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Maurizio Forte, Simona Marchitti, Flavio Di Nonno, Rosita Stanzione, Leonardo Schirone, Maria Cotugno, Franca Bianchi, Sonia Schiavon, Salvatore Raffa, Danilo Ranieri, Salvatore Fioriniello, Floriana Della Ragione, Maria Rosaria Torrisi, Roberto Carnevale, Valentina Valenti, Francesco Versaci, Giacomo Frati, Carmine Vecchione, Massimo Volpe, Speranza Rubattu, Sebastiano Sciarretta
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Cell Biology
Markus Hahn, Ulrike M. Stamer, Markus M. Luedi, Malte Book, Heinz U. Rieder, Frank Stueber
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Jing Li, Jinhua Zhu, Qiu Zhang, Linan Chen, Shengqi Ma, Ying Lu, Bin Shen, Rongyan Zhang, Mingzhi Zhang, Yan He, Lei Wu, Hao Peng
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Cardiac & Cardiovascular Systems
Linan Chen, Jing Li, Min Zhang, Qiu Zhang, Lei Wu, Ying Lu, Yan He, Jun Jiang, Xiaolong Zhang, Jianwei Hu, Yi Ding, Mingzhi Zhang, Hao Peng
Summary: This study found that increased proANP and hypomethylation at the NPPA promoter were associated with an increased risk of cardiovascular disease (CVD) in Chinese adults. Higher levels of serum proANP were associated with a higher risk of CVD during the follow-up period, while lower DNA methylation at CpG3 of the NPPA promoter was associated with a lower risk of CVD. These findings suggest that aberrant DNA methylation of the NPPA gene may contribute to the mechanisms of CVD.
Review
Endocrinology & Metabolism
Patrycja Straczynska, Krzysztof Papis, Emilia Morawiec, Michal Czerwinski, Zdzislaw Gajewski, Anita Olejek, Anna Bednarska-Czerwinska
Summary: In vitro fertilization (IVF) is an effective method for treating infertility. In vitro maturation (IVM) of oocytes can be an alternative to ovarian hyperstimulation. The development of the embryo depends on the maturity of the oocyte. The microenvironment of the ovarian follicle and maternal signals play a role in the growth and maturation of the oocyte.
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Cell Biology
Li Ang, Cao Haixia, Li Hongxia, Li Ruijiao, Guo Xingping, Wang Huaixiu
Summary: The results of the study showed that supplementation of CNP during in vitro culture benefited the development of murine preantral follicles, allowing them to reach the antral stage and maintaining good developmental competence of oocytes.
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Cell Biology
Li Ang, Guo Xingping, Cao Haixia, Wang Zhulin, Wang Huaixiu
Summary: In this study, the developmental competency of murine ovarian follicles cultured in vitro was enhanced by supplementing C-type natriuretic peptide (CNP) in the culture system. The results showed that CNP supplementation improved oocyte maturity and potentially maintained the three-dimensional structure of the follicles.
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Xiaoqiong Hao, Yakun Wang, Nana Kong, Yu Zhang, Yu Zhao, Guoliang Xia, Meijia Zhang
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Lizhao Feng, Yijing Wang, Han Cai, Guanghong Sun, Wanbao Niu, Qiliang Xin, Xiaofang Tang, Jiawei Zhang, Chao Wang, Hua Zhang, Guoliang Xia
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Biochemistry & Molecular Biology
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Multidisciplinary Sciences
Lihua Zhao, Xinhua Du, Kun Huang, Tuo Zhang, Zhen Teng, Wanbao Niu, Chao Wang, Guoliang Xia
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Cell Biology
Yu Zhao, Yu Zhang, Jia Li, Nana Zheng, Xiaoting Xu, Jing Yang, Guoliang Xia, Meijia Zhang
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Multidisciplinary Sciences
Nana Kong, Xiaoting Xu, Yu Zhang, Yakun Wang, Xiaoqiong Hao, Yu Zhao, Jie Qiao, Guoliang Xia, Meijia Zhang
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Biochemistry & Molecular Biology
Yu Zhang, Jian Yang, Jing Yang, Jia Li, Meijia Zhang
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Cell Biology
Jia Li, Yu Zhang, Nana Zheng, Biao Li, Jing Yang, Chunyu Zhang, Guoliang Xia, Meijia Zhang
HISTOCHEMISTRY AND CELL BIOLOGY
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Cell Biology
Feifei Yuan, Zhijuan Wang, Yanli Sun, Hongwei Wei, Yanying Cui, Zhanying Wu, Chunyu Zhang, Ke-Ping Xie, Fengchao Wang, Meijia Zhang
Summary: Deletion of SGPL1 leads to accumulation of S1P in the gonads, affecting the development of female and male germ cells through different signaling pathways. In the ovary, S1P inhibits granulosa cell activity and early follicle growth, while in the testis, it induces Leydig cell apoptosis and spermatogenesis arrest.
CELL DEATH & DISEASE
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Cell Biology
Xiaodan Zhang, Wenbo Zhang, Zhijuan Wang, Nana Zheng, Feifei Yuan, Biao Li, Xuelan Li, Ling Deng, Min Lin, Xin Chen, Meijia Zhang
Summary: Enhanced glycolysis in granulosa cells promotes the activation of primordial follicles through mTOR signaling.
CELL DEATH & DISEASE
(2022)
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Reproductive Biology
Biao Li, Weiyong Wang, Yingying Huang, Lincheng Han, Jia Li, Nana Zheng, Zhanying Wu, Xiaodan Zhang, Xuelan Li, Ling Deng, Min Lin, Xin Chen, Meijia Zhang
Summary: This study found that lithium can promote the activation of primordial follicles in mice and humans through the PI3K/Akt signaling pathway. Lithium achieves its promotion effect by promoting pre-granulosa cell proliferation and increasing phosphorylated Akt levels. These results are of great significance for the development of new drugs for the treatment of POI.
BIOLOGY OF REPRODUCTION
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Biochemistry & Molecular Biology
Xiaoqiong Hao, Feifei Yuan, Yanying Cui, Meijia Zhang
Summary: TGFB2 is involved in cumulus expansion through TGFBR-SMAD2/3 signaling and participates in the expression of expansion-related genes.
MOLECULAR REPRODUCTION AND DEVELOPMENT
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Biology
Zhijuan Wang, Hongwei Wei, Zhanying Wu, Xiaodan Zhang, Yanli Sun, Longwei Gao, Wenqing Zhang, You-Qiang Su, Meijia Zhang
Summary: This study reveals the molecular mechanism of the movement of mouse spermatozoa out of the isthmic reservoir in preparation for fertilization. It involves the expression of TGFB1, NPPC, and TGF-beta signaling in cumulus cells and ampullary epithelial cells. Oocyte-dependent and cumulus cell-derived TGFB1 plays a critical role in promoting sperm migration in the oviduct and subsequent fertilization.
COMMUNICATIONS BIOLOGY
(2022)
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Biochemistry & Molecular Biology
Zhanying Wu, Biao Li, Kaiwei Yu, Nana Zheng, Feifei Yuan, Jingjing Miao, Meijia Zhang, Zhijuan Wang
Summary: Porcine spermatozoa are stored in the oviductal isthmus after natural mating, and the number of spermatozoa is increased in the oviductal ampulla when the mature cumulus-oocyte complexes (COCs) are transferred into the ampulla. The study found that natriuretic peptide type C (NPPC) and its receptor natriuretic peptide receptor 2 (NPR2) play a role in sperm release from oviduct istsmic cells. The mature COCs promote NPPC expression in the ampulla through TGF-beta signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)