillan, Dana Greenia, Maria M. Corrada, Claudia H. Kawas, Michael A. Yassa
Summary: The microstructural differences in the hippocampal subfields are associated with age-related memory loss, and the submillimeter resolution diffusion weighted MRI sequence can accurately measure these differences, providing new insights into the mechanisms of age-related memory loss.
Article
Behavioral Sciences
Jenna L. Merenstein, Maria M. Corrada, Claudia H. Kawas, Ilana J. Bennett
Summary: The microstructural composition of white matter tracts connecting cortical regions to the striatum plays a crucial role in associative learning abilities. However, research on associative learning in the oldest-old adults (age 90+) is limited. This study found that better microstructure in the cortico-striatal white matter was associated with better associative learning performance in oldest-old adults, highlighting the importance of these white matter tracts for learning performance throughout the entire lifespan.
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Seyed Ahmad Sajjadi, Syed Bukhari, Kiana A. Scambray, Rui Yan, Claudia Kawas, Thomas J. Montine, Maria M. Corrada
Summary: LATE-NC is a prevalent degenerative pathology in the oldest-old, with significant associations with dementia and cognitive impairment. Past medical histories of hypertension and osteoarthritis are associated with a lower likelihood of LATE-NC.
Article
Clinical Neurology
Zarui. A. Melikyan, Claudia. H. Kawas, Annlia Paganini-Hill, Luohua Jiang, Bryce. A. Mander, Maria M. Corrada
Summary: Sleep duration and napping are associated with sex-specific risks of dementia in old age. Short sleep duration and no napping are associated with higher risk of dementia after age 90 in women, while short to moderate napping is associated with lower risk of dementia after age 90 in men.
BEHAVIORAL SLEEP MEDICINE
(2023)
Article
Clinical Neurology
Annlia Paganini-Hill, Thomas J. Montine, Syed A. Bukhari, Maria M. Corrada, Claudia H. Kawas, S. Ahmad Sajjadi
Summary: This study investigated the neuropathological construct of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and its associations with estrogen-related risk factors. The study found that there was no association between menstrual and reproductive variables with LATE-NC. However, the long-term and recent use of estrogen replacement therapy (ERT) were associated with a reduced risk of LATE-NC.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Steven J. Granger, Luis Colon-Perez, Myra Sarai Larson, Ilana J. Bennett, Michael Phelan, David B. Keator, John T. Janecek, Mithra T. Sathishkumar, Anna P. Smith, Liv McMillan, Dana Greenia, Maria M. Corrada, Claudia H. Kawas, Michael A. Yassa
Summary: The perforant path, connecting the entorhinal cortex with the hippocampal formation, deteriorates with age-related cognitive decline. Diffusion-weighted MRI has limitations in quantifying the perforant path integrity, so this study used ultra-high resolution diffusion imaging to investigate its structural connectivity and found that older age and poorer delayed recall are associated with reduced connectivity of the path. The findings suggest that intra-MTL connectivity may serve as new candidate biomarkers for age-related cognitive decline.
