Article
Biochemistry & Molecular Biology
Matheus C. Bianchini, Luiz F. W. Soares, Joao M. F. M. Sousa, Bruna P. Ramborger, Mateus C. Gayer, Jessika C. Bridi, Rafael Roehrs, Simone Pinton, Michael Aschner, Daiana S. Avila, Robson L. Puntel
Summary: This study found that exposure to methylmercury in fruit flies led to reduced survival rate, decreased levels of dopamine and octopamine, and changes in behavior. These effects were associated with inhibition of acetylcholinesterase and tyrosine hydroxylase, increased oxidative stress, and altered glutathione-S-transferase activity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Neurosciences
Silas A. Buck, Briana R. De Miranda, Ryan W. Logan, Kenneth N. Fish, J. Timothy Greenamyre, Zachary Freyberg
Summary: The study found that DA neurons expressing VGLUT2 in the VTA/SNc exhibit higher resilience to rotenone-induced neurodegeneration, with an increase in VGLUT2 expression in response to rotenone. Dopaminergic terminals with VGLUT2 expression show greater protection throughout the striatum.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Yuxiao Yao, Diego Baronio, Yu-Chia Chen, Congyu Jin, Pertti Panula
Summary: This study found that the absence of the hrh1 gene in zebrafish leads to deficits in the dopaminergic and hypocretin systems during early development, but these deficits are compensated for in adulthood. However, adult fish exhibit impaired sociability and anxious-like behavior, along with downregulation of choline O-acetyltransferase and LIM homeodomain transcription factor Islet1.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhi Dong Zhou, Wuan Ting Saw, Patrick Ghim Hoe Ho, Zhi Wei Zhang, Li Zeng, Ya Yin Chang, Alfred Xu Yang Sun, Dong Rui Ma, Hong Yan Wang, Lei Zhou, Kah Leong Lim, Eng-King Tan
Summary: This study found that the TH-DA pathway plays a critical role in the pathogenesis of Parkinson's disease. LRRK2 and PINK1 have opposing effects on the TH-DA pathway, and the balance between them affects the survival of DA neurons. Mutations in LRRK2 or PINK1 can disrupt this balance, leading to the demise of DA neurons.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biology
Sage S. Frehner, Kip T. Dooley, Michelle C. Palumbo, Aaron L. Smith, Mark M. Goodman, Karen L. Bales, Sara M. Freeman
Summary: This study found significantly lower levels of OXTR in females with autism compared to other groups. There were no differences in mRNA levels for either gene across the four groups. These results suggest that dysregulation in OXTR protein translation or increased OXTR internalization/recycling may contribute to the differences in social symptoms seen in females with autism.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Mohamad Ayajuddin, Rahul Chaurasia, Abhik Das, Priyanka Modi, Limamanen Phom, Zevelou Koza, Sarat Chandra Yenisetti
Summary: Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. Using a fly model, our laboratory has shown that there is a reduction in fluorescence intensity of secondary antibodies targeting tyrosine hydroxylase, indicating a decrease in dopamine synthesis and dysfunction of dopaminergic neurons. This quantification method of fluorescence intensity can be a sensitive and cost-effective approach for studying neurodegenerative diseases.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Weimin Kong, Xueying Sun, Siyu Yu, Peihua Liu, Xiaoke Zheng, Jiaxin Zhang, Liang Zhu, Tianxin Jiang, Mengmeng Jin, Jinghui Gao, Xiaomin Fan, Xiaodong Liu, Li Liu
Summary: Liver failure is associated with increased levels of dopamine in the brain, which can lead to psychiatric alterations. This study investigated the relationship between dopamine levels and mental abnormalities using BDL rats and SH-SY5Y cells, and explored the mechanism by which liver failure increases dopamine levels.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Alba Tristan-Noguero, Irene Fernandez-Carasa, Carles Calatayud, Cristina Bermejo-Casadesus, Meritxell Pons-Espinal, Arianna Colini Baldeschi, Leticia Campa, Francesc Artigas, Analia Bortolozzi, Rosario Domingo-Jimenez, Salvador Ibanez, Merce Pineda, Rafael Artuch, Angel Raya, Angels Garcia-Cazorla, Antonella Consiglio
Summary: This study used induced pluripotent stem cells (iPSCs) to generate dopaminergic neurons (DAn) from patients with tyrosine hydroxylase deficiency (THD) and compared them with control-DAn. THD iPSC-DAn showed lower levels of dopamine metabolites and reduced TH expression compared to controls. Additionally, THD iPSC-DAn displayed abnormal morphology and neuronal defects, which were rescued by L-Dopa treatment only in the milder form of THD (THD-A). Treatment at the stage of neuronal precursors could prevent the alterations in the severe form of THD (THD-B). This iPSC-based model recapitulates THD disease phenotypes and response to treatment.
