Article
Chemistry, Physical
Tamara Fernandez Cabada, Massimo Ruben, Amira El Merhie, Remo Proietti Zaccaria, Alessandro Alabastri, Enrica Maria Petrini, Andrea Barberis, Marco Salerno, Marco Crepaldi, Alexander Davis, Luca Ceseracciu, Tiziano Catelani, Athanassia Athanassiou, Teresa Pellegrino, Roberto Cingolani, Evie L. Papadopoulou
Summary: This study investigates the regulation of cancer stem-like cell differentiation by the electrical interface between cells and materials. Electrospun polymer fiber scaffolds with embedded graphene nanoplatelets are fabricated, providing a suitable electrical environment for cancer stem-like cell adhesion, growth, and differentiation. The results show that the electrical interface promotes the differentiation of cancer stem-like cells, offering potential applications in tissue engineering and cancer treatment.
NANOSCALE HORIZONS
(2022)
Article
Neurosciences
Nicole L. Rumian, Nicholas E. Chalmers, Jonathan E. Tullis, Paco S. Herson, K. Ulrich Bayer
Summary: CaMKIIα plays a dual role in synaptic plasticity and may have a similar role in neuronal cell death and survival. Research suggests that long-term inhibition of CaMKIIα in neurons does not lead to sensitization but instead provides neuroprotection.
Article
Endocrinology & Metabolism
Lopmudra P. Sarode, Trupti Ghatage, Vishal Mardhekar, Bhavesh Verma, Anand Prakash, Rajesh R. Ugale
Summary: Recent studies have shown that cerebrolysin has neuroprotective properties similar to endogenous neurotrophic factors, making it a potential treatment for neurodegenerative disorders such as ischemic stroke. Our research found that cerebrolysin significantly reduced neuronal cell death and decreased the expression of important cell death proteins, providing evidence for its antiexcitotoxic action in delayed ischemic reperfusion injuries.
METABOLIC BRAIN DISEASE
(2023)
Article
Biotechnology & Applied Microbiology
Douglas Ribeiro Lucas, Filipe Zaniratti Damica, Estefany Braz Toledo, Antonio Jesus Dorighetto Cogo, Anna Lvovna Okorokova-Facanha, Valdirene Moreira Gomes, Andre de Oliveira Carvalho
Summary: The research findings suggest that the bioinspired peptides induced different death kinetics in Candida tropicalis and Candida albicans, with RR and WR causing non-accidental cell death and D-RR inducing programmed cell death metacaspase-independent. These results provide a better understanding of the death process induced by these peptides.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Pediatrics
Hannah C. Glass, Courtney J. Wusthoff, Bryan A. Comstock, Adam L. Numis, Fernando F. Gonzalez, Nathalie Maitre, Shavonne L. Massey, Dennis E. Mayock, Ulrike Mietzsch, Niranjana Natarajan, Gregory M. Sokol, Sonia L. Bonifacio, Krisa P. Van Meurs, Cameron Thomas, Kaashif A. Ahmad, Patrick J. Heagerty, Sandra E. Juul, Yvonne W. Wu
Summary: This study aimed to investigate whether there was a difference in the risk and burden of seizures in neonates with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia and randomized to receive erythropoietin (Epo) or placebo. The results showed no significant difference in seizure risk or burden between the two treatment groups.
PEDIATRIC RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Shuai Xiong, Hui Xiao, Meng Sun, Yunjie Liu, Ling Gao, Ke Xu, Haiying Liang, Nan Jiang, Yuhui Lin, Lei Chang, Haiyin Wu, Dongya Zhu, Chunxia Luo
Summary: This study found that the expression and function of the BEST1 channel increased within the peri-infarct region from 8 to 48 hours after ischemic stroke in mice. Interfering with BEST1 protein expression or inhibiting channel function showed neuroprotective effects and improved motor functional deficits. Pharmacological inhibition of BEST1 during 6-72 hours post-ischemia prevented the expansion of infarct volume and exacerbation of neurological functions.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Biochemistry & Molecular Biology
Filip Benko, Dana Urminska, Michal Duracka, Eva Tvrda
Summary: This review provides an overview of specific ion channels and transporters located in the mammalian sperm plasma membrane and their functional roles in sperm development and function. It discusses the potential therapeutic targets for infertility management.
Article
Multidisciplinary Sciences
Avishai Gavish, Benny Chain, Tomer M. Salame, Yaron E. Antebi, Shir Nevo, Shlomit Reich-Zeliger, Nir Friedman
Summary: Numerous methods have emerged for ordering single cells along developmental trajectories, but accurate depiction of developmental dynamics requires rescaling the trajectory based on the relative time spent at each developmental point. We propose a model that estimates local cell densities and fluxes, and incorporates cell division and apoptosis rates to infer the real-time dimension of the developmental trajectory. We validate the model using mathematical simulations and apply it to experimental high dimensional cytometry data from the mouse thymus to construct the true time profile of the thymocyte developmental process. Our method can be easily implemented in existing trajectory inference tools.
