Article
Virology
Sai-Zhen Zeng, Le-Yun Xie, Tian Yu, Li-li Zhong, Jin-song Li, Zhao-Jun Duan, Bing Zhang, Qi-yi Zeng
Summary: For children with severe HAdV pneumonia, the duration of viral shedding is longer, with slower decrease in viral load and longer persistence for HAdV-7 infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Nabil Gastli, Julien Loubinoux, Matthieu Daragon, Jean-Philippe Lavigne, Pierre Saint-Sardos, Helene Pailhories, Carole Lemarie, Hanaa Benmansour, Camille D'Humieres, Lauranne Broutin, Olivier Dauwalder, Michael Levy, Gabriel Auger, Solen Kerneis, Vincent Cattoir
Summary: The study evaluated the performance of FA-PP in detecting bacterial pathogens and antibiotic resistance genes in respiratory specimens, showing that it performed well in detecting pathogens in most specimens. The positive and negative percentage agreement values of FA-PP compared to culture were high, but there were some false-negative results. In addition, there was some discordance between the semi-quantification results of FA-PP and culture results.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Medicine, General & Internal
Christopher C. Butler, F. D. Richard Hobbs, Oghenekome A. Gbinigie, Najib M. Rahman, Gail Hayward, Duncan B. Richards, Jienchi Dorward, David M. Lowe, Joseph F. Standing, Judith Breuer, Saye Khoo, Stavros Petrou, Kerenza Hood, Jonathan S. Nguyen-Van-Tam, Mahendra G. Patel, Benjamin R. Saville, Joe Marion, Emma Ogburn, Julie Allen, Heather Rutter, Nick Francis, Nicholas P. B. Thomas, Philip Evans, Melissa Dobson, Tracie-Ann Madden, Jane Holmes, Victoria Harris, May Ee Png, Mark Lown, Oliver van Hecke, Michelle A. Detry, Christina T. Saunders, Mark Fitzgerald, Nicholas S. Berry, Lazaro Mwandigha, Ushma Galal, Sam Mort, Bhautesh D. Jani, Nigel D. Hart, Haroon Ahmed, Daniel Butler, Micheal McKenna, Jem Chalk, Layla Lavallee, Elizabeth Hadley, Lucy Cureton, Magdalena Benysek, Monique Andersson, Maria Coates, Sarah Barrett, Clare Bateman, Jennifer C. Davies, Ivy Raymundo-Wood, Andrew Ustianowski, Andrew Carson-Stevens, Ly-Mee Yu, Paul Little
Summary: This study aimed to determine the safety, effectiveness, and cost-effectiveness of molnupiravir in vaccinated high-risk patients in the community. The results showed that molnupiravir did not reduce hospital admissions or deaths associated with COVID-19 compared to usual care in this population.
Article
Virology
Kenichiro Takahashi, Tsuguto Fujimoto, Nozomu Hanaoka, Mariko Tamura, Yoko Suzuki, Shigetaka Sugihara
Summary: This study aims to investigate the usefulness of clinical manifestations in deciding the use of adenovirus IC kits for children with upper respiratory infections (URI). The study found that when patients lack the clinical manifestations of fever, rhinorrhea, and tonsillar exudate, the results of adenovirus IC kits are often negative.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Yiman Huang, Chao Wang, Fenlian Ma, Qiong Guo, Lihong Yao, Aijun Chen, Xiaoyi Luo, Lishu Zheng
Summary: The study described the epidemiology and genotypic diversity of HAdV in hospitalized children with RTIs in Beijing, China. The main epidemic strains were found to be HAdV-B3 and HAdV-B7, with a recombinant HAdV-C strain CBJ113 forming an epidemic trend.
Article
Virology
Chuanyu Yang, Chunmei Zhu, Yuan Qian, Jie Deng, Baoyuan Zhang, Runan Zhu, Fang Wang, Yu Sun, Dongmei Chen, Qi Guo, Yutong Zhou, Lei Yu, Ling Cao, Linqing Zhao
Summary: Nosocomial infections of human adenovirus (HAdV) were investigated in a pediatric hospital in Beijing. Genotyping based on phylogenetic analysis combined with clinical data showed that most cases were community acquired infections rather than nosocomial infections, with only a minority potentially being transmitted within the hospital.
