Editorial Material
Medicine, General & Internal
David Langleben, Stylianos E. Orfanos, Benjamin D. Fox, Nathan Messas, Michele Giovinazzo, John D. Catravas
Summary: Exercise-induced increases in pulmonary blood flow can further raise pulmonary arterial pressure in patients with pulmonary arterial hypertension, due to a reduced recruitment of pulmonary capillaries. Current therapies for this condition have limited effect in lowering pulmonary arterial pressure and restoring capillary recruitment. Novel therapies with antiproliferative properties are being developed to address cellular obstruction in the arterioles and restore capillary recruitment, resulting in lower pulmonary arterial pressure during exercise testing.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Angel M. Cuesta, Eunate Gallardo-Vara, Juan Casado-Vela, Lucia Recio-Poveda, Luisa-Maria Botella, Virginia Albinana
Summary: Rare Diseases (RD), although individually may seem insignificant, collectively represent over 7000 different diseases that pose a life-threatening condition for patients. Drug repurposing, an alternative option in drug development, has been identified as a viable strategy to tackle RDs. Propranolol, initially prescribed for hypertension and other conditions, has shown promising therapeutic effects in RDs, including antiangiogenic, pro-apoptotic, vasoconstrictor, and anti-inflammatory properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Esraa Haji, Saeed Al Mahri, Yumna Aloraij, Shuja Shafi Malik, Sameer Mohammad
Summary: ADR beta(3) is a crucial receptor involved in lipid metabolism regulation, with a genetic variant W64R linked to diabetes and obesity, showing no significant functional differences compared to the wild-type counterpart.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Kazunori Omote, Hidemi Sorimachi, Masaru Obokata, Yogesh N. Reddy, Frederik H. Verbrugge, Massar Omar, Hilary M. DuBrock, Margaret M. Redfield, Barry A. Borlaug
Summary: This study aimed to characterize the pathophysiology of pulmonary vascular disease in left heart disease (PH-LHD) and found that PH-LHD patients displayed distinct features, such as poorer left atrial function and more severe right ventricular dysfunction at rest, as well as more severe impairments in cardiac output and oxygen delivery during exercise. Further study is required to identify innovative treatments for the pulmonary vasculature in PH-LHD.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Zhiyuan Ma, Gayathri Viswanathan, Mason Sellig, Chanpreet Jassal, Issac Choi, Aditi Garikipati, Xinyu Xiong, Nour Nazo, Sudarshan Rajagopal
Summary: Pulmonary arterial hypertension (PAH) is a disease characterized by abnormal pulmonary vascular remodeling, with current therapies primarily benefiting through promoting pulmonary vascular reverse remodeling and vasodilation.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Editorial Material
Hematology
John C. Wood
Summary: This study presents a 10-year follow-up of thalassemia patients with invasively documented pulmonary hypertension, revealing that pulmonary arterial hypertension (PAH) is highly lethal even with sub systemic pressures. The study also highlights the importance of echocardiography in predicting survival based on changes in predicted pulmonary artery pressure.
Article
Cardiac & Cardiovascular Systems
Ghaleb Khirfan, Manshi Li, Xiaofeng Wang, Raed A. Dweik, Gustavo A. Heresi, Adriano R. Tonelli
Summary: PVRI appears to have a stronger association than PVR with disease severity markers in PAH, but both PVR and PVRI were similarly associated with hospitalizations and survival in the overall cohort. In obese patients, PVRI was a risk factor for first PAH hospitalization, while neither PVR nor PVRI were risk factors for mortality.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Jak Grimes, Zsombor Koszegi, Yann Lanoiselee, Tamara Miljus, Shannon L. O'Brien, Tomasz M. Stepniewski, Brian Medel-Lacruz, Mithu Baidya, Maria Makarova, Ravi Mistry, Joelle Goulding, Julia Drube, Carsten Hoffmann, Dylan M. Owen, Arun K. Shukla, Jana Selent, Stephen J. Hill, Davide Calebiro
Summary: 3-arrestin plays a key role in GPCR signaling and desensitization. This study combines single-molecule microscopy and molecular dynamics simulations to investigate the interactions between 3-arrestin, receptors, and the lipid bilayer. Surprisingly, the results show that 3-arrestin spontaneously inserts into the lipid bilayer and interacts with receptors through lateral diffusion on the plasma membrane. Furthermore, the plasma membrane stabilizes 3-arrestin after receptor interaction, allowing it to separate from the activating receptor and diffuse to clathrin-coated pits. These findings provide new insights into the mechanism of 3-arrestin function at the plasma membrane.
Article
Medicine, Research & Experimental
Xiuna Sun, Erika Nakajima, Carmelissa Norbrun, Parand Sorkhdini, Alina Xiaoyu Yang, Dongqin Yang, Corey E. Ventetuolo, Julie Braza, Alexander Vang, Jason Aliotta, Debasree Banerjee, Mandy Pereira, Grayson Baird, Qing Lu, Elizabeth O. Harrington, Sharon Rounds, Chun Geun Lee, Hongwei Yao, Gaurav Choudhary, James R. Klinger, Yang Zhou
Summary: CHI3L1 is closely associated with pulmonary vascular disease, and its levels are positively correlated with the severity of PH. In mouse models, overexpression of CHI3L1 exacerbates pulmonary vascular disease, while its knockout mitigates the disease. Additionally, CHI3L1 can induce proliferation of pulmonary arterial smooth muscle cells and loss of endothelial barrier function.
Article
Biochemistry & Molecular Biology
Fabio Fonseca, Thomas M. Raffay, Kunhong Xiao, Precious J. McLaughlin, Zhaoxia Qian, Zachary W. Grimmett, Naoko Adachi, Benlian Wang, Alfred Hausladen, Brian A. Cobb, Rongli Zhang, Douglas T. Hess, Benjamin Gaston, Nevin A. Lambert, James D. Reynolds, Richard T. Premont, Jonathan S. Stamler
Summary: S-Nitrosylation is a central mechanism in β(2)-adrenergic receptor signaling, essential for both classic desensitization by PKA and NO-based signaling that mediates bronchorelaxation. Mutant β(2)AR refractory to S-nitrosylation amplifies NO-based signaling, leading to resistance to bronchoconstriction and asthma development.
Article
Agriculture, Dairy & Animal Science
Jinhee H. Hwang, John C. Kube, Stephen B. Smith
Summary: The study demonstrated that lubabegron fumarate acts as an antagonist to beta-adrenergic receptor subtypes in subcutaneous adipocytes and exhibits different responses to beta-AA and LUB in subcutaneous and intramuscular adipocytes.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Qingtong Wang, Ying Wang, Toni M. West, Yongming Liu, Gopireddy R. Reddy, Federica Barbagallo, Bing Xu, Qian Shi, Bingqing Deng, Wei Wei, Yang K. Xiang
Summary: By studying the molecular signaling and positive cardiac contractility induced by beta-blockers in the heart, it was found that carvedilol can promote cardiac inotropy and have a protective effect in diabetic mice. The observations suggest a novel beta(1)AR-NOS3 signaling pathway that may be targeted in therapy for heart diseases with reduced ejection fraction.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Qingtong Wang, Ying Wang, Toni M. West, Yongming Liu, Gopireddy R. Reddy, Federica Barbagallo, Bing Xu, Qian Shi, Bingqing Deng, Wei Wei, Yang K. Xiang
Summary: The study investigated the molecular signaling and effects of beta-blockers on cardiac inotropy in animal hearts. The results showed that carvedilol, a beta-blocker, can promote cardiac contractility through a specific signaling pathway, restoring heart function in diabetic mice and reducing cell apoptosis and hypertrophy in diabetic hearts.
CARDIOVASCULAR RESEARCH
(2021)
Review
Medicine, Research & Experimental
Ailin Yang, Ganggang Yu, Yanjun Wu, Haoyan Wang
Summary: Beta-2 adrenergic receptors play crucial roles in the pathogenesis and treatment of COPD. Progress has been made in studying these receptors, and drugs targeting beta 2-AR are rapidly being developed, which are expected to improve symptoms and prognosis for COPD patients.
