期刊
JOURNAL OF CLINICAL LABORATORY ANALYSIS
卷 24, 期 3, 页码 154-159出版社
WILEY
DOI: 10.1002/jcla.20374
关键词
interleukin; polymorphism; febrile seizure
资金
- Taiwan National Science Council [NSC93-2314-B-039-013]
- China Medical University Hospital [DMR-94-021]
Inflammation and genetics may play a role in the pathogenesis of febrile seizures (FSs). We aimed to test whether interleukin-1 beta (IL-1 beta), IL-1 receptor antagonist (IL-1 Ra), IL-6 promoter, IL-8, IL-10, or tumor necrosis factor (TNF) gene polymorphisms could be used as markers of susceptibility to FSs. An association study was performed among a cohort of 104 patients with FSs and 143 normal control subjects. There was no significant difference between patients and controls in the distribution of allele frequencies of the IL-1 beta promoter, IL-1 beta exon 5, IL-6 promoter, IL-8, IL-10, or TNF-alpha gene polymorphisms. In contrast, the IL-1 Ra-I homozygote was more frequent in patients with FSs than in healthy controls (93.2% vs. 83.92%, chi(2)=4.51, P=0.034). In addition, individuals homozygous for the IL-1 Ra-I genotype were more than twice as likely to develop FSs than individuals heterozygous for the IL-1 Ra-I/II genotype (OR, 2.63, 95% Cl: 1.08-6.39; chi(2) = 4.55, P=0.033). We conclude that the IL-1 Ra gene might be one of the useful markers for predicting susceptibility to FSs. J. Clin. Lab. Anal. 24:154-159, 2010. (C) 2010 Wiley-Liss, Inc.
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