Article
Endocrinology & Metabolism
Soyeon Kang, Yong-Moon Park, Dong Jin Kwon, Youn-Jee Chung, Jeong Namkung, Kyungdo Han, Seung-Hyun Ko
Summary: In postmenopausal women with type 2 diabetes, a longer reproductive life span is associated with a lower risk of severe hypoglycemia, and every 5-year increment in the reproductive life span reduces the risk of severe hypoglycemia. The use of hormone replacement therapy (HRT) is also associated with a lower risk of severe hypoglycemia.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Ako Adams Ako, Yvonne L. Michael, Lucy F. Robinson, Jean Wactawski-Wende, Aladdin H. Shadyab, Lorena Garcia, Bede N. Nriagu, Nazmus Saquib, Rami Nassir, Simin Liu, Robert B. Wallace
Summary: This study found that postmenopausal women with gallbladder disease have an increased risk of developing type 2 diabetes, especially among those with central obesity. The results support further research to determine whether interventions in older women with gallbladder disease would reduce the risk of type 2 diabetes.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Endocrinology & Metabolism
Yahao Wang, Yangang Wang
Summary: This study found accelerated ovarian aging in women with type 2 diabetes mellitus (T2DM) and its correlation with disturbed lipid profile. It highlights the importance of carefully managing accelerated ovarian aging and its adverse impacts in T2DM, especially with the increasing number of young female patients diagnosed with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chin-Hsiao Tseng
Summary: This study investigated the association between metformin use and malignant brain tumors in patients with type 2 diabetes mellitus. The results showed a reduction in risk of malignant brain tumors associated with metformin use, especially after approximately 2-5 years of use.
Article
Endocrinology & Metabolism
Oscar H. Roa Duenas, Anna C. Van der Burgh, Till Ittermann, Symen Ligthart, M. Arfan Ikram, Robin Peeters, Layal Chaker
Summary: Current evidence suggests an increased risk of type 2 diabetes in individuals with hypothyroidism and lower FT4 levels within the reference range. However, the evidence in this area is still limited and further population-based studies are needed to confirm this association.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cell & Tissue Engineering
Yanju Li, Feiqing Wang, Huiling Liang, Dongxin Tang, Mei Huang, Jianing Zhao, Xu Yang, Yanqing Liu, Liping Shu, Jishi Wang, Zhixu He, Yang Liu
Summary: The meta-analysis included 10 studies with a total of 239 participants, evaluating the efficacy of mesenchymal stem cells (MSCs) therapy in treating diabetes mellitus. The results showed that MSC treatment led to significantly lower HbA1c levels, higher fasting C-peptide levels, and reduced insulin requirement in T1DM patients.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Endocrinology & Metabolism
Qi Jin, Ni Shi, Desmond Aroke, Dong Hoon Lee, Joshua J. Joseph, Macarius Donneyong, Darwin L. Conwell, Phil A. Hart, Xuehong Zhang, Steven K. Clinton, Zobeida Cruz-Monserrate, Theodore M. Brasky, Rebecca Jackson, Lesley F. Tinker, Simin Liu, Lawrence S. Phillips, Aladdin H. Shadyab, Rami Nassir, Wei Bao, Fred K. Tabung
Summary: The study suggests that reducing the insulinemic and inflammatory potentials of the diet may be more effective in preventing type 2 diabetes than focusing on glycemic foods.
Review
Endocrinology & Metabolism
Esther M. Speksnijder, Gaby V. ten Noever de Brauw, Arjan Malekzadeh, Peter H. Bisschop, Dirk Jan Stenvers, Sarah E. Siegelaar
Summary: A systematic review and meta-analysis study found that postmenopausal hormone therapy (HT) has a neutral-to-beneficial impact on glucose regulation in women with type 2 diabetes, but evidence for women with type 1 diabetes is limited.
