Review
Pediatrics
Christopher Henry, Chelsea Cockburn, Mary Helen Simpson, Serenity Budd, Chen Wang, Darina Dinov
Summary: This study provides estimates for the risk of multiple febrile seizures in the same febrile illness. The estimated baseline risk is 17%.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Neurosciences
Sanja Dimitrijevic, Biljana Jekic, Suzana Cvjeticanin, Aleksandra Tucovic, Tamara Filipovic, Ivana Novakovic, Bojana Ivic, Dimitrije Nikolic
Summary: The study found that the CT and TT genotypes, as well as the T allele of the rs2297201 polymorphism of the KCC2 gene, may be predisposing factors for febrile seizures and complex febrile seizures, while different genotypes and alleles of the rs222747 TRPV1 gene polymorphism were not associated.
Article
Plant Sciences
Baohua Jin, Wanjun Bai, Jiaojiao Zhao, Xia Qin, Han Guo, Yahui Li, Jie Hao, Siruan Chen, Zuxiao Yang, Hui Bai, Zongmao Zhao, Qingzhong Jia, Changzheng Dong, Zhuo Huang, Dezhi Kong, Wei Zhang
Summary: This study found that Jujuboside B (JuB) can suppress febrile seizures by inhibiting the activity of AMPA receptors and reducing intracellular calcium levels, thereby relieving seizure symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pediatrics
Rana Sawires, Jim Buttery, Michael Fahey
Summary: This article provides an overview of febrile seizures in young children, including their pathophysiology and risk factors. It also outlines the appropriate clinical approach for this condition.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Fan Yang, Lichao Sun, Jing Li, Weihong Lin
Summary: This study aims to investigate the relationship between acute repetitive seizures and claustrum damage by analyzing the cases of 5 patients with exclusive involvement of bilateral claustrum. The patients, all young women with unremarkable medical history, presented with similar symptoms and showed good outcomes after empirical treatment with anti-viral and anti-seizure drugs. Despite characteristic clinical and imaging findings, the etiology remains unclear, but all patients had a favorable prognosis contrary to previous studies.
Article
Medicine, General & Internal
Min Jeong Han, Jun Ho Heo, Ji Seong Hwang, Young-Taek Jang, Min Lee, Sun Jun Kim
Summary: During the study period from January 2020 to June 2022, a total of 33,457 children under the age of 5 in Jeonbuk province, South Korea were diagnosed with COVID-19, and 64 of them (44 boys, 20 girls) developed febrile seizures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Elham Bakhtiari, Farhad Heydarian, Maryam Khalesi, Fatemeh Jafarian, Mohammad Heidarian
Summary: In this study, the serum selenium levels were compared in febrile children aged 6-60 months with and without febrile seizures. There was no significant difference in selenium levels between the two groups overall, but in children over 1 year old, those with febrile seizures had lower selenium levels compared to those without seizures.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Behavioral Sciences
Kerstin Alexandra Klotz, Jasmin Oezcan, Yusuf Sag, Jan Schoenberger, Klaus Kaier, Julia Jacobs
Summary: The study aimed to evaluate anxiety levels of parents and children after a first unprovoked seizure, and found that a semi-structured follow-up in a first seizure clinic (FSC) can effectively and sustainably reduce anxiety levels. In contrast, anxiety after a first febrile seizure decreases over time without additional intervention.
EPILEPSY & BEHAVIOR
(2021)
Article
Cell Biology
Yeon Hee Yu, Seong-Wook Kim, Hyuna Im, Yejin Song, Seo Jeong Kim, Yu Ran Lee, Gun Woo Kim, Changmin Hwang, Dae-Kyoon Park, Duk-Soo Kim
Summary: This study investigates the causal relationship between febrile seizures in infancy and increased levels of anxiety-related behaviors and depression-like symptoms in juvenile and adult rodents using an FS rat model.
Article
Pediatrics
Ozlem Erdede, Erdal Sari, Emek Uyur, Rabia Gonul Sezer Yamanel
Summary: By evaluating complete blood count (CBC)-associated biomarkers, including osmolarity, this study provides a comprehensive understanding of their diagnostic value in febrile seizures (FS). The results show that osmolarity can be a useful tool in distinguishing complex FS cases, with better predictive utility compared to other markers.
