Article
Psychology, Clinical
Genevieve F. F. Dash, Ian R. R. Gizer, Nicholas G. G. Martin, Wendy S. S. Slutske
Summary: This study found that the genetic and environmental influences of prescription opioid misuse and heroin use are partially distinct, and the genetic influence on prescription opioid misuse is drug-specific.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Natasa Gisev, Luke Buizen, Ria E. Hopkins, Andrea L. Schaffer, Benjamin Daniels, Chrianna Bharat, Timothy Dobbins, Sarah Larney, Fiona Blyth, David C. Currow, Andrew Wilson, Sallie-Anne Pearson, Louisa Degenhardt
Summary: The objective of this population-based cohort study was to identify 5-year trajectories of prescription opioid use and examine the characteristics of each trajectory group. The results suggest that most individuals initiating treatment with prescription opioids had relatively low and time-limited exposure over a 5-year period. A small proportion of individuals had sustained or increasing use, and they were typically older with more comorbidities and higher use of psychotropic and other analgesic drugs.
Article
Behavioral Sciences
Catalina Lopez-Quintero, Trey Warren, Alyssa Falise, Vinita Sharma, Cristina Bares, Assaf Oshri
Summary: The study found that the extra-medical use of prescription medications for sleep, particularly PPR-only and ST + PPR, is prevalent among Non-Hispanic Blacks, young adults, and individuals residing in rural areas. Most individuals reported using these medications primarily for sleep purposes rather than recreational reasons.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Psychology, Clinical
Genevieve F. Dash, Nicholas G. Martin, Arpana Agrawal, Michael T. Lynskey, Wendy S. Slutske
Summary: The study found that prescription opioid misuse may share little genetic influence with illicit opioid use, but there may be more common genetic influences between prescription stimulant misuse and illicit use. Future research could consider avoiding unitary drug classifications when examining genetic influences.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Genetics & Heredity
Maria Carla Gerra, Cristina Dallabona, Lars Arendt-Nielsen
Summary: Prescription opioids are commonly used for chronic pain conditions, but long-term therapy can lead to risks of addiction and overdose. Studies have shown that opioid addiction and chronic pain conditions involve genetic and epigenetic alterations, but the contribution and mechanisms are not fully understood.
Article
Pharmacology & Pharmacy
Nicolas Kerckhove, Noemie Delage, Celian Bertin, Emmanuelle Kuhn, Nathalie Cantagrel, Caroline Vigneau, Jessica Delorme, Celine Lambert, Bruno Pereira, Chouki Chenaf, Nicolas Authier
Summary: Public health issues related to chronic pain management and opioid misuse remain a challenge. Data on the prevalence of disorders related to the use of prescribed opioids in patients suffering from chronic pain is limited. A study found that almost half of patients with chronic pain misuse their prescribed opioid.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Belle Ngo, Jane M. Liebschutz, Debbie M. Cheng, Jonathan A. Colasanti, Jessica S. Merlin, Wendy S. Armstrong, Leah S. Forman, Marlene C. Lira, Jeffrey H. Samet, Carlos del Rio, Judith Tsui
Summary: Hazardous alcohol use among persons living with HIV on long-term opioid therapy was associated with higher pain interference and increased risk of opioid misuse, highlighting the importance of monitoring alcohol use in this population to prevent pain-related functional impairment and prescription opioid misuse.
Article
Pharmacology & Pharmacy
Richard C. Dart, Janetta L. Iwanicki, Joshua C. Black, Heather A. Olsen, Stevan G. Severtson
Summary: Prescription drug misuse in the USA increased from the 1990s to 2010, leading to the development of new analytical strategies. The most commonly misused opioid medications and trends in misuse have been consistent across multiple data sources. Interventions such as prescription drug monitoring programs and abuse deterrent formulations have been effective in decreasing misuse of opioid analgesics.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Surgery
Eleah D. Porter, Olivia A. Sacks, Niveditta Ramkumar, Richard J. Barth
Summary: This study surveyed adults in the United States who had received prescription opioids after surgery and found that misuse and diversion of opioids after surgery were common, with a misuse rate of up to one in three and a diversion rate of up to one in five. Factors such as working in healthcare, higher risk scores on opioid risk assessment tools, refilling prescriptions, and keeping leftover pills were associated with misuse and diversion.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Obstetrics & Gynecology
Olga Bougie, Jessica Blom, Grace Zhou, Ally Murji, Jackie Thurston
Summary: Postoperative opioid use following gynecologic surgery may lead to side effects and negative health consequences. Strategies such as adherence to Enhanced Recovery After Surgery Protocols and multimodal analgesia management can help decrease the need for opioid use.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Article
Oncology
Jeana E. Havidich, Julie E. Weiss, Tracy L. Onega, Ying H. Low, Martha E. Goodrich, Mathew A. Davis, Brian D. Sites
Summary: This study examined the association between prescription opioids and incident cancers, and found a complex relationship where opioids were negatively associated with breast and colon cancer, but positively associated with kidney, leukemia, liver, lung, and lymphoma cancers. This suggests that cancer site may play an important role in the relationship between opioids and cancer development.
