Review
Chemistry, Medicinal
Mahmoud Hashemzaei, Ramin Rezaee
Summary: Berberine, a natural alkaloid found in Coptis and Berberis species, exhibits various therapeutic effects such as anti-oxidant, anti-inflammatory, analgesic, and hepatoprotective activities. It can alleviate neuropathic pain and inflammation through multiple mechanisms, making it a versatile compound with potential clinical applications.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Feifei He, Shangbiao Feng, Yulong Zhao, Hongliang Shi, Xiaoguang Duan, Huilin Li, Xingang Xie, Xuegong She
Summary: A gold-catalyzed reaction is developed to access tricyclic cores using the commonly shared bicyclic decahydroquinoline motif. These cores are then used for the divergent total syntheses of five Lycopodium alkaloids in a concise manner. Key transformations include ring cyclization, hydration, fragmentation, and construction of specific motifs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Seiya Katahara, Yasukazu Sugiyama, Mina Yamane, Yukinori Komiya, Takaaki Sato, Noritaka Chida
Summary: A five-step total synthesis of (+/-)-aspidospermidine based on a lactam strategy is reported, featuring an iridium-catalyzed reductive Michael addition/[3+2] cycloaddition cascade for the generation of a tricyclic ketone intermediate from a simple lactam. This strategy allows for easily available lactams to be used as stable surrogates of multisubstituted amines and could be applicable to a unified total synthesis of complex Aspidosperma alkaloids.
Article
Chemistry, Analytical
Ning Wang, Yue-Wu Xie, Meng-Yu Li, Fei-Fei Li, Li-Yuan Zhang, Yu-Lin You, Shu-Qi Wang
Summary: A liquid chromatography-tandem mass spectrometry method was developed and validated for studying the pharmacokinetic behavior of five ingredients of Rauvolfia vomitoria in rats. The results showed that diabetes mellitus significantly altered the pharmacokinetic characteristics of yohimbine, ajmaline, and ajmalicine in rats, providing evidence for clinicians to guide the use of antidiabetic medicine in clinical practice.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Biochemical Research Methods
Lisa Monika Klein, Angelika Miriam Gabler, Michael Rychlik, Christoph Gottschalk, Florian Kaltner
Summary: This study developed a sensitive analytical approach for simultaneous detection and quantification of unsaturated pyrrolizidine alkaloids, their corresponding N-oxides, and tropane alkaloids in milk of dairy cows. The method showed low limits of detection and quantification, good recovery rates and repeatability. Traces of pyrrolizidine alkaloids were detected in three milk samples obtained from milk vending stations and local marketers in Bavaria, Germany.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Fan Ding, Leilei Liang, Jiacan Yao, Bo Wang, Chang Xu, Dandan Liu
Summary: This research presents the total synthesis of (+)-pancratistatin in 10 linear steps using a known aldehyde as a chiral source. The synthetic route involves a highly stereoselective intermolecular Michael addition and intramolecular Henry reaction to construct a cyclohexane ring with 6 successive stereocenters. All of the synthetic steps are reliable and efficient and can be easily scaled up, allowing for pharmacological tests of (+)-pancratistatin. Importantly, this study discovered a new pharmacological mechanism of action where (+)-pancratistatin is able to inhibit the activity of topoisomerase I, suggesting its potential as a new type of Topo I inhibitor.
Article
Chemistry, Multidisciplinary
Pingzhou Wu, Qilong Zhou, Xiao-Yu Liu, Fei Xue, Yong Qin
Summary: The asymmetric synthesis of 16,17,20-epi-deserpidine and a derivative of (-)-deserpidine has been achieved through visible-light photocatalytic reactions, showcasing the key features in the construction of the pentacyclic framework.