Article
Pediatrics
Lingling Shao, Youna Yu
Summary: The study aimed to develop a prediction nomogram for recurrent febrile seizures in pediatric children based on identified predictors. The medical records of 320 children with febrile seizures were retrospectively reviewed, and predictors were identified through analyses. A prediction nomogram was developed and validated for clinical utility. The nomogram demonstrated good performance and clinical utility, serving as a convenient tool for detecting high-risk recurrent febrile seizures in pediatric patients and providing early interventions and counseling.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Anna Loussouarn, Anita Devlin, Thomas Bast, Gregoire Benoist, Francois Corrard, Helen Cross, Alessandro Ferretti, Fernando Garcia-Sala Viguer, Renzo Guerrini, Joerg Klepper, Thomas Meissner, Mathieu Milh, Violeta Poltorak, Umberto Raucci, Victoria San Antonio-Arce, Adrian Sie, Patricia Smeyers, Nicola Specchio, Alastair Sutcliffe, Adeline Trauffler, Blandine Dozieres-Puyravel, Stephane Auvin
Summary: Febrile seizures are often traumatic for families, but a consensus statement on delivering information to families following a febrile seizure has been established through a Delphi process involving child neurologists and pediatricians, aiming to reassure caregivers and prevent inappropriate anxiety-driven behaviors.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Alexandra V. Griflyuk, Tatyana Y. Postnikova, Sergey L. Malkin, Aleksey V. Zaitsev
Summary: Febrile seizures during early childhood can cause central nervous system developmental disorders. The specific mechanisms of how febrile seizures affect the developing brain are not well understood. In this study, we used a hyperthermic model of febrile seizures in 10-day-old rats and tracked their development for two months. Our findings suggest that febrile seizures reduce the number of neurons in various regions of the hippocampus and impair glutamatergic transmission, leading to decreased local field potential amplitude.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Elham Bakhtiari, Farhad Heydarian, Fatemeh Azmoudeh, Maziyar Kaffashbashi, Mohammad Heidarian
Summary: This study compared the serum vitamin A level in febrile children with and without seizures for the first time and found no difference between the two groups. However, in children aged more than 24 months, the serum vitamin A level was significantly higher in the febrile seizure group compared to the febrile group. Further studies are needed to confirm these findings.
Article
Neurosciences
Yao Cheng, Yujie Zhai, Yi Yuan, Hao Li, Wenke Zhao, Zhenhai Fan, Ling Zhou, Xue Gao, Yan Zhan, Hongliu Sun
Summary: This study evaluates the effectiveness of xenon in treating prolonged febrile seizures and preventing epilepsy. The results suggest that xenon treatment can alleviate the damage caused by prolonged febrile seizures and reduce the risk of developing epilepsy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Immunology
Cheng-Yin Tseng, Mao-Feng Sun, Tzu-Chien Kao, Tsai-Chung Li, Ching -Ting Lin
Summary: The study found that Coptis chinensis and its compounds have potential antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae (CRKP) and can enhance the effectiveness of colistin. They may represent a promising component of combination therapy in clinical settings for CRKP infections.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Health Care Sciences & Services
Ying-Yi Chen, Tsai-Chung Li, Chia-Ing Li, Shih-Pin Lin, Pin-Kuei Fu
Summary: This study found a correlation between statin prescription and lower mortality rates in older patients diagnosed with chronic obstructive pulmonary disease (COPD). Particularly, statin prescription had a protective effect on long-term survival in patients who experienced acute exacerbation and required hospitalization.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Chia-Ing Li, Cheng-Chieh Lin, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li
Summary: This study found a J-shaped association between sleep duration and all-cause and cardiovascular disease mortality in patients with type 2 diabetes. A sleep duration of 5-7 hours was associated with the lowest mortality risk. Sleep duration also showed significant interactions with diabetes duration and age and obesity.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Peripheral Vascular Disease
Cheng-Chieh Lin, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Mu-Cyun Wang, Shing-Yu Yang, Tsai-Chung Li
Summary: This study aimed to evaluate the effects of BP trajectory and variability on chronic kidney disease (CKD) incidence in patients with type 2 diabetes. The study found that there is an association between BP trajectory and variability and CKD risk, with patients in the high-downward-upward DBP trajectory and high variability group facing a higher risk of CKD.
HYPERTENSION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Cheng-Chieh Lin, May Jingchee Niu, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li
Summary: This study aimed to develop a risk prediction model for chronic kidney disease (CKD) in patients with type 2 diabetes in Taiwan. The model identified age, duration of diabetes, insulin use, estimated glomerular filtration rate, and albumin-to-creatinine ratio as significant risk factors for CKD. The model showed good accuracy in predicting CKD risk for 1 year, 3 years, and 5 years.
SCIENTIFIC REPORTS
(2022)
Article
Virology
Long-Bin Jeng, Tsai-Chung Li, Shih-Chao Hsu, Chiao-Fang Teng
Summary: This study found that higher levels of PD-L1 expression and Tregs infiltration in tumor tissues were associated with an increased risk of HCC recurrence in pre-S2 mutant-positive HCC patients after curative surgical resection.
Article
Geriatrics & Gerontology
Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li, Cheng-Chieh Lin
Summary: This study found that skeletal muscle mass and physical performance are significantly associated with all-cause mortality in elderly individuals. The combined use of skeletal muscle mass and physical performance can provide improved risk stratification, which may be used as a screening tool for targeting high-risk elders to prevent sarcopenia-related mortality effectively.
Article
Medicine, General & Internal
Pei-Chun Lin, Cheng-Chieh Lin, Chia-Ing Li, Tang-Chuan Wang, Yi-Hao Peng, Tung-Ti Chang, Chin-Yi Lin, Tsai-Chung Li, Ching-Liang Hsieh
Summary: Patients with type 2 diabetes have a higher risk of COPD and asthma. Traditional Chinese medicine (TCM) may be beneficial for these patients. A retrospective cohort study found that TCM use was associated with a reduced risk of respiratory hospitalizations, especially in patients with diabetes for <3 years.
Article
Endocrinology & Metabolism
Cheng-Chieh Lin, Chia-Ing Li, Chiu-Shong Liu, Li-Na Liao, Chuan-Wei Yang, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li
Summary: Through Mendelian randomization (MR) analysis, this study aimed to evaluate the causal relationship between high-sensitivity C-reactive protein (hsCRP) level and diabetic nephropathy (DN). The results showed that hsCRP level was causally related to DN, providing experimental evidence for understanding the mechanism and treatment of DN.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Biochemistry & Molecular Biology
Long-Bin Jeng, Tsai-Chung Li, Wen-Ling Chan, Chiao-Fang Teng
Summary: This study aimed to identify independent prognostic biomarkers from 75 HBV-related HCC patients and validate their potential as a combination biomarker for HCC recurrence with pre-S2 gene deletion mutation. The study found that patients with both pre-S2 gene deletion mutation and TNM stage IIIA-IIIC had a higher risk of HCC recurrence. Furthermore, the combination of pre-S2 gene deletion mutation and TNM stage had better performance in predicting HCC recurrence than either factor alone. In conclusion, the study proposed that TNM stage holds significance as a combination biomarker with pre-S2 gene deletion mutation for predicting HCC recurrence after curative surgical resection.
Article
Integrative & Complementary Medicine
Yi-Chun Ma, Jaung-Geng Lin, Cheng-Chieh Lin, Chia-Ing Li, Hui-Man Cheng, Tsai -Chung Li
Summary: This study found that traditional Chinese medicine formulas were significantly associated with a decreased risk of infectious hospitalization among patients with SLE. TCM formulas can be used as a part of SLE treatments to decrease the risk of infectious hospitalization.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li, Cheng-Chieh Lin
Summary: This study investigated the relationship between body shape index (ABSI) and mortality rate in patients with type 2 diabetes. The results showed that ABSI was closely associated with mortality rate, along with other indices such as BMI, WC, WHR, WHtR, and BRI. The combined use of ABSI and BMI provided better explanation of the variation in death risk compared to the independent use of BMI or other indices.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Endocrinology & Metabolism
Li-Na Liao, Tsai-Chung Li, Chih-Ching Yeh, Chia-Ing Li, Chiu-Shong Liu, Chuan-Wei Yang, Ya-Fei Yang, Chih-Hsueh Lin, Fuu-Jen Tsai, Cheng-Chieh Lin
Summary: This study developed and validated a risk prediction model for diabetic nephropathy (DN) in the Han Chinese population by integrating clinical factors and genetic SNPs from multiple CKD-related pathways. This model can be used as a screening tool for early intervention and prevention in clinical risk management practice.
ACTA DIABETOLOGICA
(2023)
Article
Medicine, General & Internal
Cheng-Hung Lee, Chia- Tsai, Yi-Chang Su, Shih-Yi Lin, I-Te Lee, Tsai-Chung Li
Summary: This study found that body constitution independently predicts new-onset albuminuria in individuals with type 2 diabetes. Yin deficiency and phlegm stasis are associated with an increased risk of albuminuria, and this relationship is influenced by glucose control status.
Article
Health Care Sciences & Services
Yu-Shan Chang, Yi-Chuan Cheng, Tsai-Chung Li, Li-Chi Huang
Summary: This study explored the perceived level of stress in mothers one month after hospital discharge following the birth of singleton and multiple preterm infants. The findings suggest that social support and sleep deprivation are predictive indicators of maternal stress in preterm infants. It is recommended that the differences in stress and needs of mothers with singleton and multiple births be recognized and addressed in clinics.