Article
Public, Environmental & Occupational Health
Sharon Reif, Eric A. Lauer, Rachel Sayko Adams, Debra L. Brucker, Grant A. Ritter, Monika Mitra
Summary: The study found that adults with disabilities were more likely to use prescription opioids compared to those without disabilities, but the likelihood of opioid use disorder did not vary by disability status. Pain relief as the reason for last misuse was associated with an increased risk of prescription opioid use disorder.
PREVENTIVE MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Wui Ling Chan, David M. Wood, Paul I. Dargan
Summary: The misuse of prescription medicine, particularly opioids, has become a major public health concern in many developed countries such as the USA and Australia. Limited available information suggests that prescription medicine misuse is also likely to be an issue in the Asia-Pacific region, with similar prevalence rates and commonly misused medicines as in other countries. Further studies are needed to determine the overall prevalence of misuse, associated harms, and sources of drugs being misused in order to implement appropriate interventions.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Pilar Carrasco-Garrido, Carmen Gallardo-Pino, Isabel Jimenez-Trujillo, Valentin Hernandez-Barrera, Soledad Garcia-Gomez-Heras, Lidiane Lima Florencio, Domingo Palacios-Cena
Summary: Prescription opioid use and misuse are prevalent among young adults in Spain, with higher rates observed among women. Factors associated with higher probability of prescription opioid use and misuse include misuse of tranquilizers, sedatives, and sleeping pills, as well as the use of cannabis and other illicit psychoactive drugs.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Pamela C. Griesler, Mei-Chen Hu, Melanie M. Wall, Denise B. Kandel
Summary: This study shows that parental medical prescription opioid use is associated with adolescent use and misuse, while parental misuse is not. Parental marijuana use, parent-adolescent conflict, adolescent depression, delinquency, and perception of schoolmates' drug use are also associated with adolescent prescription opioid misuse.
Article
Medicine, Research & Experimental
Niranjan S. Karnik, Cynthia I. Campbell, Megan E. Curtis, David A. Fiellin, Udi Ghitza, Kathryn Hefner, Yih-Ing Hser, R. Kathryn McHugh, Sean M. Murphy, Sterling M. McPherson, Landhing Moran, Larissa J. Mooney, Li-Tzy Wu, Dikla Shmueli-Blumberg, Matisyahu Shulman, Robert P. Schwartz, Kari A. Stephens, Katherine E. Watkins, John Marsden
Summary: This study seeks to develop a Core Outcome Set (COS) for interventions, treatment studies, and service delivery related to opioid use disorder (OUD) through a modified, stepwise e-Delphi methodology overseen by an expert workgroup. The results will be disseminated through peer-reviewed scientific journals and conferences to support evidence synthesis and clinical guidelines.
Article
Health Care Sciences & Services
Georgiy Bobashev, Lauren Warren, Li-Tzy Wu
Summary: This study utilized a novel predictive approach to examine factors predicting multiple visits to emergency departments within a year. The findings highlighted that factors such as poor self-rated health, anxiety or restlessness, low income, and asthma were the most influential predictors of multiple emergency department visits within a year.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Substance Abuse
William S. John, He Zhu, Lawrence H. Greenblatt, Li-Tzy Wu
Summary: This study examined the extent and correlates of problematic substance use by substance-specific risk categories among primary care patients. The results showed a prevalent intervention need for problematic substance use in the sample, with certain demographics such as male sex, white race, being unmarried, and having lower education level being associated with increased odds of moderate/high-risk substance use.
Article
Substance Abuse
Li-Tzy Wu, William S. John, Eric D. Morse, Steve Adkins, Jennifer Pippin, Robert K. Brooner, Robert P. Schwartz
Summary: The study examined the feasibility and acceptability of pharmacy administration and dispensing of methadone for methadone maintenance treatment. The results showed that this model is feasible and satisfactory to patients.
Article
Public, Environmental & Occupational Health
Andrew M. Subica, Erick G. Guerrero, Phong Hong, Nia Aitaoto, Howard B. Moss, Derek K. Iwamoto, Li-Tzy Wu
Summary: This study identified major risk factors for hazardous drinking and AUDs among PI young adults, including significant life stressors, peer/social pressure to drink, permissive drinking norms, and frequent access to alcohol.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2022)
Article
Substance Abuse
Niranjan S. Karnik, John Marsden, Connor McCluskey, Randy A. Boley, Katharine A. Bradley, Cynthia Campbell, Megan E. Curtis, David Fiellin, Udi Ghitza, Kathryn Hefner, Yih-Ing Hser, R. Kathryn McHugh, Sterling M. McPherson, Larissa J. Mooney, Landhing M. Moran, Sean M. Murphy, Robert P. Schwartz, Dikla Shmueli-Blumberg, Matisyahu Shulman, Kari A. Stephens, Katherine E. Watkins, Roger D. Weiss, Li-Tzy Wu
Summary: The aim of this study was to develop a core outcomes set for evaluating treatments for opioid use disorder. After an expert consensus study and discussion, five core outcomes were determined. This helps improve consistency and comparability in research.
