Article
Environmental Sciences
Yong Cai, Zhaoying Sheng, Jiying Wang
Summary: Xanthorrhizol, a sesquiterpenoid agent isolated from Curcuma xanthorrhiza, has shown anti-cancer properties by inducing oxidative stress, altering mitochondrial membrane potential, and modulating apoptotic signaling events in non-small cell lung carcinoma cells.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zengxin Jiang, Guobin Qi, Wei Lu, Hao Wang, Defang Li, Weibin Chen, Lei Ding, Xiuying Yang, Hengfeng Yuan, Qingmin Zeng
Summary: This study found that omaveloxolone exerts antioxidative, anti-inflammatory, antiapoptotic and anti-ECM degradation effects via activation of the Nrf2/ARE signaling pathway and inhibition of the NF-kappa B signaling pathway in chondrocytes in vitro and attenuates osteoarthritis progression in vivo, suggesting its potential as a therapeutic agent for OA.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Maojian Chen, Chanchan Xiao, Wei Jiang, Weiping Yang, Qinghong Qin, Qixing Tan, Bin Lian, Zhijie Liang, Changyuan Wei
Summary: Capsaicin from hot peppers has shown anti-cancer effects against breast cancer by inhibiting proliferation and inducing apoptosis, potentially through down-regulation of FBI-1-mediated NF-kappa B pathway. Overexpression of FBI-1 attenuated capsaicin's effects, while silencing FBI-1 reversed them. This suggests that targeting FBI-1 with capsaicin could be a promising therapeutic strategy for breast cancer patients.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Immunology
Yunfei Wang, Kaikai Yi, Xing Liu, Yanli Tan, Weili Jin, Yansheng Li, Junhu Zhou, Hongjun Wang, Chunsheng Kang
Summary: HOTAIR activates NF-kappa B pathway in glioma cells, promoting inflammatory signaling and immune escape.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Yumei Cao, Su'an Tang, Xiaoyu Nie, Zuoqing Zhou, Guangfeng Ruan, Weiyu Han, Zhaohua Zhu, Changhai Ding
Summary: The study identified miR-214-3p as a key regulator in osteoarthritis, impacting ECM metabolism and cell apoptosis in cartilage by modulating the NF-kappa B signaling pathway. Targeting IKKP, decreased miR-214-3p exacerbates OA development, suggesting it as a potential novel therapeutic target for OA.
Article
Endocrinology & Metabolism
Ruidong Liu, Xiaoli Wang, Guoliang Ma, Yuanhao Zhao, Jiude Qi, Yuguo Ren
Summary: The purpose of this study is to investigate the role of RhoB in cell growth and apoptosis in osteosarcoma. The results showed that overexpression of RhoB significantly inhibited proliferation and promoted apoptosis in MG63 and HOS cells. In vivo experiments also demonstrated that RhoB overexpression blocked tumor growth and lung metastasis. Additionally, RhoB overexpression decreased the phosphorylation of AKT and PI3K.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Immunology
Zhangping He, Jian Xiao, Jianye Wang, Simin Lu, Kang Zheng, Maoying Yu, Jie Liu, Chuan Wang, Nan Ding, Mingxing Liang, Yimou Wu
Summary: CPSIT_0556 inhibits hPMN apoptosis through the PI3K/Akt and NF-kappa B signaling pathways by releasing IL-8, delaying procaspase-3 processing, and regulating the expression of apoptosis-related proteins, providing new insights into the molecular pathogenesis and immune escape mechanisms of C. psittaci.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Jinwang Ye, Suyue Zhong, Yunsong Deng, Xuanbao Yao, Qiong Liu, Jian-Zhi Wang, Shifeng Xiao
Summary: Class IIa histone deacetylases (HDAC) play a role in inflammation by promoting IKK activation and subsequent NF-kappa B activation. In this study, HDAC7 was found to be elevated in astrocytes after LPS challenge, leading to NF-kappa B activation, pro-inflammatory gene upregulation, and anxiety-like behaviors. Inhibition of HDAC7 attenuated LPS-induced inflammation and anxiety-like behaviors.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Genetics & Heredity
Qian Yang, Shan Tian, Zhengru Liu, Weiguo Dong
Summary: This study revealed that RIPK2 is overexpressed in gastric cancer and downregulating RIPK2 in GC cells can suppress cell growth, migration, and induce apoptosis through the NF-κB signaling pathway. RIPK2 functions as a potential oncogene in modulating GC cell proliferation, migration, and apoptosis. These findings suggest that RIPK2 could serve as a candidate biomarker, diagnostic tool, and therapeutic target for GC.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, Research & Experimental
Mao-xu Ge, Yi-kang Shi, Dong Liu
Summary: As a critical E3 ubiquitin ligase, TRIM25 is involved in glioma progression and immune regulation, playing a potential therapeutic role in gliomas.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Virology
Andrew J. McNamara, Austin D. Brooks, Pranav Danthi
Summary: This study reveals that mammalian reovirus can block the function of NF-κB, an important protein family for the host cell's response to viral infection, through the expression of a viral protein called sigma 3. The expression of sigma 3 diminishes the host's response to infection and promotes viral replication. The differences in NF-κB target gene expression following infection with different reovirus strains are controlled by polymorphisms in the amino acid sequence of sigma 3.
JOURNAL OF VIROLOGY
(2022)
Article
Cell Biology
Dong Huang, Yanlin Guo, Xinxin Li, Mingzhu Pan, Jiahuan Liu, Wenbing Zhang, Kangsen Mai
Summary: This study investigates the role of vitamin D-3 and its receptor VDR in regulating the NF-kappa B pathway in mollusks, specifically in abalone. The results show that VDR knockdown leads to increased NF-kappa B signaling, apoptosis, and autophagy. Furthermore, the combination of vitamin D-3 and VDR is crucial for maintaining a delicate balance between autophagy and apoptosis in response to inflammation.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Oncology
Yu-Chang Liu, Bo-Han Huang, Jing-Gung Chung, Wei-Lin Liu, Fei-Ting Hsu, Song-Shei Lin
Summary: Lenvatinib suppresses the activation of AKT/NF-κB signaling in NSCLC cells, induces apoptosis, and inhibits cell migration and invasion potential.
ANTICANCER RESEARCH
(2021)
Article
Immunology
Tai-Wei Li, Adam D. D. Kenney, Jun-Gyu Park, Guillaume N. N. Fiches, Helu Liu, Dawei Zhou, Ayan Biswas, Weiqiang Zhao, Jianwen Que, Netty Santoso, Luis Martinez-Sobrido, Jacob S. Yount, Jian Zhu
Summary: This study reveals a novel role of SARS-CoV-2 Nsp14 in inducing NF-kappa B activation through IMPDH2, contributing to viral infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Hong Du, Hui Zhang, Rong Yang, Li Qiao, Huiyu Shao, Xiaolin Zhang
Summary: The study revealed that PVT1 is highly expressed in atherosclerosis, and silencing PVT1 can inhibit the development of AS by reducing serum lipid levels and inflammatory factors, decreasing plaque formation, and suppressing cell proliferation.