Article
Plant Sciences
Yajie Cai, Xiaojiaoyang Li, Qi Han, Jinzhao Bai, Qi Zheng, Rong Sun, Runping Liu
Summary: This study aimed to investigate the effect of Si-Ni-San (SNS) on acute murine colitis and the underlying mechanisms involving gut microbiota. The results demonstrated that SNS significantly inhibited acute inflammatory responses induced by DSS through improving gut microbiota dysbiosis, and specifically favoring the growth of beneficial bacteria Akkermansia genus, thus providing a potential therapeutic strategy against colitis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Rui Guo, Qisheng Zhong, Jiaqi Liu, Peiming Bai, Zongpeng Wang, Jieling Kou, Peijie Chen, Jie Zhang, Bo Zhang
Summary: In this study, a method called 2D-LC/TQMS was developed for simultaneous analysis of hydrophilic and hydrophobic metabolites using the combination of HILIC and RPLC. The method can detect 417 metabolites involved in various metabolic pathways with good reproducibility, linearity, and wide linear range. It was tested using different biological samples and applied to a bladder cancer case/control study, identifying 30 differential metabolites related to carbohydrate and amino acid metabolism.
ANALYTICA CHIMICA ACTA
(2023)
Article
Plant Sciences
Yajie Cai, Bing Xu, Fei Zhou, Jianzhi Wu, Shuo Li, Qi Zheng, Yajing Li, Xiaojiaoyang Li, Feng Gao, Shifen Dong, Runping Liu
Summary: UC is a chronic inflammatory disease with a high risk of colon cancers and disability, where disrupted immune homeostasis plays a major role. Current therapies based on immunoregulation have unsatisfactory remission rates. SNS, a traditional Chinese medicine, has been effective in relieving UC symptoms, with mechanisms involving the inhibition of inflammatory response genes and suppression of type I interferon responses through STING and RIG-I pathways. The study suggests the potential of SNS or its bioactive compounds as novel therapeutic strategies for UC treatment by interfering with type I interferon-mediated inflammation.
Article
Medicine, Research & Experimental
Yuanyuan Liu, Baojiang Lv, Kanran Tang, Haotian Qu, Fangjun Yu, Yafei Shi
Summary: This study found that depressed mice have a defect in fat absorption, leading to weight loss and reduced circulating lipid levels. Si-Ni-San (SNS), a traditional Chinese medicine formula, not only alleviates depression-like behaviors but also reverses the weight loss and dietary fat absorption in depressed mice. SNS improves body weight and lipid levels by up-regulating proteins in the fat absorption pathway. Mechanistic studies reveal the involvement of the NR1D1/BMAL1/DGAT2 axis. These findings enhance our understanding of the relationship between depression and energy loss and highlight the potential of SNS in treating depression and related disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Physics, Condensed Matter
Gourab Bhattacharya, N. Vijay Prakash Chaudhary, Tapasendra Adhikary, Shampa Aich, A. Venimadhav
Summary: This study investigated electron transport across Galfenol and Nickel-based Schottky contacts on n-Si substrates through DC current-voltage measurements and AC Impedance spectroscopy. Improper back contact can cause additional bias dependent Resistance-capacitance components, which were studied using proper equivalent circuit models. The results showed distinct behavior in capacitance and barrier height, with negative capacitance observed in certain conditions. The use of an equivalent circuit with inductor-resistor relaxation provided a better fit for the experimental results.
