Article
Physiology
Antonio G. Soares, Jorge Contreras, Crystal R. Archer, Elena Mironova, Rebecca Berdeaux, James D. Stockand, Tarek Mohamed Abd El-Aziz
Summary: The study demonstrates that targeted activation of Gs signaling exclusively in renal principal cells (PC) is sufficient to increase ENaC activity and decrease urinary sodium excretion in live animals.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qiu-Shi Wang, Chen Liang, Shuai Jiang, Di Zhu, Yu Sun, Na Niu, Xu Yang, Yan-Chao Yang, Bi-Han Dong, Jie Yao, Chang-Jiang Yu, Jie Lou, Liang-Liang Tang, Ming-Ming Wu, Zhi-Ren Zhang, He-Ping Ma
Summary: The study found that the mechanism by which CsA induces hypertension is by increasing ENaC activity, and is associated with intracellular reactive oxygen species, activation of Sgk1, and inactivation of Nedd4-2. Lovastatin, NaHS, and amiloride all reversed CsA-induced hypertension, with NaHS acting through inhibition of oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Yabin Chen, Xiao Yu, Zhiping Yan, Shuijun Zhang, Jiacheng Zhang, Wenzhi Guo
Summary: The epithelial sodium channel (ENaC) is widely distributed in various organs and plays a crucial role in mediating the entry of sodium ions into cells. It has regulatory functions in blood pressure, airway surface liquid, and endothelial cell function. ENaC dysregulation has been found to contribute to inflammation-related diseases such as hypertension, cystic fibrosis, and tumors. However, there is still controversy and unclear understanding about the exact mechanisms involved.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Puja Paudel, Fiona J. McDonald, Martin Fronius
Summary: Delta-ENaC, the fourth subunit of vascular epithelial sodium channels, has been less understood but recent discovery of its presence in human vascular cells suggests its potential significant role in vascular physiology and pathophysiology in humans. It has different properties compared to the alpha subunit, making it a potential new drug target for cardiovascular disease treatment.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yeni Wahyuni Hartati, Dina Ratna Komala, Diana Hendrati, Shabarni Gaffar, Ari Hardianto, Yulia Sofiatin, Husein Hernandi Bahti
Summary: ENaC protein plays a crucial role in regulating sodium levels in blood plasma, and having a family history of hypertension may increase the risk of having an excessive amount of ENaC protein. An aptasensor method utilizing electrochemical techniques has been developed to detect ENaC protein levels, showing potential for urine sample testing.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Zhangyan Shi, Ze Zhao, Puyan Zhu, Caiyan An, Kejin Zhang
Summary: Observational associations between milk consumption and essential hypertension have been reported, but causal inferences and effects of different types of milk consumption on hypertension risk are unclear. This study used Mendelian randomization analysis to investigate the effects of different milk consumption types on essential hypertension. The findings showed that semi-skimmed and soya milk products were protective against hypertension, while skim milk had the opposite effect. This study provides genetic evidence for a causal link between milk consumption and hypertension risk.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Physiology
Jose Wilson N. Correa, Karoline R. Boaro, Leticia B. Sene, Juliano Z. Polidoro, Thiago A. Salles, Flavia L. Martins, Lusiane M. Bendhack, Adriana C. C. Girardi
Summary: This study demonstrated that dual RAS blockade in renovascular hypertensive rats exerts its antiproteinuric effect by restoring the abundance of podocin, cubilin, and ClC-5, while the hyperkalemia induced by dual RAS blockade may be due to an exaggerated downregulation of cleaved alpha-ENaC in the non-clipped kidney of renovascular hypertensive rats.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Pediatrics
Erika Jones, Brian Rayner
Summary: Hypertension is highly prevalent in Black Africans, who are more salt sensitive and have increased variants in the ENaC, leading to worse blood pressure control. Increased ENaC activity contributes to sodium and water retention as well as vascular stiffness, making hypertension more difficult to control. The use of the diuretic amiloride may be beneficial for severe and resistant hypertension in Black Africans.
