B7-H1–expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets

Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation

(2014) K. Kim et al.   CARCINOGENESIS

IL-22+CD4+ T Cells Promote Colorectal Cancer Stemness via STAT3 Transcription Factor Activation and Induction of the Methyltransferase DOT1L

(2014) Ilona Kryczek et al.   IMMUNITY

Tumor-Educated Tolerogenic Dendritic Cells Induce CD3  Down-Regulation and Apoptosis of T Cells through Oxygen-Dependent Pathways

(2014) D.-M. Kuang et al.   JOURNAL OF IMMUNOLOGY

Increased Intratumoral Interleukin 22 Levels and Frequencies of Interleukin 22–Producing CD4+ T Cells Correlate With Pancreatic Cancer Progression

(2014) Xuejun Xu et al.   PANCREAS

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

(2013) Stefanie Kirchberger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-22 Promotes Proliferation of Liver Stem/Progenitor Cells in Mice and Patients With Chronic Hepatitis B Virus Infection

(2012) Dechun Feng et al.   GASTROENTEROLOGY

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

Increased Circulating Th22 and Th17 Cells are Associated with Tumor Progression and Patient Survival in Human Gastric Cancer

(2012) Tao Liu et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

(2012) J. M. Taube et al.   Science Translational Medicine

Innate IL-17 and IL-22 responses to enteric bacterial pathogens

(2012) Stephen J. Rubino et al.   TRENDS IN IMMUNOLOGY

Functional role of IL-22 in psoriatic arthritis

(2012) Anupam Mitra et al.   ARTHRITIS RESEARCH & THERAPY

Expressions of IL-22 in circulating CD4+/CD8+ T cells and their correlation with disease activity in SLE patients

(2011) Wei-Zi Qin et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Interleukin-17-educated monocytes suppress cytotoxic T-cell function through B7-H1 in hepatocellular carcinoma patients

(2011) Qiyi Zhao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3

(2011) Runqiu Jiang et al.   HEPATOLOGY

Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology

(2011) Masahito Kamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activated CD69+ T Cells Foster Immune Privilege by Regulating IDO Expression in Tumor-Associated Macrophages

(2011) Q. Zhao et al.   JOURNAL OF IMMUNOLOGY

IL-17 + Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer

(2011) Ilona Kryczek et al.   JOURNAL OF IMMUNOLOGY

Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop

(2011) Yan Wu et al.   JOURNAL OF PATHOLOGY

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

(2011) Gregory F Sonnenberg et al.   NATURE IMMUNOLOGY

Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma

(2010) Dong-Ming Kuang et al.   JOURNAL OF HEPATOLOGY

Tumor-Activated Monocytes Promote Expansion of IL-17-Producing CD8+ T Cells in Hepatocellular Carcinoma Patients

(2010) D.-M. Kuang et al.   JOURNAL OF IMMUNOLOGY

Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells

(2009) Dong-Ming Kuang et al.   HEPATOLOGY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients

(2009) Jia Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling

(2009) Stefanie Eyerich et al.   JOURNAL OF CLINICAL INVESTIGATION

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unique Phenotype of Human Tonsillar and In Vitro-Induced FOXP3+CD8+ T Cells

(2009) K. Siegmund et al.   JOURNAL OF IMMUNOLOGY

Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells

(2009) Sara Trifari et al.   NATURE IMMUNOLOGY

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells

(2009) Thomas Duhen et al.   NATURE IMMUNOLOGY

IL-22 is required for Th17 cell–mediated pathology in a mouse model of psoriasis-like skin inflammation

(2008) Hak-Ling Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY