Berberine attenuates pulmonary arterial hypertension via protein phosphatase 2A signaling pathway both in vivo and in vitro

Berberine Attenuates Calyculin A-Induced Cytotoxicity and Tau Hyperphosphorylation in HEK293 Cells

(2018) Guang Yu et al.   JOURNAL OF ALZHEIMERS DISEASE

Norepinephrine stimulation of alpha1D-adrenoceptor promotes proliferation of pulmonary artery smooth muscle cells via ERK-1/2 signaling

(2017) Ruxia Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Prognostic Value of Follow-Up Hemodynamic Variables After Initial Management in Pulmonary Arterial Hypertension

(2017) Jason Weatherald et al.   CIRCULATION

Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension

(2016) Laszlo Kovacs et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Beta-3 adrenergic agonists reduce pulmonary vascular resistance and improve right ventricular performance in a porcine model of chronic pulmonary hypertension

(2016) Ana García-Álvarez et al.   BASIC RESEARCH IN CARDIOLOGY

Inflammatory stimuli promote growth and invasion of pancreatic cancer cells through NF-κB pathway dependent repression of PP2Ac

(2016) Min Tao et al.   CELL CYCLE

Efficacy and Safety of Pulmonary Arterial Hypertension-specific Therapy in Pulmonary Arterial Hypertension

(2016) Huan-long Liu et al.   CHEST

Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies

(2015) Angela Pirillo et al.   ATHEROSCLEROSIS

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase

(2015) Jaya Sangodkar et al.   FEBS Journal

Pulmonary Artery Denervation Attenuates Pulmonary Arterial Remodeling in Dogs With Pulmonary Arterial Hypertension Induced by Dehydrogenized Monocrotaline

(2015) Ling Zhou et al.   JACC-Cardiovascular Interventions

Nebivolol for Improving Endothelial Dysfunction, Pulmonary Vascular Remodeling, and Right Heart Function in Pulmonary Hypertension

(2015) Frédéric Perros et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve activity following chronic intermittent hypoxia

(2014) Mikiyasu Shirai et al.   BASIC RESEARCH IN CARDIOLOGY

Advances in Therapeutic Interventions for Patients With Pulmonary Arterial Hypertension

(2014) Marc Humbert et al.   CIRCULATION

Andrographolide induces vascular smooth muscle cell apoptosis through a SHP-1-PP2A-p38MAPK-p53 cascade

(2014) Yu-Ying Chen et al.   Scientific Reports

Rapid Estrogen Receptor Signaling Mediates Estrogen-Induced Inhibition of Vascular Smooth Muscle Cell Proliferation

(2013) Kazutaka Ueda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cross talk between p38MAPK and ERK is mediated through MAPK-mediated protein phosphatase 2A catalytic subunit α and MAPK phosphatase-1 expression in human leukemia U937 cells

(2013) Wen-Hsin Liu et al.   CELLULAR SIGNALLING

Functional Class Improvement and 3-Year Survival Outcomes in Patients With Pulmonary Arterial Hypertension in the REVEAL Registry

(2013) Robyn J. Barst et al.   CHEST

Effects of β-cyclodextrin on the intestinal absorption of berberine hydrochloride, a P-glycoprotein substrate

(2013) Ye Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Pulmonary Artery Denervation to Treat Pulmonary Arterial Hypertension

(2013) Shao-Liang Chen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

New Trial Designs and Potential Therapies for Pulmonary Artery Hypertension

(2013) Mardi Gomberg-Maitland et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

New Treatment Strategies for Pulmonary Arterial Hypertension

(2013) Nazzareno Galiè et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Protein phosphatase 2A: a target for anticancer therapy

(2013) Danilo Perrotti et al.   LANCET ONCOLOGY

Percutaneous pulmonary artery denervation completely abolishes experimental pulmonary arterial hypertension in vivo

(2013) Shao-Liang Chen et al.   EuroIntervention

BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAH

(2012) Md Talat Nasim et al.   HUMAN MOLECULAR GENETICS

Molecular pathogenesis of pulmonary arterial hypertension

(2012) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

Monocrotaline-induced pulmonary arterial hypertension is attenuated by TNF-α antagonists via the suppression of TNF-α expression and NF-κB pathway in rats

(2012) Qiang Wang et al.   VASCULAR PHARMACOLOGY

PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosphorylation of IKKα and sustained activation of the NF-κB pathway

(2011) Wei Li et al.   CANCER LETTERS

Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway

(2011) Wei Li et al.   EUROPEAN JOURNAL OF CANCER

Hydroxytyrosol Induces Vascular Smooth Muscle Cells Apoptosis through NO Production and PP2A Activation with Subsequent Inactivation of Akt

(2011) Houda Zrelli et al.   PLANTA MEDICA

Prognostic Significance of Sympathetic Nervous System Activation in Pulmonary Arterial Hypertension

(2010) Agnieszka Ciarka et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era

(2010) Marc Humbert et al.   CIRCULATION

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Impaired cardiac autonomic control relates to disease severity in pulmonary hypertension

(2009) R. Wensel et al.   EUROPEAN RESPIRATORY JOURNAL

Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension

(2008) Frédéric Perros et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CPU86017 and its isomers improve hypoxic pulmonary hypertension by attenuating increased ETA receptor expression and extracellular matrix accumulation

(2008) Na Li et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY