Article
Engineering, Chemical
Qi Zhang, Siru Ren, Song Xue, Ang Li, Siyao Liu, Xiaodong Sun
Summary: The study evaluated six novel ionic liquids as chiral selectors in capillary electrophoresis, showing better enantioseparation performance compared to traditional chiral selectors.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chen Yuan, Wenyan Jia, Ziyun Yu, Yanan Li, Min Zi, Li-Ming Yuan, Yong Cui
Summary: This study demonstrates that two olefin-linked covalent organic frameworks (COFs) featuring chiral crown ether groups can be general chiral stationary phases (CSPs) for extensive separation in gas chromatography (GC) and both normal-phase and reversed-phase high-performance liquid chromatography (HPLC). These COFs show high stability under different chemical environments and have the ability for enantioselective recognition of guest molecules.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Tingting Hong, Xing Liu, Yibing Ji, Songwen Tan, Zhiqiang Cai
Summary: Novel chiral capillary electrochromatography (CEC) microsystems were constructed based on Aspergillus sp. CM96. As cell chirality is a newly discovered intrinsic characteristic of the cell, it plays an essential role in life evolution. Aspergillus sp. CM96 spore (CM96s) was chosen to develop chiral capillary columns, and baseline separation of various amino acid (AA) enantiomers was achieved under optimized conditions. The time-dependent chiral interactions between AAs and CM96s were also explored. Immobilization of pectinases generated from Aspergillus sp. CM96 fermentation onto graphene oxide-functionalized capillary silica monoliths facilitated the separation of AA enantiomers. Molecular docking simulations were performed to understand the chiral separation mechanisms of pectinase for AA enantiomers. These results highlight the significant advantage of Aspergillus sp. CM96-based CEC microsystems in chiral separation.
Review
Chemistry, Analytical
Huifeng Liu, Jia Chen, Mingli Chen, Jianhua Wang, Hongdeng Qiu
Summary: Ionic liquids (ILs), as salts in a molten state, have gained significant attention due to their unique properties such as low vapor pressure, high thermal stability, and adjustable viscosity. Chiral ionic liquids (CILs) have been applied in various chromatography and capillary electrophoresis fields to enhance the separation of enantiomers. This review focuses on the recent applications of CILs in high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) for enantiomeric separation, discussing the separation mechanisms and their potential prospects in chiral liquid chromatography (LC) and CE analysis.
ANALYTICA CHIMICA ACTA
(2023)
Article
Engineering, Chemical
Qi Zhang, Siru Ren, Ang Li, Jing Zhang, Song Xue, Xiaodong Sun
Summary: This study designed and successfully synthesized six tartaric acid-based IL-type chiral selectors, which demonstrated good enantioseparation performance in chiral capillary electrophoresis. Among them, [BMPIP](2)-L-TT showed the best performance, indicating the significant role of cations in enantiorecognition process.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Chengchen Zhang, Xiaofei Ma
Summary: A synergistic system for enantioseparation in capillary electrophoresis (CE) with a chiral ionic liquid (CIL) based on D-10-camphorsulfonic acid as an additive and carboxymethyl-beta-cyclodextrin (CM-beta-CD) as the chiral selector is presented in this work. The proposed method showed excellent enantioseparation performance towards sixteen chiral drugs, with notably improved resolution (Rs) and selectivity factor (alpha) compared to the single CM-beta-CD system. Several key parameters were investigated, and Statistical Product and Service Solutions (SPSS) was used to prove the potential synergistic effect. The nuclear magnetic resonance (NMR) results further demonstrated the function of the CIL and the superiority of the synergistic system. Chiral impurity determination of chlorpheniramine maleate sample was successfully carried out using the established method.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Review
Chemistry, Analytical
Piotr Kowalski, Ilona Oledzka, Alina Plenis, Anna Roszkowska, Tomasz Baczek
Summary: This article discusses the applications of ionic liquids (ILs) in capillary electrophoresis (CE). ILs are used to modify the electroosmotic flow in CE by influencing the silanol groups on the capillary surface. The interactions between ILs and analytes can change the separation mechanism and efficiency of CE, making ILs important additives in CE.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Audrius Maruska, Tomas Drevinskas, Mantas Stankevicius, Kristina Bimbiraite-Surviliene, Vilma Kaskoniene, Linas Jonusauskas, Roaldas Gadonas, Staffan Nilsson, Olga Kornysova
Summary: This work describes the design and characterization of a multi-cell capacitively coupled contactless conductivity detection system, capable of simultaneously acquiring data from multiple detector cells and easily upgradable to 64 detection cells. The system demonstrated sensitivity to low concentrations of various solutions in water and the ability to distinguish different mixtures of organic solvents. It is expected to be used in conjunction with multi-channel separation devices for monitoring simultaneous processes.
