Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

(2013) Akihito Ohta et al.   BIOCHEMICAL JOURNAL

Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension

(2013) Mai Wakabayashi et al.   Cell Reports

Phosphorylation of Na–Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination

(2012) Muhammad Zakir Hossain Khan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions

(2012) Tao Na et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

(2012) Lynn M. Boyden et al.   NATURE

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

(2012) Hélène Louis-Dit-Picard et al.   NATURE GENETICS

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

(2012) M. Castaneda-Bueno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin Ligase Activity of Cul3-KLHL7 Protein Is Attenuated by Autosomal Dominant Retinitis Pigmentosa Causative Mutation

(2011) Yu Kigoshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural assembly of cullin-RING ubiquitin ligase complexes

(2010) Erik S Zimmerman et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Down-regulation of Intestinal Apical Calcium Entry Channel TRPV6 by Ubiquitin E3 Ligase Nedd4-2

(2010) Wei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WNK4 Diverts the Thiazide-sensitive NaCl Cotransporter to the Lysosome and Stimulates AP-3 Interaction

(2009) Arohan R. Subramanya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway

(2009) David J. Rozansky et al.   JOURNAL OF CLINICAL INVESTIGATION

WNK4 Enhances the Degradation of NCC through a Sortilin-Mediated Lysosomal Pathway

(2009) B. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

(2009) P. San-Cristobal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BTB Protein KLHL12 Targets the Dopamine D4 Receptor for Ubiquitination by a Cul3-based E3 Ligase

(2008) Pieter Rondou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE