☆ 4.8 Editorial Material

Oxidative stress and intracellular infections: more iron to the fire

JOURNAL OF CLINICAL INVESTIGATION (2012)

Journal

JOURNAL OF CLINICAL INVESTIGATION

Volume 122, Issue 7, Pages 2352-2354

Publisher

AMER SOC CLINICAL INVESTIGATION INC

DOI: 10.1172/JCI64239

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Categories

Medicine, Research & Experimental

Funding

NIAID NIH HHS [R01AI067979, R37 AI034867, R01 AI067979, R37AI34867] Funding Source: Medline
NIGMS NIH HHS [R01GM064625, R01 GM064625] Funding Source: Medline

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Abstract

The immune system's battle against pathogens includes the respiratory burst, a rapid release of ROS from leukocytes, thought to play a role in destroying the invading species. In this issue of the JCI, Paiva et al. demonstrate that oxidative stress actually enhances infection with the protozoan Trypanosoma cruzi, by a mechanism that may involve facilitating parasite access to iron. Their findings suggest a novel direction for the development of drugs against intracellular parasites.

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