Article
Biochemistry & Molecular Biology
Wojciech Fabianowski, Miroslaw Maziejuk, Monika Szyposzynska, Monika Wisnik-Sawka
Summary: The article presents a technique of differential ion mobility spectrometry (DMS) for the detection and identification of volatile organic compounds (VOCs) from various categories. It analyzes the possibility of mixture identification using only the DMS spectrometer and provides several examples. The article also discusses the analysis of different compounds, their mechanisms of fragmentation, influence on effective ion temperature, and high electric field intensity.
Article
Multidisciplinary Sciences
Dominique Grandjean, Caroline Elie, Capucine Gallet, Clotilde Julien, Vinciane Roger, Loic Desquilbet, Guillaume Alvergnat, Severine Delarue, Audrey Gabassi, Marine Minier, Laure Choupeaux, Solen Kerneis, Constance Delaugerre, Jerome Le Goff, Jean-Marc Treluyer
Summary: The study evaluates the diagnostic accuracy of canine olfaction in non-invasive detection of SARS-CoV-2 infection. The results show that canine detection has a high sensitivity and can be used as an alternative method in mass screening.
Article
Chemistry, Analytical
Chun-Pei Shih, Kai-Chiang Yu, Hsuan-Ting Ou, Pawel L. Urban
Summary: A portable cloud-integrated pen-probe analyzer based on Ion Mobility Spectrometry (IMS) was developed for rapid in situ chemical analysis of volatile organic compounds (VOCs), allowing for automatic analysis by approaching the penprobe to a surface. The device demonstrated high sensitivity and specificity, and the data were stored in the Internet cloud for further retrieval and processing, showcasing potential for real-time environmental monitoring and analysis.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Chi-Hsiang Chen, Kai-Chiang Yu, Decibel P. Elpa, Pawel L. Urban, Gurpur Rakesh D. Prabhu
Summary: Fizzy extraction (FE) technique uses effervescence phenomenon to extract volatile organic compounds (VOCs) from liquid matrices, and combines with a commercial ion-mobility spectrometry (IMS) module to develop a portable analytical platform for in-situ VOCs analysis. The platform, similar in size to an airline catering trolley, is equipped with electronic and electromechanical components for operation, data acquisition, processing, and cloud storage. Characterization with standards and analysis of real samples demonstrate the platform's effectiveness and reliability.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
V. Ruzsanyi, H. Wiesenhofer, C. Ager, J. Herbig, G. Aumayr, M. Fischer, M. Renzler, T. Ussmueller, K. Lindner, C. A. Mayhew
Summary: Human smuggling is a significant part of transnational organized crime, posing a growing threat to national and international security. Detecting and intercepting hidden humans in containers or trucks at transportation hubs is crucial. A portable device combining ion mobility spectrometry and sensor array system can quickly detect volatile organic compounds emitted by humans, with a classification algorithm providing a simple YES or NO decision. Field measurements show that it takes 20 to 30 minutes for emitted trace compounds to reach detectable concentrations.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Medicine, General & Internal
Michelle Bous, Erol Tutdibi, Nasenien Nourkami-Tutdibi, Elisabeth Kaiser, Regine Stutz, Sascha Meyer, Jorg Ingo Baumbach, Michael Zemlin, Sybelle Goedicke-Fritz
Summary: This study successfully analyzed the volatile organic compound (VOC) profiles in diapers of premature infants using ion mobility spectrometry coupled with multi-capillary columns. Further research is needed to identify specific VOC profiles in infections and other diseases of premature infants in order to establish quick and noninvasive diagnostics.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Chemistry, Multidisciplinary
Elina Gashimova, Azamat Temerdashev, Vladimir Porkhanov, Igor Polyakov, Dmitry Perunov, Ekaterina Dmitrieva
Summary: Development of simple, fast, and non-invasive tests for lung cancer diagnostics is crucial in clinical practice. This paper explores the use of exhaled breath and skin as potential objects for diagnosing lung cancer, and develops diagnostic models using machine learning algorithms. The results show that artificial neural networks perform well in classifying lung cancer patients and healthy individuals. Additionally, the study identifies significant differences in parameters in exhaled breath samples of lung cancer patients and evaluates the potential of skin analysis for lung cancer diagnosis.
Article
Chemistry, Applied
Siyang Deng, Yunhe Liu, Feng Huang, Jiqian Liu, Dong Han, Chunhui Zhang, Christophe Blecker
Summary: The study showed that white pig and black pig bacon have different volatile components during refrigerated storage, with white pig bacon having higher phenols and acids while black pig bacon containing more alcohols, ketones, and nitrogen-containing compounds. White pig bacon was more affected by storage compared to black pig bacon, and the difference in raw materials between the two types of bacon was found to be the main reason for their flavor variations.
Article
Multidisciplinary Sciences
Jianxiong Zhu, Zhongda Sun, Jikai Xu, Rafal D. Walczak, Jan A. Dziuban, Chengkuo Lee
Summary: The study presents a machine learning-enhanced ion mobility analyzer with a triboelectric-based ionizer, which provides effective identification and measurement of VOCs with specific design. The device is compact, easy to operate, and features real-time response and low power consumption, suitable for future IoT environmental monitoring applications.
Review
Biotechnology & Applied Microbiology
Nils Kunze-Szikszay, Maximilian Euler, Thorsten Perl
Summary: Traditional microbiological methods for diagnosing bacterial infections have led to long turnaround times, but detecting VOCs emitted by bacteria presents a potential innovative approach for rapid diagnosis. Spectrometric methods allow for the detection and quantification of bacterial VOCs with high sensitivity.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Analytical
Yongqiang Cheng, Maoke Liu, Bin Zhao, Li Yang, Cuilian Guo, Linbo Zhang
Summary: The sandwich temperature control membrane inlet mass spectrometer (STC-MIMS) presented in this study demonstrates improved analytical performance for the measurement of dissolved gases and VOCs in aqueous solution. The system allows for temperature compensation, increased sensitivity, reduced response time, and effective removal of memory effect. This new method has the potential for online analysis of organic pollution in aquatic environments.
Review
Biochemical Research Methods
Kenta Iitani, Sai Sathish Ramamurthy, Xudong Ge, Govind Rao
Summary: Improving life expectancy requires active self-monitoring and biochemical analysis for prevention and early diagnosis of diseases, emphasizing the need for non-invasive measurement of molecular biomarkers reflecting metabolism and health. Transdermal sampling via the skin is a suitable method for in-situ biochemical monitoring, offering potential for greater understanding of important biochemical markers.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Kathleen Van Malderen, Nikita Hanning, Helen Lambrechts, Tine Haverhals, Silke Van Marcke, Hannah Ceuleers, Joris G. De Man, Benedicte Y. De Winter, Kevin Lamote, Heiko U. De Schepper
Summary: This study evaluates the potential of volatile organic compounds (VOCs) as diagnostic and phenotypic biomarkers for irritable bowel syndrome (IBS). The results show that VOC analysis in breath and fecal samples can differentiate IBS patients from healthy controls and differentiate different subtypes of IBS patients. Furthermore, VOC models can differentiate IBS patients based on clinical characteristics.
FRONTIERS IN MEDICINE
(2022)
Article
Food Science & Technology
Mickael Le Bechec, Marine Reyrolle, Valerie Chesneau, Marine Breuil, Valerie Desauziers
Summary: This study used selected ion flow tube-mass spectrometry (SIFT-MS) analysis to explore caviar products. The results showed that the volatile profile and sensory perception of caviar are influenced by factors such as sturgeon species, production sites, water quality, production seasonality, and storage time. This study demonstrated the potential of SIFT-MS as a strategic decision-making support tool for sturgeon producers.
Article
Food Science & Technology
Ruixiao Wu, Chunjie Yang, Linjie Xi, Tian Wang, Ju Zhang, Liping Kou, Wu Ding
Summary: This study investigated the impact of high pressure and temperature (HTHP) and electron-beam irradiations on the volatile compounds and sensory characteristics of cooked bacon. The results showed that higher irradiation doses significantly reduced the variety of volatile compounds and sensory features, but increased the concentration of certain compounds. Treatments with doses below 5 kGy did not affect the volatile compounds and sensory properties. High-temperature-high-pressure conditions had a significant impact on the concentrations of volatile compounds and sensory traits. Electronic nose was effective in detecting flavor differences among different sterilization methods. Fingerprinting analysis revealed significant differences between the HTHP and 9 kGy-treated groups and other treatments. The study suggested that 5 kGy might be the optimal dose for maintaining the original flavor and sensory properties of cooked bacon.
Letter
Respiratory System
Ramon Farre, Antonio Artigas, Antoni Torres, Guillermo M. Albaiceta, Anh Tuan Dinh-Xuang, David Gozal
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Respiratory System
Carolina Cubillos-Zapata, Miguel Angel Martinez-Garcia, Elena Diaz-Garcia, Sara Garcia-Tovar, Francisco Campos-Rodriguez, Manuel Sanchez-de-la-Torre, Eduardo Nagore, Antonio Martorell-Calatayud, Luis Hernandez Blasco, Esther Pastor, Jorge Abad-Capa, Josep Maria Montserrat, Valentin Cabriada-Nuno, Irene Cano-Pumarega, Jaime Corral-Penafiel, Eva Arias, Olga Mediano, Maria Somoza-Gonzalez, Joan Dalmau-Arias, Isaac Almendros, Ramon Farre, David Gozal, Francisco Garcia-Rio
Summary: In patients with obstructive sleep apnoea (OSA), high levels of paraspeckle component (PSPC)1 are associated with increased tumor aggressiveness in cutaneous melanoma. Intermittent hypoxia and soluble PSPC1 play a role in promoting epithelial-mesenchymal transition (EMT) and acquisition of cancer stem cell (CSC)-like features in melanoma cells. These findings suggest a potential link between OSA severity, PSPC1 levels, and melanoma aggressiveness.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Letter
Respiratory System
Ramon Farre
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Esther Marhuenda, Alvaro Villarino, Maria Narciso, Linda Elowsson, Isaac Almendros, Gunilla Westergren-Thorsson, Ramon Farre, Nuria Gavara, Jorge Otero
Summary: The study presents a novel physiomimetic in vitro model for Acute Respiratory Distress Syndrome using lung extracellular matrix-derived hydrogels and organ-on-a-chip devices. Results show that the developed model provides a more accurate simulation of the inflammatory response compared to traditional models, with the potential for further in vitro studies to test different drugs or cell therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Ramon Farre, Miguel A. Rodriguez-Lazaro, Julian Gonzalez-Martin, Pedro Castro, Teresa Hospital, Yaroslau Compta, Gorka Solana, David Gozal, Jorge Otero
Summary: This study designed and tested a cheap and easy-to-build negative pressure device for wound healing. By providing a detailed open-source description, it enables free replication and use, thereby facilitating the wider application of this therapy in low- and middle-income countries.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Respiratory System
David J. Durgan, Ramon Farre
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Constanca Junior, Anna Ulldemolins, Maria Narciso, Isaac Almendros, Ramon Farre, Daniel Navajas, Javier Lopez, Mar Eroles, Felix Rico, Nuria Gavara
Summary: The extracellular matrix (ECM) of the lung, composed mainly of collagens, elastin, and proteoglycans, provides support to lung cells. Aberrant increased deposition of ECM in lung fibrosis changes filament organization and stiffens the ECM, leading to the profibrotic profile of pulmonary cells. The study examines changes in ECM properties during fibrosis development and identifies potential pharmacological targets to hinder its progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Alicia Jurado, Anna Ulldemolins, Helena Lluis, Xavier Gasull, Nuria Gavara, Raimon Sunyer, Jorge Otero, David Gozal, Isaac Almendros, Ramon Farre
Summary: Researchers have developed an experimental approach to expose cells to high-frequency intermittent hypoxia in a 3D environment, simulating the effects of obstructive sleep apnea. This method allows for the study of cells of interest while preserving the tissue environment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Engineering, Multidisciplinary
Abdelwahhab Bouras, Agustin Gutierrez-Galvez, Javier Burgues, Yasser Bouzid, Antonio Pardo, Mohamed Guiatni, Santiago Marco
Summary: In this paper, a mobile gas monitoring system based on Nano-drones is presented, which can map indoors gas distributions and locate the gas source. The system combines a small-sized, lightweight, and low-consumption gas sensing unit with a commercial Nano-drone. The gas sensing unit is equipped with a metal oxide gas sensor for detecting Volatile Organic Compounds (VOC). The experiments conducted in this study include characterizing the effect of the rotors on sensor signals and testing the system in generating gas distribution maps and localizing the source.
Article
Cell Biology
Juan F. Abenza, Leone Rossetti, Maleke Mouelhi, Javier Burgues, Ion Andreu, Keith Kennedy, Pere Roca-Cusachs, Santiago Marco, Jordi Garcia-Ojalvo, Xavier Trepat
Summary: Autonomous circadian clocks exist in nearly every mammalian cell type. These clocks are regulated by both biochemical and mechanical cues. In this study, it is shown that the fibroblast circadian clock is mechanically regulated through YAP/TAZ nuclear levels. This mechanobiological regulation affects the expression and localization of transcriptional regulators, leading to disruptions in circadian rhythms.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Polymer Science
Hector Sanz-Fraile, Carolina Herranz-Diez, Anna Ulldemolins, Bryan Falcones, Isaac Almendros, Nuria Gavara, Raimon Sunyer, Ramon Farre, Jorge Otero
Summary: A novel cardiac bioink based on hydrogels derived from decellularized porcine myocardium has been developed for producing cell-laden cardiac patches without additional biomaterials or crosslinkers.
Meeting Abstract
Cell & Tissue Engineering
Jorge Otero, Bryan Falcones, Hector Sanz, Esther Marhuenda, Irene Mendizabal, Ignacio Cabrera, Isaac Almendros, Daniel Navajas, Ramon Farre
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Critical Care Medicine
E. Marhuenda, A. Villarino, M. Narciso, N. Gavara, R. Farre, I. Almendros, J. Otero
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
L. Fernandez-Barat, R. Lopez-Aladid, V. Alcaraz, N. Vazquez, L. Bueno, R. Pastor, L. Lingren, H. Sanz, P. Oscanoa, R. Amaro, A. Motos, R. Cabrera, J. Vila, D. Martinez, J. Otero, R. Farre, N. Hoiby, A. Torres
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)