Review
Biochemistry & Molecular Biology
Michalis Michailidis, Despina Moraitou, Despina A. Tata, Kallirhoe Kalinderi, Theodora Papamitsou, Vasileios Papaliagkas
Summary: This review article discusses the shared pathophysiological connections between Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM), emphasizing the role of insulin in the brain and the mechanistic interplay between the two diseases. The findings highlight the need for routine evaluation and treatment of cognitive impairment in T2DM patients and the evaluation of insulin levels or T2DM in AD patients. The hypothesis of AD as a type 3 diabetes is strongly supported.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Mingrui Li, Yifan Li, Yujie Liu, Haoming Huang, Xi Leng, Yuna Chen, Yue Feng, Xiaomeng Ma, Xin Tan, Yi Liang, Shijun Qiu
Summary: In patients with type 2 diabetes mellitus, reductions in hippocampal subfield volumes were found to be associated with factors like fasting insulin, blood glucose levels, and insulin resistance, which may contribute to memory dysfunction. The study also revealed a correlation between abnormal hippocampal subfield volumes and memory function in these patients, indicating a potential mechanism for memory impairment in type 2 diabetes mellitus.
FRONTIERS IN NEUROLOGY
(2021)
Article
Oncology
Hui-Shan Liu, Chin-Der Chen, Chung-Chen Lee, Yong-Chen Chen, Wen-Fang Cheng
Summary: The incidence of uterine cancer is increasing worldwide, especially in the young age population. Diabetes mellitus (DM) and obesity are known risk factors of uterine cancer, and the risk is higher in younger populations. It is recommended that individuals with DM, especially younger women with respective comorbidities, undergo appropriate uterine cancer screenings for early detection.
Article
Endocrinology & Metabolism
Tianqi Zhang, Marnie Shaw, Nicolas Cherbuin
Summary: This study systematically reviews and estimates the association between type 2 diabetes mellitus (T2DM) and brain volumetric differences and atrophy. The results show that individuals with T2DM have smaller total and regional brain volumes, as well as greater brain atrophy over time. Meta-regression analysis suggests that diabetes-related brain volume differences start occurring in early adulthood, decrease with age, and increase with diabetes duration. These findings highlight the urgent need to develop interventions to reduce the risk of T2DM for brain health.
DIABETES & METABOLISM JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Xuemin Peng, Rongping Fan, Lei Xie, Xiaoli Shi, Kun Dong, Shujun Zhang, Jing Tao, Weijie Xu, Delin Ma, Juan Chen, Yan Yang
Summary: T2DM patients are at higher risk of developing AD, and circadian rhythm disruption may contribute to both diseases. Promising therapeutic strategies for T2DM and AD include pharmacological and non-pharmacological treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Cheng-Xu Ma, Xiao-Ni Ma, Cong-Hui Guan, Ying-Dong Li, Didac Mauricio, Song-Bo Fu
Summary: This review mainly discusses the important issues in choosing antidiabetic agents and lipid, blood pressure, and antiplatelet treatments for patients with T2DM, considering their cardiovascular status. Additionally, changes in therapy principles for CVDs in T2DM are also addressed.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Anna Obermayer, Norbert J. Tripolt, Peter N. Pferschy, Harald Kojzar, Faisal Aziz, Alexander Mueller, Markus Schauer, Abderrahim Oulhaj, Felix Aberer, Caren Sourij, Hansjoerg Habisch, Tobias Madl, Thomas Pieber, Barbara Obermayer-Pietsch, Vanessa Stadlbauer, Harald Sourij
Summary: The study investigated the safety and feasibility of 3 nonconsecutive days of intermittent fasting per week in insulin-treated individuals with type 2 diabetes. The results showed that the intermittent fasting group achieved a significant reduction in HbA(1c) and body weight over 12 weeks, with no severe hypoglycemia.
Article
Geriatrics & Gerontology
Mark A. Espeland, Kathleen M. Hayden, Samuel N. Lockhart, Hussein N. Yassine, Siobhan Hoscheidt, Sevil Yasar, Jose A. Luchsinger, Rebecca H. Neiberg, Roberta Diaz Brinton, Owen Carmichael
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Clinical Neurology
Tian Wang, Jia Yao, Shuhua Chen, Zisu Mao, Roberta Diaz Brinton
Article
Biochemistry & Molecular Biology
Moulun Luo, Wuqiong Ma, Zoe Sand, Jean Finlayson, Tian Wang, Roberta Diaz Brinton, Wayne T. Willis, Lawrence J. Mandarino
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Yuan Shang, Aarti Mishra, Tian Wang, Yiwei Wang, Maunil Desai, Shuhua Chen, Zisu Mao, Loi Do, Adam S. Bernstein, Theodore P. Trouard, Roberta D. Brinton
Article
Multidisciplinary Sciences
Douglas Barthold, Geoffrey Joyce, Roberta Diaz Brinton, Whitney Wharton, Patrick Gavin Kehoe, Julie Zissimopoulos
Article
Multidisciplinary Sciences
Jennifer Cable, David M. Holtzman, Bradley T. Hyman, Malu Gamez Tansey, Marco Colonna, Manolis Kellis, Roberta D. Brinton, Marilyn Albert, Cheryl L. Wellington, Sangram S. Sisodia, Rudolph E. Tanzi
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Yashi Mi, Guoyuan Qi, Roberta Diaz Brinton, Fei Yin
Summary: The paper summarizes the importance, recent advances, critical issues, and future directions of Alzheimer's disease (AD) therapeutics. The authors emphasize that emerging non-energetic aspects of mitochondria targeting strategies may have the potential to modify AD risk and progression.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Multidisciplinary Sciences
Yiwei Wang, Yuan Shang, Aarti Mishra, Eliza Bacon, Fei Yin, Roberta Brinton
SCIENTIFIC REPORTS
(2020)
Review
Clinical Neurology
Johanna Thunell, Yi Chen, Geoffrey Joyce, Douglas Barthold, Paul G. Shekelle, Roberta Diaz Brinton, Julie Zissimopoulos
Summary: The study identified 29 drug classes associated with increasing or decreasing ADRD risk, with a need for further research in certain areas. Some areas of study still have limited evidence and require more data to support conclusions.
ALZHEIMERS & DEMENTIA
(2021)
Article
Cell Biology
Guoyuan Qi, Yashi Mi, Xiaojian Shi, Haiwei Gu, Roberta Diaz Brinton, Fei Yin
Summary: This study reveals the detrimental effects of ApoE4 on fatty acid metabolism in neurons and astrocytes, leading to lipid accumulation and energy imbalance. ApoE4 decreases the transport efficiency of neuronal lipids, compromising metabolic and synaptic support from astrocytes to neurons.
Review
Obstetrics & Gynecology
Y. J. Kim, R. D. Brinton
Summary: The therapeutic impact of MHT remains under debate, with variations in neurodegenerative diseases among individuals. Characteristics of women in observational studies and clinical trials, as well as different MHT treatments and regimens, may impact outcomes. Precision hormone therapy in the future will require identification of symptomatic women appropriate for MHT and personalized treatment based on genetic profile and health risks.
Article
Behavioral Sciences
Eliza R. Bacon, Roberta Diaz Brinton
Summary: Brain development is a lifelong process that undergoes significant cognitive changes during critical periods of transition. Environmental factors can impact embryonic development, puberty, and reproductive senescence. Epigenetic marks, such as DNA methylation and histone modifications, play a role in how early events affect development, cognition, and health outcomes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Oncology
Gregory L. Branigan, Georgina Torrandell-Haro, Maira Soto, Edward P. Gelmann, Francesca Vitali, Kathleen E. Rodgers, Roberta Diaz Brinton
Summary: This study investigated the impact of androgen-targeting therapeutics on the risk of neurodegenerative diseases in men with prostate cancer. It found that GnRH agonists were associated with increased NDD risk, while abiraterone acetate was associated with decreased risk. These findings suggest potential strategies for mitigating the risk of NDD in prostate cancer patients.
Article
Endocrinology & Metabolism
Yashi Mi, Guoyuan Qi, Francesca Vitali, Yuan Shang, Adam C. Raikes, Tian Wang, Yan Jin, Roberta D. Brinton, Haiwei Gu, Fei Yin
Summary: Mi, Qi et al. have identified a mechanism in which defective oxidative phosphorylation in astrocytes disrupts astroglial lipid homeostasis, leading to neuronal damage and microglial reactivity. This mechanism involves the accumulation of lipid droplets in astrocytes, which triggers neurodegeneration resembling Alzheimer's disease. The study reveals the importance of astrocytic oxidative phosphorylation in fatty acid degradation and lipid homeostasis maintenance, and highlights the role of astrocyte dysfunction in neuroinflammation and neurodegeneration.
Article
Obstetrics & Gynecology
Yiwei Wang, Gerson Hernandez, Wendy J. Mack, Lon S. Schneider, Fei Yin, Roberta D. Brinton
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2020)