EMBO MOLECULAR MEDICINE
(2023)
Article
Peripheral Vascular Disease
Laia Canes, Judith Alonso, Carme Ballester-Servera, Saray Varona, Jose R. Escudero, Vicente Andres, Cristina Rodriguez, Jose Martinez-Gonzalez
Summary: The upregulation of the sympathetic nervous system pathway involving tyrosine hydroxylase (TH) may play a critical role in the pathophysiology of AAA. Pharmacological strategies targeting TH show potential for the management of AAA by normalizing vascular Th expression and preserving vascular integrity.
Article
Biochemistry & Molecular Biology
Laura M. Vecchio, Patricia Sullivan, Amy R. Dunn, Marie Kristel Bermejo, Rong Fu, Shababa T. Masoud, Emil Gregersen, Nikhil M. Urs, Reza Nazari, Poul Henning Jensen, Amy Ramsey, David S. Goldstein, Gary W. Miller, Ali Salahpour
Summary: TH plays a crucial role in Parkinson's disease, increasing TH activity leads to oxidative stress and accumulation of toxic dopamine metabolites in vivo, augmenting toxicity.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Agronomy
Shimin Chen, Satyabrata Nanda, Mujuan Guo, Lan Kong, Chunxiao Yang, Zhuoqi Liu, Ran Gao, Baoli Qiu, Youjun Zhang, Xuguo Zhou, Huipeng Pan
Summary: The role of tyrosine hydroxylase (HvTH) in the 28-spotted potato ladybeetle (Henosepilachna vigintioctopunctata) was investigated using dietary RNA interference (RNAi) and hematoxylin and eosin (H&E) staining. The results showed that HvTH is involved in larval-pupal-adult cuticle melanization, sclerotization, and reproduction. Ingestion of dsHvTH led to cuticle tanning impairment and larval feeding arrest, resulting in 100% mortality. HvTH inhibition disrupted cuticle tanning and prevented pupation. HvTH silencing in adult females reduced offspring hatching rates.
PEST MANAGEMENT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
G. E. Pennacchio, F. E. Santonja, F. J. Neira, C. Bregonzio, M. Soaje
Summary: Prenatal exposure to amphetamine affects dopamine receptors and tyrosine hydroxylase expression, with gender differences observed. Estrogen modulates mRNA levels of dopamine receptors in the brain and plays a role in stress responses.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shunya Inukai, Satoshi Hara, Hiroshi Ichinose
Summary: In this study, the researchers found that the modification of the cysteine residue Cys176 in tyrosine hydroxylase (TH) can inhibit its activity, even in the phosphorylated active state. They also discovered that dopamine oxides react with TH through Cys176 and inhibit its activity, potentially contributing to the mechanisms of neurotoxicity caused by dopamine oxides.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Developmental Biology
Alexandra A. Naumova, Ekaterina A. Oleynik, Anna V. Khramtsova, Svetlana D. Nikolaeva, Elena V. Chernigovskaya, Margarita V. Glazova
Summary: The effect of 3-day hindlimb unloading and social isolation on dopamine transmission in the nigrostriatal system of CD1 mice was analyzed. Hindlimb unloading led to a decrease in dopamine synthesis, while social isolation mainly affected dopamine phosphorylation. Overall, hindlimb unloading was identified as the main factor impairing dopamine transmission in the nigrostriatal system.
