Review
Neurosciences
Xiaodi Guo, Guoxin Zhang, Qinyu Peng, Liqin Huang, Zhaohui Zhang, Zhentao Zhang
Summary: Meningeal lymphatic vessels (mLVs) are responsible for draining molecules and cells from the cerebrospinal fluid and interstitial fluid into lymph nodes. Aging and ApoE4, two risk factors for Alzheimer's disease (AD), can disrupt mLV function, leading to the accumulation of metabolic products, neuroinflammation, and the release of pro-inflammatory cytokines in the brain. Understanding the role of mLV dysfunction in AD pathogenesis can help identify new therapeutic targets for neurodegenerative and neuroinflammatory diseases.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Endocrinology & Metabolism
Ruonan Zhou, Yue Cao, Yingying Xiang, Penghua Fang, Wenbin Shang
Summary: Brown and beige adipose tissues regulate body energy expenditure through adaptive thermogenesis, and histone deacetylases (HDACs) play an important role in adipose tissue thermogenesis regulation. This review systematically summarizes the effects of different HDACs on adaptive thermogenesis and their underlying mechanisms. The differences among HDACs in thermogenesis regulation are emphasized, which may help in finding new efficient anti-obesity drugs targeting specific HDAC subtypes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Salimata Bagayoko, Etienne Meunier
Summary: Lipid peroxidation is a continuously occurring cellular process in living organisms, affecting various physiological and pathological contexts. Polyunsaturated fatty acids are a major target of oxidation, especially in membranous phospholipids. Recent studies have identified ferroptosis as an iron- and lipid peroxidation-dependent cell necrosis, with implications in a wide range of physiological and pathological processes, such as cancer, neurodegenerative diseases, and metabolic disorders.
Review
Microbiology
John E. Mamatis, Isabella E. Pellizzari-Delano, Carla E. Gallardo-Flores, Che C. Colpitts
Summary: Cellular cyclophilins, such as CypA, play crucial roles at the virus-host interface and act as host factors for the replication of various viruses. Understanding how these viruses exploit Cyps to promote their replication is still unclear. Recent studies have revealed that CypA plays a role in cloaking viral replication intermediates and interfering with cellular antiviral signaling pathways. Inhibiting CypA can restore antiviral immunity and induce expression of antiviral genes, which restrict viral infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Cell Biology
Hui Yang, Bruce Beutler, Duanwu Zhang
Summary: The spliceosome, while crucial for cell function, can also be implicated in diseases and serve as a target for cancer therapy. Research has shown connections between the spliceosome and immune signaling, leading to immune dysregulation. Furthermore, core spliceosome components have splicing-independent immune functions, adding to their functional diversity.
Review
Cell Biology
Wenjing Zhu, Dandan Zheng, Dandan Wang, Lehe Yang, Chengguang Zhao, Xiaoying Huang
Summary: The article summarizes the roles of the deubiquitinating enzyme USP25 in disease progression. Previous studies have mainly focused on its role in antiviral immunity and neurodegenerative diseases, but recent research has gradually revealed the mechanisms of action of USP25 in cancer and other diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Konstantin I. Ivanov, Olga V. Samuilova, Andrey A. Zamyatnin Jr
Summary: Recent advancements in RNA sequencing technology have allowed for the exploration of the complex and versatile world of long noncoding RNAs (lncRNAs) in the human genome. Once thought to be transcriptional noise, lncRNAs are now recognized as essential regulators of gene expression networks that control development, homeostasis, and disease progression. The regulatory functions of lncRNAs are diverse, acting at various levels within the cell, and there is growing evidence for their involvement in lymphatic vascular development and disease.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Immunology
Xiaoying Chen, David M. Holtzman
Summary: Alzheimer's disease is the most common neurodegenerative disease with innate immune pathway regulators as genetic risk factors. Innate and adaptive immune responses play important roles in disease development and may serve as therapeutic targets.
Review
Cell Biology
Yimeng Wang, Lifang Li, Jiaqi Li, Bin Zhao, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou
Summary: m6A, the most prevalent RNA modification, plays a crucial role in physiological and pathological processes, particularly in the pathogenesis of immune-related diseases. It may serve as a promising epitranscriptomic target for preventing and treating autoimmune disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Xintian Chen, Menghan Cao, Pengfei Wang, Sufang Chu, Minle Li, Pingfu Hou, Junnian Zheng, Zhongwei Li, Jin Bai
Summary: TRIM21 plays a dual role in cancer, promoting and suppressing tumor progression, and has effects on metabolism, immunity, and tumor treatment, but no systematic review has been conducted.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yuran Chen, Wenjing Wang, Wuchao Zhang, Mei He, Yuming Li, Guosheng Qu, Jie Tong
Summary: N6-methyladenosine (m6A) is a prevalent chemical modification in intracellular RNA, with multifaceted effects on viral genomic RNA. Three groups of biological proteins, m6A writers, erasers, and readers, control the levels of m6A modification in eukaryotic cells. These proteins play important roles in regulating viral infection, including interferon expression, innate immune responses, and virus-host interactions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Wei Yang, Zhou Zhou, Zhaohui Chu
Summary: Salicylic acid (SA), an important phytohormone, regulates plant growth, development, ripening, and defense responses. Its role in plant-pathogen interactions has attracted much attention and it has potential for improving stress resistance in agricultural crops. However, SA utilization depends on dosage, application technique, and plant status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Massar Alsamraae, Leah M. Cook
Summary: Metastasis, especially bone metastasis, is a major cause of cancer-related deaths, linked to long-term pain and poor quality of life. Tumor cells alter the bone microenvironment, leading to cancer growth, but bone-targeted therapies have shown limited improvement in patient survival.
CANCER AND METASTASIS REVIEWS
(2021)
Review
Cell Biology
Ryan Lim, Avinanda Banerjee, Ritusree Biswas, Anana Nandakumar Chari, Srikala Raghavan
Summary: Stem cells have a significant role in regenerative medicine, but controlling their potential is a challenge. Biochemical and mechanical signals regulate stem cells, with the latter being less explored. This review discusses the influence of mechanical cues perceived by cell adhesion molecules on stem cell regulation and highlights the therapeutic implications of understanding stem cell mechanobiology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Shuainan Zhu, Ying Yu, Yun Ren, Liying Xu, Huilin Wang, Xiaomin Ling, Lin Jin, Yan Hu, Hao Zhang, Changhong Miao, Kefang Guo
Summary: Delayed wound healing can cause issues for many patients, with prolonged or excessive inflammation being a common cause. Excessive NET formation may hinder wound healing.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Hongmei Li, Shann S. Yu, Martina Miteva, Christopher E. Nelson, Thomas Werfel, Todd D. Giorgio, Craig L. Duvall
ADVANCED FUNCTIONAL MATERIALS
(2013)
Article
Immunology
Catherine M. Card, Yoav Keynan, Julie Lajoie, Courtney P. Bell, Magdy Dawood, Marissa Becker, Ken Kasper, Keith R. Fowke
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2012)
Article
Medicine, Research & Experimental
Shann S. Yu, Cheryl M. Lau, Whitney J. Barham, Halina M. Onishko, Christopher E. Nelson, Hongmei Li, Chelsey A. Smith, Fiona E. Yull, Craig L. Duvall, Todd D. Giorgio
MOLECULAR PHARMACEUTICS
(2013)
Review
Virology
Catherine M. Card, Terry Blake Ball, Keith R. Fowke
Article
Cell & Tissue Engineering
Angela L. Zachman, Spencer W. Crowder, Ophir Ortiz, Katarzyna J. Zienkiewicz, Christine M. Bronikowski, Shann S. Yu, Todd D. Giorgio, Scott A. Guelcher, Joachim Kohn, Hak-Joon Sung
TISSUE ENGINEERING PART A
(2013)
Article
Multidisciplinary Sciences
Brian C. Evans, Christopher E. Nelson, Shann S. Yu, Kelsey R. Beavers, Arnold J. Kim, Hongmei Li, Heather M. Nelson, Todd D. Giorgio, Craig L. Duvall
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2013)
Article
Multidisciplinary Sciences