Article
Environmental Sciences
Yi-Ping Hsieh, Yun-Ju Wang, Ling-Yi Feng, Li-Tzy Wu, Jih-Heng Li
Summary: The restrictive policy on mifepristone regulation in Taiwan may violate women's rights and hinder the acceptability and accessibility of safe mifepristone use.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Substance Abuse
Andrew M. Subica, Erick G. Guerrero, Tammy K. K. Martin, Scott K. Okamoto, Nia Aitaoto, Howard B. Moss, Brittany N. Morey, Li-Tzy Wu
Summary: Research findings indicated that during COVID-19, Native Hawaiians/Pacific Islanders (NH/PI) adults reported heavy alcohol, tobacco, and other drug (ATOD) use, as well as high levels of depression, anxiety, and treatment need. Targeted research and treatment services are needed to mitigate the negative behavioral health impact of COVID-19 on NH/PI communities.
DRUG AND ALCOHOL REVIEW
(2022)
Article
Public, Environmental & Occupational Health
Andrew M. Subica, Nia Aitaoto, Quixi Li, Brittany N. Morey, Li-Tzy Wu, Derek K. Iwamoto, Erick G. Guerrero, Howard B. Moss
Summary: The study explored the impact of COVID-19 on Native Hawaiian/Pacific Islander communities, revealing poor health conditions, high infection rates, and heightened anxiety and distress related to the disease. Additionally, the study found that age, disease distress, and past vaccine experiences were associated with higher rates of COVID-19 vaccine uptake.
PUBLIC HEALTH REPORTS
(2023)
Article
Health Care Sciences & Services
Asher J. Schranz, Casey Tak, Li-Tzy Wu, Vivian H. Chu, David A. Wohl, David L. Rosen
Summary: This study aimed to assess readmissions following O-IE and quantify the impact of DAMA on outcomes. Results showed a high occurrence of DAMA in O-IE patients, which was strongly associated with short-term readmission.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Shabbar Ranapurwala, Ishrat Z. Alam, Brian W. Pence, Timothy S. Carey, Sean Christensen, Marshall Clark, Paul R. Chelminski, Li-Tzy Wu, Lawrence H. Greenblatt, Jeffrey E. Korte, Mark Wolfson, Heather E. Douglas, Lynn A. Bowlby, Michael Capata, Stephen W. Marshall
Summary: In the U.S., over 200 lives are lost from opioid overdoses each day. Accurate and prompt diagnosis of opioid use disorders (OUD) is important for preventing overdose deaths. The international classification of disease (ICD) codes for OUD are not accurate and their specificity and sensitivity are unknown. Researchers developed algorithms to identify OUD in electronic health records and tested the validity of OUD ICD codes.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Substance Abuse
Amanda M. Bunting, Robert P. Schwartz, Li-Tzy Wu, Aimee Wahle, Margaret Kline, Geetha Subramaniam, Jennifer McNeely
Summary: This study evaluated the performance of the TAPS tool for screening unhealthy opioid use in primary care. The results showed that the TAPS tool accurately identified past-month use, problem use, opioid use disorder, and moderate-severe opioid use disorder. However, self-disclosure remained an issue in primary care settings.
JOURNAL OF ADDICTION MEDICINE
(2023)
Article
Substance Abuse
Li-Tzy Wu, William S. John, Paolo Mannelli, Eric D. Morse, Alyssa Anderson, Robert P. Schwartz
Summary: PADMOUD is underutilized in the US, and this study examines OUD patients' perspectives on it. The findings suggest that patients find it convenient to receive methadone treatment at pharmacies, and PADMOUD is seen as a good option for stable patients and those with transportation barriers. These insights can inform the implementation strategies of PADMOUD.
ADDICTION SCIENCE & CLINICAL PRACTICE
(2023)
Article
Substance Abuse
Li-Tzy Wu, Paolo Mannelli, William S. John, Alyssa Anderson, Robert P. Schwartz
Summary: This study explores the perspectives of staff from a pharmacy and an opioid treatment program (OTP) on the implementation of pharmacy administration and dispensing of methadone for opioid use disorder (PADMOUD) in the US. The results show that staff were supportive of PADMOUD and identified several benefits, including increased access for patients, additional service opportunities and revenues for pharmacies and OTPs, and reduced costs for patients. The findings of this study can guide the development of strategies to implement PADMOUD and address the US opioid crisis.
SUBSTANCE ABUSE TREATMENT PREVENTION AND POLICY
(2023)
Article
Substance Abuse
Jane M. Liebschutz, Geetha A. Subramaniam, Rebecca Stone, Noa Appleton, Lillian Gelberg, Travis I. Lovejoy, Amanda M. Bunting, Charles M. Cleland, Karen E. Lasser, Donna Beers, Catherine Abrams, Jennifer Mccormack, Gail E. Potter, Ashley Case, Leslie Revoredo, Eve M. Jelstrom, Margaret M. Kline, Li-Tzy Wu, Jennifer Mcneely
Summary: The STOP trial aims to study the efficacy of a collaborative care intervention to reduce risky opioid use and prevent progression to moderate or severe OUD in adult primary care patients.
ADDICTION SCIENCE & CLINICAL PRACTICE
(2023)