NEUROBIOLOGY OF AGING
(2023)
Article
Neuroimaging
Batool Rizvi, Mithra Sathishkumar, Soyun Kim, Freddie Marquez, Steven J. Granger, Myra S. Larson, Blake A. Miranda, Martina K. Hollearn, Liv McMillan, Bin Nan, Nicholas J. Tustison, Patrick J. Lao, Adam M. Brickman, Dana Greenia, Maria M. Corrada, Claudia H. Kawas, Michael A. . Yassa
Summary: This study examined the relationship between white matter hyperintensities, medial temporal lobe subregional volumes, and hippocampal memory in older adults. The results suggest that white matter hyperintensities may be associated with memory decline through their impact on medial temporal lobe atrophy. These findings provide new insights into the role of vascular pathologies in memory loss in older adults.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Raumin S. Neuville, Roshni Biswas, Chu-Ching Ho, Syed Bukhari, Seyed Ahmad Sajjadi, Annlia Paganini-Hill, Thomas J. Montine, Maria M. Corrada, Claudia H. Kawas
Summary: This study investigated the relationship between neuropathological changes and dementia in centenarians and nonagenarians. The results showed that the prevalence of at least four neuropathological changes was 59% for centenarians and 47% for nonagenarians. In centenarians, neuropathological changes were strongly associated with dementia and this association was not attenuated with age compared to nonagenarians. Each additional neuropathological change was associated with a 2-point decrease in the Mini-Mental State Examination score for both groups. This highlights the importance of slowing or preventing the development of multiple neuropathological changes in the aging brain to maintain cognitive health.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Roshni Biswas, Claudia Kawas, Thomas J. Montine, Syed A. Bukhari, Luohua Jiang, Maria M. Corrada
Summary: A study explores the neuropathological changes in the brains of oldest-old individuals with superior cognitive performance. It found that Alzheimer's disease and low levels of vascular pathologic change were not associated with superior cognition, but Lewy body disease and hippocampal sclerosis were more likely to be non-superior cognitive performers. Multiple comorbid neuropathologic features were also associated with a lower likelihood of being superior cognitive performers.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Lorena Sordo, Tianchen Qian, Syed A. Bukhari, Katelynn M. Nguyen, Davis C. Woodworth, Elizabeth Head, Claudia H. Kawas, Maria M. Corrada, Thomas J. Montine, S. Ahmad Sajjadi
Summary: Hippocampal sclerosis of aging (HS-A) is a common age-related neuropathological lesion characterized by neuronal loss and astrogliosis in the subiculum and CA1 subfield of the hippocampus. It is associated with cognitive decline similar to Alzheimer's disease. This study compares the traditional binary diagnosis of HS-A with a novel quantitative measure, revealing associations between HS-A and other neuropathologies and cognitive impairment that were not detected using the traditional approach.
ACTA NEUROPATHOLOGICA
(2023)
Article
Neurosciences
Lon R. White, Claudia H. Kawas, Brenna A. Cholerton, Steve E. Edland, Margaret E. Flanagan, Thomas J. Montine
Summary: This study assesses the associations between late-life cognitive impairment and five different neuropathologic changes (NC), and evaluates the prevalence of impairment among individuals resistant to each type of NC.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Anne-Marie C. Leiby, Kiana A. Scambray, Hannah L. Nguyen, Farheen Basith, Shahrzad Fakhraee, Zarui A. Melikyan, Syed A. Bukhari, Thomas J. Montine, Maria M. Corrada, Claudia H. Kawas, S. Ahmad Sajjadi
Summary: This study describes the clinical and cognitive characteristics of LATE-NC without ADNC and LB, and compares it with other neurodegenerative diseases. It found that this type of pathology is rare in the oldest old cohort, but is associated with significant cognitive decline and other symptoms.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Annlia Paganini-Hill, Syed Bukhari, Thomas J. J. Montine, Maria M. M. Corrada, Claudia H. H. Kawas
Summary: Alzheimer's disease (AD) is the leading cause of dementia. AD neuropathologic change (ADNC) may start decades before clinical symptoms. Oxidative stress is one mechanism implicated in AD. This study investigates the potential association between ADNC and antioxidant vitamin supplements taken about 30 years prior to death.
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
(2023)
Article
Geriatrics & Gerontology
Diana Petrosyan, Maria M. Corrada, Claudia H. Kawas, Asmeret Demoz, Czarina Ganzon, Oksana Popovich, Reham Gaied, Dan Mungas, Paola Gilsanz, Katharine E. Vieira, Rachel A. Whitmer, Charles DeCarli
Summary: This study aims to test if there are disparities in dementia rates among individuals aged 90 or older based on race or ethnicity. By using baseline clinical evaluation of 541 ethnically and racially diverse participants, the study found differences in associations between core demographic characteristics and measures of physical and cognitive performance across different racial/ethnic groups.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