CHINESE CHEMICAL LETTERS
(2021)
Review
Pharmacology & Pharmacy
Melia Bokaeng Bonokwane, Makhotso Lekhooa, Madeleen Struwig, Adeyemi Oladapo Aremu
Summary: This study reviews ethnobotanical, ethnopharmacological, and phytochemical studies on South African medicinal plants used to manage depression, aiming to explore their potential in treating depression. The results indicate that there are still many promising plants that require further pharmacological research.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Tirtha Mandal, Shilpi Karmakar, Ajoy Kapat, Jyotirmayee Dash
Summary: A modular and flexible three-step synthetic strategy has been developed for the synthesis of acridone natural products of biological significance. The method has been successful in the efficient synthesis of acronycine and noracronycine alkaloids with improved overall yields. The synthetic utility of the present strategy has also been showcased by the synthesis of oxa and thia analogues of acronycine alkaloid.
Review
Medicine, General & Internal
Dominika Kwasnicka, Dimitra Kale, Verena Schneider, Jan Keller, Bernard Yeboah-Asiamah Asare, Daniel Powell, Felix Naughton, Gill A. ten Hoor, Peter Verboon, Olga Perski
Summary: This review focuses on EMA studies investigating psychological or contextual predictors of key health behaviors in non-clinical populations. Studies will cover five public health behaviors and exclude those focusing solely on physiological outcomes or conducted under controlled conditions. Results will be disseminated through publications and presentations, with data available for other researchers to use.
Article
Agriculture, Dairy & Animal Science
C. M. Rundle, V. Artuso-Ponte, H. H. Stein
Summary: Two experiments were conducted to test the effects of feeding isoquinoline alkaloid (IQ) obtained from Macleaya cordata on pig's nutrient digestibility and plasma amino acids. The results showed that adding 40 or 160 mg/kg of IQ to the diets can increase the AID of amino acids and crude protein.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2023)
Article
Anatomy & Morphology
Zhihao Liu, Xiaolin Li, Yuyang Zhao, Yan Jin, Junhui Zhou, Luqi Huang, Liangping Zha, Yuan Yuan
Summary: This study observed the microscopic features of five commonly misidentified Artemisia species using light microscopy and scanning electron microscopy. The differences in morphology and density of glandular and non-glandular trichomes were found to be key features for the identification of these species.
MICROSCOPY RESEARCH AND TECHNIQUE
(2022)
Article
Energy & Fuels
Paulo A. P. Decote, Luana Negris, Amanda P. Vidoto, Luiz A. N. Mendes, Erico M. M. Flores, Maristela A. Vicente, Maria F. P. Santos
Summary: This study theoretically compares and experimentally verifies the precision of TAN determination methods for Brazilian crude oil samples. The results show that the precision is influenced by factors such as sample solubility, sample size, and hydrolysable salt type and content. These findings provide valuable reference information and help minimize the adverse effects of inaccurate TAN determination in the oil refining and production chain.
Article
Veterinary Sciences
Xinjian Wang, Zhen Yang, Yujun Zhang, Feng Cheng, Xiaoyong Xing, Fengqin Wen, Yonghao Hu, Changjiang Chen, Bin Wei, Pengxia Bai, Xuehong Wang, Yu Liu, Hongjuan Zhang, Baocheng Hao, Shengyi Wang
Summary: This study revealed the mechanism of Aconitum flavum Hand.-Mazz. total alkaloids in killing Melophagus ovinus. It was found that the alkaloids affected the regulation of protein disulfide isomerase and related proteins, leading to the disruption of protein folding and eventually killing Melophagus ovinus. These findings provide a theoretical basis for the development of new veterinary drugs.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemical Research Methods
Lingyun Pan, Min Xu, Nan Wang, Yiqun Jia, Yanfeng Xiu
Summary: This study developed a sensitive and specific method to investigate the tissue distribution of five xanthones in rats. The results showed that these xanthones rapidly distributed to rat tissues and could be detected in all selected tissues after oral administration. Additionally, the contents of two xanthones in the gastrointestinal tract significantly decreased after processing.
BIOMEDICAL CHROMATOGRAPHY
(2023)