DEVELOPMENTAL NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Haelim Jeong, Jun Young Park, Ji-Hyun Lee, Ja-Hyun Baik, Chae-Yeon Kim, Jin-Young Cho, Monica Driscoll, Young-Ki Paik
Summary: The discovery of rcat-1 as a novel negative transcriptional regulator for dopamine metabolism genes has provided insights into the regulation of food search-associated locomotion. The mutants of rcat-1 exhibit abnormal movement behaviors and potential deficiencies in food sensing or locomotion toward food. This finding not only identifies a new subtype of dopamine-related behaviors but also suggests a potential therapeutic target in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Adriana Aguilar-Galarza, Teresa Garcia-Gasca, C. Mejia, Mauricio Diaz-Munoz, Moises Perez-Mendoza, Miriam Aracely Anaya-Loyola, Marta Garaulet
Summary: In two independent populations of young adults from Europe and America, individuals with evening chronotypes have a higher cardiometabolic risk and lipid alterations compared to those with neither or morning chronotypes. Lifestyle factors such as smoking and alcohol consumption also differed among chronotypes.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Rosario Baltazar-Lara, Jose Avila-Mendoza, Carlos G. Martinez-Moreno, Martha Carranza, Santiago Pech-Pool, Olivia Vazquez-Martinez, Mauricio Diaz-Munoz, Maricela Luna, Carlos Aramburo
Summary: GH and IGF-1 have been shown to have protective effects against neural damage, leading to increased cell viability and decreased apoptosis and necrosis in embryonic chicken cerebellar cell cultures exposed to acute HI injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Fernando Lizcano-Cortes, Jalil Rasgado-Toledo, Averi Giudicessi, Magda Giordano
Summary: This study did not find statistically significant associations between Theory of Mind (ToM) performance and brain structural measures after correction. Results suggest that in neurotypical and homogeneous populations, a reliable association between brain anatomy measures and ToM performance, as measured with specific tasks, may be unlikely to be found.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
M. Reyna-Jeldes, M. Diaz-Munoz, J. A. Madariaga, C. Coddou, F. G. Vazquez-Cuevas
Summary: Cancer is characterized by abnormal and uncontrolled cell growth, leading to tumor formation. Purinergic signaling, with changes in receptors and nucleotide metabolism in tumor cells, could serve as a potential biomarker or therapeutic target for the ten most lethal cancers.
PURINERGIC SIGNALLING
(2021)
Article
Neurosciences
Jalil Rasgado-Toledo, Fernando Lizcano-Cortes, Victor Enrique Olalde-Mathieu, Giovanna Licea-Haquet, Miguel Angel Zamora-Ursulo, Magda Giordano, Azalea Reyes-Aguilar
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Mayra Lopez-Cervantes, Andres Quintanar-Stephano, Sarael Alcauter-Solorzano, Rogelio Hernandez-Pando, Raul Aguilar-Roblero, Deisy Gasca-Martinez, Juan J. Ortiz, Olivia Vazquez-Martinez, Cecilia Ximenez-Camilli, Mauricio Diaz-Munoz
Summary: The study investigated a model of hepatic encephalopathy in male rats, finding distinctive cerebellar multi-disruption in PCA rats, characterized by cellular alterations, cytotoxic edema, metabolic adjustments, inflammasome activation, and locomotor deficits.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Review
Neurosciences
Maribel Delgado-Herrera, Azalea Reyes-Aguilar, Magda Giordano
Summary: This study systematically examined deception tasks and classified them based on their ecological validity. The results showed that intention to lie was the least included component, while monetary reward was the most common motivator. Meta-analysis revealed that tasks with high ecological validity recruited fewer brain areas, suggesting they may be more natural and realistic.