ANALYTICAL METHODS
(2021)
Article
Engineering, Chemical
Francesco Galiano, Raffaella Mancuso, Lorenzo Guazzelli, Michele Mauri, Cinzia Chiappe, Roberto Simonutti, Adele Brunetti, Christian S. Pomelli, Giuseppe Barbieri, Bartolo Gabriele, Alberto Figoli
Summary: This study developed novel polymeric membranes based on polymerized ionic liquids for CO2 separation, which showed a preference towards CO2 permeation in wet conditions and some membranes exceeded the Robeson upper bound for the CO2/H2 gas pair.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Chemistry, Analytical
Xiaofei Ma, Bohua Chen, Liangliang Cai
Summary: This study utilized chiral ionic liquids to enhance the enantioseparation performance of a traditional chiral selector in capillary electrophoresis. Two polyhydroxy compound-based chiral ionic liquids were designed and used as additives for chiral separation, leading to improved enantioseparations of various model drugs. The chiral recognition mechanism was elucidated through spectroscopic and computational analyses.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Biochemical Research Methods
Katerina A. Ioannou, Georgia D. Ioannou, Atalanti Christou, Ioannis J. Stavrou, Martin G. Schmid, Constantina P. Kapnissi-Christodoulou
Summary: The combined use of amino acid-based ionic liquids (AAILs) and deep eutectic solvents (DESs) with cyclodextrin-(CD) or cyclofructan-(CF) based chiral selectors for chiral separation of amphetamine derivatives was investigated. The addition of DESs to the dual carboxymethyl-β-cyclodextrin/DES system resulted in marked improvement in chiral separation, while the CF/DES dual system showed worsened separation. Overall, DESs show promise as additives in capillary electrophoresis for improving chiral separation with CDs, but not CFs.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Biochemistry & Molecular Biology
Ting He, Cheng-Bin Hong, Peng-Chong Jiao, Heng Xiang, Yan Zhang, Hua-Qiang Cai, Shuang-Long Wang, Guo-Hong Tao
Summary: The study systematically examined the Bronsted acidity of [AAE]X PILs in green solvents and found that the cationic structures had little effect on the acidity, while the anions had no effect. Four different methods were used to determine the acidic strength, including the overlapping indicator method, potential titration method, Hammett method, and DFT method. These methods were reliable for assessing the acidity of [AAE]X.
Article
Chemistry, Physical
Ang Li, Siru Ren, Chuanjiang Teng, Hongmei Liu, Qi Zhang
Summary: Deep eutectic solvents (DESs) have potential applications as additives/modifiers in chiral electrokinetic chromatography (EKC) and can moderately improve the enantioseparation performance. The improvement is mainly attributed to the contribution of hydrogen-bond acceptors (HBAs) rather than hydrogen-bond donors (HBDs). However, using chiral DESs does not show obvious advantages compared to achiral DESs, which is different from the performance of chiral ionic liquids (ILs) as additives in chiral EKC.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
M. A. Deyab, M. I. Nessim, Abdelfattah Haikal, Q. Mohsen, N. A. Khalil
Summary: This paper describes the corrosion inhibiting action of four new imidazolium-derived ionic liquids (ILs). Various analytical techniques were used to confirm their molecular formula and characterize their adsorption behavior on a steel substrate. Results showed that these ILs exhibited effective corrosion suppression and adsorbed onto the steel surface through physi-chemisorption. SEM/EDX and FTIR analysis further supported the adsorption process of the ILs.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Environmental Sciences
Yun Deng, Sheng Wang, Ian Beadham, Xin Gao, Mengmeng Ji, Guang Wang, Changbo Zhang, Wenquan Ruan
Summary: The Cd-removing ability of 15 different amino acid-based ionic liquids as soil washing agents was studied, and the glycine hydrochloride ([Gly][Cl]) was found to be the most effective in removing Cd. The washing process did not significantly alter the morphology of the soil. After rinsing the soil with water and adjusting the pH, the germination index and growth of rice plants increased significantly. These experiments demonstrate the potential of amino acid-derived ionic liquids as promising soil-washing agents for Cd-contaminated paddy soil.
Review
Chemistry, Analytical
Qi Zhang
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2018)
Article
Pharmacology & Pharmacy
Chunlai Feng, Haisheng Zhang, Jiaming Chen, Siqi Wang, Yuanrong Xin, Yang Qu, Qi Zhang, Wei Ji, Fumiyoshi Yamashita, Mengjie Rui, Ximing Xu
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Biochemical Research Methods
Siru Ren, Song Xue, Xiaodong Sun, Mengjie Rui, Li Wang, Qi Zhang
JOURNAL OF CHROMATOGRAPHY A
(2020)
Article
Biochemical Research Methods
Song Xue, Siru Ren, Li Wang, Qi Zhang
JOURNAL OF CHROMATOGRAPHY A
(2020)
Article
Engineering, Chemical
Qi Zhang, Siru Ren, Song Xue
SEPARATION AND PURIFICATION TECHNOLOGY
(2020)
Article
Biochemical Research Methods
Siru Ren, Qi Zhang, Song Xue, Siyao Liu, Mengjie Rui
JOURNAL OF CHROMATOGRAPHY A
(2020)
Article
Engineering, Chemical
Qi Zhang, Siru Ren, Song Xue, Ang Li, Siyao Liu, Xiaodong Sun
Summary: The study evaluated six novel ionic liquids as chiral selectors in capillary electrophoresis, showing better enantioseparation performance compared to traditional chiral selectors.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Chemistry, Physical
Qi Zhang, Siru Ren, Chenming Gu, Ang Li, Song Xue
Summary: This study introduces a systematic approach to improve the enantioseparation performance of tartaric acid in capillary electrophoresis using ionic liquid technology. It found that achiral ILs exhibit better performance when combined with tartaric acid compared to chiral ILs.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Chemistry, Inorganic & Nuclear
Qi Zhang, Song Xue, Ang Li, Siru Ren
Summary: Researchers in the field of chiral science have been working on developing high-performance analytical methods for enantioseparations. The application of various functional materials in chiral CE has attracted considerable attention, with this article providing an overview of the development and state-of-the-art of advanced functional materials in chiral CE, focusing on innovative concepts and significant progress in the past decade.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Engineering, Chemical
Qi Zhang, Siru Ren, Ang Li, Jing Zhang, Song Xue, Xiaodong Sun
Summary: This study designed and successfully synthesized six tartaric acid-based IL-type chiral selectors, which demonstrated good enantioseparation performance in chiral capillary electrophoresis. Among them, [BMPIP](2)-L-TT showed the best performance, indicating the significant role of cations in enantiorecognition process.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaodong Sun, Bing Niu, Qi Zhang, Qin Chen
Summary: In this study, a homochiral metal-organic framework (MOF) was successfully synthesized and used as a chiral coating in capillary electrochromatography (CEC), demonstrating high enantioselectivity. The MOF and the fabricated capillary coating were characterized using various techniques, providing insights for the design and establishment of MOF-based chiral CEC systems.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Chemistry, Analytical
Ang Li, Song Xue, Siru Ren, Yu Xu, Qi Zhang
Summary: Research on the application of deep eutectic solvents (DESs) in capillary electrophoresis (CE) is still in the early stage, and there is controversy over their true role. This study established a CE system using a hydrophobic DES as a pseudo-stationary phase (PSP). The hydrophobic DES formed stable aggregates and exhibited impressive selectivities through a hydrophobic mechanism.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Physical
Ang Li, Siru Ren, Chuanjiang Teng, Hongmei Liu, Qi Zhang
Summary: Deep eutectic solvents (DESs) have potential applications as additives/modifiers in chiral electrokinetic chromatography (EKC) and can moderately improve the enantioseparation performance. The improvement is mainly attributed to the contribution of hydrogen-bond acceptors (HBAs) rather than hydrogen-bond donors (HBDs). However, using chiral DESs does not show obvious advantages compared to achiral DESs, which is different from the performance of chiral ionic liquids (ILs) as additives in chiral EKC.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Analytical
Ang Li, Song Xue, Yu Xu, Sihui Ding, Di Wen, Qi Zhang
Summary: The study explores the feasibility of using hydrophobic eutectic solvents (HESs) as pseudo-stationary phases (PSPs) in capillary electrophoresis (CE) for chiral separations. It demonstrates that there is a potential synergistic effect between HESs and traditional chiral selectors, improving enantioseparations of basic drugs.
ANALYTICA CHIMICA ACTA
(2023)
Article
Pharmacology & Pharmacy
Xiangtai Zheng, Qi Zhang, Qianjie Ma, Xinyu Li, Liang Zhao, Xiaodong Sun
Summary: In this study, a chiral metal-organic framework (CMOF) was constructed as a chiral stationary phase (CSP) for the analysis of chiral amino acids and drugs. The CMOF exhibited strong enantioselectivity and was characterized using various analytical techniques. The study not only introduces a new member of the MOF-type CSP family, but also demonstrates the potential of improving the enantioselectivities of traditional chiral recognition reagents.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Correction
Biochemical Research Methods
Yong Wang, Suhua Yu, Rui Li, Jing Wan, Yuheng Wang, Zongli Huo, Chunyong Wu, Li Mi, Songqin Liu
JOURNAL OF CHROMATOGRAPHY A
(2024)
Review
Biochemical Research Methods
Israel D. Souza, Maria Eugenia C. Queiroz
Summary: Organic-silica hybrid monolithic materials have gained significant attention in separation science and sample preparation due to their unique properties. This review summarizes the characteristics, current status, and recent developments of these materials, as well as discusses synthesis methods, characterization techniques, and strategies for improving extraction efficiency in various applications.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Bhagwat Upreti, Bhanu Prasad Vempatapu, Jagdish Kumar, Pankaj K. Kanaujia
Summary: Lubricating oils are essential for the effective performance of internal combustion engines. This study presents a new HPLC method for determining additives in finished lubricating oils and polar substances in used engine oils.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zongqing Huang, Haoju Hua, Xiuzhen Du, Zipeng Zhen, Wei Zhao, Jun Feng, Ji-an Li
Summary: This study successfully isolated VHHs against the SUMO protein for the first time using biopanning of an immune camelid nanobody library. The VHHs were coupled to agarose resins to form affinity chromatography resins, allowing for one-step purification of various SUMO fusions.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Xueting Qiu, Xuben Hou, Yue Yang, Hao Fang, Fei Cui, Xinying Yang
Summary: In this study, a new method based on electrophoretically mediated microanalysis was developed for the investigation of PTPRO enzymatic activity. The method was successfully used to determine the kinetics of PTPRO and the inhibitory concentration of PTPRO inhibitors. The method exhibited improved accuracy and reduced consumption compared to traditional methods.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Feifei Luo, Mengmeng Hao, Lei Zhang, Yangguo Xie, Wei Hou, Hongya Wang, Zhongli Zhang
Summary: In this study, a comprehensive screening and structure elucidation of 23 nonvolatile organic compounds (NVOCs) in two antibody drugs was conducted. Seven previously unreported compounds were identified. A quantitative method with high sensitivity, accuracy, and precision was developed for evaluating the safety of NVOCs in drug products.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zuzana Vosahlova, Kveta Kalfkova, Martin Gilar, Jakub Szymarek, Maria Mazurkiewicz-Beldzinska, Sylwia Studzi
Summary: A hydrophilic interaction liquid chromatography method was developed for the separation and identification of oligonucleotide impurities and metabolites, and successfully applied to the analysis of serum samples from Spinraza-treated patients.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Aswanidevi Kongasseri, Thirumalai Madhesan, Sangeetha Krishna Kumar, Sushmitha Pedugu Sivaraman, Suchashrita Mitra, Pitchaiah Kancharlapalli Chinaraga, C. V. S. Brahmmananda Rao, Sivaraman Nagarajan, Prabhakaran Deivasigamani, Akhila Maheswari Mohan
Summary: This study focuses on the sequential separation of trivalent lanthanides using modified C-18 silica-packed supports and reversed-phase HPLC technique. By tuning the column modifiers and separation parameters, the researchers achieved systematic separation of Ln(3+). The results showed that the choice of column modifiers and fine-tuning of the modification procedure were crucial for achieving excellent separation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Raquel Perez-Robles, Szabolcs Fekete, Robert Kormany, Natalia Navas, Davy Guillarme
Summary: There is a mismatch between the sample diluent and the mobile phase in HILIC analysis, leading to analyte breakthrough and peak distortion. Adding a weak solvent for pre-injection can effectively prevent these issues and improve sensitivity.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oleg Pokrovskiy, Irina Rostovschikova, Konstantin Ustinovich, Ilya Voronov, Dmitry Kosyakov
Summary: A chromatography-like propagation of water through the material bed was observed during supercritical fluid extraction of aroma plants with high moisture content, which could be significant for modeling the kinetics of supercritical fluid extraction of non-volatile compounds.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Yasar Kemal Recepoglu, Ozguer Arar, Asli Yuksel
Summary: Biosorption using phosphorylated hazelnut shell waste (FHS) is a promising method for lithium removal and recovery. This study investigated the performance of a continuous-flow packed-bed column system using FHS for ultra-low level lithium removal. The results showed that the lihium biosorption capacity of the FHS column was unaffected by the bed height, but decreased with increasing flow rate.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Jian Sun, Zheheng Zheng, Zixiao Jia, Jiabin Wang, Xucong Lin
Summary: In this study, an ionic covalent organic framework (iCOF) surface grafting monolithic sorbent was prepared for in-tube solid-phase microextraction (SPME) of aristolochic acids (AAs) in various samples. The density of quaternary ammonium ions in the iCOF was modulated for enhanced adsorption of AAs. The iCOF surface grafting monolithic sorbent was confirmed by different means. Several operating conditions were optimized to develop the online in-tube SPME-HPLC method, which showed good linearity, low limits of detection, and high recoveries for AAs in serum samples. This study presents a feasible approach for the application of COF-based monolithic sorbents in sample preparation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zeng Wen, Ruihan Peng, Die Gao, Jing Lin, Jia Zeng, Zhou Li, Famin Ke, Zhining Xia, Dandan Wang
Summary: A chitosan-alginate sponge with multiple cross-linking networks was developed for adsorption and enrichment of anionic dyes from food samples. The sponge showed better three-dimensional network structure, mechanical behavior, and stability compared to pure chitosan and alginate sponges. The adsorption performance and selectivity of the sponge were systematically studied, and it maintained high adsorption capacity and selectivity for anionic dyes. The sponge also showed satisfactory reusability and was successfully combined with high-performance liquid chromatography for the enrichment and detection of anionic dyes in candy and cocktail samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Hairong Zhang, Xiaojuan Jiang, Dandan Zhang, Yuexin Yang, Qiang Xie, Caisheng Wu
Summary: Analysis of in vivo exposure to traditional Chinese medicine using mass spectrometry is helpful for identifying effective ingredients and developing new drugs. This study focused on Forsythia suspensa (Lian Qiao) and used metabolomics technology to explore its in vivo exposure. By comparing the differences before and after administration, a complete set of nontargeted analysis strategies for TCM exposure was established. The study identified 393 Lian Qiao-related chemical components in mice after administration, including prototypes and metabolites. This study provides a reference for research on the active ingredients of Lian Qiao in vivo.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oscar Castejon-Musulen, Ricardo Lopez, Ignacio Ontan, Vicente Ferreira
Summary: A quantitative analytical method was developed and validated in this study to determine the concentrations of 81 aroma-relevant wine volatiles. The method utilizes stir bar sorptive extraction and multidimensional gas chromatography with flame ionization detector or mass spectrometer. The method demonstrated good linearity, reproducibility, and recovery, and was successfully applied to analyze 20 wine samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)