SUPERLATTICES AND MICROSTRUCTURES
(2021)
Article
Plant Sciences
Jianchao Li, Kaiyi Wu, Ying Zhong, Jiangying Kuang, Nana Huang, Xin Guo, Hang Du, Chong Guo, Rongrong Li, Xiaomin Zhu, Tianyu Zhang, Liping Gong, Lisong Sheng, Rong Sun
Summary: Si-Ni-San (SNS), a famous Chinese herbal formula, has therapeutic effects on obesity by improving lipid accumulation through the AMPK signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Siliang Wang, Cheng Tang, Heng Zhao, Peiliang Shen, Chao Lin, Yun Zhu, Dan Han
Summary: SNS effectively impedes liver fibrosis progression by alleviating inflammation, ECM accumulation, aberrant angiogenesis, and apoptosis of hepatic parenchymal cells, along with inhibiting activation of hepatic stellate cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hui-Yu Chen, Jian Liu, Ding-Zhou Weng, Li Yan, Chun-Shui Pan, Kai Sun, Xiao Guo, Di Wang, Gulinigaer Anwaier, Ying-Qian Jiao, Zhi-Xin Li, Jing-Yan Han
Summary: The study demonstrated that SNS could improve stress-induced diarrhea in rats by inhibiting the abnormal expression of D beta H and c-fos in the locus coeruleus, NE content in the ileum and plasma, and the contraction of isolated mesenteric arteries induced by chronic restraint stress; inhibiting abnormal energy metabolism and decreased occludin expression; inhibiting the increase of ECs and MCs in the ileum, and the increase of 5-HT content in the ileum and plasma.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Kangning Zheng, Wenhan Zhou, Jingmin Ji, Yu Xue, Yiwei Liu, Caige Li, Zhiqin Zhang, Junlan Lu, Xinli Shi, Yongmin Li
Summary: The study on the mechanism of Si-Ni-San in reducing lipid droplet deposition in metabolic dysfunction-associated fatty liver disease (MAFLD) found that Si-Ni-San can reduce lipid droplet accumulation in liver cells and exert its effects by reducing the expression of YAP1.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.
Article
Chemistry, Medicinal
Ning Zhang, Tong Liu, Jianan Wang, Yingying Xiao, Ying Zhang, Jun Dai, Zhihong Ma, Donglai Ma
Summary: The study revealed that SNS could reduce hepatic lipid deposition by inhibiting lipid synthesis and promoting fatty acid oxidation, potentially through activating the AMPK/SIRT1 signaling pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Medicine, General & Internal
Dandan Zhang, Liu Hong, Rui Su Zhang, Qian Zhang, Jing Yao, Jiadi Wang, Ning Zhang
Summary: This study explored the potential mechanisms of Si-Ni-San (SNS) in the treatment of uveitis using network pharmacology and bioinformatics. The results suggest that JUN, RELA, and MAPK may play important roles in the treatment of uveitis by SNS, and the mechanism may be related to anti-inflammatory and immune regulation.
Article
Chemistry, Physical
A. Ashery, Mohamed M. M. Elnasharty, I. M. El Radaf
Summary: Ni/SiO2/p-Si MIS diode was successfully developed by liquid phase epitaxy process. The structural and surface morphology were investigated, and the electrical properties were evaluated in relation to different dielectric parameters and bias dc voltage.
Article
Chemistry, Analytical
Tian Tian, Xin Xu, Xian Li, Wenhua Zhang, Haitao Lu
Summary: The study focused on the precise identification of chemicals in a traditional Chinese medicine formula, Si-Ni-San, using mass spectrometry techniques. A total of 37 compounds were accurately identified for the first time, and a quantitative profiling method for these compounds was developed.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Energy & Fuels
Stefan Lange, Bastian Fett, Ozde S. Kabakli, Angelika Hahnel, David Adner, Thomas Kroyer, Shankar Bogati, Patricia S. C. Schulze, Bettina Herbig, Christian Hagendorf, Gerhard Sextl, Karl Mandel
Summary: In this study, we investigated the NiOx/p(+) poly-Si interface and found that the contact resistivity can be greatly reduced by intentionally inserting a nanometer-thin metallic Ni interlayer. This finding has important implications for improving the efficiency of tandem solar cells.
SOLAR ENERGY MATERIALS AND SOLAR CELLS
(2023)