Article
Neurosciences
Qinjun Zhang, Rui Shi, Minghua Hao, Dongyun Feng, Rui Wu, Ming Shi
Summary: In response to cortical stab injury, the expression of N-myc downstream-regulated gene 2 (NDRG2) is significantly elevated in the cerebral cortex of adult rats. NDRG2-expressing cells are co-labeled with Nestin, a neural stem cell marker, and some of these cells also express the cell proliferation marker Ki67. Overexpression or knockdown of NDRG2 regulates the expression of Notch intracellular domain NICD and Notch target gene Hes1. These findings suggest that NDRG2 plays a role in controlling the formation of reactive astrocytes-derived progenitor cells (Rad-PCs) in the adult rat cerebral cortex following traumatic injury, and the Notch signaling pathway is involved in this process.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Cyrus Ayubcha, Mona-Elisabeth Revheim, Andrew Newberg, Mateen Moghbel, Chaitanya Rojulpote, Thomas J. Werner, Abass Alavi
Summary: PET has been widely used in the study of traumatic brain injury (TBI) for decades, with recent focus on imaging biomarkers related to TBI and chronic traumatic encephalopathy (CTE). This review critically assesses the use of glycolysis, beta-amyloid, and tau protein radiotracers in the context of TBI, weighing their strengths and weaknesses. Despite the ongoing debate, PET remains a powerful modality in diagnosing TBI-related conditions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Biotechnology & Applied Microbiology
Jared A. Rifkin, Taotao Wu, Adam C. Rayfield, Erin D. Anderson, Matthew B. Panzer, David F. Meaney
Summary: Research on data from the Human Connectome Project (HCP) reveals similar brain architecture groups in both men and women, with some architectures being more vulnerable to traumatic brain injuries (TBI).
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chiara Mele, Valeria Pingue, Marina Caputo, Marco Zavattaro, Loredana Pagano, Flavia Prodam, Antonio Nardone, Gianluca Aimaretti, Paolo Marzullo
Summary: The incidence of traumatic brain injury (TBI) has been increasing, impacting public health. Research indicates that post-TBI neuroinflammation may lead to long-term clinical consequences, such as hypopituitarism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
William P. Flavin, Helia Hosseini, Jeffrey W. Ruberti, H. Pirouz Kavehpour, Christopher C. Giza, Mayumi L. Prins
Summary: This review summarizes the structure and functions of Tau protein, highlighting its associations with various diseases and conditions including diabetes, stroke, Alzheimer's disease, brain injury, aging, and drug use. It explores the role of Tau phosphorylation in disease progression and discusses the potential for therapeutic interventions to prevent or reverse tau-mediated neurodegeneration.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Michael C. Scott, Karthik S. Prabhakara, Andrew J. Walters, Scott D. Olson, Charles S. Cox
Summary: In a rodent model of traumatic brain injury, sex-based differences in pathology and neuroinflammation are limited, and only noted in one specific analysis of BBB permeability.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Sarah E. Svirsky, Youming Li, Jeremy Henchir, Anna Rodina, Shaun W. Carlson, Gabriela Chiosis, C. Edward Dixon
Summary: This study investigates the formation of the epichaperome in traumatic brain injury (TBI) and suggests that this mechanism may contribute to protein misfolding, degradation, aggregation, and transport. Further understanding of this pathological mechanism can provide insights into the connection between TBI and increased risk of neurodegenerative diseases, as well as potential therapeutic targets.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Neurosciences
Hazem S. Ghaith, Asmaa Ahmed Nawar, Mohamed Diaa Gabra, Mohamed Essam Abdelrahman, Mohamed H. Nafady, Eshak Bahbah, Mahmoud Ahmed Ebada, Ghulam Md Ashraf, Ahmed Negida, George E. Barreto
Summary: Research into TBI biomarkers has accelerated in the past decade, but there is still a need to develop novel biomarkers entirely correlating with TBI pathologies; extracellular vesicles and miRNA are considered as promising candidates to overcome the limitations of traditional blood and CSF assays.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rafael Carecho, Diogo Carregosa, Bernardo Oliveira Ratilal, Ines Figueira, Maria Angeles Avila-Galvez, Claudia Nunes dos Santos, Natasa Loncarevic-Vasiljkovic
Summary: Traumatic brain injury (TBI) is a major cause of death and disability in young adults worldwide. The underlying mechanisms of TBI are still not fully understood, despite advances in our knowledge. Secondary brain injury processes occur gradually following the initial acute damage, providing a therapeutic window for interventions. Nutritional interventions, particularly (poly)phenols found in fruits and vegetables, have shown promise in enhancing the repair processes after TBI. However, more research is needed to fully understand the effects and limitations of (poly)phenols in TBI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Reproductive Biology
Vahid Ganjiani, Nasrollah Ahmadi, Mohammad Reza Divar, Hassan Sharifiyazdi, Abdolhamid Meimandi-Parizi
Summary: The study revealed that I/R injury significantly affects sperm parameters, but crocin treatment did not significantly improve them. Crocin significantly improved histopathological parameters and hormone levels, reversing oxidative stress injuries caused by torsion/detorsion.
Article
Clinical Neurology
Andrea Klang, Yasmina Molero, Paul Lichtenstein, Henrik Larsson, Brian Matthew D'Onofrio, Niklas Marklund, Christian Oldenburg, Elham Rostami
Summary: The study found that there is insufficient and unequal access to rehabilitation for traumatic brain injury (TBI) patients. It highlights the importance of organizing and standardizing post-TBI rehabilitation to meet the needs of all patients, regardless of their age, socioeconomic status, or living area.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Immunology
Pengju Wei, Ke Wang, Chen Luo, Yichen Huang, Dilidaer Misilimu, Huimei Wen, Peng Jin, Chuhua Li, Ye Gong, Yanqin Gao
Summary: The study demonstrates that cordycepin can protect neurological function by suppressing neutrophil infiltration, preserving blood-brain barrier integrity, and altering microglia/macrophage polarization after traumatic brain injury.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Chemistry, Medicinal
Julio J. Secades
Summary: Citicoline, a neuroprotective drug, has the potential to accelerate recovery of consciousness and improve the outcomes of patients with TBI. It could play a role in the management of TBI with its excellent safety profile.
Article
Critical Care Medicine
Rohan Mathur, Jose I. Suarez
Summary: Traumatic Brain Injury (TBI) is associated with altered hemostasis and coagulopathy. Isolated Traumatic Brain Injury (iTBI) is also associated with systemic coagulopathy and derangements in hemostasis.
NEUROCRITICAL CARE
(2023)
Article
Neurosciences
Leilei Mao, Limin Sun, Jingyi Sun, Baoliang Sun, Yanqin Gao, Hong Shi
Summary: The study demonstrates that EP treatment can improve sensorimotor function following TBI, reduce white matter injury, and modulate microglia polarization toward the anti-inflammatory M2 phenotype during the acute phase of TBI recovery, improving the release of inflammatory-related factors.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)