PEDIATRIC NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tiantian Zhou, Shengnan Zhang, Chunyu Du, Kun Wang, Xiabing Gu, Shijin Sun, Xianrui Zhang, Yayan Niu, Can Wang, Meng Liu, Ningzheng Dong, Qingyu Wu
Summary: This study demonstrates the importance of renal Corin function in enhancing natriuresis upon high salt intake and the inability of cardiac Corin function to compensate for it.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Matthew A. Sparks, Emre Dilmen, Donna L. Ralph, Fitra Rianto, Thien A. Hoang, Alison Hollis, Edward J. Diaz, Rishav Adhikari, Gabriel Chew, Enrico G. Petretto, Susan B. Gurley, Alicia A. McDonough, Thomas M. Coffman
Summary: The study demonstrates that the specific deletion of angiotensin receptors in smooth muscle cells leads to alterations in tubular transporter amount and function, highlighting the importance of vascular-tubular cross talk in the control of blood pressure.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Thomas S. Ehlers, Jennifer van der Horst, Sophie Moller, Peter K. Piil, Lasse Gliemann, Christian Aalkjaer, Thomas A. Jepps, Ylva Hellsten
Summary: The aim of this study was to investigate the effects of colchicine on beta adrenoceptor-mediated vasodilation in humans. The results showed that acute treatment with colchicine increased vasodilation induced by beta adrenoceptor agonist and nitric oxide in humans with essential hypertension. This finding has important implications for the treatment of hypertension.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yasunobu Iwata, Qinyuan Deng, Yutaka Kakizoe, Terumasa Nakagawa, Yoshikazu Miyasato, Miyuki Nakagawa, Kayo Nishiguchi, Yu Nagayoshi, Yuki Narita, Yuichiro Izumi, Takashige Kuwabara, Masataka Adachi, Masashi Mukoyama
Summary: This study investigated the effects of CM on plasmin activity, ENaC activation, and podocyte injury in DS rats. The results showed that CM can inhibit plasmin activity, alleviate hypertension and proteinuria in rats, and reduce plasmin attachment to podocytes, thus protecting them from injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Mernea, Roxana Stefania Ulareanu, Dana Cucu, Jasim Hafedh Al-Saedi, Cristian-Emilian Pop, Sergiu Fendrihan, Giorgiana Diana Carmen Anghelescu, Dan Florin Mihailescu
Summary: This study used THz spectroscopy to investigate the inhibition of ion channels and successfully distinguished between native and inhibited ENaC channels.
Article
Biochemistry & Molecular Biology
Giovanna Blacona, Roberto Raso, Stefano Castellani, Silvia Pierandrei, Paola Del Porto, Giampiero Ferraguti, Fiorentina Ascenzioni, Massimo Conese, Marco Lucarelli
Summary: The pathogenic mechanism of cystic fibrosis involves the interaction between the CFTR protein and the ENaC channel. By inhibiting the protease-dependent activation of ENaC and manipulating its coding genes, it is possible to reduce ENaC activity and potentially treat cystic fibrosis. The study found that inhibition of extracellular peptidases and epigenetic manipulations can effectively reduce ENaC activity, with better results in primary cells. The SCNN1B gene appears to be the most effective target for reducing ENaC activity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eric R. Barros Lamus, Valentina Carotti, Christine R. S. de Vries, Femke Witsel, Onno J. Arntz, Fons A. J. van de Loo, Cristian A. Carvajal, Rene J. M. Bindels, Joost G. J. Hoenderop, Juan P. Rigalli
Summary: This study investigates the regulatory effect of EVs from renal proximal tubule and collecting duct cells on extracellular ATP levels and the expression of the alpha subunit of the epithelial sodium channel. The findings reveal that EVs can modulate purinergic signaling through mechanisms such as miRNA regulation and ATPase activity, impacting renal physiological and pathophysiological processes. Further research on EV release and cargo content may shed light on the role of EVs in renal purinergic signaling.