Efthymia Vokali, Shann S. Yu, Sachiko Hirosue, Marcela Rincon-Restrepo, Fernanda Duraes, Stefanie Scherer, Patricia Corthesy-Henrioud, Witold W. Kilarski, Anna Mondino, Dietmar Zehn, Stephanie Hugues, Melody A. Swartz
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Catherine Card, David S. Wilson, Sachiko Hirosue, Marcela Rincon-Restrepo, Alexandre de Titta, Esra Guc, Coralie Martin, Odile Bain, Melody A. Swartz, Witold W. Kilarski
SCIENTIFIC REPORTS
(2020)
Article
Immunology
Catherine M. Card, Bernard Abrenica, Lyle R. McKinnon, Terry Blake Ball, Ruey-Chyi Su
Summary: The study found that endothelial cells (ECs) can influence the HIV infection susceptibility of resting CD4(+) T cells by regulating cell trafficking pathways. When co-cultured with ECs, infected T cells were primarily central memory cells expressing integrins LFA-1 and VLA-4, and the ECs expressed the ligands for these integrins. Blocking LFA-1 and VLA-4 on cell surfaces significantly reduced HIV infection of CD4(+) T cells.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2022)
Article
Chemistry, Multidisciplinary
Lisa R. Volpatti, Rachel P. Wallace, Shijie Cao, Michal M. Raczy, Ruyi Wang, Laura T. Gray, Aaron T. Alpar, Priscilla S. Briquez, Nikolaos Mitrousis, Tiffany M. Marchell, Maria Stella Sasso, Mindy Nguyen, Aslan Mansurov, Erica Budina, Ani Solanki, Elyse A. Watkins, Mathew R. Schnorenberg, Andrew C. Tremain, Joseph W. Reda, Vlad Nicolaescu, Kevin Furlong, Steve Dvorkin, Shann S. Yu, Balaji Manicassamy, James L. LaBelle, Matthew Tirrell, Glenn Randall, Marcin Kwissa, Melody A. Swartz, Jeffrey A. Hubbell
Summary: The study found that decorating multiple copies of the SARS-CoV-2 spike protein receptor-binding domain (RBD) on the surface of polymersomes can promote a potent neutralizing antibody response. Both RBDsurf and RBDencap induce robust T cell immune responses, producing multiple Th1-type cytokines.
ACS CENTRAL SCIENCE
(2021)
Article
Engineering, Biomedical
Laura T. Gray, Michal M. Raczy, Priscilla S. Briquez, Tiffany M. Marchell, Aaron T. Alpar, Rachel P. Wallace, Lisa R. Volpatti, Maria Stella Sasso, Shijie Cao, Mindy Nguyen, Aslan Mansurov, Erica Budina, Elyse A. Watkins, Ani Solanki, Nikolaos Mitrousis, Joseph W. Reda, Shann S. Yu, Andrew C. Tremain, Ruyi Wang, Vlad Nicolaescu, Kevin Furlong, Steve Dvorkin, Balaji Manicassamy, Glenn Randall, D. Scott Wilson, Marcin Kwissa, Melody A. Swartz, Jeffrey A. Hubbell
Summary: Spike-p(Man-TLR7) vaccination induces robust antigen-specific cellular and humoral responses in mice, generating high and long-lasting titers of antibodies with neutralizing abilities surpassing convalescent human serum. The vaccine also enhances germinal center B cells, antigen-specific antibody secreting cells, activated T follicular helper cells, and polyfunctional Th1-cytokine producing CD4(+) and CD8(+) T cells.
Article
Instruments & Instrumentation
Shann S. Yu, Jeffrey A. Hubbell, Melody A. Swartz
Summary: Immunotherapies aim to treat diseases by modulating immune cell activity, but transport barriers may hinder delivery and retention at diseased sites. Overcoming these barriers by exploiting immunobiology to engineer molecular and cellular approaches is crucial. Integrating expertise from pathologists, clinicians, immunologists, biophysicists, immunoengineers and more is essential for impactful and practical solutions across various diseases.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Aloysious Ssemaganda, Huong Mai Nguyen, Faisal Nuhu, Naima Jahan, Catherine M. Card, Sandra Kiazyk, Giulia Severini, Yoav Keynan, Ruey-Chyi Su, Hezhao Ji, Bernard Abrenica, Paul J. McLaren, T. Blake Ball, Jared Bullard, Paul Van Caeseele, Derek Stein, Lyle R. McKinnon
Summary: This study investigates T cells in the nasal mucosa and blood after vaccination with the Pfizer-BioNTech COVID-19 vaccine. The results show an increase in tissue-resident memory CD8(+) T cells expressing CD69(+)CD103(+) in the nasal mucosa after the first and second doses, while CD69(+)CD103(+)CD8(+) T cells in the blood decrease post-vaccination. There is also an increase in nasal CD8(+)CD69(+)CD103(-) T cells, particularly following the second dose. Additionally, CD4(+) cells co-expressing CCR6 and CD161 are increased in abundance following both doses. Stimulation of nasal CD8(+) T cells with SARS-CoV-2 spike peptides elevates expression of CD107a and cytokines.
NATURE COMMUNICATIONS
(2022)