Review
Health Care Sciences & Services
Zhuangzhuang Jia, Shuai Wang, Haifeng Yan, Yawen Cao, Xuan Zhang, Lin Wang, Zeyu Zhang, Shanshan Lin, Xianliang Wang, Jingyuan Mao
Summary: Pulmonary vascular remodeling, involving changes in the intima, media and adventitia, is a critical structural alteration and pathological feature in pulmonary hypertension. It includes the proliferation and phenotypic transformation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs), as well as interactions with pulmonary artery fibroblasts (PAFs) and extracellular matrix (ECM). Inflammatory mechanisms, apoptosis, and other factors are influenced by different mechanisms that contribute to disease progression. This article reviews these pathological changes and discusses the underlying mechanisms in the remodeling process.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Emiliano A. Rodriguez-Caulo, Oscar R. Blanco-Herrera, Elisabet Berastegui, Javier Arias-Dachary, Souhayla Souaf-Khalafi, Gertrudis Parody-Cuerda, Gregorio Laguna
Summary: This study compared the long-term outcomes of biological and mechanical prostheses for aortic valve replacement in patients aged 50 to 65. The results showed no significant difference in long-term survival between the two groups, but patients with mechanical prostheses had a higher risk of major bleeding while those with biological prostheses had a higher reoperation rate. Therefore, for patients in this age group in Spain, biological prostheses may be a reasonable choice.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea Perrotti, Alessandra Francica, Francesco Monaco, Edward Quintana, Sandro Sponga, Zein El-Dean, Stefano Salizzoni, Tommaso Loizzo, Antonio Salsano, Alessandro Di Cesare, Filippo Benassi, Manuel Castella, Mauro Rinaldi, Sidney Chocron, Igor Vendramin, Giuseppe Faggian, Francesco Santini, Francesco Nicolini, Aldo Domenico Milano, Vito Giovanni Ruggieri, Francesco Onorati
Summary: This study compared quality of life (QoL) after full sternotomy aortic valve replacement (fsAVR) and ministernotomy AVR (msAVR) and found no significant differences in patient baseline characteristics, hospital outcomes, and improvements in physical and mental health between the two surgical approaches over a one-year period.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Shantanu P. Sengupta, Bernard Prendergast, Cecile Laroche, Shumaila Furnaz, Ricardo Ronderos, Abdallah Almaghraby, Federico M. Asch, Kamila Blechova, Hosam Zaky, Jacob Strahilevitz, Rafal Dworakowski, Yoko Miyasaka, Igal Sebag, Chisato Izumi, Olivier Axler, Abdulrahman Jamiel, Mary Philip, Marcelo Luiz Campos Vieira, Patrizio Lancellotti, Gilbert Habib
Summary: Socioeconomic factors influence the clinical profile of patients presenting with infective endocarditis (IE) worldwide. Patients from lower-middle income countries are younger and have a higher risk of complications and mortality, associated with delayed diagnosis and lower use of surgery, compared to patients from high-income and upper-middle income countries.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Luis Ortega-Paz, Helena Cristobal, Jose Tomas Ortiz-Perez, Pablo Garcia de Frutos, Guiomar Mendieta, Elena Sandoval, Juan Jose Rodriguez, Emilio Ortega, Ana Garcia-Alvarez, Salvatore Brugaletta, Manel Sabate, Ana Paula Dantas
Summary: In-vitro experiments on myocardial fibroblasts from patients with HFrEF found that Dapagliflozin alone dose-dependently slowed migration of the fibroblasts, and the combination of Dapagliflozin + LCZ696 further reduced migration rate, while Dapagliflozin + spironolactone altered the effects of SGLT2i on biomarkers.
Review
Pharmacology & Pharmacy
Raquel Toribio-Fernandez, Carlos Ceron, Catarina Tristao-Pereira, Irene Fernandez-Nueda, Ana Perez-Castillo, Jose Fernandez-Ferro, Maria Angeles Moro, Borja Ibanez, Valentin Fuster, Marta Cortes-Canteli
Summary: Alzheimer's disease (AD) and cardiovascular disease (CVD) are strongly associated, with similar risk factors and vascular components. Clinical studies suggest that anticoagulants, particularly direct oral anticoagulants, may decrease the incidence of dementia in patients with CVD. However, more research is needed to understand the differential effects on different types of dementia and determine the best drug and strategy for prevention and treatment of AD.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
J. J. Coughlan, Borja Ibanez
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Javier Urmeneta Ulloa, Vicente Martinez de Vega, Ana Alvarez Vazquez, Cristina Andreu-Vazquez, Israel John Thuissard-Vasallo, Manuel Recio Rodriguez, Gonzalo Pizarro, Jose Angel Cabrera
Summary: This study aimed to explore the correlation between left ventricular (LV) myocardial feature tracking (FT) and deep learning-based strain (DLS) analysis in the diagnostic (CMRd) and follow-up (CMRf) cardiac magnetic resonance imaging of patients with acute myocarditis. The study included 17 patients with acute myocarditis and 20 healthy controls. Significant decreases in FTc (-16.1 +/- 2.2% vs. -18.9 +/- 1.9%, p = 0.001) and DLSc (-38.1 +/- 5.2% vs. -41.3 +/- 4.5%, p = 0.015) were observed in the patients with acute myocarditis. There was a correlation between LV DLSc/FTc and LV ejection fraction (LVEF).