Article
Pediatrics
Li Wang, Xiaoting Hu, Zhenzhen Huang, Yangjie Zhang, Xiaoyuan Zhao, Xiaohua Liu, Hua Mao, Huixiang Hao, Wanli Xue
Summary: The typing and clinical characteristics of adenovirus (AdV) infection in children hospitalized with acute respiratory tract infection (ARTI) were investigated in this study. Among the hospitalized children with ARTIs, 4.48% (328/7832) tested positive for AdV. AdV type 3 and 7 were frequently found, with type 7 being associated with more severe outcomes. Clinical symptoms included cough, sputum not easily coughable, wheezing or shortness of breath, and fever.
Article
Immunology
Cheng-Chun Tai, Cheng-Hsien Tsai, Yu-Han Huang, Chia-Lin Lee, Hsin-Pai Chen, Yu-Jiun Chan
Summary: Respiratory viruses, particularly NIRVs, were frequently detected in adults hospitalized with RTIs, showing distinctive seasonal variations. A substantial number of RVs were identified in lower RT specimens or from patients admitted to ICU, highlighting their important role in causing severe respiratory infections.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Review
Virology
Veridiane Maria Pscheidt, Tatiana Schaffer Gregianini, Leticia Garay Martins, Ana Beatriz Gorini da Veiga
Summary: The study found that the infection rate of HAdV in respiratory infection patients in Rio Grande do Sul, Brazil was 2.8%, with a mortality rate of 3%. HAdV cases were mainly concentrated in winter and early spring, more common in male patients, and mostly in children. Patients with heart diseases and immunocompromised conditions were at higher risk of mortality.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Fen Pan, Bingjie Wang, Hong Zhang, Yingying Shi, Qi Xu
Summary: This study enrolled 90 children, among whom 58 patients (64.4%) tested positive for 13 pathogens using FARP, with 18 patients showing multiple-virus infections. Human rhinovirus/enterovirus were most common in infants and toddlers, while adenovirus were common in the 3-5-year-old group. Only three pathogens were found in the 6-14-year-old group.
BMC INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Wen Xu, Juan Du, Ting-Ting Wei, Lin-Yi Chen, Xin-Xin Yang, Tu Bo, Han-Yu Liu, Ming-Zhu Xie, Tian-Shuo Zhao, Jun-Lian Yang, Fuqiang Cui, Wei-Wei Chen, Qing-Bin Lu
Summary: This study found that there were changes in bile acids in patients with HAdV-7 infection, which may be metabolic signatures of HAdV-7 infection. Bile acids may play a protective role against HAdV-7 infection by inhibiting its replication.
FRONTIERS IN MEDICINE
(2022)
Article
Microbiology
Kosuke Kosai, Norihiko Akamatsu, Kenji Ota, Fujiko Mitsumoto-Kaseida, Kei Sakamoto, Hiroo Hasegawa, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara
Summary: This study investigated the diagnostic utility of the BioFire FilmArray Pneumonia Panel, and found that it enhanced the detection of pathogens and antimicrobial resistance markers in lower respiratory tract specimens.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2022)
Review
Anesthesiology
Anne-Clotilde Moy, Antoine Kimmoun, Thomas Merkling, Beatrice Bercot, Francois Camelena, Thibaut Poncin, Benjamin Deniau, Alexandre Mebazaa, Emmanuel Dudoignon, Nabil PCR Multiplex Study Group PMS Group, Nabil Gastli, Vincent Cattoir, Naouale Maataoui, Laurence Armand-Lefevre, Barend Mitton, Jonathan Hoover, John R. Greenland, Brunella Posteraro, Maurizio Sanguinetti, Evdoxia Kyriazopoulou, Evangelos J. Giamarellos-Bourboulis, Giulia Menchinelli, Brune Joannard
Summary: This study evaluated the diagnostic performance of the FilmArray (R) Pneumonia Plus Panel (FAPP) for detecting typical bacteria in respiratory samples through a systematic review. The results showed that FAPP has high accuracy and may serve as an adjunct tool for diagnosing pulmonary bacterial infections and guiding antimicrobial stewardship.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2023)
Article
Infectious Diseases
Evdoxia Kyriazopoulou, Athanasios Karageorgos, Lydia Liaskou-Antoniou, Panagiotis Koufargyris, Asimina Safarika, Georgia Damoraki, Vasileios Lekakis, Maria Saridaki, George Adamis, Evangelos J. Giamarellos-Bourboulis
Summary: The study found that the PNplus panel can detect pathogens of severe pneumonia at a greater rate compared to conventional microbiology, with bacterial detection being associated with high levels of inflammation.