Review
Medicine, Research & Experimental
Zihuan Shen, Mi Xiang, Chen Chen, Fan Ding, Yuling Wang, Chang Shang, Laiyun Xin, Yang Zhang, Xiangning Cui
Summary: This article reviews the glutamate-mediated excitotoxicity mechanism in post-ischemic stroke damage, focusing on the pathological changes in glutamate release, reuptake, NMDAR, and cellular signaling pathways. It also discusses new treatment targets and potential neuroprotective drugs for ischemic stroke.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Fuying Li, Keiko Ichinose, Satoru Ishibashi, Syunsuke Yamamoto, Eri Iwasawa, Motohiro Suzuki, Kie Yoshida-Tanaka, Kotaro Yoshioka, Tetsuya Nagata, Hideki Hirabayashi, Kaoru Mogushi, Takanori Yokota
Summary: The study reveals that lipid-ligand conjugated DNA/RNA heteroduplex oligonucleotide (lipid-HDO) can be efficiently delivered to the ischemic area of the brain, achieving gene knockdown and potentially being a promising technology for stroke treatment in the hyperacute stage.
Article
Multidisciplinary Sciences
Luyun Zhang, Wei Lu, Cheng Lu, Yanjun Guo, Xiongying Chen, Jun Chen, Feng Xu, Hanxing Wan, Hui Dong
Summary: This study investigates the actions of capsaicin on the gastrointestinal tract, particularly on mesenteric arterioles in normal and colitis mice. The results suggest that capsaicin induces vasorelaxation through the activation of TRPV4 channels and calcium-activated potassium channels in endothelial cells. Additionally, capsaicin exerts anti-colitis effects by restoring impaired vasorelaxation in colitis mice.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Oykum Kaplan-Arabaci, Alperen Acari, Pinar Ciftci, Devrim Gozuacik
Summary: Stroke is the second leading cause of death and disability globally. Ischemic stroke, caused by blood vessel blockage, has limited treatment options. Previous studies aimed at reducing glutamate in ischemic stroke and other neurodegenerative diseases have failed due to delivery obstacles. Systemic glutamate scavenging, a new therapeutic approach, offers the advantage of working in the circulating blood without interfering with brain neurophysiology.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Neurosciences
Abhilash Ludhiadch, Rashmi Sharma, Aishwarya Muriki, Anjana Munshi
Summary: Stroke is the second leading cause of death worldwide, mainly due to insufficient oxygen supply to the brain. Calcium ions play a crucial role in cell death pathways, and disruption in calcium homeostasis can lead to ischemic cell death. Mitochondrial dysfunction is also associated with delayed neuronal death, triggered by calcium accumulation.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2022)
Article
Biochemistry & Molecular Biology
Fei Yao, Jingjie Peng, Endong Zhang, Dan Ji, Zhaolin Gao, Yixiong Tang, Xueyan Yao, Xiaobo Xia
Summary: This study reveals the role of NCOA4-FTH1-mediated disturbance of iron metabolism and ferroptosis in retinal ganglion cells (RGCs) during glaucoma. The protective effect of Deferiprone on RGCs via inhibition of ferroptosis is demonstrated, providing a research direction to understand and treat glaucoma via the iron homeostasis and ferroptosis pathways.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Multidisciplinary Sciences
Hung-Ju Chen, Jowy Tani, Cindy Shin-Yi Lin, Tsui-San Chang, Yi-Chen Lin, Ting-Wei Hsu, Jia-Ying Sung
Summary: This study investigated the changes in peripheral axonal excitability in ischemic stroke patients with hemiparesis or hemiplegia. The results showed that upper motor neuron injury after stroke can alter nerve excitability in lower motor neurons, with more obvious changes in severely affected limbs. Further investigation is necessary to explore the downstream effects of upper motor neuron insult in the peripheral nerve system.
Article
Clinical Neurology
Kevin B. Koronowski, Kunjan R. Dave, Isabel Saul, Vladimir Camarena, John W. Thompson, Jake T. Neumann, Juan I. Young, Miguel A. Perez-Pinzon
Article
Multidisciplinary Sciences
Kahlilia C. Morris-Blanco, Kunjan R. Dave, Isabel Saul, Kevin B. Koronowski, Holly M. Stradecki, Miguel A. Perez-Pinzon
SCIENTIFIC REPORTS
(2016)
Article
Endocrinology & Metabolism
Charles H. Cohan, Holly M. Stradecki-Cohan, Kahlilia C. Morris-Blanco, Nathalie Khoury, Kevin B. Koronowski, Mehdi Youbi, Clinton B. Wright, Miguel A. Perez-Pinzon
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Article
Clinical Neurology
Kevin B. Koronowski, Nathalie Khoury, Isabel Saul, Zachary B. Loris, Charles H. Cohan, Holly M. Stradecki-Cohan, Kunjan R. Dave, Juan I. Young, Miguel A. Perez-Pinzon
Review
Biochemistry & Molecular Biology
Nathalie Khoury, Kevin B. Koronowski, Juan I. Young, Miguel A. Perez-Pinzon
ANTIOXIDANTS & REDOX SIGNALING
(2018)
Article
Neurosciences
Kevin B. Koronowski, Nathalie Khoury, Kahlilia C. Morris-Blanco, Holly M. Stradecki-Cohan, Timothy J. Garrett, Miguel A. Perez-Pinzon
FRONTIERS IN NEUROSCIENCE
(2018)
Review
Biophysics
John W. Thompson, Srinivasan V. Narayanan, Kevin B. Koronowski, Kahlilia Morris-Blanco, Kunjan R. Dave, Miguel A. Perez-Pinzon
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2015)
Article
Neurosciences
Nathalie Khoury, Jing Xu, Samuel D. Stegelmann, Charles W. Jackson, Kevin B. Koronowski, Kunjan R. Dave, Juan Young, Miguel A. Perez-Pinzon
MOLECULAR NEUROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Kevin B. Koronowski, Kenichiro Kinouchi, Patrick-Simon Welz, Jacob G. Smith, Valentina M. Zinna, Jiejun Shi, Muntaha Samad, Siwei Chen, Christophe N. Magnan, Jason M. Kinchen, Wei Li, Pierre Baldi, Salvador Aznar Benitah, Paolo Sassone-Corsi
Article
Multidisciplinary Sciences
Carolina Magdalen Greco, Marlene Cervantes, Jean-Michel Fustin, Kakeru Ito, Nicholas Ceglia, Muntaha Samad, Jiejun Shi, Kevin Brian Koronowski, Ignasi Forne, Suman Ranjit, Jonathan Gaucher, Kenichiro Kinouchi, Rika Kojima, Enrico Gratton, Wei Li, Pierre Baldi, Axel Imhof, Hitoshi Okamura, Paolo Sassone-Corsi
Review
Multidisciplinary Sciences
Kevin B. Koronowski, Paolo Sassone-Corsi
Summary: Circadian clocks coordinate physiology by molecular oscillators within cells, forming a system in complex organisms. Misalignment of clocks can disrupt coordination and is linked to various diseases.
Article
Multidisciplinary Sciences
Carolina M. Greco, Kevin B. Koronowski, Jacob G. Smith, Jiejun Shi, Paolo Kunderfranco, Roberta Carriero, Siwei Chen, Muntaha Samad, Patrick-Simon Welz, Valentina M. Zinna, Thomas Mortimer, Sung Kook Chun, Kohei Shimaji, Tomoki Sato, Paul Petrus, Arun Kumar, Mireia Vaca-Dempere, Oleg Deryagian, Cassandra Van, Jose Manuel Monroy Kuhn, Dominik Lutter, Marcus M. Seldin, Selma Masri, Wei Li, Pierre Baldi, Kenneth A. Dyar, Pura Munoz-Canoves, Salvador Aznar Benitah, Paolo Sassone-Corsi
Summary: The study investigated the interaction between feeding and the liver clock by reconstituting Bmal1 in hepatocytes, finding that BMAL1 and CEBPB cooperate to regulate daily liver metabolic transcriptional programs. The liver clock and feeding rhythm are sufficient to drive temporal carbohydrate homeostasis, while liver rhythms tied to redox and lipid metabolism require communication with the skeletal muscle clock, highlighting peripheral clock cross-talk.
Article
Multidisciplinary Sciences
Paul Petrus, Jacob G. Smith, Kevin B. Koronowski, Siwei Chen, Tomoki Sato, Carolina M. Greco, Thomas Mortimer, Patrick-Simon Welz, Valentina M. Zinna, Kohei Shimaji, Marlene Cervantes, Daniela Punzo, Pierre Baldi, Pura Munoz-Canoves, Paolo Sassone-Corsi, Salvador Aznar Benitah
Summary: Life on Earth relies on molecular clocks and intertissue communication to regulate circadian and metabolic rhythms, with the central clock playing a crucial role in governing metabolic rhythms.
Article
Biochemical Research Methods
Thomas Mortimer, Patrick-Simon Welz, Salvador Aznar Benitah, Paolo Sassone-Corsi, Kevin B. Koronowski
Summary: Molecular daily rhythms can be captured by precise tissue harvests from animals to identify transcriptional rhythms in the mouse liver and provide a template for similar analyses in other metabolic organs. The protocol includes steps for mouse entrainment, liver dissection, and rhythmicity analysis from total RNA sequencing data. The resulting rhythmic transcriptome serves as a starting point for defining specific biological processes undergoing daily rhythms.