Leukocyte Adhesion Deficiency III - When Integrins Activation Fails

Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding

(2014) Matthias Canault et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17-Driven Inflammatory Bone Loss

(2014) N. M. Moutsopoulos et al.   Science Translational Medicine

The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis

(2013) S. J. Cohen et al.   BLOOD

The  2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo

(2013) V. L. Morrison et al.   BLOOD

Leukocyte adhesion deficiencies

(2012) Suhair Hanna et al.   Annals of the New York Academy of Sciences

Loss of kindlin-3 alters the threshold for NK cell activation in human leukocyte adhesion deficiency-III

(2012) R. Gruda et al.   BLOOD

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

(2012) C. T. Lefort et al.   BLOOD

Leukocyte Adhesion Deficiencies

(2012) Edith van de Vijver et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Novel aspects of Kindlin-3 function in humans based on a new case of leukocyte adhesion deficiency III

(2012) J. MELLER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The molecular basis of leukocyte recruitment and its deficiencies

(2012) Sarah Schmidt et al.   MOLECULAR IMMUNOLOGY

Leukocyte adhesion deficiency-I variant syndrome (LAD-Iv, LAD-III): Molecular characterization of the defect in an index family

(2011) Estelle S. Harris et al.   AMERICAN JOURNAL OF HEMATOLOGY

Defects in Glanzmann thrombasthenia and LAD-III (LAD-1/v) syndrome: the role of integrin  1 and  3 in platelet adhesion to collagen

(2011) E. van de Vijver et al.   BLOOD

Hematologically important mutations: Leukocyte adhesion deficiency (first update)

(2011) Edith van de Vijver et al.   BLOOD CELLS MOLECULES AND DISEASES

Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption

(2011) Sarah Schmidt et al.   JOURNAL OF CELL BIOLOGY

A Novel Leukocyte Adhesion Deficiency III Variant: Kindlin-3 Deficiency Results in Integrin- and Nonintegrin-Related Defects in Different Steps of Leukocyte Adhesion

(2011) P. Robert et al.   JOURNAL OF IMMUNOLOGY

Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro

(2010) A. McDowall et al.   BLOOD

Novel integrin-dependent platelet malfunction in siblings with leukocyte adhesion deficiency-III (LAD-III) caused by a point mutation in FERMT3

(2010) Kerstin Jurk et al.   THROMBOSIS AND HAEMOSTASIS

Prompt recovery of recipient hematopoiesis after two consecutive haploidentical peripheral blood SCTs in a child with leukocyte adhesion defect III syndrome

(2009) R Elhasid et al.   BONE MARROW TRANSPLANTATION

Genetic etiologies of leukocyte adhesion defects

(2009) Amos Etzioni   CURRENT OPINION IN IMMUNOLOGY

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

The Kindlin protein family: new members to the club of focal adhesion proteins

(2009) Alexander Meves et al.   TRENDS IN CELL BIOLOGY

LAD-1/variant syndrome is caused by mutations inFERMT3

(2008) Taco W. Kuijpers et al.   BLOOD

Kindlin-3: a new gene involved in the pathogenesis of LAD-III

(2008) A. Mory et al.   BLOOD

The Clinical Spectrum of Leukocyte Adhesion Deficiency (LAD) III due to Defective CalDAG-GEF1

(2008) Sara S. Kilic et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE