Journal
SCHIZOPHRENIA RESEARCH
Volume 114, Issue 1-3, Pages 39-49Publisher
ELSEVIER
DOI: 10.1016/j.schres.2009.06.019
Keywords
Schizophrenia; DISC1; Genetic association; LIS1; NUDEL; PDE4B
Categories
Funding
- CIHR Genomic Medicine and Human Development [GMH79044]
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Convergent evidence from genetic linkage, genetic association and biological studies implicates the Disrupted in schizophrenia 1 (DISC1) gene in the etiology and pathophysiology of schizophrenia. We conducted genetic association studies in matched case-control and family sample sets (N = 117 families; N = 210 case-control pairs), testing polymorphisms across DISC1 and DISCI interacting genes: LIS1, NUDEL, FEZ1 and PDE4B. We found that DISC1 variants, particularly in the exon 9/intron 9/intron 10 region of the gene, may be associated with risk for schizophrenia in our sample Population. There was no strong evidence for association with LIS1, NUDEL, FEZ1 and PDE4B. Gene-gene interaction analyses and mRNA quantification in post-mortem brains from schizophrenia patients and control Subjects did not reveal significant differences. (C) 2009 Elsevier B.V. All rights reserved.
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