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ines Garcia-Lunar, Borja Ibanez, Valentin Fuster
Summary: This commentary discusses the effects of a comprehensive lifestyle intervention on cardiovascular health in the TANSNIPPESA trial, and also refers to the discussion piece by Naslund et al. which suggests that the trial is not the end of the story.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Ascaso, Elena Sandoval, Anna Muro, Clemente Barriuso, Eduard Quintana, Jorge Alcocer, Marta Sitges, Barbara Vidal, Jose-Luis Pomar, Manuel Castella, Ana Garcia-Alvarez, Daniel Pereda
Summary: This study compares the outcomes of thoracoscopic and conventional surgery for repair of leaflet prolapse in patients with severe mitral regurgitation. The results show that the thoracoscopic group had shorter mechanical ventilation, shorter ICU stay, and higher postoperative hemoglobin levels compared to the conventional group. There were no differences in mortality, repair failures, and reinterventions between the two groups.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Medicine, General & Internal
Manuel Lopez-Baamonde, Maria Jose Arguis, Ricard Navarro-Ripoll, Elena Gimeno-Santos, Barbara Romano-Andrioni, Marina Siso, Silvia Teres-Belles, Antonio Lopez-Hernandez, Adria Burniol-Garcia, Marta Farrero, Raquel Sebio-Garcia, Elena Sandoval, Maria Sanz-de la Garza, Julian Librero, Ana Garcia-Alvarez, Maria Angeles Castel, Graciela Martinez-Palli
Summary: This study aimed to investigate the impact of prehabilitation on the postoperative outcomes of heart transplantation and its cost-effectiveness. The results showed that prehabilitation significantly improved patients' preoperative functional capacity and quality of life, while reducing the rate and severity of postoperative complications, mechanical ventilation time, ICU stay, total hospitalization stay, and the need for transfer to nursing/rehabilitation facilities after discharge. Cost-consequence analysis demonstrated that prehabilitation did not increase the total surgical process costs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Helena Cristobal, Cristina Enjuanes, Montserrat Batlle, Marta Tajes, Begona Campos, Josep Francesch, Pedro Moliner, Marta Farrero, Rut Andrea, Jose Tomas Ortiz-Perez, Albert Morales, Manel Sabate, Josep Comin-Colet, Pablo Garcia de Frutos
Summary: Heart failure (HF) is classified based on left ventricular ejection fraction (EF) into HF with reduced, mildly reduced, and preserved EF. Biomarkers may differ depending on EF type. This study analyzed the levels of soluble form of the AXL receptor tyrosine kinase (sAXL) in HF patients with reduced and preserved EF. The results showed that sAXL levels were a reliable predictor for all-cause and cardiovascular mortality only in the HFpEF cohort.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
John Louca, Marco Ochsner, Ashish Shah, Jordan Hoffman, Francisco Gonzalez Vilchez, Iris Garrido, Mario Royo-Villanova, Beatriz Dominguez-Gil, Deane Smith, Leslie James, Nader Moazami, Filip Rega, Janne Brouckaert, Johan Van Cleemput, Katrien Vandendriessche, Vincent Tchana-Sato, Diawara Bandiougou, Marian Urban, Alex Manara, Marius Berman, Simon Messer, Stephen Large
Summary: Heart transplantation is an effective treatment for severe heart failure, but the availability of donor organs is limited. The reintroduction of heart donation after circulatory death in 2014 has increased transplant activity by 30%. The use of thoraco-abdominal normothermic regional perfusion (taNRP) allows for successful transplantation of DCD donor hearts.
Letter
Cardiac & Cardiovascular Systems
Fernando Alfonso, Ricardo Sanz-Ruiz, Manel Sabate, Gerard Roura, Maite Velazquez, Fernando Macaya, Gabriela Veiga, Santiago Camacho-Freire, Teresa Bastante, Marcos Garcia-Guimaraes
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Urology & Nephrology
Victor Duque-Santana, Ana Diaz-Gavela, Manuel Recio, Luis Leonardo Guerrero, Marina Pena, Sofia Sanchez, Fernando Lopez-Campos, Israel J. Thuissard, Cristina Andreu, David Sanz-Rosa, Verane Achard, Alfonso Gomez-Iturriaga, Yolanda Molina, Elia Del Cerro Penalver, Felipe Counago
Summary: This study analyzes the long-term survival outcomes of localized prostate adenocarcinoma patients treated with radiotherapy and androgen deprivation therapy. The results show that multiparametric magnetic resonance imaging is a key tool in diagnosing and establishing risk groups for these patients, leading to optimized treatment.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Anton Tomsic, Elena Sandoval, Maria C. Meucci, Takeru Nabeta, Manuel Castella, Anna Muro, Robert J. M. Klautz, Nina Ajmone Marsan, Daniel Pereda, Meindert Palmen
Summary: This study aims to compare the impact of partial band annuloplasty and full ring repair on post-repair mitral valve diastolic performance. The results show that partial band annuloplasty can improve haemodynamic profile immediately after surgery, but the effect is short-lived.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)