Article
Neurosciences
G. L. Licea-Haquet, A. Reyes-Aguilar, S. Alcauter, M. Giordano
Summary: Pragmatic competence requires linguistic, communicative, social, and cognitive competence. Successful language use in social interaction necessitates mutual understanding of the speaker's intentions, with speech act recognition involving inferring intention, executive functions, and activation of social cognition areas.
Article
Biochemistry & Molecular Biology
Olivia Vazquez-Martinez, Mauricio Diaz-Munoz, Fernando Lopez-Barrera, Rolando Hernandez-Munoz
Summary: This study explored the impact of isoproterenol-induced myocardial damage on mitochondrial function, specifically focusing on the malate-aspartate shuttle activity. The results showed minimal effects on endogenous shuttle activity, but significant enhancement in a reconstituted system during the post-infarction period, suggesting a compensatory response of cardiomyocytes to the metabolic consequences of myocardial infarction. These findings highlight the sequential biochemical and metabolic modifications within cardiomyocytes during heart damage associated with myocardial infarction, emphasizing the potential role of mitochondrial activity in controlling the redox state.
Article
Environmental Sciences
Oscar Samuel Avila-Rosales, Mauricio Diaz-Munoz, Rafael Camacho-Carranza, Elvia Coballase-Urrutia, Jose Pedraza-Chaverri, Jorge Omar Garcia-Rebollar, Jesus Javier Espinosa-Aguirre
Summary: The study found that DRF can modify the expression of ARNT and CYP1A1 genes, and can protect the body from the toxicity of benzo[a]pyrene.
Article
Behavioral Sciences
Pamela Reyes-Ortega, Maria Berenice Soria-Ortiz, Veronica M. Rodriguez, Eva Olivia Vazquez-Martinez, Mauricio Diaz-Munoz, Daniel Reyes-Haro
Summary: In this study, researchers found that anorexia disrupts glutamate-glutamine homeostasis associated with astrocyte dysfunction in the prefrontal cortex of young female rats.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Anai del Rocio Campos-Contreras, Adriana Gonzalez-Gallardo, Mauricio Diaz-Munoz, Francisco G. Vazquez-Cuevas
Summary: The purinergic system plays a crucial role in the tumor microenvironment, regulating tumor cell interactions and migration. This study investigated the role of the adenosine A2B receptor (A2BR) in ovarian cancer cells and found that high A2BR expression is associated with a better prognosis. In vitro experiments showed that A2BR activation reduces cell migration and actin stress fiber expression, while A2BR knockdown increases cell migration and actin stress fiber expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Multidisciplinary
Elizabeth Valles-Capetillo, Cristian Ibarra, Domingo Martinez, Magda Giordano
Summary: An irony identification task was created and evaluated for use in neuroimaging studies. The study found that contextual discrepancy, prosody, and facial expression were relevant cues for detecting ironic statements. However, the correlation between irony comprehension and cognitive functions did not yield consistent results.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Chemistry, Medicinal
Esperanza Mata-Martinez, Adriana Gonzalez-Gallardo, Mauricio Diaz-Munoz, Francisco G. G. Vazquez-Cuevas
Summary: Store-operated calcium entry (SOCE) is an important process in calcium signaling and its role in cancer aggression and regulation by ligands is poorly understood. This study investigated the effect of the P2Y2 receptor on intracellular calcium response in metastatic and non-metastatic ovarian cell lines. The results showed that SOCE activation by the P2Y2 receptor is involved in ovarian cancer aggressiveness and cell migration.
Article
Toxicology
D. Y. Reyes-Bravo, P. Villalobos-Aguilera, J. T. Almonte-Zepeda, M. S. Mendoza-Trejo, M. Giordano, A. Orozco, V. M. Rodriguez
Summary: The herbicide atrazine has effects on the GABAergic and glutamatergic systems in rats, leading to increased expression of related genes. These findings suggest that the GABAergic and glutamatergic systems are targets of ATR exposure.
FRONTIERS IN TOXICOLOGY
(2022)