INFECTIOUS DISEASES AND THERAPY
(2021)
Article
Microbiology
Zhenli Diao, Huiying Lai, Dongsheng Han, Bin Yang, Rui Zhang, Jinming Li
Summary: This study is the first to comprehensively validate the mNGS assay for the diagnosis of lower respiratory infections (LRIs) from bronchoalveolar lavage fluid (BALF). It provides a ready-made example for clinical laboratories to standardize their in-house mNGS assays through the preparation of reference materials and development of comprehensive validation schemes.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Christopher D. Doern, Jason Y. Park, Michael Gallegos, Debbie Alspaugh, Carey-Ann D. Burnham
JOURNAL OF CLINICAL MICROBIOLOGY
(2016)
Editorial Material
Microbiology
Chris D. Doern, James J. Dunn, Alexander J. McAdam
JOURNAL OF CLINICAL MICROBIOLOGY
(2016)
Editorial Material
Microbiology
Christopher D. Doern
JOURNAL OF CLINICAL MICROBIOLOGY
(2016)
Article
Microbiology
Melanie K. Brown, Betty A. Forbes, Kristin Stitley, Christopher D. Doern
JOURNAL OF CLINICAL MICROBIOLOGY
(2016)
Review
Microbiology
Christopher D. Doern, Susan E. Richardson
JOURNAL OF CLINICAL MICROBIOLOGY
(2016)
Editorial Material
Microbiology
Christopher D. Doern
JOURNAL OF CLINICAL MICROBIOLOGY
(2018)
Article
Pathology
Zhen Yan, Linlin Wang, Jake Dennis, Christopher Doern, Jonathan Baker, Jason Y. Park
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2014)
Article
Medical Laboratory Technology
Stacy G. Beal, Marc Roger Couturier, Rita M. Gander, Christopher D. Doern
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2016)
Article
Microbiology
Christopher D. Doern, Sean T. Nguyen, Folashade Afolabi, Carey-Ann D. Burnham
JOURNAL OF CLINICAL MICROBIOLOGY
(2014)
Article
Microbiology
Lori D. Racsa, Rita M. Gander, Paul M. Southern, Erin McElvania TeKippe, Christopher Doern, Hung S. Luu
JOURNAL OF CLINICAL MICROBIOLOGY
(2015)
Article
Microbiology
Christopher D. Doern, Stanley Mirrett, Diane Halstead, Joan Abid, Pamela Okada, L. Barth Reller
JOURNAL OF CLINICAL MICROBIOLOGY
(2014)
Review
Microbiology
Christopher D. Doern
JOURNAL OF CLINICAL MICROBIOLOGY
(2014)
Review
Pediatrics
Andrea Ronchi, Christopher Doern, Evangeline Brock, Lorenza Pugni, Pablo J. Sanchez
JOURNAL OF PEDIATRICS
(2014)
Article
Microbiology
Sara L. Revolinski, Christopher D. Doern
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Review
Microbiology
Christopher D. Doern, Melissa B. Miller, Kevin Alby, Michael A. Bachman, Stephen M. Brecher, Aida Casiano-Colon, Marc Roger Couturier, J. Kristie Johnson, James E. Kirby, Erin McElvania, Duane W. Newton, Frederick S. Nolte, Preeti Pancholi, Peggy McNult, Vaishali Dharmarha, Sherry Dunbar
Summary: Clinical Microbiology Open (CMO) is a meeting that brings together leaders from diagnostic microbiology laboratories, industry, and federal agencies to discuss the current and future state of the clinical microbiology laboratory. The discussions focus on innovative technologies, laboratory diagnostic stewardship, and addressing challenges such as the COVID-19 pandemic. The meetings have been critical in guiding the response to the pandemic and planning for future pandemics.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)